{"id":48596,"date":"2024-04-17T11:46:53","date_gmt":"2024-04-17T18:46:53","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=48596"},"modified":"2024-04-17T20:07:30","modified_gmt":"2024-04-18T03:07:30","slug":"protecting-brain-cells-with-cannabinol","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/protecting-brain-cells-with-cannabinol\/","title":{"rendered":"Protegiendo las c\u00e9lulas cerebrales con cannabinol"},"content":{"rendered":"

LA JOLLA\u2014Uno de cada 10 individuos mayores de 65 a\u00f1os desarrolla un trastorno neurol\u00f3gico relacionado con la edad, como el Alzheimer o el Parkinson, pero las opciones de tratamiento siguen siendo escasas para esta poblaci\u00f3n. Los cient\u00edficos han comenzado a explorar si los cannabinoides \u2014compuestos derivados de la planta de cannabis, como el conocido THC (tetrahidrocannabinol) y el CBD (cannabidiol)\u2014 podr\u00edan ofrecer una soluci\u00f3n. Un tercer cannabinoide, menos conocido, llamado CBN (cannabinol), ha despertado recientemente el inter\u00e9s de los investigadores, quienes han empezado a explorar el potencial cl\u00ednico de esta sustancia m\u00e1s suave y menos psicoactiva. \r\n<\/p>\r\n

\"The<\/a>
El contorno de una persona y su cerebro frente a una hoja de cannabis y una pastilla simb\u00f3lica de CBN, demostrando el potencial del CBN para tratar trastornos neurol\u00f3gicos en el futuro.
\r\nHaga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\r\n

\r\nEn un nuevo estudio, cient\u00edficos del Instituto Salk ayudan a explicar c\u00f3mo el CBN protege al cerebro contra el envejecimiento y la neurodegeneraci\u00f3n, y luego utilizan sus hallazgos para desarrollar posibles terapias. Los investigadores crearon cuatro compuestos inspirados en el CBN que fueron m\u00e1s neuroprotectores que la mol\u00e9cula de CBN est\u00e1ndar, uno de los cuales fue muy eficaz en el tratamiento de lesiones cerebrales traum\u00e1ticas en un modelo de mosca de la fruta Drosophila.\r\n<\/p>

\r\nLos hallazgos, publicados en Biolog\u00eda Redox<\/em><\/a> El 29 de marzo de 2024, se sugiri\u00f3 la promesa del CBN en el tratamiento de trastornos neurol\u00f3gicos como el traumatismo craneoencef\u00e1lico, la enfermedad de Alzheimer y la enfermedad de Parkinson, y tambi\u00e9n se destac\u00f3 c\u00f3mo estudios adicionales de los efectos del CBN en el cerebro podr\u00edan inspirar el desarrollo de nuevas terapias para uso cl\u00ednico.\r\n<\/p>

\r\n\u201cNo solo el CBN tiene propiedades neuroprotectoras, sino que sus derivados tienen el potencial de convertirse en nuevas terapias para diversos trastornos neurol\u00f3gicos\u201d, afirma el Profesor de Investigaci\u00f3n. Pamela Maher<\/a>, autor principal del estudio. \u201cPudimos identificar los grupos activos en el CBN que est\u00e1n realizando esa neuroprotecci\u00f3n, luego mejorarlos para crear compuestos derivados que tengan una mayor capacidad neuroprotectora y una eficacia similar a la de los medicamentos\u201d.\u201d\r\n<\/p>\r\n

Muchos trastornos neurol\u00f3gicos implican la muerte de c\u00e9lulas cerebrales llamadas neuronas, debido a la disfunci\u00f3n de sus mitocondrias productoras de energ\u00eda. El CBN logra su efecto neuroprotector al prevenir esta disfunci\u00f3n mitocondrial, pero c\u00f3mo exactamente el CBN hace esto, y si los cient\u00edficos pueden mejorar las habilidades neuroprotectoras del CBN, ha permanecido sin aclararse. \r\n<\/p>\r\n\r\n

\"Pamela<\/a>
De izquierda a derecha: Pamela Maher y Zhibin Liang.
\r\nHaga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>

\r\nEl equipo de Salk encontr\u00f3 previamente que el CBN estaba modulando m\u00faltiples caracter\u00edsticas de la funci\u00f3n mitocondrial para proteger las neuronas contra una forma de muerte celular llamada oxitosis\/feroptosis. Despu\u00e9s de descubrir este mecanismo de actividad neuroprotectora del CBN, comenzaron a aplicar m\u00e9todos acad\u00e9micos e industriales de descubrimiento de f\u00e1rmacos para caracterizar a\u00fan m\u00e1s e intentar mejorar esa actividad. \r\n<\/p>

