{"id":2449,"date":"2013-09-06T00:00:00","date_gmt":"2013-09-06T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/salk-scientists-and-colleagues-discover-important-mechanism-underlying-alzheimers-disease\/"},"modified":"2013-09-06T00:00:00","modified_gmt":"2013-09-06T07:00:00","slug":"salk-scientists-and-colleagues-discover-important-mechanism-underlying-alzheimers-disease","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-and-colleagues-discover-important-mechanism-underlying-alzheimers-disease\/","title":{"rendered":"Cient\u00edficos de Salk y colegas descubren importante mecanismo subyacente a la enfermedad de Alzheimer"},"content":{"rendered":"<p>LA JOLLA, CA\u2014<a href=\"\/es\/ra\/alzheimers_and_aging.html\/\">Enfermedad de Alzheimer<\/a> afecta a m\u00e1s de 26 millones de personas en todo el mundo. Se prev\u00e9 que se disparar\u00e1 a medida que los \"baby boomers\" envejezcan: se proyecta que casi 106 millones de personas tendr\u00e1n la enfermedad para 2050. Afortunadamente, los cient\u00edficos est\u00e1n logrando progresos en terapias. Una colaboraci\u00f3n entre varias entidades de investigaci\u00f3n, incluido el Salk Institute y el Sanford-Burnham Medical Research Institute, ha definido un mecanismo clave detr\u00e1s del progreso de la enfermedad, lo que da esperanzas de que un nuevo f\u00e1rmaco modificado contra el Alzheimer sea efectivo.<\/p>\n<p>\nEn un estudio previo en 2009, <a href=\"\/es\/faculty\/heinemann.html\/\">Stephen F. Heinemann<\/a>, profesor del Instituto Salk <a href=\"\/es\/faculty\/molecular_neurobiology_laboratory.html\/\">Laboratorio de Neurobiolog\u00eda Molecular<\/a>, descubri\u00f3 que un receptor nicot\u00ednico llamado Alfa-7 podr\u00eda ayudar a desencadenar la enfermedad de Alzheimer. \u201cEstudios previos expusieron una posible interacci\u00f3n entre los receptores nicot\u00ednicos Alfa-7 (\u03b17Rs) con la beta amiloide, la prote\u00edna t\u00f3xica que se encuentra en las placas, caracter\u00edstica distintiva de la enfermedad\u201d, dice Gustavo Dziewczapolski, investigador del laboratorio de Heinemann. \u201cDemostramos por primera vez, in vivo, que la uni\u00f3n de estas dos prote\u00ednas, \u03b17Rs y beta amiloide, provoca efectos perjudiciales en ratones, similares a los s\u00edntomas observados en la enfermedad de Alzheimer\u201d.\u201d <\/p>\n<p>\nSus experimentos, publicados en <em>El Journal of Neuroscience<\/em>, con Dziewczapolski como primer autor, consisti\u00f3 en probar ratones inducidos con la enfermedad de Alzheimer con el gen de los receptores \u03b17 y sin \u00e9l. Descubrieron que, si bien ambos tipos de ratones desarrollaron placas, solo aquellos con receptores \u03b17 mostraron las deficiencias asociadas con el Alzheimer. <\/p>\n<p>\nPero eso a\u00fan dejaba una pregunta clave: <em>\u00bfPor qu\u00e9?<\/em> \u00bfFue la combinaci\u00f3n perjudicial? <\/p>\n<p>\nEn un art\u00edculo reciente publicado en la revista <em><a href=\"http:\/\/www.pnas.org\/content\/early\/2013\/06\/13\/1306832110\">Actas de la Academia Nacional de Ciencias<\/a><\/em>, Heinemann y Dziewczapolski, aqu\u00ed en el Instituto Salk, junto con Juan Pi\u00f1a-Crespo, Sara Sanz-Blasco, Stuart A. Lipton, del Instituto de Investigaci\u00f3n M\u00e9dica Sanford-Burnham, y sus colaboradores, anunciaron que hab\u00edan encontrado la respuesta en unas interacciones inesperadas entre las neuronas y otras c\u00e9lulas cerebrales. <\/p>\n<p>\nLas neuronas se comunican