{"id":25815,"date":"2020-02-27T08:14:07","date_gmt":"2020-02-27T16:14:07","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=25815"},"modified":"2020-02-27T11:03:39","modified_gmt":"2020-02-27T19:03:39","slug":"eat-less-live-longer","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/eat-less-live-longer\/","title":{"rendered":"Come menos, vive m\u00e1s"},"content":{"rendered":"<p>LA JOLLA\u2014Si desea reducir los niveles de inflamaci\u00f3n en todo el cuerpo, retrasar la aparici\u00f3n de enfermedades relacionadas con la edad y vivir m\u00e1s tiempo, coma menos. Esa es la conclusi\u00f3n de un nuevo estudio realizado por cient\u00edficos de Estados Unidos y China que proporciona el informe m\u00e1s detallado hasta la fecha de los efectos celulares de una dieta con restricci\u00f3n cal\u00f3rica en ratas. Si bien los beneficios de la restricci\u00f3n cal\u00f3rica se conocen desde hace mucho tiempo, los nuevos resultados muestran c\u00f3mo esta restricci\u00f3n puede proteger contra el envejecimiento en las v\u00edas celulares, como se detalla en <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867420301525?via%3Dihub\"><em>C\u00e9lula<\/em><\/a> el 27 de febrero de 2020.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-ypAdKPq6MD4\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/ypAdKPq6MD4?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>\u201cYa sab\u00edamos que la restricci\u00f3n cal\u00f3rica aumenta la esperanza de vida, pero ahora hemos demostrado todos los cambios que ocurren a nivel de una sola c\u00e9lula para causar eso\u201d, dice <a href=\"https:\/\/www.salk.edu\/es\/scientist\/juan-carlos-izpisua-belmonte\/\">Juan Carlos Izpisua Belmonte<\/a>, coautor correspondiente del nuevo art\u00edculo, profesor del Laboratorio de Expresi\u00f3n G\u00e9nica de Salk y titular de la C\u00e1tedra Roger Guillemin. \u201cEsto nos da objetivos sobre los que eventualmente podr\u00edamos actuar con medicamentos para tratar el envejecimiento en humanos\u201d.\u201d<\/p>\n<p>El envejecimiento es el factor de riesgo m\u00e1s alto para muchas enfermedades humanas, incluido el c\u00e1ncer, la demencia, la diabetes y el s\u00edndrome metab\u00f3lico. Se ha demostrado en modelos animales que la restricci\u00f3n cal\u00f3rica es una de las intervenciones m\u00e1s efectivas contra estas enfermedades relacionadas con la edad. Y aunque los investigadores saben que las c\u00e9lulas individuales experimentan muchos cambios a medida que un organismo envejece, no han sabido c\u00f3mo la restricci\u00f3n cal\u00f3rica podr\u00eda influir en estos cambios.<\/p>\n<p>En el nuevo art\u00edculo, Belmonte y sus colaboradores \u2014incluyendo tres exalumnos de su laboratorio Salk que ahora son profesores y dirigen sus propios programas de investigaci\u00f3n en China\u2014 compararon ratas que consumieron un 30 por ciento menos de calor\u00edas con ratas que siguieron dietas normales. Las dietas de los animales fueron controladas desde los 18 hasta los 27 meses de edad. (En humanos, esto ser\u00eda aproximadamente equivalente a que una persona siguiera una dieta restringida en calor\u00edas desde los 50 hasta los 70 a\u00f1os).<\/p>\n<p>Tanto al inicio como al final de la dieta, el equipo de Belmonte aisl\u00f3 y analiz\u00f3 un total de 168 703 c\u00e9lulas de 40 tipos diferentes en las 56 ratas. Las c\u00e9lulas proced\u00edan de tejidos adiposos, h\u00edgado, ri\u00f1\u00f3n, aorta, piel, m\u00e9dula \u00f3sea, cerebro y m\u00fasculo. En cada c\u00e9lula aislada, los investigadores utilizaron tecnolog\u00eda de secuenciaci\u00f3n gen\u00e9tica de c\u00e9lula \u00fanica para medir los niveles de actividad de los genes. Tambi\u00e9n analizaron la composici\u00f3n general de los tipos de c\u00e9lulas dentro de cada tejido. Luego, compararon ratones viejos y j\u00f3venes en cada dieta.<\/p>\n<figure id=\"attachment_25828\"  class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"226\" class=\"img-responsive wp-image-25828 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-458x226.jpg\" alt=\"The illustration represents the ways in which caloric restriction affects various aspects of cellular function, with the overall result of reducing inflammation and the activity of many aging-related genes.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-458x226.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-300x148.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-768x379.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-1024x505.