{"id":33789,"date":"2022-03-07T00:00:52","date_gmt":"2022-03-07T08:00:52","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=33789"},"modified":"2023-01-05T10:37:37","modified_gmt":"2023-01-05T18:37:37","slug":"cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice\/","title":{"rendered":"La terapia de rejuvenecimiento celular revierte de manera segura los signos del envejecimiento en ratones"},"content":{"rendered":"<p>LA JOLLA\u2014La edad puede ser solo un n\u00famero, pero es un n\u00famero que a menudo conlleva efectos secundarios no deseados, desde huesos fr\u00e1giles y m\u00fasculos m\u00e1s d\u00e9biles hasta un mayor riesgo de enfermedades cardiovasculares y c\u00e1ncer. Ahora, cient\u00edficos del Instituto Salk, en colaboraci\u00f3n con Genentech, miembro del grupo Roche, han demostrado que pueden revertir de forma segura y eficaz el proceso de envejecimiento en ratones de mediana y avanzada edad, restableciendo parcialmente sus c\u00e9lulas a estados m\u00e1s juveniles. El estudio se public\u00f3 en <a href=\"https:\/\/www.nature.com\/articles\/s43587-022-00183-2\" target=\"_blank\" rel=\"noopener\"><em>Envejecimiento Natural<\/em><\/a> el 7 de marzo de 2022.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-XryS6SnGTho\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/XryS6SnGTho?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>\u201cEstamos encantados de poder usar este enfoque en todo el ciclo de vida para ralentizar el envejecimiento en animales normales. La t\u00e9cnica es segura y eficaz en ratones\u201d, afirma el coautor correspondiente. <a href=\"https:\/\/www.salk.edu\/es\/scientist\/juan-carlos-izpisua-belmonte\/\">Juan Carlos Izpisua Belmonte<\/a><u>,<\/u> profesor en el Laboratorio de Expresi\u00f3n G\u00e9nica de Salk y titular de la C\u00e1tedra Roger Guillemin. \u201cAdem\u00e1s de abordar las enfermedades relacionadas con la edad, este enfoque puede proporcionar a la comunidad biom\u00e9dica una nueva herramienta para restaurar la salud de tejidos y organismos al mejorar la funci\u00f3n celular y la resiliencia en diferentes situaciones de enfermedad, como las enfermedades neurodegenerativas\u201d.\u201d<\/p>\n<figure id=\"attachment_33881\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" class=\"img-responsive wp-image-33881 size-medium\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-300x300.jpg\" alt=\"Cellular rejuvenation therapy safely reverses signs of aging in mice \" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-1024x1024.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-768x768.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-945x945.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-1250x1250.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-200x200.jpg 200w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500.jpg 1500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-caption-text\">La terapia de rejuvenecimiento celular revierte de forma segura los signos del envejecimiento en ratones.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<br \/>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>A medida que los organismos envejecen, no solo cambian sus apariencias externas y su salud; cada c\u00e9lula de su cuerpo lleva un reloj molecular que registra el paso del tiempo. Las c\u00e9lulas aisladas de personas o animales mayores tienen patrones qu\u00edmicos diferentes a lo largo de su ADN \u2014llamados marcadores epigen\u00e9ticos\u2014 en comparaci\u00f3n con las personas o animales j\u00f3venes. Los cient\u00edficos saben que a\u00f1adir una mezcla de cuatro mol\u00e9culas de reprogramaci\u00f3n \u2014Oct4, Sox2, Klf4 y cMyc, tambi\u00e9n conocidas como \u201cfactores de Yamanaka\u201d\u2014 a las c\u00e9lulas puede restablecer estas marcas epigen\u00e9ticas a sus patrones originales. Este enfoque es c\u00f3mo los investigadores pueden retroceder las c\u00e9lulas adultas, en t\u00e9rminos de desarrollo, hasta convertirlas en c\u00e9lulas madre.