{"id":37390,"date":"2023-01-03T00:00:01","date_gmt":"2023-01-03T08:00:01","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=37390"},"modified":"2024-01-30T14:18:47","modified_gmt":"2024-01-30T22:18:47","slug":"microprotein-increases-appetite-in-mice","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/microprotein-increases-appetite-in-mice\/","title":{"rendered":"Microprotein increases appetite in mice"},"content":{"rendered":"

LA JOLLA\u2014Obesity and metabolic diseases, such as diabetes, are extremely common in the United States. Tiny proteins called microproteins have long been overlooked in research, but new evidence demonstrates that they have an important role in metabolism. Salk scientists have discovered that both brown and white fat is filled with thousands of previously unknown microproteins, and show that one of these microproteins, called Gm8773, can increase appetite in mice.<\/p>\n

These findings, published in Metabolismo celular<\/em><\/a> on January 3, 2023, could lead to the development of a therapeutic to help people gain weight in certain disease situations, such as during chemotherapy for cancer. Furthermore, by establishing the existence of these microproteins, the team provides a valuable resource for the scientific community to study microproteins as well.<\/p>\n

\"From
De izquierda a derecha: Alan Saghatelian y Thomas Martinez
Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Credit: From left: Salk Institute and Steve Zylius from UC Irvine<\/figcaption><\/figure>\n

\u201cIt is vital to better understand the processes that regulate obesity and metabolic health in order to provide improved therapies for the future,\u201d says Salk Professor\u00a0Alan Saghatelian<\/a>, co-corresponding author of the study and holder of the Dr. Frederik Paulsen Chair. \u201cHaving this list of microproteins will aid the field of metabolism in identifying new players in a variety of metabolic diseases. And we\u2019ve demonstrated one biologically active microprotein that promotes feeding, as well as other microproteins that are involved in fat metabolism.\u201d<\/p>\n

Fat tissue secretes many different proteins to regulate feeding, energy balance, and the production of heat. White fat, known as \u201cbad fat,\u201d is often found just beneath the skin and in the abdominal region. This type of fat acts as an energy storage depot and is related to obesity and other diseases caused by excess weight. In contrast, brown fat or \u201cgood fat\u201d is located around the shoulders and along the spinal cord. Brown fat is associated with proper nutrition, exercise, and health.<\/p>\n

In this study, the scientists used innovative genomics technologies to examine the brown, white, and beige fat (another type of fat with features similar to both white and brown fat) in mouse cells. They discovered 3,877 genes that produce microproteins in both white and brown fat. Additionally, they explored the levels of these genes in mice fed a high-fat Western diet, and linked hundreds of microproteins to changes in fat tissue metabolism. Overall, the analysis highlights many likely metabolically relevant microproteins for the first time.<\/p>\n

\u201cWe\u2019ve provided a roadmap on how to best use our data to link and eventually characterize the roles of microproteins in fundamental metabolic pathways,\u201d says first author Thomas Martinez, a former postdoctoral fellow in Saghatelian\u2019s lab who is now an assistant professor at UC Irvine.<\/p>\n

\"Microproteins
Microproteins and small proteins called smORFs are potentially a rich source of uncharacterized regulators of metabolism.
Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Credit: Salk Institute and Metabolismo celular<\/em><\/figcaption><\/figure>\n

The team also focused in on a microprotein called Gm8773, located in the feeding center of the brain, called the hypothalamus. The location of the microprotein in the brain suggested it may play a role in appetite. Indeed, when the scientists administered Gm8773 to obese mice, the mice consumed more food. There is also a human gene similar to Gm8773 called FAM237B, and this gene could act similarly in humans to promote eating. According to the researchers, this microprotein could eventually be developed into a therapeutic to promote weight gain in those experiencing extreme weight loss.<\/p>\n

“The new microproteins presented in our study are exciting discoveries for the field of metabolism and for the study of fat biology,\u201d says co-corresponding author Chris Barnes, formerly of Novo Nordisk Research Center Seattle, Inc., now head of proteomics at Velia Therapeutics.\u00a0\u201cWe hope that this resource will be used to generate numerous new experimental hypotheses for the scientific community to test in their own labs, and that this work leads to the identification of novel mechanisms in biology.\u201d<\/p>\n

In the future, the scientists plan to develop tools to investigate the roles of Gm8773 and FAM237B with the goal of eventually developing a therapeutic that can increase appetite in humans.<\/p>\n

Other authors include Cynthia Donaldson, Joan M. Vaughan, Calvin Lau, and Maxim N. Shokhirev of Salk; Brian C. Searle of Ohio State University; Lindsay K. Pino and Michael J. MacCoss of the University of Washington; Eduardo V. De Souza, and Cristiano V. Bizarro of the Pontifcia Universidade Catolica do Rio Grande do Sul in Brazil; and Sally Lyons-Abbott, Angie L. Bookout, Ariel Abramov, Arian F. Baquero, Karalee Baquero, Dave Friedrich, Justin Huard, Ray Davis, Bong Kim, Ty Koch, Aaron J. Mercer, Ayesha Misquith, Sara A. Murray, Sakara Perry, Christina Sanford, Alex Simon, Yu Zhang, Garrett Zipp, and Andrew J. Whittle of Novo Nordisk Research Center Seattle, Inc.<\/p>\n

The work was supported by the National Institutes of Health (R01 GM133981, P41 GM103533, R24GM141156, U19 AG065156, P30CA014195, R01GM102491, RC2DK129961, and K01CA249038), Frederick Paulsen and the Ferring Foundation, a sponsored research agreement with Novo Nordisk Research Center Seattle, Inc., the National Institute of Science and Technology on Tuberculosis, Brazil (421703-2017-2\/17-1265-8\/14.2.0914.1), the National Council for Scientific and Technological Development of Brazil (310344\/2016-6), and the Coordenac\u0327a\u0303o de Aperfeic\u0327oamento de Pessoal de Ni\u0301vel Superior\u2014Brasil.<\/p>","protected":false},"featured_media":37503,"template":"","faculty":[111],"disease-research":[449,173,165,166],"class_list":["post-37390","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-alan-saghatelian","disease-research-biochemistry-and-biophysics","disease-research-diabetes-type-1","disease-research-diabetes-type-2","disease-research-obesity"],"acf":[],"yoast_head":"\nMicroprotein increases appetite in mice - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/microprotein-increases-appetite-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Microprotein increases appetite in mice - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Obesity and metabolic diseases, such as diabetes, are extremely common in the United States. 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