{"id":36928,"date":"2022-12-01T00:00:33","date_gmt":"2022-12-01T08:00:33","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=36928"},"modified":"2024-01-30T14:19:47","modified_gmt":"2024-01-30T22:19:47","slug":"deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/","title":{"rendered":"Las neuronas deterioradas son la fuente de la inflamaci\u00f3n cerebral humana en la enfermedad de Alzheimer"},"content":{"rendered":"

LA JOLLA\u2014A pesar de d\u00e9cadas de investigaci\u00f3n, la enfermedad de Alzheimer sigue siendo una demencia debilitante y, finalmente, mortal sin opciones de tratamiento efectivas. M\u00e1s del 95 por ciento de los casos de enfermedad de Alzheimer no tienen un origen conocido. Ahora, cient\u00edficos del Salk Institute han descubierto que las neuronas de personas con enfermedad de Alzheimer muestran deterioro y sufren un proceso de estr\u00e9s en la vejez llamado senescencia. Estas neuronas presentan una p\u00e9rdida de actividad funcional, metabolismo alterado e inflamaci\u00f3n cerebral aumentada.<\/p>\n

Los investigadores tambi\u00e9n descubrieron que atacar las neuronas deterioradas con tratamientos podr\u00eda ser una estrategia eficaz para prevenir o tratar la enfermedad de Alzheimer. Los hallazgos se publicaron en l\u00ednea en C\u00e9lulas Madre<\/em><\/a> el 1 de diciembre de 2022.<\/p>\n

\"Neurons
Neuronas (verdes) derivadas de un paciente con enfermedad de Alzheimer. Tambi\u00e9n se muestran los n\u00facleos (azules) de las neuronas.
Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n

\u201cNuestro estudio demuestra claramente que estas c\u00e9lulas no replicantes est\u00e1n pasando por el proceso de deterioro de la senescencia y que est\u00e1 directamente relacionado con la neuroinflamaci\u00f3n y la enfermedad de Alzheimer\u201d, dice el coautor correspondiente y profesor\u00a0Rusty Gage<\/a>, el presidente del Salk Institute y titular de la C\u00e1tedra Vi y John Adler para la Investigaci\u00f3n de Enfermedades Neurodegenerativas Relacionadas con la Edad.<\/p>\n

A medida que las c\u00e9lulas envejecen, pueden experimentar senescencia celular, lo que contribuye a la disfunci\u00f3n tisular y a los trastornos relacionados con la edad. Tambi\u00e9n se cree que la senescencia juega un papel en el estr\u00e9s celular, el da\u00f1o molecular y la iniciaci\u00f3n del c\u00e1ncer. Sin embargo, los cient\u00edficos cre\u00edan anteriormente que la senescencia ocurr\u00eda principalmente en c\u00e9lulas en divisi\u00f3n, no en neuronas. Se sab\u00eda poco sobre el estado similar a la senescencia de las neuronas humanas envejecidas.<\/p>\n

En este estudio, Gage y su equipo tomaron muestras de piel de personas con enfermedad de Alzheimer y convirtieron esas c\u00e9lulas directamente en neuronas en el laboratorio. Probaron estas neuronas para ver si experimentaban senescencia y examinaron los mecanismos involucrados en el proceso. Tambi\u00e9n exploraron los marcadores de senescencia y la expresi\u00f3n g\u00e9nica de cerebros post mortem de 20 personas con enfermedad de Alzheimer y controles sanos emparejados. Esto permiti\u00f3 al equipo confirmar que sus resultados de laboratorio eran v\u00e1lidos en tejido cerebral humano real.<\/p>\n

El equipo de Gage descubri\u00f3 que las neuronas senescentes son una fuente de la inflamaci\u00f3n cerebral de la vejez observada en la enfermedad de Alzheimer. A medida que las neuronas se deterioran, liberan factores inflamatorios que desencadenan una cascada de inflamaci\u00f3n cerebral y provocan que otras c\u00e9lulas cerebrales funcionen mal. Adem\u00e1s, el gen KRAS, com\u00fanmente involucrado en el c\u00e1ncer, podr\u00eda activar la respuesta senescente.<\/p>\n

\u201cLos cient\u00edficos normalmente no validan sus resultados de laboratorio en tejido cerebral humano. El hecho de que nuestros hallazgos fueran consistentes en ambos entornos respalda nuestros resultados de que estas neuronas senescentes est\u00e1n realmente teniendo una respuesta inflamatoria robusta que est\u00e1 afectando significativamente al cerebro\u201d, dice el primer autor Joseph Herdy, estudiante de posgrado en el laboratorio de Gage.<\/p>\n