<\/p>\n<p>En 2016, el laboratorio de Izpisua Belmonte inform\u00f3 por primera vez que pod\u00edan usar los factores de Yamanaka para <a href=\"https:\/\/www.salk.edu\/es\/news-release\/turning-back-time-salk-scientists-reverse-signs-aging\/\">contrarrestar los signos del envejecimiento y aumentar la esperanza de vida<\/a> en ratones con una enfermedad de envejecimiento prematuro. M\u00e1s recientemente, el equipo descubri\u00f3 que, incluso en ratones j\u00f3venes, los factores de Yamanaka pueden <a href=\"https:\/\/www.salk.edu\/es\/news-release\/new-study-shows-how-to-boost-muscle-regeneration-and-rebuild-tissue\/\">acelerar la regeneraci\u00f3n muscular<\/a>. Tras estas observaciones iniciales, otros cient\u00edficos han utilizado el mismo enfoque para mejorar la funci\u00f3n de otros tejidos como el coraz\u00f3n, el cerebro y el nervio \u00f3ptico, que est\u00e1 involucrado en la visi\u00f3n.<\/p>\n<p>En el nuevo estudio, Izpisua Belmonte y sus colegas probaron variaciones del enfoque de rejuvenecimiento celular en animales sanos a medida que envejec\u00edan. Un grupo de ratones recibi\u00f3 dosis regulares de los factores de Yamanaka desde los 15 meses de edad hasta los 22 meses, equivalente aproximadamente a los 50 a 70 a\u00f1os en humanos. Otro grupo fue tratado desde los 12 hasta los 22 meses, aproximadamente de los 35 a los 70 a\u00f1os en humanos. Y un tercer grupo fue tratado durante solo un mes a los 25 meses de edad, similar a los 80 a\u00f1os en humanos.<\/p>\n<p>\u201cLo que realmente quer\u00edamos establecer era que usar este enfoque durante un per\u00edodo de tiempo m\u00e1s prolongado es seguro\u201d, dice Pradeep Reddy, cient\u00edfico del personal de Salk y coautor principal del nuevo art\u00edculo. \u201cDe hecho, no vimos ning\u00fan efecto negativo en la salud, el comportamiento o el peso corporal de estos animales\u201d.\u201d<\/p>\n<p>En comparaci\u00f3n con los animales de control, no hubo alteraciones en las c\u00e9lulas sangu\u00edneas ni cambios neurol\u00f3gicos en los ratones que recibieron los factores de Yamanaka. Adem\u00e1s, el equipo no encontr\u00f3 c\u00e1ncer en ninguno de los grupos de animales.<\/p>\n<figure id=\"attachment_33879\"  class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" class=\"img-responsive wp-image-33879 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-300x300.jpg\" alt=\"Juan Carlos Izpisua Belmonte and Pradeep Reddy\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-1024x1024.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-768x768.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-1536x1536.jpg 1536w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-945x945.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-1250x1250.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-200x200.jpg 200w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr.jpg 1568w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-caption-text\">De izquierda a derecha: Juan Carlos Izpisua Belmonte y Pradeep Reddy.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<br \/>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>Cuando los investigadores observaron los signos normales de envejecimiento en los animales que hab\u00edan recibido el tratamiento, descubrieron que los ratones, en muchos aspectos, se parec\u00edan a animales m\u00e1s j\u00f3venes. Tanto en los ri\u00f1ones como en la piel, la epigen\u00e9tica de los animales tratados se asemejaba m\u00e1s a los patrones epigen\u00e9ticos observados en animales m\u00e1s j\u00f3venes. Cuando las c\u00e9lulas de la piel de los animales tratados sufr\u00edan lesiones, ten\u00edan una mayor capacidad de proliferaci\u00f3n y era menos probable que formaran cicatrices permanentes; los animales mayores suelen mostrar una menor proliferaci\u00f3n de c\u00e9lulas cut\u00e1neas y m\u00e1s cicatrizaci\u00f3n. Adem\u00e1s, las mol\u00e9culas metab\u00f3licas en la sangre de los animales tratados no mostraron los cambios normales relacionados con la edad.