{"id":36367,"date":"2022-10-17T00:00:19","date_gmt":"2022-10-17T07:00:19","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=36367"},"modified":"2022-10-17T07:30:09","modified_gmt":"2022-10-17T14:30:09","slug":"san-diego-nathan-shock-center-leverages-long-running-human-study-to-enable-cellular-research-on-diversity-of-aging","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/san-diego-nathan-shock-center-leverages-long-running-human-study-to-enable-cellular-research-on-diversity-of-aging\/","title":{"rendered":"San Diego Nathan Shock Center leverages long-running human study to enable cellular research on diversity of aging"},"content":{"rendered":"

LA JOLLA\u2014The San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging, a collaboration between the Salk Institute, UC San Diego, and Sanford Burnham Prebys, received new funding from the National Institutes of Health (NIH) to enroll participants from the Rancho Bernardo Study of Healthy Aging into their own clinical cohort to study differences in how individuals age. Initiated 50 years ago by the late UC San Diego Distinguished Professor Elizabeth Barrett-Connor, the Rancho Bernardo Study is one of the longest, continuously NIH-funded studies in existence.<\/p>\n

\"Gerald
Gerald Shadel
Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n

El Centro de Choque Nathan de San Diego<\/a> was established in 2020 with the goal of understanding the diversity of human aging. For this project, scientists at the center will collect skin samples from the living Rancho Bernardo Study participants whose individual trajectories of aging have been followed and measured for many years. Using stem cell technology, researchers will be able to transform these into other cell types, such as heart muscle, neurons, or liver cells, for studies aimed at better understanding the complexity of cellular aging. Cellular drivers of aging include, for example: DNA damage, inflammation, shortening of telomeres (protective caps at the end of chromosomes), and damage to mitochondria (cellular power plants). The approach will allow scientists to understand cellular drivers of aging that can potentially be targeted as personalized interventions to improve resilience and increase health span (the number of years of healthy life).<\/p>\n

\u201cWe want to provide a bank of various cell types from individuals who represent the variability of normal aging that can be used by researchers around the world,\u201d says Salk Professor Gerald Shadel<\/a>, director of the San Diego Nathan Shock Center. \u201cWhat makes this venture so unique is that we\u2019re now accessing cells from older adults with a documented history of normal aging metrics, which will allow aging researchers to connect specific cellular changes to other age-related physiological changes for the first time.\u201d<\/p>\n

The Rancho Bernardo Study of Healthy Aging was established between 1972 and 1974 when roughly 80 percent of adult residents of Rancho Bernardo, a San Diego suburb, were enrolled.\u00a0Until now, researchers have primarily documented the lifestyles of study participants, revealing much about how factors such as diet, exercise, and education affect a person\u2019s health later in life.<\/p>\n

\u201cAging is complex. It is influenced by inherited genetic factors as well as behavior, lifestyle, and environmental factors like diet, smoking, exposure to toxins, infections, and an array of possible comorbidities,\u201d says Anthony Molina, associate professor of medicine at UC San Diego and co-director of the Human Cell Models of Aging research core at the Shock Center. \u201cTo understand how these factors conspire to determine individual rates of aging and disease susceptibility, we need to identify people that represent different aging trajectories so that we can study their cells at a molecular and cellular level.\u201d<\/p>\n

The San Diego Nathan Shock Center is supported by the National Institute of Aging of the NIH, award number P30AG068635, to which a $500,000 supplement was recently awarded to include enrollment of Rancho Bernardo Study participants.<\/p>","protected":false},"featured_media":36544,"template":"","faculty":[308],"disease-research":[333,146,123],"class_list":["post-36367","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-gerald-shadel","disease-research-genetics","disease-research-aging-and-regenerative-medicine","disease-research-metabolism-and-diabetes"],"acf":[],"yoast_head":"\nSan Diego Nathan Shock Center leverages long-running human study to enable cellular research on diversity of aging - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/san-diego-nathan-shock-center-leverages-long-running-human-study-to-enable-cellular-research-on-diversity-of-aging\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"San Diego Nathan Shock Center leverages long-running human study to enable cellular research on diversity of aging - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014The San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging, a collaboration between the Salk Institute, UC San Diego, and Sanford Burnham Prebys, received new funding from the National Institutes of Health (NIH) to enroll participants from the Rancho Bernardo Study of Healthy Aging into their own clinical cohort to study differences in how individuals age. 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