{"id":2566,"date":"2015-09-22T00:00:00","date_gmt":"2015-09-22T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/can-your-sense-of-smell-predict-when-youll-die\/"},"modified":"2015-11-15T08:10:36","modified_gmt":"2015-11-15T16:10:36","slug":"can-your-sense-of-smell-predict-when-youll-die","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/can-your-sense-of-smell-predict-when-youll-die\/","title":{"rendered":"\u00bfPuede tu sentido del olfato predecir cu\u00e1ndo morir\u00e1s?"},"content":{"rendered":"<p>LA JOLLA\u2013Al medir c\u00f3mo se mueven los gusanos hacia un olor atractivo similar a la comida, los investigadores del Instituto Salk pudieron predecir si los gusanos tendr\u00edan una vida larga. El hallazgo, publicado el 22 de septiembre de 2015 en la revista <a href=\"http:\/\/dx.doi.org\/10.7554\/eLife.10181\" target=\"_blank\"><em>eLife<\/em><\/a>, muestra c\u00f3mo los nematodos (<em>Caenorhabditis elegans<\/em>procesar informaci\u00f3n sobre el entorno y c\u00f3mo cambian los circuitos cerebrales a medida que un animal envejece.\n<\/p>\n<p>\n\u201cNo decimos que tu capacidad de oler te har\u00e1 vivir m\u00e1s tiempo\u201d, dice <a href=\"https:\/\/www.salk.edu\/es\/faculty\/chalasani.html\/\">Sreekanth Chalasani<\/a>, profesor asistente en el Salk <a href=\"https:\/\/www.salk.edu\/es\/faculty\/molecular_neurobiology_laboratory.html\/\">Laboratorio de Neurobiolog\u00eda Molecular<\/a>. \u201cPero este comportamiento olfativo es probable que sea indicativo de alg\u00fan tipo de fisiolog\u00eda subyacente.\u201d\n<\/p>\n<p>\nEl peque\u00f1o <em>C. elegans<\/em> tiene 12 pares de neuronas especializadas en su cerebro que detectan est\u00edmulos en el ambiente. Los cient\u00edficos hab\u00edan identificado previamente pares individuales de estas neuronas como necesarios para que los animales respondan a olores atractivos. Chalasani y sus colegas quer\u00edan comprender todo este proceso con m\u00e1s detalle. En su nuevo trabajo, los investigadores midieron las respuestas de las 24 neuronas a medida que <em>C. elegans<\/em> fue expuesto a benzaldeh\u00eddo, una sustancia qu\u00edmica que desprende un agradable olor similar al de las almendras. Sorprendentemente, a diferencia de los pares individuales que se hab\u00edan demostrado previamente, descubrieron que tambi\u00e9n estaban involucradas neuronas adicionales.\n<\/p>\n<div class=\"imageCaption\"><img decoding=\"async\" style=\"border-bottom: 1px #006699 solid;\" alt=\"\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/01\/2112-Shrek-Chalasani.jpg\"><\/p>\n<p>Sreekanth Chalasani, un profesor asistente de Salk, midi\u00f3 las respuestas neuronales de gusanos expuestos a un qu\u00edmico que desprende un olor similar al de las almendras. Al medir la velocidad a la que los gusanos se mov\u00edan hacia el olor similar a la comida, los investigadores pudieron predecir si los gusanos vivir\u00edan mucho tiempo.<\/p>\n<p><a target=\"_blank\" href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/02\/2112-Shrek-Chalasani.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/p>\n<p>\nImagen: Cortes\u00eda del Instituto Salk de Estudios Biol\u00f3gicos\n<\/p>\n<\/div>\n<p>\nCuriosamente, estas c\u00e9lulas se dividieron en neuronas primarias y secundarias. Las neuronas primarias mostraron actividad en respuesta al benzaldeh\u00eddo, mientras que las neuronas secundarias respondieron a las se\u00f1ales enviadas por las neuronas primarias. Al tener un circuito neuronal estructurado de esta manera, el equipo hipotetiza que el gusano puede obtener mejor informaci\u00f3n sobre la intensidad o concentraci\u00f3n de un olor.\n<\/p>\n<p>\n\u201cSi tienes m\u00faltiples c\u00e9lulas diferentes que detectan un est\u00edmulo, puedes usar la combinaci\u00f3n de ellas para obtener informaci\u00f3n m\u00e1s din\u00e1mica\u201d, dice Sarah Leinwand, estudiante de posgrado en el laboratorio de Chalasani y autora principal del nuevo art\u00edculo. \u201cUsar esta estrategia permite a un animal generar respuestas de comportamiento flexibles a su entorno\u201d. Por ejemplo, algunos comportamientos solo pod\u00edan desencadenarse cuando un olor era lo suficientemente fuerte como para causar actividad en combinaciones particulares de neuronas. Los investigadores especulan que otras especies con cerebros m\u00e1s grandes pueden usar circuitos neuronales estructurados de manera similar para representar informaci\u00f3n sensorial y afinar sus comportamientos.