<\/p>\n<p>Esta juventud se observ\u00f3 en los animales tratados durante siete o 10 meses con los factores de Yamanaka, pero no en los animales tratados solo por un mes. Adem\u00e1s, cuando se analizaron los animales tratados a mitad de su tratamiento, los efectos a\u00fan no eran tan evidentes. Esto sugiere que el tratamiento no est\u00e1 simplemente deteniendo el envejecimiento, sino que lo est\u00e1 revirtiendo activamente, aunque se necesita m\u00e1s investigaci\u00f3n para diferenciar entre ambos.<\/p>\n<p>El equipo ahora est\u00e1 planeando investigaciones futuras para analizar c\u00f3mo mol\u00e9culas y genes espec\u00edficos son modificados por el tratamiento a largo plazo con los factores de Yamanaka. Tambi\u00e9n est\u00e1n desarrollando nuevas formas de administrar los factores.<\/p>\n<p>\u201cAl final del d\u00eda, queremos devolver la resiliencia y la funci\u00f3n a las c\u00e9lulas m\u00e1s antiguas para que sean m\u00e1s resistentes al estr\u00e9s, las lesiones y las enfermedades\u201d, dice Reddy. \u201cEste estudio demuestra que, al menos en ratones, hay un camino a seguir para lograrlo\u201d.\u201d<\/p>\n<p>Belmonte es actualmente Director de Instituto en Altos Labs, Inc., adem\u00e1s de ser profesor en el Salk Institute.<\/p>\n<p>Otros autores incluyeron a Mako Yamamoto, Isabel Guillen Guillen, Sanjeeb Sahu, Chao Wang, Yosu Luque, Javier Prieto, Lei Shi, Kensaku Shojima, Tomoaki Hishida y Concepci\u00f3n Rodr\u00edguez Esteban del Salk; Kristen Browder, Zijuan Lai, Qingling Li, Feroza Choudhury, Weng Wong, Yuxin Liang, Dewakar Sangaraju, Wendy Sandoval, Michal Pawlak, Jason Vander Heiden y Heinrich Jasper de Genentech, Inc.; Amin Haghani y Steve Horvath de UCLA; Estrella N\u00fa\u00f1ez Delicado de la Universidad Cat\u00f3lica San Antonio de Murcia; y Pedro Guill\u00e9n Garc\u00eda de la Cl\u00ednica CEMTRO.<\/p>\n<p>El estudio fue apoyado por la Universidad Cat\u00f3lica San Antonio de Murcia (UCAM) y la Fundaci\u00f3n Dr. Pedro Guill\u00e9n.<\/p>","protected":false},"featured_media":33881,"template":"","faculty":[85],"disease-research":[146],"class_list":["post-33789","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-juan-carlos-izpisua-belmonte","disease-research-aging-and-regenerative-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cellular rejuvenation therapy safely reverses signs of aging in mice - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cellular rejuvenation therapy safely reverses signs of aging in mice - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Age may be just a number, but it\u2019s a number that often carries unwanted side effects, from brittle bones and weaker muscles to increased risks of cardiovascular disease and cancer. Now, scientists at the Salk Institute, in collaboration with Genentech, a member of the Roche group, have shown that they can safely and effectively reverse the aging process in middle-aged and elderly mice by partially resetting their cells to more youthful states. The study was published in Nature Aging on March 7, 2022.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-05T18:37:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"1500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice\\\/\",\"name\":\"Cellular rejuvenation therapy safely reverses signs of aging in mice - 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Now, scientists at the Salk Institute, in collaboration with Genentech, a member of the Roche group, have shown that they can safely and effectively reverse the aging process in middle-aged and elderly mice by partially resetting their cells to more youthful states. 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