{"id":2550,"date":"2015-07-14T00:00:00","date_gmt":"2015-07-14T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\/"},"modified":"2015-11-15T08:18:01","modified_gmt":"2015-11-15T16:18:01","slug":"rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\/","title":{"rendered":"Rusty Gage receives Allen Distinguished Investigator Award to reveal biology of Alzheimer\u2019s disease"},"content":{"rendered":"

\nLA JOLLA\u2013The Salk Institute today announced that Rusty Gage<\/a>, Salk professor in the Laboratorio de Gen\u00e9tica<\/a>, has been selected as one of five recipients of the Paul G. Allen Family Foundation\u2019s Allen Distinguished Investigator (ADI) program and will be awarded $1.5 million to conduct his research. These researchers have projects aimed at uncovering the elusive biological foundations of Enfermedad de Alzheimer<\/a>. The projects are funded at a total of $7 million over three years.\n<\/p>\n

\nAlzheimer\u2019s disease is the sixth leading cause of death in the United States, impacting an estimated 5.3 million Americans. Currently, someone develops Alzheimer\u2019s every 67 seconds, with that number projected to grow to every 33 seconds by 2050.\n<\/p>\n

\nDespite widespread research into treatments for Alzheimer\u2019s disease, there is a staggering 99.6% failure rate in clinical trials to bring new treatments to market.\n<\/p>\n

\n\u201cWe cannot hope to fight Alzheimer\u2019s until we understand the basic biology that underlies the onset and progression of disease,\u201d says Tom Skalak, executive director for Science and Technology for the Paul G. Allen Family Foundation. \u201cThe Allen Distinguished Investigator projects will provide crucial fresh direction in Alzheimer\u2019s disease research, in part because they include team member perspectives both from within and outside the Alzheimer\u2019s field. We know that these kinds of creative, cutting-edge projects will produce new diagnostics, treatments or even cures for this devastating disease.\u201d\n<\/p>\n

\nGage, who is the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease, studies the underlying cellular and molecular mechanisms of neurogenesis and neurodegeneration to develop avenues to repair damaged or aging brains, such as in Alzheimer\u2019s. The goal of Gage\u2019s research effort with this award is to separate out the role of aging from the role of disease in Alzheimer\u2019s disease progression. Gage will use cutting-edge cell culture methods capable of developing patient-specific neurons, as well as high-throughput RNA sequencing and bioinformatics analysis, to compare changes in gene expression due to age with changes specific to Alzheimer\u2019s disease. Since both aging and disease impact neuron function, synapses and network function, this work will provide valuable insights into the role of normal aging in disease progression.\n<\/p>\n

\nThrough the ADI program, the Paul G. Allen Family Foundation seeks to open new frontiers in science by supporting early-stage research that incorporates novel, creative and ambitious approaches with the potential to reinvent entire fields. The call for proposals in Alzheimer\u2019s research focused on generating insight into the basic biological foundations of Alzheimer\u2019s, with an emphasis on cell biology, and called for multidisciplinary teams that included researchers with a background in Alzheimer\u2019s paired with scientists who bring fresh perspectives from outside the field.\n<\/p>\n

\nAbout The Paul G. Allen Family Foundation:<\/strong>
\nLaunched by Microsoft co-founder and philanthropist Paul G. Allen and Jody Lynn Allen in 1988, the Allen family\u2019s philanthropy is dedicated to transforming lives and strengthening communities by fostering innovation, creating knowledge and promoting social progress. Since inception, the Foundation has awarded $575 million to more than 1,500 nonprofit groups to support and advance their critical charitable endeavors in the Pacific Northwest and beyond. The Foundation\u2019s funding programs nurture the arts, engage children in learning, address the needs of vulnerable populations, advance scientific and technological discoveries, and move new knowledge to global impact that creates economic growth and societal benefit. For more information, go to www.pgafamilyfoundation.org<\/a>. <\/p>","protected":false},"featured_media":0,"template":"","faculty":[76],"disease-research":[127,124],"class_list":["post-2550","disclosure","type-disclosure","status-publish","hentry","faculty-rusty-gage","disease-research-alzheimers-disease","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nRusty Gage receives Allen Distinguished Investigator Award to reveal biology of Alzheimer\u2019s disease - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rusty Gage receives Allen Distinguished Investigator Award to reveal biology of Alzheimer\u2019s disease - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2013The Salk Institute today announced that Rusty Gage, Salk professor in the Laboratory of Genetics, has been selected as one of five recipients of the Paul G. Allen Family Foundation\u2019s Allen Distinguished Investigator (ADI) program and will be awarded $1.5 million to conduct his research. These researchers have projects aimed at uncovering the elusive biological foundations of Alzheimer\u2019s disease. The projects are funded at a total of $7 million over three years.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2015-11-15T16:18:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\\\/\",\"name\":\"Rusty Gage receives Allen Distinguished Investigator Award to reveal biology of Alzheimer\u2019s disease - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"datePublished\":\"2015-07-14T07:00:00+00:00\",\"dateModified\":\"2015-11-15T16:18:01+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\\\/#breadcrumb\"},\"inLanguage\":\"es-MX\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Rusty Gage receives Allen Distinguished Investigator Award to reveal biology of Alzheimer\u2019s disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es-MX\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rusty Gage receives Allen Distinguished Investigator Award to reveal biology of Alzheimer\u2019s disease - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/es\/news-release\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\/","og_locale":"es_MX","og_type":"article","og_title":"Rusty Gage receives Allen Distinguished Investigator Award to reveal biology of Alzheimer\u2019s disease - Salk Institute for Biological Studies","og_description":"LA JOLLA\u2013The Salk Institute today announced that Rusty Gage, Salk professor in the Laboratory of Genetics, has been selected as one of five recipients of the Paul G. Allen Family Foundation\u2019s Allen Distinguished Investigator (ADI) program and will be awarded $1.5 million to conduct his research. These researchers have projects aimed at uncovering the elusive biological foundations of Alzheimer\u2019s disease. The projects are funded at a total of $7 million over three years.","og_url":"https:\/\/www.salk.edu\/es\/news-release\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\/","og_site_name":"Salk Institute for Biological Studies","article_modified_time":"2015-11-15T16:18:01+00:00","og_image":[{"width":628,"height":329,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\/","url":"https:\/\/www.salk.edu\/news-release\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\/","name":"Rusty Gage receives Allen Distinguished Investigator Award to reveal biology of Alzheimer\u2019s disease - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"datePublished":"2015-07-14T07:00:00+00:00","dateModified":"2015-11-15T16:18:01+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\/#breadcrumb"},"inLanguage":"es-MX","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/rusty-gage-receives-allen-distinguished-investigator-award-to-reveal-biology-of-alzheimers-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Rusty Gage receives Allen Distinguished Investigator Award to reveal biology of Alzheimer\u2019s disease"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Instituto Salk de Estudios Biol\u00f3gicos","description":"The Power of Science","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es-MX"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Instituto Salk de Estudios Biol\u00f3gicos","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"paper_url":"","journal_title":"","paper_author_list":"","paper_title":"","subhead":"Salk Institute research team aims to discover the fundamental causes of disease to generate successful treatments","home_photo":"2097.jpg","listing_photo":"2097.jpg","gallery":false,"legacy_boilerplate":["Show"]},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/2550","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":0,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/2550\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media?parent=2550"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/faculty?post=2550"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disease-research?post=2550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}