{"id":2523,"date":"2015-01-05T00:00:00","date_gmt":"2015-01-05T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/"},"modified":"2015-11-03T16:31:04","modified_gmt":"2015-11-04T00:31:04","slug":"imaginary-meal-tricks-the-body-into-losing-weight","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/","title":{"rendered":"&#8220;Imaginary meal&#8221; tricks the body into losing weight"},"content":{"rendered":"<p>\nLA JOLLA\u2013Salk researchers have developed an entirely new type of pill that tricks the body into thinking it has consumed calories, causing it to burn fat. The compound effectively stopped weight gain, lowered cholesterol, controlled blood sugar and minimized inflammation in mice, making it an excellent candidate for a rapid transition into human clinical trials.\n<\/p>\n<p>\nUnlike most diet pills on the market, this new pill, called fexaramine, doesn\u2019t dissolve into the blood like appetite suppressants or caffeine-based diet drugs, but remains in the intestines, causing fewer side effects.\n<\/p>\n<div class=\"imageCaption530\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/01\/2068-evans-ghost-meal.jpg\"><\/p>\n<p>\nRonald Evans, director of Salk\u2019s Gene Expression Laboratory, has developed a compound called fexaramine that acts like an imaginary meal. Fexaramine, which tricks the body into reacting as if it has consumed calories, could lead to an effective obesity and diabetes treatment in humans. <\/p>\n<p><a target=\"_blank\" href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/02\/2068-evans-ghost-meal.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/p>\n<p>\nImagen: Cortes\u00eda del Instituto Salk de Estudios Biol\u00f3gicos\n<\/p>\n<\/div>\n<p>\n\t\u201cThis pill is like an imaginary meal,\u201d says <a href=\"https:\/\/www.salk.edu\/es\/faculty\/evans.html\/\">Ronald Evans<\/a>, director of Salk\u2019s <a href=\"https:\/\/www.salk.edu\/es\/faculty\/gene_expression_laboratory.html\/\">Laboratorio de Expresi\u00f3n G\u00e9nica<\/a> and senior author of the new paper, published January 5, 2015 in <a href=\"http:\/\/www.nature.com\/nm\/journal\/vaop\/ncurrent\/full\/nm.3760.html\"><em>Nature Medicine<\/em><\/a>. \u201cIt sends out the same signals that normally happen when you eat a lot of food, so the body starts clearing out space to store it. But there are no calories and no change in appetite.\u201d\n\t<\/p>\n<p>\n\tIn the United States, more than a third of adults are obese and 29.1 million people have diabetes, according to the <a href=\"http:\/\/www.cdc.gov\/\">Centers for Disease Control and Prevention<\/a>. Both obesity and diabetes lead to an increase in health spending, a greater risk of health complications and a shorter lifespan.\n\t<\/p>\n<div class=\"imageCaption530\">\n<iframe src=\"\/\/www.youtube.com\/embed\/QNYkD7lgkXU\" frameborder=\"0\" allowfullscreen><\/iframe><\/p>\n<p>\nResearchers at the Salk Institute have developed a fat-burning compound called fexaramine that leads to weight loss without typical side effects in animal models. Fexaramine tricks the body into reacting as if it has consumed calories and could lead to an effective treatment for type 2 diabetes and obesity in humans.\n<\/p>\n<p>\nVideo: Courtesy of the Salk Institute for Biological Studies\n<\/p>\n<\/div>\n<p>\nEvans\u2019 laboratory has spent nearly two decades studying the farensoid X receptor (FXR), a protein that plays a role in how the body releases bile acids from the liver, digests food and stores fats and sugars. The human body turns on FXR at the beginning of a meal, Evans and others have shown, to prepare for an influx of food. FXR not only triggers the release of bile acids for digestion, but also changes blood sugar levels and causes the body to burn some fats in preparation for the incoming meal.\n<\/p>\n<p>\n\tPharmaceutical companies aiming to treat obesity, diabetes, liver disease and other metabolic conditions have developed systemic drugs that activate FXR, turning on many pathways that FXR controls. But these drugs affect several organs and come with side effects. Evans wondered whether switching on FXR only in the intestines\u2013rather than the intestines, liver, kidneys and adrenal glands all at once\u2013might have a different outcome.\n\t<\/p>\n<div class=\"imageCaption530\"><img decoding=\"async\" style=\"border-bottom: 1px #006699 solid;\" alt=\"\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/01\/2068-diet-pill-comp.jpg\"><\/p>\n<p>Salk researchers demonstrated that fexaramine stops weight gain and burns fat in animal models. Fexaramine is only absorbed in the gut and does not go into the bloodstream, so it does not cause side effects common for typical diet pills. After additional testing, researchers believe this will lead to an effective weight loss diabetes treatment for humans.<\/p>\n<p><a target=\"_blank\" href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/02\/2068-diet-pill-comp.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/p>\n<p>\n\tImagen: Cortes\u00eda del Instituto Salk de Estudios Biol\u00f3gicos\n\t<\/p>\n<\/div>\n<p>\n\t\u201cWhen you eat, you have to quickly activate a series of responses all throughout the body,\u201d says Evans. \u201cAnd the reality is that the very first responder for all this is the intestine.