{"id":2486,"date":"2014-05-29T00:00:00","date_gmt":"2014-05-29T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\/"},"modified":"2014-05-29T00:00:00","modified_gmt":"2014-05-29T07:00:00","slug":"pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\/","title":{"rendered":"Pedal the Cause funds local ground-breaking cancer research with inaugural grant awards"},"content":{"rendered":"

\nLA JOLLA\u2014Pedal the Cause, the region’s only multiday cycling fundraiser where 100 percent of the net proceeds goes to support cancer research in San Diego, today announced five research projects funded by the inaugural 2013 event. The Pedal the Cause<\/a> grants offer enough support for initial experiments, which will ideally lead to grants from federal sources and to large-scale studies.\n<\/p>\n

\nMore than $400,000 was awarded for collaborative, translational cancer research, including five projects at UC San Diego Moores Cancer Center<\/a>, Sanford-Burnham Medical Research Institute<\/a> and the Instituto Salk de Estudios Biol\u00f3gicos<\/a>. These collaborative research projects highlight the potential for groundbreaking science when institutes work together. The funded research projects include targeting pancreatic c\u00e1ncer<\/a>, one of the deadliest recalcitrant cancers; developing inhibitors for a protein pathway that drives a high percentage of cancer metastasis; and searching for a novel hereditary breast cancer susceptibility gene.\n<\/p>\n

\n“We founded Pedal to help fund transformative research with the potential for rapid impact on the way cancer is treated. Each of our five grantees will explore novel approaches to fighting cancer that could make a big difference for patients here in San Diego and around the world,” said Pedal the Cause executive director Patrick Connor.\n<\/p>\n

\nPedal the Cause beneficiaries UC San Diego Moores Cancer Center<\/a>, Sanford-Burnham Medical Research Institute<\/a>, y el Salk Institute<\/a> have formed the San Diego National Cancer Institute Cancer Centers Council<\/a>, or C3. The ultimate mission of the C3 is to leverage distinct and combined resources and talents of the member institutes to accelerate, understand, and create innovative approaches for the treatment and prevention of cancer.\n<\/p>\n

\n“Each of these grants will fund leading-edge research that has the potential to significantly change the way we fight different cancers by developing new therapies and rapidly translating them from the research bench to the bedside, helping us achieve our goal of making personalized cancer care a reality in San Diego. These high-impact projects would not be funded without Pedal the Cause,” said Scott M. Lippman, MD, director of UC San Diego Moores Cancer Center.\n<\/p>\n

\n“These types of pioneering research initiatives are extremely important. The exciting collaborations they represent can only happen here in San Diego with the caliber of researchers and clinicians we have working together through the Cancer Centers Council. With Pedal the Cause’s support, and the collective resources the C3 provides, we will be able to translate discoveries from these initiatives into innovative treatments faster than ever before,” said Garth Powis, DPhil director of Sanford-Burnham’s NCI-designated Cancer Center and team captain of the Institute’s Pedal the Cause<\/a> team.\n<\/p>\n

\n“Working with our colleagues around San Diego is offering unprecedented opportunity for new and exciting discoveries. Every Pedal the Cause rider should know that they are an integral part of the research, through the funding that they are generating through this event,” said Tony Hunter<\/a>, PhD, a professor in the Laboratorio de Biolog\u00eda Molecular y Celular<\/a> and director of Salk Institute Cancer Center<\/a>.\n<\/p>\n

\nThe five grant recipients were reviewed and approved by an esteemed panel of doctors and scientists on the C3 Grant Review and Approval Committee, chaired by Dr. Hunter. The criteria on which they were evaluated was thorough and rigorous, with an emphasis on collaborative, translational research. Each grant recipient has the potential to make a huge difference in cancer treatment.\n<\/p>\n

\nFinding New Hereditary Breast Cancer Markers<\/strong>
\nOnly 10 percent of breast cancer cases are linked to BRCA. Lisa Madlensky, PhD, (Moores Cancer Center) and Geoffrey Wahl<\/a>, PhD, (Salk) are working with a family that is strongly suspected of carrying a hereditary breast cancer gene, even though all members are BRCA-negative. The study aims to find a new susceptibility gene for which families with unexplained hereditary breast cancer can be tested. This information could help determine which family members have the gene and therefore need to be monitored carefully or undertake breast cancer prevention measures, and which family members did not inherit the gene and are considered to be at average risk.\n<\/p>\n