\"From
De izquierda a derecha: Joseph Herdy y Rusty Gage.
Haga clic aqu\u00ed<\/a> para una imagen de alta resoluci\u00f3n.
Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n

Los autores se\u00f1alan que las consecuencias de incluso un peque\u00f1o n\u00famero de neuronas senescentes en el cerebro envejecido podr\u00edan tener un impacto significativo en su funci\u00f3n. Esto se debe a que una sola neurona puede establecer m\u00e1s de 1.000 conexiones con otras neuronas, afectando el sistema de comunicaci\u00f3n del cerebro.<\/p>\n

Adem\u00e1s de estos hallazgos, los autores tambi\u00e9n administraron un tratamiento terap\u00e9utico (un c\u00f3ctel de Dasatinib + Quercetina) a las neuronas del paciente en un plato. Ambos f\u00e1rmacos se utilizan para eliminar c\u00e9lulas senescentes en el cuerpo en afecciones como la osteoartritis, por lo que los autores quisieron ver si tambi\u00e9n eran eficaces en las c\u00e9lulas senescentes del sistema nervioso central. Descubrieron que el c\u00f3ctel de f\u00e1rmacos redujo el n\u00famero de neuronas senescentes a niveles normales. Por lo tanto, el tratamiento de las c\u00e9lulas senescentes podr\u00eda ser un enfoque \u00fatil para ralentizar la neuroinflamaci\u00f3n y la neurodegeneraci\u00f3n en la enfermedad de Alzheimer.<\/p>\n

Los investigadores dicen que es importante notar que el c\u00f3ctel terap\u00e9utico que se prob\u00f3 en este estudio normalmente no puede ingresar al cerebro. Sin embargo, existen medicamentos conocidos que pueden cruzar la barrera hematoencef\u00e1lica que probablemente act\u00faan de manera similar y que, posiblemente, podr\u00edan usarse como una opci\u00f3n de tratamiento en el futuro.<\/p>\n

A\u00fan se necesita investigar m\u00e1s sobre c\u00f3mo las neuronas senescentes conducen a la enfermedad de Alzheimer, as\u00ed como las consecuencias de eliminar estas neuronas del cerebro. En el futuro, los autores planean probar algunos medicamentos que pueden ingresar al cerebro para ver c\u00f3mo afectan a las neuronas senescentes. Tambi\u00e9n explorar\u00e1n los mecanismos impulsores de la senescencia y ver\u00e1n si ciertas regiones del cerebro son m\u00e1s propensas a este deterioro que otras.<\/p>\n

Otros autores incluyeron a Ravi Agarwal, Lukas Karbacher, Dina Zangwill y Jerome Mertens del Salk; Johannes Schlachetzki, Doug Galasko y Christopher Glass de UC San Diego; y Larissa Traxler y Lena Boehnke de la Universidad Leopold-Franzens-Innsbruck en Austria.<\/p>\n