\u201d\n\t<\/p>\n<p>\n\tEvans and his colleagues developed the fexaramine compound by departing from the drug scaffold that most pharmaceutical companies typically pursue when targeting FXR. \u201cIt turns out that when we administer this orally, it only acts in the gut,\u201d explains Michael Downes, a senior staff scientist at Salk and co-corresponding author of the new work. Giving one such drug in a daily pill form that only reaches the intestines\u2013without transporting into the bloodstream that would carry the drug throughout the body\u2013not only curtails side effects but also made the compound better at stopping weight gain.\n\t<\/p>\n<p>\n\tWhen the group gave obese mice a daily pill of fexaramine for five weeks, the mice stopped gaining weight, lost fat and had lower blood sugar and cholesterol levels than untreated mice. In addition, the mice had a rise in body temperature\u2013which signals metabolism ramping up\u2013and some deposits of white fat in their bodies converted into a healthier, energy-burning beige form of the tissue. Even the collection of bacteria in the guts of mice shifted when they received the drug, although what those changes mean isn\u2019t clear yet.<\/p>\n<p>\tSo, why does fexaramine in the intestines work even better than drugs that simultaneously activate FXR throughout the body? Evans thinks it has to do with the natural order in which the body\u2019s molecular pathways normally responds to a meal.  <\/p>\n<p>\t\u201cThe body\u2019s response to a meal is like a relay race, and if you tell all the runners to go at the same time, you\u2019ll never pass the baton,\u201d says Evans. \u201cWe\u2019ve learned how to trigger the first runner so that the rest of the events happen in a natural order.\u201d\n\t<\/p>\n<div class=\"imageCaption530\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/01\/2068-evans-lab.jpg\"><\/p>\n<p>\n\tFrom left: Salk researchers Ruth Yu, Sungsoon Fang, Annette Atkins, Ronald Evans, Michael Downes and Sandra Jacinto<\/p>\n<p><a target=\"_blank\" href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/02\/2068-evans-lab.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/p>\n<p>\n\tImagen: Cortes\u00eda del Instituto Salk de Estudios Biol\u00f3gicos\n\t<\/p>\n<\/div>\n<p>\n\tSince fexaramine doesn\u2019t reach the bloodstream, it is also likely safer in humans than other FXR-targeting drugs, the researchers hypothesize. They\u2019re already working to set up human clinical trials to test the effectiveness of fexaramine to treat obesity and metabolic disease. Ideally the drug, administered under a doctor\u2019s guidance, would work in conjunction with diet and lifestyle changes, similar to weight-loss surgeries or other obesity or diabetes drugs.\n\t<\/p>\n<div class=\"imageCaption530\">\n<iframe src=\"\/\/www.youtube.com\/embed\/qY5HgH_6Fz8\" frameborder=\"0\" allowfullscreen><\/iframe><\/p>\n<p>\nVideo: Courtesy of the Salk Institute for Biological Studies\n<\/p>\n<\/div>\n<p>\nOther researchers on the study were Sungsoon Fang, Jae Myoung Suh, Elizabeth Yu, Eiji Yoshihara, Sandra Jacinto, Yelizaveta Lukasheva, Annette Atkins and Ruth Yu of the Salk Institute; Shannon Reilly and Alan Saltiel of the <a href=\"https:\/\/www.umich.edu\/\" target=\"_blank\">University of Michigan<\/a>; Olivia Osborn, Denise Lackey, Bernd Schnabl, David Brenner and Jerrold Olefsky of the <a href=\"http:\/\/ucsd.edu\/\" target=\"_blank\">Universidad de California, San Diego<\/a>; Alessia Perino and Kristina Schoonjans of the <a href=\"http:\/\/www.epfl.ch\/\" target=\"_blank\">\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne<\/a>; Alexander Khvat of ChemDiv; and Sally Coulter and Christopher Liddle of the <a href=\"http:\/\/sydney.edu.au\/\" target=\"_blank\">University of Sydney<\/a>.\n<\/p>\n<p>\nThe work was supported by grants from the <a href=\"http:\/\/nih.gov\">Institutos Nacionales de Salud<\/a>, <a href=\"http:\/\/glennfoundation.org\/\" target=\"_blank\">Glenn Foundation for Medical Research<\/a>, <a href=\"http:\/\/helmsleytrust.org\/\" target=\"_blank\">Fundaci\u00f3n Ben\u00e9fica Leona M. y Harry B. Helmsley<\/a>, <a href=\"http:\/\/www.ipsen.com\/\" target=\"_blank\">Ipsen Bioscience<\/a>, <a href=\"http:\/\/www.cirm.ca.gov\/\">California Institute for Regenerative Medicine<\/a>, la <a href=\"http:\/\/www.ellisonfoundation.org\/\">Ellison Medical Foundation<\/a> and the <a href=\"http:\/\/www.nhmrc.gov.au\/\" target=\"_blank\">National Health and Medical Research Council of Australia<\/a>. Ronald Evans also receives funding from the <a href=\"http:\/\/www.hhmi.org\/\" target=\"_blank\">Howard Hughes Medical Institute<\/a>.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[91],"disease-research":[173,165,123,166],"class_list":["post-2523","disclosure","type-disclosure","status-publish","hentry","faculty-ronald-evans","disease-research-diabetes-type-1","disease-research-diabetes-type-2","disease-research-metabolism-and-diabetes","disease-research-obesity"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>&quot;Imaginary meal&quot; tricks the body into losing weight - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"&quot;Imaginary meal&quot; tricks the body into losing weight - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2013Salk researchers have developed an entirely new type of pill that tricks the body into thinking it has consumed calories, causing it to burn fat. The compound effectively stopped weight gain, lowered cholesterol, controlled blood sugar and minimized inflammation in mice, making it an excellent candidate for a rapid transition into human clinical trials.