\n<\/p>\n<p>\nDado que sab\u00edan que los gusanos (al igual que otros animales y personas) a menudo comienzan a perder el sentido del olfato con la edad, Chalasani y Leinwand midieron a continuaci\u00f3n c\u00f3mo cambia el circuito compuesto por neuronas primarias y secundarias a medida que <em>C. elegans<\/em> envejece. Si bien las neuronas primarias no muestran una disminuci\u00f3n en su actividad, encontraron que las neuronas secundarias se vuelven menos activas con la edad. Esto sugiere que la comunicaci\u00f3n entre neuronas podr\u00eda degradarse a medida que los animales envejecen, dice Chalasani, un fen\u00f3meno que tambi\u00e9n podr\u00eda ser cierto en otros circuitos neuronales de muchas especies diferentes. Los cient\u00edficos demostraron adem\u00e1s una correlaci\u00f3n entre el bajo rendimiento en una prueba basada en el olfato (moverse hacia una fuente puntual de benzaldeh\u00eddo), la actividad de las neuronas secundarias y la esperanza de vida del animal. Los animales mayores que tuvieron m\u00e1s \u00e9xito en encontrar el olor vivieron unos 16% m\u00e1s que los animales que fueron menos eficientes al moverse hacia el olor.\n<\/p>\n<p>\n\u201cIncluso si todos estos animales son hermanos y tienen genomas similares, si observas la actividad neuronal, el rendimiento conductual o la esperanza de vida, hay diferencias significativas\u201d, dice Chalasani. \u201cTal vez eso se deba a que algunos animales tienen una mejor se\u00f1alizaci\u00f3n entre c\u00e9lulas primarias y secundarias\u201d.\u201d\n<\/p>\n<p>\nSi la se\u00f1alizaci\u00f3n entre neuronas resulta ser importante en c\u00f3mo envejecen otros organismos \u2014incluidos los humanos\u2014, entonces la manipulaci\u00f3n del sistema nervioso podr\u00eda resultar una forma fruct\u00edfera de minimizar los efectos del envejecimiento o rejuvenecer las funciones cerebrales, afirma.\n<\/p>\n<p>\n\u201cTodav\u00eda hay muchas preguntas sobre qu\u00e9 es exactamente lo que cambia a medida que un animal envejece\u201d, dice Leinwand. \u201cQueremos seguir investigando qu\u00e9 es lo que cambia y hace que algunos animales tengan sistemas nerviosos que funcionan mejor y vivan m\u00e1s tiempo\u201d.\u201d\n\t<\/p>\n<p>\nOtros investigadores en el estudio fueron Claire Yang del Instituto Salk, Daphne Bazopoulou y Nikos Chronis de la Universidad de Michigan, y Jagan Srinivasan del Instituto Polit\u00e9cnico de Worcester.\n<\/p>\n<p>\nEl trabajo y los investigadores involucrados fueron apoyados por <a href=\"http:\/\/www.ritaallenfoundation.org\/\" target=\"_blank\">Fundaci\u00f3n Rita Allen<\/a>, la <a href=\"http:\/\/www.wmkeck.org\/\" target=\"_blank\">Fundaci\u00f3n W.M. Keck<\/a>, la <a href=\"http:\/\/www.nih.gov\/\" target=\"_blank\">Institutos Nacionales de Salud<\/a>, <a href=\"https:\/\/www.arcsfoundation.org\/\" target=\"_blank\">Recompensas por logros para cient\u00edficos universitarios<\/a> y el <a href=\"http:\/\/www.nsf.gov\/\" target=\"_blank\">Fundaci\u00f3n Nacional de Ciencias<\/a>.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[77],"disease-research":[],"class_list":["post-2566","disclosure","type-disclosure","status-publish","hentry","faculty-sreekanth-chalasani"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Can your sense of smell predict when you&#039;ll die? - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/can-your-sense-of-smell-predict-when-youll-die\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can your sense of smell predict when you&#039;ll die? - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2013By measuring how worms move toward an appealing, food-like scent, researchers at the Salk Institute were able to predict whether the worms would be long-lived. 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