\r\nPrimero, descompusieron el CBN en peque\u00f1os fragmentos y observaron cu\u00e1les de esos fragmentos eran los neuroprotectores m\u00e1s efectivos, analizando qu\u00edmicamente las propiedades del fragmento. Segundo, dise\u00f1aron y construyeron cuatro an\u00e1logos de CBN novedosos \u2014imitaciones qu\u00edmicas\u2014 en los que se amplificaron esos fragmentos, y luego los trasladaron a la detecci\u00f3n de f\u00e1rmacos.\r\n<\/p>

\r\n\u201cBusc\u00e1bamos an\u00e1logos de CBN que pudieran entrar al cerebro de manera m\u00e1s eficiente, actuar m\u00e1s r\u00e1pido y producir un efecto neuroprotector m\u00e1s fuerte que el propio CBN\u201d, dice Zhibin Liang, primer autor e investigador postdoctoral en el laboratorio de Maher. \u201cLos cuatro an\u00e1logos de CBN en los que nos detuvimos ten\u00edan propiedades qu\u00edmicas medicinales mejoradas, lo cual fue emocionante y muy importante para nuestro objetivo de usarlos como terap\u00e9uticos\u201d.\u201d\r\n<\/p>

\r\nPara probar las propiedades medicinales qu\u00edmicas de los cuatro an\u00e1logos de CBN, el equipo los aplic\u00f3 a cultivos de c\u00e9lulas nerviosas de rat\u00f3n y humanas. Cuando iniciaron la oxitosis\/feroptosis de tres maneras diferentes, descubrieron que cada uno de los cuatro an\u00e1logos pudo 1) proteger a las c\u00e9lulas de la muerte y 2) tuvo habilidades neuroprotectoras similares en comparaci\u00f3n con el CBN regular.\r\n<\/p>\r\n

\"Mouse<\/a>
Cultivo de c\u00e9lulas neuronales de rat\u00f3n con mitocondrias (rojo) y n\u00facleos (azul).
\r\nHaga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\r\n

\r\nLos an\u00e1logos exitosos fueron puestos a prueba en un modelo de mosca de la fruta Drosophila de lesi\u00f3n cerebral traum\u00e1tica. Uno de los an\u00e1logos, CP1, fue especialmente efectivo en el tratamiento de la lesi\u00f3n cerebral traum\u00e1tica, produciendo la mayor tasa de supervivencia despu\u00e9s del inicio de la condici\u00f3n.\r\n<\/p>

\r\n\u201cNuestros hallazgos ayudan a demostrar el potencial terap\u00e9utico del CBN, as\u00ed como la oportunidad cient\u00edfica que tenemos de replicar y refinar sus propiedades similares a las de un f\u00e1rmaco\u201d, dice Maher. \u201c\u00bfPodr\u00edamos alg\u00fan d\u00eda administrar este an\u00e1logo de CBN a jugadores de f\u00fatbol el d\u00eda antes de un partido importante, o a sobrevivientes de accidentes automovil\u00edsticos al llegar al hospital? Estamos emocionados de ver cu\u00e1n efectivos podr\u00edan ser estos compuestos para proteger el cerebro de da\u00f1os mayores\u201d.\u201d\r\n<\/p>

\r\nEn el futuro, los investigadores continuar\u00e1n evaluando y caracterizando estos an\u00e1logos de CBN y refinando sus dise\u00f1os qu\u00edmicos. Tambi\u00e9n comenzar\u00e1n a examinar m\u00e1s de cerca la neurodegeneraci\u00f3n relacionada con la edad y los cambios en las c\u00e9lulas cerebrales, particularmente en las mitocondrias, y se preguntar\u00e1n c\u00f3mo podemos adaptar mejor estos compuestos similares a f\u00e1rmacos para promover la salud celular y prevenir la disfunci\u00f3n neuronal con la edad.\r\n<\/p>

\r\nOtros autores incluyen a David Soriano-Castell y Wolfgang Fischer del Salk; y a Alec Candib y Kim Finley del Shiley Bioscience Center de la Universidad Estatal de San Diego.\r\n<\/p>

\r\nEl trabajo fue apoyado por el Paul F. Glenn Center for Biology of Aging Research del Salk Institute, la Bundy Foundation, la Shiley Foundation, los National Institutes of Health (R01AG067331, R21AG064287, R01AG069206, RF1AG061296, R21AG067334, NCI CCSG P30CA01495, NIA P30AG068635, S10OD021815) y el Helmsley Center for Genomic Medicine.\r\n<\/p>","protected":false},"featured_media":48609,"template":"","faculty":[410],"disease-research":[127,146,124],"class_list":["post-48596","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-pamela-maher","disease-research-alzheimers-disease","disease-research-aging-and-regenerative-medicine","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nProtecting brain cells with cannabinol - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/protecting-brain-cells-with-cannabinol\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Protecting brain cells with cannabinol - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014One in every 10 individuals above the age of 65 develops an age-related neurological disorder like Alzheimer\u2019s or Parkinson\u2019s, yet treatment options remain sparse for this population. 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