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-147x73.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-585x289.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-553x273.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-750x370.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-767x378.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-945x466.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-1250x617.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-400x197.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500.jpg 1500w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><figcaption class=\"wp-caption-text\">La ilustraci\u00f3n muestra c\u00f3mo la restricci\u00f3n cal\u00f3rica afecta a diversos aspectos de la funci\u00f3n celular, lo que tiene como resultado general la reducci\u00f3n de la inflamaci\u00f3n y de la actividad de muchos genes relacionados con el envejecimiento.<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/p>\n<p>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>Muchos de los cambios que ocurrieron a medida que las ratas con dieta normal envejec\u00edan no ocurrieron en las ratas con dieta restringida; incluso en la vejez, muchos de los tejidos y c\u00e9lulas de los animales con dieta se parec\u00edan mucho a los de las ratas j\u00f3venes. En general, el 57 por ciento de los cambios relacionados con la edad en la composici\u00f3n celular observados en los tejidos de ratas con dieta normal no estaban presentes en las ratas con dieta restringida en calor\u00edas.<\/p>\n<p>\u201cEste enfoque no solo nos revel\u00f3 el efecto de la restricci\u00f3n cal\u00f3rica en estos tipos de c\u00e9lulas, sino que tambi\u00e9n nos proporcion\u00f3 el estudio m\u00e1s completo y detallado de lo que ocurre a nivel celular durante el envejecimiento\u201d, afirma el coautor correspondiente Guang-Hui Liu, profesor de la Academia China de Ciencias.<\/p>\n<p>Algunas de las c\u00e9lulas y genes m\u00e1s afectados por la dieta estaban relacionados con la inmunidad, la inflamaci\u00f3n y el metabolismo lip\u00eddico. El n\u00famero de c\u00e9lulas inmunitarias en casi todos los tejidos estudiados aument\u00f3 dr\u00e1sticamente a medida que las ratas del grupo de control envejec\u00edan, pero no se vio afectado por la edad en las ratas sometidas a una dieta hipocal\u00f3rica. En el tejido adiposo marr\u00f3n \u2014un tipo de tejido graso\u2014, una dieta hipocal\u00f3rica revirti\u00f3 los niveles de expresi\u00f3n de muchos genes antiinflamatorios a los observados en animales j\u00f3venes.<\/p>\n<p>\u201cEl principal hallazgo del presente estudio es que el aumento de la respuesta inflamatoria durante el envejecimiento podr\u00eda reprimirse de forma sistem\u00e1tica mediante la restricci\u00f3n cal\u00f3rica\u201d, afirma el coautor correspondiente Jing Qu, tambi\u00e9n profesor de la Academia China de Ciencias.<\/p>\n<figure id=\"attachment_25005\"  class=\"wp-caption alignright\"><img decoding=\"async\" class=\"img-responsive wp-image-25005 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-200211-551A2362-2-458x305.jpg\" alt=\"Concepcion Rodriguez Esteban and Juan Carlos Izpisua Belmonte\" \/><figcaption class=\"wp-caption-text\">De izquierda a derecha: Concepci\u00f3n Rodr\u00edguez Esteban y Juan Carlos Izpisua Belmonte.<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-200211-551A2362-2.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/p>\n<p>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>Cuando los investigadores se centraron en los factores de transcripci\u00f3n \u2014que, en esencia, son interruptores maestros capaces de modificar de manera generalizada la actividad de muchos otros genes\u2014 que se ve\u00edan alterados por la restricci\u00f3n cal\u00f3rica, uno de ellos destac\u00f3 sobre los dem\u00e1s. Los niveles del factor de transcripci\u00f3n Ybx1 se vieron alterados por la dieta en 23 tipos de c\u00e9lulas diferentes. Los cient\u00edficos creen que Ybx1 podr\u00eda ser un factor de transcripci\u00f3n relacionado con el envejecimiento y tienen previsto seguir investigando sus efectos.<\/p>\n<p>\u201cLa gente dice que \u2018eres lo que comes\u2019, y estamos comprobando que eso es cierto de muchas maneras\u201d, dice Concepcion Rodriguez Esteban, otra de las autoras del art\u00edculo y investigadora del Salk. \u201cEl estado de tus c\u00e9lulas a medida que envejeces depende claramente de tus interacciones con el entorno, lo que incluye qu\u00e9 y cu\u00e1nto comes\u201d.