El trabajo fue financiado por la BrightFocus Foundation; National Institute on Aging (AG056306, AG05611, AG057706, K99-AG056679 y AG072502); la Uni\u00f3n Europea (ERC-STG-2019-852086 y H2020-MSCA-IF-2017-797205); la Chen Foundation; el Fondo Austriaco para la Ciencia (FWF-I5057); el Paul G. Allen Frontiers Group (#19PABHI34610000); la Grace Foundation; la JPB Foundation; Annette C. Merle-Smith; Lynn y Edward Streim, y el Ray and Dagmar Dolby Family Fund; la Milky Way Research Foundation; la Paul G. Allen Family Foundation; la Stichting ASC Academy; el California Institute for Regenerative Medicine (RT2-01927); el Shiley-Marcos Alzheimer\u2019s Disease Research Center (ADRC; AG062429) de UC San Diego; la Waitt Foundation y la Chapman Foundation.<\/p>","protected":false},"featured_media":36972,"template":"","faculty":[76],"disease-research":[127,146,124],"class_list":["post-36928","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-rusty-gage","disease-research-alzheimers-disease","disease-research-aging-and-regenerative-medicine","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nDeteriorating neurons are source of human brain inflammation in Alzheimer\u2019s disease - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Deteriorating neurons are source of human brain inflammation in Alzheimer\u2019s disease - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Despite decades of research, Alzheimer\u2019s disease remains a debilitating and eventually fatal dementia with no effective treatment options. More than 95 percent of Alzheimer\u2019s disease cases have no known origin. Now, scientists from the Salk Institute have found that neurons from people with Alzheimer\u2019s disease show deterioration and undergo a late-life stress process called senescence. These neurons have a loss of functional activity, impaired metabolism, and increased brain inflammation.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-30T22:19:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/12\/NK3single_E1_2_1_BG-767.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"767\" \/>\n\t<meta property=\"og:image:height\" content=\"767\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\\\/\",\"name\":\"Deteriorating neurons are source of human brain inflammation in Alzheimer\u2019s disease - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/NK3single_E1_2_1_BG-767.jpg\",\"datePublished\":\"2022-12-01T08:00:33+00:00\",\"dateModified\":\"2024-01-30T22:19:47+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\\\/#breadcrumb\"},\"inLanguage\":\"es-MX\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/NK3single_E1_2_1_BG-767.jpg\",\"contentUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/NK3single_E1_2_1_BG-767.jpg\",\"width\":767,\"height\":767,\"caption\":\"Neurons (green) derived from a patient with Alzheimer\u2019s disease. The nuclei (blue) of the neurons are also shown.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Deteriorating neurons are source of human brain inflammation in Alzheimer\u2019s disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es-MX\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Deteriorating neurons are source of human brain inflammation in Alzheimer\u2019s disease - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/es\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/","og_locale":"es_MX","og_type":"article","og_title":"Deteriorating neurons are source of human brain inflammation in Alzheimer\u2019s disease - Salk Institute for Biological Studies","og_description":"LA JOLLA\u2014Despite decades of research, Alzheimer\u2019s disease remains a debilitating and eventually fatal dementia with no effective treatment options. More than 95 percent of Alzheimer\u2019s disease cases have no known origin. Now, scientists from the Salk Institute have found that neurons from people with Alzheimer\u2019s disease show deterioration and undergo a late-life stress process called senescence. These neurons have a loss of functional activity, impaired metabolism, and increased brain inflammation.","og_url":"https:\/\/www.salk.edu\/es\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/","og_site_name":"Salk Institute for Biological Studies","article_modified_time":"2024-01-30T22:19:47+00:00","og_image":[{"width":767,"height":767,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/12\/NK3single_E1_2_1_BG-767.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/","url":"https:\/\/www.salk.edu\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/","name":"Deteriorating neurons are source of human brain inflammation in Alzheimer\u2019s disease - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/12\/NK3single_E1_2_1_BG-767.jpg","datePublished":"2022-12-01T08:00:33+00:00","dateModified":"2024-01-30T22:19:47+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/#breadcrumb"},"inLanguage":"es-MX","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/"]}]},{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/#primaryimage","url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/12\/NK3single_E1_2_1_BG-767.jpg","contentUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/12\/NK3single_E1_2_1_BG-767.jpg","width":767,"height":767,"caption":"Neurons (green) derived from a patient with Alzheimer\u2019s disease. The nuclei (blue) of the neurons are also shown."},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/deteriorating-neurons-are-source-of-human-brain-inflammation-in-alzheimers-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Deteriorating neurons are source of human brain inflammation in Alzheimer\u2019s disease"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Instituto Salk de Estudios Biol\u00f3gicos","description":"El Poder de la Ciencia","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es-MX"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Instituto Salk de Estudios Biol\u00f3gicos","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"hero":"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/12\/NK3single_E1_2_1_BG-header-1.jpg","line_1":"Deteriorating neurons are source of human brain inflammation in Alzheimer\u2019s disease","line_2":"A therapy administered to patient-derived neurons in the lab can eliminate deteriorating cells, leading to positive consequences for the remaining healthy cells","poster_quote":"","paper_url":"https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(22)00457-X","journal_title":"Cell Stem Cell","paper_author_list":"Joseph R. Herdy, Larissa Traxler, Ravi K. Agarwal, Lukas Karbacher, Johannes C.M. Schlachetzki, Lena Boehnke, Dina Zangwill, Doug Galasko, Christopher K. Glass, Jerome Mertens & Fred H. Gage","doi":"10.1016\/j.stem.2022.11.010","paper_title":"Increased Post-Mitotic Senescence in Aged Human Neurons is a Pathological Feature of Alzheimer\u2019s Disease","subhead":"A therapy administered to patient-derived neurons in the lab can eliminate deteriorating cells, leading to positive consequences for the remaining healthy cells","home_photo":"","listing_photo":"","legacy_boilerplate":[],"hide_boilerplate":[],"disable_date":false,"listing_excerpt":"","descriptive_blurb":"","has_journal_cover":false,"og_image_override":false,"gallery":false},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/36928","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":8,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/36928\/revisions"}],"predecessor-version":[{"id":37128,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/36928\/revisions\/37128"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media\/36972"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media?parent=36928"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/faculty?post=36928"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disease-research?post=36928"}],"curies":[{"name":"la hora de","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}