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2015-11-04T00:31:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/imaginary-meal-tricks-the-body-into-losing-weight\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/imaginary-meal-tricks-the-body-into-losing-weight\\\/\",\"name\":\"\\\"Imaginary meal\\\" tricks the body into losing weight - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/imaginary-meal-tricks-the-body-into-losing-weight\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/imaginary-meal-tricks-the-body-into-losing-weight\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/01\\\/2068-evans-ghost-meal.jpg\",\"datePublished\":\"2015-01-05T08:00:00+00:00\",\"dateModified\":\"2015-11-04T00:31:04+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/imaginary-meal-tricks-the-body-into-losing-weight\\\/#breadcrumb\"},\"inLanguage\":\"es-MX\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/imaginary-meal-tricks-the-body-into-losing-weight\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/imaginary-meal-tricks-the-body-into-losing-weight\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/01\\\/2068-evans-ghost-meal.jpg\",\"contentUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/01\\\/2068-evans-ghost-meal.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/imaginary-meal-tricks-the-body-into-losing-weight\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"&#8220;Imaginary meal&#8221; tricks the body into losing weight\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es-MX\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\"Imaginary meal\" tricks the body into losing weight - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/es\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/","og_locale":"es_MX","og_type":"article","og_title":"\"Imaginary meal\" tricks the body into losing weight - Salk Institute for Biological Studies","og_description":"LA JOLLA\u2013Salk researchers have developed an entirely new type of pill that tricks the body into thinking it has consumed calories, causing it to burn fat. The compound effectively stopped weight gain, lowered cholesterol, controlled blood sugar and minimized inflammation in mice, making it an excellent candidate for a rapid transition into human clinical trials.","og_url":"https:\/\/www.salk.edu\/es\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/","og_site_name":"Salk Institute for Biological Studies","article_modified_time":"2015-11-04T00:31:04+00:00","og_image":[{"width":628,"height":329,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/","url":"https:\/\/www.salk.edu\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/","name":"\"Imaginary meal\" tricks the body into losing weight - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/#primaryimage"},"thumbnailUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/01\/2068-evans-ghost-meal.jpg","datePublished":"2015-01-05T08:00:00+00:00","dateModified":"2015-11-04T00:31:04+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/#breadcrumb"},"inLanguage":"es-MX","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/"]}]},{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/#primaryimage","url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/01\/2068-evans-ghost-meal.jpg","contentUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/01\/2068-evans-ghost-meal.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/imaginary-meal-tricks-the-body-into-losing-weight\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"&#8220;Imaginary meal&#8221; tricks the body into losing weight"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Instituto Salk de Estudios Biol\u00f3gicos","description":"The Power of Science","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es-MX"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Instituto Salk de Estudios Biol\u00f3gicos","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"paper_url":"http:\/\/www.nature.com\/nm\/journal\/vaop\/ncurrent\/full\/nm.3760.html","journal_title":"Nature Medicine","paper_author_list":"Sungsoon Fang, Jae Myoung Suh, Elizabeth Yu, Eiji Yoshihara, Sandra Jacinto, Yelizaveta Lukasheva, Annette R. Atkins, Ruth T. Yu, Michael Downes, and Ronald M. Evans of the Salk Institute for Biological Studies; Shannon M. Reilly and Alan R. Saltiel of the University of Michigan; Olivia Osborn, Denise Lackey, Bernd Schnabl, David A. Brenner, and Jerrold M. Olefsky of the University of California, San Diego; Alessia Perino and Kristina Schoonjans of the \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne; Alexander Khvat of ChemDiv; and Sally Coulter and Christopher Liddle of the University of Sydney","paper_title":"Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance","subhead":"Salk scientists made a more effective diet pill","home_photo":"2068.jpg","listing_photo":"2068.jpg","gallery":false,"legacy_boilerplate":["Show"]},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/2523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":0,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/2523\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media?parent=2523"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/faculty?post=2523"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disease-research?post=2523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}