\u201d<\/p>\n<p>El equipo ahora est\u00e1 intentando utilizar esta informaci\u00f3n en un esfuerzo por descubrir objetivos farmacol\u00f3gicos relacionados con el envejecimiento e implementar estrategias para aumentar la esperanza de vida y la salud.<\/p>\n<p>Otros investigadores que participaron en el estudio fueron Shuai Ma, Shuhui Sun, Lingling Geng, Moshi Song, Wei Wang, Yanxia Ye, Qianzhao Ji, Zhiran Zou, Si Wang y Qi Zhou, de la Academia China de Ciencias; Xiaojuan He, Wei Li, Piu Chan y Weiqi Zhang, del Hospital Xuanwu de la Universidad M\u00e9dica de la Capital; Xiao Long, del Hospital de la Facultad de Medicina de la Uni\u00f3n de Pek\u00edn; y Guoji Guo, de la Facultad de Medicina de la Universidad de Zhejiang.<\/p>\n<p>El trabajo y los investigadores involucrados fueron apoyados por subvenciones del Programa Nacional Clave de Investigaci\u00f3n y Desarrollo de China, el Programa de Investigaci\u00f3n Prioritaria Estrat\u00e9gica de la Academia China de Ciencias, la Fundaci\u00f3n Nacional de Ciencias Naturales de China, la Fundaci\u00f3n de Ciencias Naturales de Beijing, la Comisi\u00f3n Municipal de Salud y Planificaci\u00f3n Familiar de Beijing, el Centro de Innovaci\u00f3n Avanzada para la Protecci\u00f3n del Cerebro Humano, el Laboratorio Estatal Clave de Biolog\u00eda de Membranas, la Fundaci\u00f3n Moxie y la Fundaci\u00f3n Glenn.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[85],"disease-research":[146],"class_list":["post-25815","disclosure","type-disclosure","status-publish","hentry","faculty-juan-carlos-izpisua-belmonte","disease-research-aging-and-regenerative-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Eat less, live longer - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/eat-less-live-longer\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Eat less, live longer - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014If you want to reduce levels of inflammation throughout your body, delay the onset of age-related diseases and live longer\u2014eat less food. That\u2019s the conclusion of a new study by scientists from the US and China that provides the most detailed report to date of the cellular effects of a calorie-restricted diet in rats. While the benefits of caloric restriction have long been known, the new results show how this restriction can protect against aging in cellular pathways, as detailed in Cell on February 27, 2020.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/eat-less-live-longer\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2020-02-27T19:03:39+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.salk.edu\/wp-content\/uploads\/2020\/02\/Belmonte-CR-image-1500-458x226.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/eat-less-live-longer\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/eat-less-live-longer\\\/\",\"name\":\"Eat less, live longer - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/eat-less-live-longer\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/eat-less-live-longer\\\/#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2020\\\/02\\\/Belmonte-CR-image-1500-458x226.jpg\",\"datePublished\":\"2020-02-27T16:14:07+00:00\",\"dateModified\":\"2020-02-27T19:03:39+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/eat-less-live-longer\\\/#breadcrumb\"},\"inLanguage\":\"es-MX\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/eat-less-live-longer\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/eat-less-live-longer\\\/#primaryimage\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2020\\\/02\\\/Belmonte-CR-image-1500-458x226.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2020\\\/02\\\/Belmonte-CR-image-1500-458x226.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/eat-less-live-longer\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Eat less, live longer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es-MX\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Eat less, live longer - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/es\/news-release\/eat-less-live-longer\/","og_locale":"es_MX","og_type":"article","og_title":"Eat less, live longer - Salk Institute for Biological Studies","og_description":"LA JOLLA\u2014If you want to reduce levels of inflammation throughout your body, delay the onset of age-related diseases and live longer\u2014eat less food. 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