\nStopping Cancer Growth<\/strong>
\nThe process of secretion by which cells export proteins was not previously known to play an important role in cancer. However, a newly discovered pathway that functions in secretion, named for its key protein GOLPH3, drives a high fraction of cancers that together account for the majority of cancer deaths, making an unprecedented link between secretion and cancer. Seth Field, MD, PhD, (UC San Diego) and Michael Jackson, PhD, (Sanford-Burnham) will collaborate on research to take advantage of this unique pathway as a target for a new class of cancer treatments. They will identify inhibitors of the GOLPH3 pathway to study their potential as novel cancer drugs.\n<\/p>\n

\nReprogramming Pancreatic Cancer’s Hard Shell<\/strong>
\nEvery day, a San Diegan will be diagnosed with pancreatic cancer, yet only one in 20 will survive for five years after this diagnosis. Pancreatic cancer is the fourth deadliest cancer, yet very little progress has been made in fighting the disease over the last 50 years. Pancreatic cancer is difficult to treat in part because the cancer grows encased in a thick tissue protective layer called the “activated stroma.” Andrew Lowy, MD, (Moores Cancer Center) and Geoffrey Wahl, PhD, (Salk) will study a novel way to treat this recalcitrant cancer by focusing on smart-drugs that can reprogram the stroma to allow other smart-drugs to attack the cancer inside.\n<\/p>\n

\nHalting Breast Cancer’s Spread<\/strong>
\nThe spread of cancer cells from the primary tumor to distant organs, termed metastasis, is the leading cause of cancer-related death. Even the removal of early-diagnosed primary breast cancer cannot guarantee prevention of metastatic recurrence many years later. Michael Karin, PhD, (Moores Cancer Center) and Geoffrey Wahl, PhD, (Salk) will research ways of halting breast cancer metastasis by inhibiting Ubc13 and p38, enzymes involved in controlling metastatic spread..\n<\/p>\n

\nDiscovering Gastrointestinal Stromal Tumor Weaknesses<\/strong>
\nGastrointestinal stromal tumor (GIST) is a cancer that arises from nerve cells that control the movement of muscles in the intestine. Many GISTs have a high level of a protein called KIT, which led to the use of a drug called imatinib that could attack KIT. This became the first targeted, personalized treatment of solid tumors. However, it did not completely cure the disease, because some GISTs don’t have the KIT target or develop a drug-resistant form of KIT. Jason Sicklick, MD, (Moores Cancer Center) and Robert Weschler-Reya, PhD, (Sanford-Burnham) will use advanced screening technology to discover new drugs that can target GISTs resistant to current therapies.\n<\/p>\n

\nPedal the Cause 2014<\/strong>
\nThe second annual event will take place September 20 and 21, featuring courses for any riding ability, from 10-miles, up to a two-day ride between La Jolla and Temecula. Participants can register to ride, become a virtual rider, or volunteer. Event registration is now open to the public at: sandiego.pedalthecause.org<\/a>.\n<\/p>\n

\nA unique cycling experience, Pedal the Cause offers riders and supporters a world-class experience, raising support and awareness for the incredible work being done to fight cancer in San Diego. From the training support to the finish-line celebration, Pedal the Cause courses offer an unforgettable riding experience through San Diego County.\n<\/p>\n

\nFor more information about courses, free training, volunteer opportunities, registering, or donating, please visit sandiego.pedalthecause.org<\/a>.\n<\/p>\n

\nAbout UC San Diego Moores Cancer Center:<\/strong>
\nUC San Diego Moores Cancer Center is home to nearly 350 medical and radiation oncologists, cancer surgeons, and researchers. It is one of only 41 National Cancer Institute-designated comprehensive cancer centers in the country, a rare honor distinguishing exceptionally high achievement in research, clinical care, education and community outreach and partnerships. For more information, visit cancer.ucsd.edu<\/a>.\n<\/p>\n

\nAbout Sanford-Burnham Medical Research Institute:<\/strong>
\nSanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. Sanford-Burnham takes a collaborative approach to medical research with major programs in cancer, neurodegeneration and stem cells, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is recognized for its National Cancer Institute-designated Cancer Center and expertise in drug discovery technologies. Sanford-Burnham is a nonprofit, independent institute that employs 1,200 scientists and staff in San Diego (La Jolla), Calif., and Orlando (Lake Nona), Fla. For more information, visit us at sanfordburnham.org<\/a>.\n<\/p>\n

