{"id":33123,"date":"2021-12-17T01:02:32","date_gmt":"2021-12-17T09:02:32","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=33123"},"modified":"2021-12-17T09:56:29","modified_gmt":"2021-12-17T17:56:29","slug":"salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/","title":{"rendered":"Cient\u00edficos de Salk reciben el premio ASPIRE 2021 para estudiar el c\u00e1ncer de p\u00e1ncreas"},"content":{"rendered":"<p>LA JOLLA\u2014Professor <a href=\"https:\/\/www.salk.edu\/es\/scientist\/ronald-evans\/\">Ronald Evans<\/a> and Assistant Professor <a href=\"https:\/\/www.salk.edu\/es\/scientist\/dannielle-engle\/\">Dannielle Engle<\/a> have been granted a 2021 ASPIRE (Accelerating Scientific Platforms and Innovative Research) award to study the cellular and molecular drivers of pancreatic cancer, one of the deadliest cancers with few effective treatment options. The $250,000 award, supported by the Mark Foundation for Cancer Research, enables innovative approaches to solving impactful problems in cancer research. The 23 scientists chosen to lead 2021 ASPIRE projects represent disciplines across the spectrum of cancer research at top academic institutions worldwide. <\/p>\n<figure id=\"attachment_23252\"  class=\"wp-caption alignright\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/12\/Evans-Engle-Mark-Foundation-20210928-551A0922-scaled.jpg\"><img decoding=\"async\" class=\"img-responsive wp-image-23252 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/12\/Evans-Engle-Mark-Foundation-20210928-551A0922-400x267.jpg\" alt=\"Salk Professor Ronald Evans and Assistant Professor Dannielle Engle\" \/><\/a><figcaption class=\"wp-caption-text\">From left: Ronald Evans and Dannielle Engle<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/12\/Evans-Engle-Mark-Foundation-20210928-551A0922-scaled.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/p>\n<p>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>\u201cWith the support of the ASPIRE award, Ron and Dannie will take a novel approach to uncover what is driving pancreatic cancer,\u201d says Salk President <a href=\"https:\/\/www.salk.edu\/es\/scientist\/rusty-gage\/\">Rusty Gage<\/a>. \u201cTheir work will hopefully fuel new avenues of pancreatic cancer research and lead to new, more-effective treatment options for those experiencing the disease.\u201d<\/p>\n<p>Pancreatic cancer, specifically pancreatic ductal adenocarcinoma, is the third-leading cause of cancer-related deaths in the United States. Abnormal levels of bile acids, which help digest fats, are commonly observed in pancreatic cancer, but scientists are unsure of the significance. Evans and Engle previously found that the sugar <a href=\"https:\/\/www.salk.edu\/es\/news-release\/sugars-that-coat-proteins-are-a-possible-drug-target-for-pancreatitis\/\">CA19-9 causes pancreatitis<\/a>, the precursor to pancreatic cancer. CA19-9 also plays a role in bile acid signaling, and the scientists believe this mechanism could be driving the progression of pancreatitis to pancreatic cancer. For this project, the team will use liver and pancreatic organoids, three-dimensional clusters of cells in a dish that mimic the tissues from which they were derived, to better understand the cellular and molecular basis of how CA19-9 and bile acids may interact to promote tumor growth. Evans and Engle think this work could lead to the development of new therapies for pancreatic cancer and other gastrointestinal cancers. <\/p>","protected":false},"featured_media":0,"template":"","faculty":[345,91],"disease-research":[46,172],"class_list":["post-33123","disclosure","type-disclosure","status-publish","hentry","faculty-dannielle-engle","faculty-ronald-evans","disease-research-cancer-biology","disease-research-pancreatic-cancer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Salk scientists receive the 2021 ASPIRE award to study pancreatic cancer - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk scientists receive the 2021 ASPIRE award to study pancreatic cancer - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Professor Ronald Evans and Assistant Professor Dannielle Engle have been granted a 2021 ASPIRE (Accelerating Scientific Platforms and Innovative Research) award to study the cellular and molecular drivers of pancreatic cancer, one of the deadliest cancers with few effective treatment options. The $250,000 award, supported by the Mark Foundation for Cancer Research, enables innovative approaches to solving impactful problems in cancer research. The 23 scientists chosen to lead 2021 ASPIRE projects represent disciplines across the spectrum of cancer research at top academic institutions worldwide.