{"id":31187,"date":"2021-06-07T08:30:59","date_gmt":"2021-06-07T15:30:59","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=31187"},"modified":"2024-01-30T14:32:30","modified_gmt":"2024-01-30T22:32:30","slug":"research-advances-one-step-closer-to-stem-cell-therapy-for-type-1-diabetes","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/research-advances-one-step-closer-to-stem-cell-therapy-for-type-1-diabetes\/","title":{"rendered":"Avances en investigaci\u00f3n acercan un paso m\u00e1s la terapia con c\u00e9lulas madre para la diabetes tipo 1"},"content":{"rendered":"

LA JOLLA\u2014Type 1 diabetes, which arises when the pancreas doesn\u2019t create enough insulin to control levels of glucose in the blood, is a disease that currently has no cure and is difficult for most patients to manage. Scientists at the Salk Institute are developing a promising approach for treating it: using stem cells to create insulin-producing cells (called beta cells) that could replace nonfunctional pancreatic cells.<\/p>\n

In a study published on June 7, 2021, in the journal Nature Communications<\/em><\/a>, the investigators reported that they have developed a new way to create beta cells that is much more efficient than previous methods. Additionally, when these beta cells were tested in a mouse model of type 1 diabetes, the animals\u2019 blood sugar was brought under control within about two weeks.<\/p>\n

\"This
This image shows functional beta cells made from human pluripotent stem cells. Insulin (red) and NKX6.1 (green) indicate two proteins produced by beta cells.<\/p>\n

Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/figcaption><\/figure>\n

\u201cStem cells are an extremely promising approach for developing many cell therapies, including better treatments for type 1 diabetes,\u201d says Salk Professor Juan Carlos Izpisua Belmonte<\/a>, the paper\u2019s senior author. \u201cThis method for manufacturing large numbers of safe and functional beta cells is an important step forward.\u201d<\/p>\n

In the current work, the investigators started with human pluripotent stem cells (hPSCs). These cells, which can be derived from adult tissues (most often the skin), have the potential to become any kind of cell found in the adult body. Using various growth factors and chemicals, the investigators coaxed hPSCs into beta cells in a stepwise fashion that mimicked pancreatic development.<\/p>\n

Producing beta cells from hPSCs in the lab is not new, but in the past the yields of these precious cells have been low. With existing methods, only about 10 to 40 percent of cells become beta cells. By comparison, techniques used to create nerve cells from hPSCs have yields of about 80 percent. Another issue is that if undifferentiated cells are left in the mix, they could eventually turn into another kind cell that would be unwanted.<\/p>\n

\u201cIn order for beta cell-based treatments to eventually become a viable option for patients, it\u2019s important to make these cells easier to manufacture,\u201d says co-first author Haisong Liu, a former member of the Belmonte lab. \u201cWe need to find a way to optimize the process.\u201d<\/p>\n

To address the problem, the researchers took a stepwise approach to create beta cells. They identified several chemicals that are important for inducing hPSCs to become more specialized cells. They ultimately identified several cocktails of chemicals that resulted in beta cell yields of up to 80 percent.<\/p>\n

They also looked at the ways in which these cells are grown in the lab. \u201cNormally cells are grown on a flat plate, but we allowed them to grow in three dimensions,\u201d says co-first author Ronghui Li, a postdoctoral fellow in the Belmonte lab. Growing the cells in this way creates more shared surface area between the cells and allows them to influence each other, just as they would during human development.<\/p>\n

After the cells were created, they were transplanted into a mouse model of type 1 diabetes, The model mice had a modified immune system that would not reject transplanted human cells. \u201cWe found that within two weeks these mice had a reduction of their high blood sugar level into normal range,\u201d says co-first author Hsin-Kai Liao, a staff researcher in the Belmonte lab. \u201cThe transplanted hPSC-derived beta cells were biologically functional.\u201d<\/p>\n

The researchers will continue to study this technique in the lab to further optimize the production of beta cells. More research is needed to assess safety issues before clinical trials can be initiated in humans. The investigators say the methods reported in this paper may also be useful for developing specialized cells to treat other diseases.<\/p>\n

Other authors included Chao Wang, Yang Yu, Lei Shi, and Jiameng Dan of Salk; Zheying Min of Peking University; Alberto Hayek of the University of California San Diego; and Llanos Martinez Martinez and Estrella Nu\u00f1ez Delicado of Universidad Cat\u00f3lica San Antonio de Murcia, in Spain.<\/p>\n

This work was funded by Universidad Cato\u0301lica San Antonio de Murcia, Primafrio, The Larry L. Hillblom Foundation, The Moxie Foundation, and Diabetes Research Connection (Project Number: 15; Institution Project Number: Liu-DRC-2019).<\/p>","protected":false},"featured_media":31193,"template":"","faculty":[85],"disease-research":[123,335],"class_list":["post-31187","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-juan-carlos-izpisua-belmonte","disease-research-metabolism-and-diabetes","disease-research-regeneration"],"acf":[],"yoast_head":"\nResearch advances one step closer to stem cell therapy for type 1 diabetes - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/research-advances-one-step-closer-to-stem-cell-therapy-for-type-1-diabetes\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research advances one step closer to stem cell therapy for type 1 diabetes - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Type 1 diabetes, which arises when the pancreas doesn\u2019t create enough insulin to control levels of glucose in the blood, is a disease that currently has no cure and is difficult for most patients to manage. 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