About Pedal the Cause:<\/strong>
\nFounded in 2012, Pedal The Cause-San Diego is a California non-profit public benefit corporation established to fund, plan and manage an annual cycling fundraiser in which 100% of the net proceeds stay in San Diego to benefit cancer research at the three National Cancer Institute-designated cancer centers. It is our hope that research funded by Pedal The Cause will ultimately lead to a cure for cancer, and propel San Diego to the forefront of cancer cures and care. For more information, please visit sandiego.pedalthecause.org<\/a>. Find us on Facebook at www.facebook.com\/PedalTheCauseSanDiego<\/a> and on Twitter, @pedalSD<\/a>.\n<\/p>\n

\nAcerca del Instituto Salk de Estudios Biol\u00f3gicos:<\/strong>
\nEl Instituto Salk de Estudios Biol\u00f3gicos es una de las instituciones de investigaci\u00f3n b\u00e1sica m\u00e1s destacadas del mundo, donde un cuerpo docente de prestigio internacional investiga cuestiones fundamentales de las ciencias de la vida en un entorno \u00fanico, colaborativo y creativo. Centrados tanto en el descubrimiento como en la formaci\u00f3n de las futuras generaciones de investigadores, los cient\u00edficos del Salk realizan contribuciones revolucionarias a nuestra comprensi\u00f3n del c\u00e1ncer, el envejecimiento, el Alzheimer, la diabetes y las enfermedades infecciosas mediante el estudio de la neurociencia, la gen\u00e9tica, la biolog\u00eda celular y vegetal, y otras disciplinas relacionadas. <\/p>\n

\nFaculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, MD, the Institute is an independent nonprofit organization and architectural landmark.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[90,72],"disease-research":[163,46,172],"class_list":["post-2486","disclosure","type-disclosure","status-publish","hentry","faculty-geoffrey-wahl","faculty-tony-hunter","disease-research-breast-cancer","disease-research-cancer-biology","disease-research-pancreatic-cancer"],"acf":[],"yoast_head":"\nPedal the Cause funds local ground-breaking cancer research with inaugural grant awards - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pedal the Cause funds local ground-breaking cancer research with inaugural grant awards - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Pedal the Cause, the region’s only multiday cycling fundraiser where 100 percent of the net proceeds goes to support cancer research in San Diego, today announced five research projects funded by the inaugural 2013 event. The Pedal the Cause grants offer enough support for initial experiments, which will ideally lead to grants from federal sources and to large-scale studies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\\\/\",\"name\":\"Pedal the Cause funds local ground-breaking cancer research with inaugural grant awards - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"datePublished\":\"2014-05-29T07:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\\\/#breadcrumb\"},\"inLanguage\":\"es-MX\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pedal the Cause funds local ground-breaking cancer research with inaugural grant awards\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es-MX\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Pedal the Cause funds local ground-breaking cancer research with inaugural grant awards - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/es\/news-release\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\/","og_locale":"es_MX","og_type":"article","og_title":"Pedal the Cause funds local ground-breaking cancer research with inaugural grant awards - Salk Institute for Biological Studies","og_description":"LA JOLLA\u2014Pedal the Cause, the region’s only multiday cycling fundraiser where 100 percent of the net proceeds goes to support cancer research in San Diego, today announced five research projects funded by the inaugural 2013 event. The Pedal the Cause grants offer enough support for initial experiments, which will ideally lead to grants from federal sources and to large-scale studies.","og_url":"https:\/\/www.salk.edu\/es\/news-release\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\/","og_site_name":"Salk Institute for Biological Studies","og_image":[{"width":628,"height":329,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\/","url":"https:\/\/www.salk.edu\/news-release\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\/","name":"Pedal the Cause funds local ground-breaking cancer research with inaugural grant awards - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"datePublished":"2014-05-29T07:00:00+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\/#breadcrumb"},"inLanguage":"es-MX","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/pedal-the-cause-funds-local-ground-breaking-cancer-research-with-inaugural-grant-awards\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Pedal the Cause funds local ground-breaking cancer research with inaugural grant awards"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Instituto Salk de Estudios Biol\u00f3gicos","description":"The Power of Science","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es-MX"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Instituto Salk de Estudios Biol\u00f3gicos","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"paper_url":"","journal_title":"","paper_author_list":"","paper_title":"","subhead":"","home_photo":"2031.jpg","listing_photo":"2031.jpg","line_2":"","line_1":"Pedal the Cause funds local ground-breaking cancer research with inaugural grant awards"},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/2486","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":0,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/2486\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media?parent=2486"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/faculty?post=2486"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disease-research?post=2486"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}