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2021-12-17T17:56:29+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.salk.edu\/wp-content\/uploads\/2021\/12\/Evans-Engle-Mark-Foundation-20210928-551A0922-400x267.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\\\/\",\"name\":\"Salk scientists receive the 2021 ASPIRE award to study pancreatic cancer - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2021\\\/12\\\/Evans-Engle-Mark-Foundation-20210928-551A0922-400x267.jpg\",\"datePublished\":\"2021-12-17T09:02:32+00:00\",\"dateModified\":\"2021-12-17T17:56:29+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\\\/#breadcrumb\"},\"inLanguage\":\"es-MX\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\\\/#primaryimage\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2021\\\/12\\\/Evans-Engle-Mark-Foundation-20210928-551A0922-400x267.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2021\\\/12\\\/Evans-Engle-Mark-Foundation-20210928-551A0922-400x267.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Salk scientists receive the 2021 ASPIRE award to study pancreatic cancer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es-MX\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Salk scientists receive the 2021 ASPIRE award to study pancreatic cancer - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/","og_locale":"es_MX","og_type":"article","og_title":"Salk scientists receive the 2021 ASPIRE award to study pancreatic cancer - Salk Institute for Biological Studies","og_description":"LA JOLLA\u2014Professor Ronald Evans and Assistant Professor Dannielle Engle have been granted a 2021 ASPIRE (Accelerating Scientific Platforms and Innovative Research) award to study the cellular and molecular drivers of pancreatic cancer, one of the deadliest cancers with few effective treatment options. The $250,000 award, supported by the Mark Foundation for Cancer Research, enables innovative approaches to solving impactful problems in cancer research. The 23 scientists chosen to lead 2021 ASPIRE projects represent disciplines across the spectrum of cancer research at top academic institutions worldwide.","og_url":"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/","og_site_name":"Salk Institute for Biological Studies","article_modified_time":"2021-12-17T17:56:29+00:00","og_image":[{"url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2021\/12\/Evans-Engle-Mark-Foundation-20210928-551A0922-400x267.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/","url":"https:\/\/www.salk.edu\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/","name":"Salk scientists receive the 2021 ASPIRE award to study pancreatic cancer - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/#primaryimage"},"thumbnailUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2021\/12\/Evans-Engle-Mark-Foundation-20210928-551A0922-400x267.jpg","datePublished":"2021-12-17T09:02:32+00:00","dateModified":"2021-12-17T17:56:29+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/#breadcrumb"},"inLanguage":"es-MX","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/"]}]},{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/#primaryimage","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2021\/12\/Evans-Engle-Mark-Foundation-20210928-551A0922-400x267.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2021\/12\/Evans-Engle-Mark-Foundation-20210928-551A0922-400x267.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-receive-the-2021-aspire-award-to-study-pancreatic-cancer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Salk scientists receive the 2021 ASPIRE award to study pancreatic cancer"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Instituto Salk de Estudios Biol\u00f3gicos","description":"The Power of Science","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es-MX"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Instituto Salk de Estudios Biol\u00f3gicos","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"gallery":false,"paper_url":"","journal_title":"","paper_author_list":"","doi":"","paper_title":"","subhead":"","home_photo":"","listing_photo":"","legacy_boilerplate":[],"hide_boilerplate":[],"disable_date":false,"listing_excerpt":"","descriptive_blurb":"","has_journal_cover":false,"og_image_override":false},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/33123","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":5,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/33123\/revisions"}],"predecessor-version":[{"id":33131,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/33123\/revisions\/33131"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media?parent=33123"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/faculty?post=33123"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disease-research?post=33123"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}