{"id":36367,"date":"2022-10-17T00:00:19","date_gmt":"2022-10-17T07:00:19","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=36367"},"modified":"2022-10-17T07:30:09","modified_gmt":"2022-10-17T14:30:09","slug":"san-diego-nathan-shock-center-leverages-long-running-human-study-to-enable-cellular-research-on-diversity-of-aging","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/san-diego-nathan-shock-center-leverages-long-running-human-study-to-enable-cellular-research-on-diversity-of-aging\/","title":{"rendered":"El Centro Nathan Shock de San Diego aprovecha un estudio humano de larga duraci\u00f3n para posibilitar la investigaci\u00f3n celular sobre la diversidad del envejecimiento."},"content":{"rendered":"

LA JOLLA\u2014El Centro de Excelencia en Biolog\u00eda B\u00e1sica del Envejecimiento Nathan de San Diego, una colaboraci\u00f3n entre el Salk Institute, la UC San Diego y Sanford Burnham Prebys, recibi\u00f3 nueva financiaci\u00f3n de los Institutos Nacionales de Salud (NIH) para incorporar a participantes del Estudio de Envejecimiento Saludable de Rancho Bernardo a su propia cohorte cl\u00ednica para estudiar las diferencias en c\u00f3mo envejecen los individuos. Iniciado hace 50 a\u00f1os por la Dra. Elizabeth Barrett-Connor, distinguida profesora em\u00e9rita de la UC San Diego, el Estudio de Rancho Bernardo es uno de los estudios financiados de forma continua por los NIH de mayor duraci\u00f3n existente.<\/p>\n

\"Gerald
Gerald Shadel
Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n

El Centro de Choque Nathan de San Diego<\/a> fue establecido en 2020 con el objetivo de comprender la diversidad del envejecimiento humano. Para este proyecto, los cient\u00edficos del centro recolectar\u00e1n muestras de piel de los participantes vivos del Rancho Bernardo Study, cuyas trayectorias individuales de envejecimiento han sido seguidas y medidas durante muchos a\u00f1os. Utilizando tecnolog\u00eda de c\u00e9lulas madre, los investigadores podr\u00e1n transformarlas en otros tipos de c\u00e9lulas, como m\u00fasculo card\u00edaco, neuronas o c\u00e9lulas hep\u00e1ticas, para estudios dirigidos a comprender mejor la complejidad del envejecimiento celular. Los impulsores celulares del envejecimiento incluyen, por ejemplo: da\u00f1o al ADN, inflamaci\u00f3n, acortamiento de tel\u00f3meros (capuchas protectoras al final de los cromosomas) y da\u00f1o a las mitocondrias (centrales energ\u00e9ticas celulares). El enfoque permitir\u00e1 a los cient\u00edficos comprender los impulsores celulares del envejecimiento que potencialmente pueden ser dirigidos como intervenciones personalizadas para mejorar la resiliencia y aumentar la esperanza de vida saludable (el n\u00famero de a\u00f1os de vida sana).<\/p>\n

\u201cQueremos proveer un banco de diversos tipos de c\u00e9lulas de individuos que representen la variabilidad del envejecimiento normal, que pueda ser utilizado por investigadores de todo el mundo\u201d, dice el Profesor Salk Gerald Shadel<\/a>, director del Centro Nathan Shock de San Diego. \u201cLo que hace que esta iniciativa sea tan \u00fanica es que ahora estamos accediendo a c\u00e9lulas de adultos mayores con un historial documentado de m\u00e9tricas de envejecimiento normales, lo que permitir\u00e1 a los investigadores del envejecimiento conectar por primera vez cambios celulares espec\u00edficos con otros cambios fisiol\u00f3gicos relacionados con la edad\u201d.\u201d<\/p>\n

El Estudio Rancho Bernardo sobre el Envejecimiento Saludable se estableci\u00f3 entre 1972 y 1974, cuando aproximadamente el 80 por ciento de los residentes adultos de Rancho Bernardo, un suburbio de San Diego, se inscribieron. Hasta ahora, los investigadores han documentado principalmente los estilos de vida de los participantes del estudio, revelando mucho sobre c\u00f3mo factores como la dieta, el ejercicio y la educaci\u00f3n afectan la salud de una persona en etapas posteriores de la vida.<\/p>\n

\u201cEl envejecimiento es complejo. Est\u00e1 influenciado por factores gen\u00e9ticos heredados, as\u00ed como por el comportamiento, el estilo de vida y factores ambientales como la dieta, el tabaquismo, la exposici\u00f3n a toxinas, las infecciones y una serie de posibles comorbilidades\u201d, dice Anthony Molina, profesor asociado de medicina en la UC San Diego y codirector del grupo de investigaci\u00f3n de Modelos Celulares Humanos de Envejecimiento en el Shock Center. \u201cPara comprender c\u00f3mo estos factores conspiran para determinar las tasas individuales de envejecimiento y la susceptibilidad a enfermedades, necesitamos identificar personas que representen diferentes trayectorias de envejecimiento para poder estudiar sus c\u00e9lulas a nivel molecular y celular\u201d.\u201d<\/p>\n

El Centro Nathan Shock de San Diego es apoyado por el Instituto Nacional sobre el Envejecimiento de los NIH, n\u00famero de premio P30AG068635, al cual se le otorg\u00f3 recientemente un suplemento de $500.000 para incluir la inscripci\u00f3n de participantes del Estudio Rancho Bernardo.<\/p>","protected":false},"featured_media":36544,"template":"","faculty":[308],"disease-research":[333,146,123],"class_list":["post-36367","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-gerald-shadel","disease-research-genetics","disease-research-aging-and-regenerative-medicine","disease-research-metabolism-and-diabetes"],"acf":[],"yoast_head":"\nSan Diego Nathan Shock Center leverages long-running human study to enable cellular research on diversity of aging - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/san-diego-nathan-shock-center-leverages-long-running-human-study-to-enable-cellular-research-on-diversity-of-aging\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"San Diego Nathan Shock Center leverages long-running human study to enable cellular research on diversity of aging - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014The San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging, a collaboration between the Salk Institute, UC San Diego, and Sanford Burnham Prebys, received new funding from the National Institutes of Health (NIH) to enroll participants from the Rancho Bernardo Study of Healthy Aging into their own clinical cohort to study differences in how individuals age. 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