{"id":37390,"date":"2023-01-03T00:00:01","date_gmt":"2023-01-03T08:00:01","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=37390"},"modified":"2024-01-30T14:18:47","modified_gmt":"2024-01-30T22:18:47","slug":"microprotein-increases-appetite-in-mice","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/microprotein-increases-appetite-in-mice\/","title":{"rendered":"La microprote\u00edna aumenta el apetito en ratones"},"content":{"rendered":"

LA JOLLA\u2014La obesidad y las enfermedades metab\u00f3licas, como la diabetes, son extremadamente comunes en Estados Unidos. Las diminutas prote\u00ednas llamadas microprote\u00ednas han sido pasadas por alto en la investigaci\u00f3n durante mucho tiempo, pero nueva evidencia demuestra que tienen un papel importante en el metabolismo. Cient\u00edficos del Salk descubrieron que tanto la grasa marr\u00f3n como la blanca est\u00e1n llenas de miles de microprote\u00ednas previamente desconocidas, y demuestran que una de estas microprote\u00ednas, llamada Gm8773, puede aumentar el apetito en ratones.<\/p>\n

Estos hallazgos, publicados en Metabolismo celular<\/em><\/a> El 3 de enero de 2023, podr\u00eda conducir al desarrollo de una terapia que ayude a las personas a ganar peso en ciertas situaciones de enfermedad, como durante la quimioterapia para el c\u00e1ncer. Adem\u00e1s, al establecer la existencia de estas microprote\u00ednas, el equipo proporciona un recurso valioso para que la comunidad cient\u00edfica estudie tambi\u00e9n las microprote\u00ednas.<\/p>\n

\"From
De izquierda a derecha: Alan Saghatelian y Thomas Martinez
Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Cr\u00e9dito: De izquierda a derecha: Instituto Salk y Steve Zylius de UC Irvine<\/figcaption><\/figure>\n

\u201cEs vital comprender mejor los procesos que regulan la obesidad y la salud metab\u00f3lica para poder ofrecer terapias mejoradas en el futuro\u201d, afirma el profesor del Salk\u00a0Alan Saghatelian<\/a>, coautor correspondiente del estudio y titular de la C\u00e1tedra Dr. Frederik Paulsen. \u201cTener esta lista de microprote\u00ednas ayudar\u00e1 al campo del metabolismo a identificar nuevos actores en una variedad de enfermedades metab\u00f3licas. Y hemos demostrado una microprote\u00edna biol\u00f3gicamente activa que promueve la alimentaci\u00f3n, as\u00ed como otras microprote\u00ednas que est\u00e1n involucradas en el metabolismo de las grasas\u201d.\u201d<\/p>\n

El tejido adiposo secreta muchas prote\u00ednas diferentes para regular la alimentaci\u00f3n, el balance energ\u00e9tico y la producci\u00f3n de calor. La grasa blanca, conocida como \u201cgrasa mala\u201d, se encuentra a menudo justo debajo de la piel y en la regi\u00f3n abdominal. Este tipo de grasa act\u00faa como un dep\u00f3sito de almacenamiento de energ\u00eda y est\u00e1 relacionado con la obesidad y otras enfermedades causadas por el exceso de peso. En contraste, la grasa parda o \u201cgrasa buena\u201d se localiza alrededor de los hombros y a lo largo de la m\u00e9dula espinal. La grasa parda est\u00e1 asociada con la nutrici\u00f3n adecuada, el ejercicio y la salud.<\/p>\n

En este estudio, los cient\u00edficos utilizaron tecnolog\u00edas gen\u00f3micas innovadoras para examinar la grasa marr\u00f3n, blanca y beige (otro tipo de grasa con caracter\u00edsticas similares a la grasa blanca y marr\u00f3n) en c\u00e9lulas de rat\u00f3n. Descubrieron 3,877 genes que producen microprote\u00ednas tanto en la grasa blanca como en la marr\u00f3n. Adem\u00e1s, exploraron los niveles de estos genes en ratones alimentados con una dieta occidental alta en grasas y vincularon cientos de microprote\u00ednas a cambios en el metabolismo del tejido adiposo. En general, el an\u00e1lisis destaca por primera vez muchas microprote\u00ednas probablemente relevantes metab\u00f3licamente.<\/p>\n

\u201cHemos proporcionado una hoja de ruta sobre c\u00f3mo usar mejor nuestros datos para vincular y, finalmente, caracterizar los roles de las microprote\u00ednas en las v\u00edas metab\u00f3licas fundamentales\u201d, dice el primer autor Thomas Martinez, un ex becario postdoctoral en el laboratorio de Saghatelian que ahora es profesor asistente en UC Irvine.<\/p>\n

\"Microproteins
Las microprote\u00ednas y prote\u00ednas peque\u00f1as, llamadas smORFs, son una fuente potencialmente rica de reguladores del metabolismo sin caracterizar.
Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Cr\u00e9dito: Salk Institute y Metabolismo celular<\/em><\/figcaption><\/figure>\n

El equipo tambi\u00e9n se centr\u00f3 en una microprote\u00edna llamada Gm8773, ubicada en el centro de alimentaci\u00f3n del cerebro, llamado hipot\u00e1lamo. La ubicaci\u00f3n de la microprote\u00edna en el cerebro sugiri\u00f3 que podr\u00eda desempe\u00f1ar un papel en el apetito. De hecho, cuando los cient\u00edficos administraron Gm8773 a ratones obesos, estos consumieron m\u00e1s comida. Tambi\u00e9n existe un gen humano similar a Gm8773 llamado FAM237B, y este gen podr\u00eda actuar de manera similar en humanos para promover la ingesta de alimentos. Seg\u00fan los investigadores, esta microprote\u00edna podr\u00eda desarrollarse eventualmente como un tratamiento para promover el aumento de peso en personas que experimentan p\u00e9rdida extrema de peso.<\/p>\n

\u201cLas nuevas microprote\u00ednas presentadas en nuestro estudio son descubrimientos emocionantes para el campo del metabolismo y para el estudio de la biolog\u00eda de la grasa\u201d, comenta el coautor correspondiente Chris Barnes, anteriormente del Novo Nordisk Research Center Seattle, Inc., y ahora jefe de prote\u00f3mica en Velia Therapeutics. \u201cEsperamos que este recurso sea utilizado para generar numerosas hip\u00f3tesis experimentales nuevas que la comunidad cient\u00edfica pueda probar en sus propios laboratorios, y que este trabajo conduzca a la identificaci\u00f3n de mecanismos novedosos en biolog\u00eda\u201d.\u201d<\/p>\n

En el futuro, los cient\u00edficos planean desarrollar herramientas para investigar los roles de Gm8773 y FAM237B con el objetivo de eventualmente desarrollar una terapia que pueda aumentar el apetito en humanos.<\/p>\n

Otros autores incluyen a Cynthia Donaldson, Joan M. Vaughan, Calvin Lau y Maxim N. Shokhirev de Salk; Brian C. Searle de la Universidad Estatal de Ohio; Lindsay K. Pino y Michael J. MacCoss de la Universidad de Washington; Eduardo V. De Souza y Cristiano V. Bizarro de la Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul en Brasil; y Sally Lyons-Abbott, Angie L. Bookout, Ariel Abramov, Arian F. Baquero, Karalee Baquero, Dave Friedrich, Justin Huard, Ray Davis, Bong Kim, Ty Koch, Aaron J. Mercer, Ayesha Misquith, Sara A. Murray, Sakara Perry, Christina Sanford, Alex Simon, Yu Zhang, Garrett Zipp y Andrew J. Whittle del Novo Nordisk Research Center Seattle, Inc.<\/p>\n

El trabajo fue apoyado por los National Institutes of Health (R01 GM133981, P41 GM103533, R24GM141156, U19 AG065156, P30CA014195, R01GM102491, RC2DK129961 y K01CA249038), Frederick Paulsen y la Ferring Foundation, un acuerdo de investigaci\u00f3n patrocinado con Novo Nordisk Research Center Seattle, Inc., el Instituto Nacional de Ciencia y Tecnolog\u00eda sobre Tuberculosis, Brasil (421703-2017-2\/17-1265-8\/14.2.0914.1), el Consejo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico de Brasil (310344\/2016-6) y la Coordinaci\u00f3n de Perfeccionamiento de Personal de Nivel Superior\u2014Brasil.<\/p>","protected":false},"featured_media":37503,"template":"","faculty":[111],"disease-research":[449,173,165,166],"class_list":["post-37390","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-alan-saghatelian","disease-research-biochemistry-and-biophysics","disease-research-diabetes-type-1","disease-research-diabetes-type-2","disease-research-obesity"],"acf":[],"yoast_head":"\nMicroprotein increases appetite in mice - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/microprotein-increases-appetite-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Microprotein increases appetite in mice - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Obesity and metabolic diseases, such as diabetes, are extremely common in the United States. 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