enviando se\u00f1ales el\u00e9ctricas y qu\u00edmicas entre s\u00ed a trav\u00e9s de espacios llamados sinapsis. La mezcla bioqu\u00edmica en las sinapsis se asemeja a un importante aeropuerto en un fin de semana festivo: est\u00e1 abarrotado, es complicado y extremadamente sensible a los aumentos y disminuciones del tr\u00e1fico. Una de estas sustancias qu\u00edmicas de se\u00f1alizaci\u00f3n es el glutamato, un neurotransmisor excitatorio, esencial para el aprendizaje y el almacenamiento de recuerdos. En el equilibrio adecuado, el glutamato forma parte del funcionamiento normal de las sinapsis neuronales. Pero las neuronas no son las \u00fanicas c\u00e9lulas del cerebro capaces de liberar glutamato. Los astrocitos, que alguna vez se pens\u00f3 que eran simplemente pegamento celular entre neuronas, tambi\u00e9n liberan este neurotransmisor. <\/p>\n<p>\nEn esta nueva comprensi\u00f3n de la enfermedad de Alzheimer, existe una cascada de se\u00f1alizaci\u00f3n celular, en la cual el beta amiloide estimula los receptores nicot\u00ednicos alfa 7, que activan a los astrocitos para que liberen glutamato adicional en la sinapsis, sobrecarg\u00e1ndola con se\u00f1ales excitatorias (\u201cir\u201d). <\/p>\n<p>\nEsta liberaci\u00f3n, a su vez, activa otro conjunto de receptores fuera de la sinapsis, llamados receptores extrasin\u00e1pticos de N-metil-D-aspartato (eNMDARs), que deprimen la actividad sin\u00e1ptica. Desafortunadamente, los eNMDARs parecen deprimir excesivamente la funci\u00f3n sin\u00e1ptica, lo que lleva a la p\u00e9rdida de memoria y la confusi\u00f3n asociadas con el Alzheimer.<\/p>\n<p>\nAhora que el equipo ha logrado finalmente identificar los pasos de esta v\u00eda destructiva, la buena noticia es que un f\u00e1rmaco desarrollado por el Laboratorio Lipton, llamado NitroMemantine \u2014una modificaci\u00f3n del medicamento anterior para el Alzheimer, la memantina\u2014, podr\u00eda bloquear la entrada de los eNMDAR en la cascada.<\/p>\n<p>\n\u201cGracias al esfuerzo conjunto de nuestros colegas y colaboradores, finalmente parece que tenemos un v\u00ednculo mecanicista claro entre un objetivo clave de la beta amiloide en el cerebro, los receptores nicot\u00ednicos Alpha7, que desencadena efectos da\u00f1inos posteriores asociados con el inicio y la progresi\u00f3n de la enfermedad de Alzheimer\u201d, dice Dziewczapolski. \u201cEsta es una clara demostraci\u00f3n del valor de la investigaci\u00f3n biom\u00e9dica b\u00e1sica. El desarrollo de f\u00e1rmacos no puede avanzar sin conocer los detalles de las interacciones a nivel molecular y celular. Nuestra investigaci\u00f3n revel\u00f3 dos objetivos potenciales, los \u03b17Rs y los eNMDARs, para futuras terapias que modifiquen la enfermedad, y que el Dr. Heinemann y yo esperamos que se traduzcan en un mejor tratamiento para los pacientes con Alzheimer\u201d.\u201d <\/p>\n<p>\nOtros investigadores que participaron en el estudio fueron Maria Talantova, Xiaofei Zhang, Peng Xia, Mohd Waseem Akhtar, Shu-ichi Okamoto, Tomohiro Nakamura, Gang Cao, Alexander E. Pratt, Yeon-Joo Kang, Shichun Tu, Elena Molokanova, Gary Tong, Scott R. McKercher, James Parker, Emily A. Holland, Traci Fang-Newmeyer, Dongxian Zhang, Nobuki Nakanishi, H.-S. Vincent Chen y Rajesh Ambasudhan, del Instituto de Investigaci\u00f3n M\u00e9dica Sanford-Burnham; Samuel Andrew Hires, del Instituto de Investigaci\u00f3n M\u00e9dica Howard Hughes; Herman Wolosker y Hagit Sason, del Instituto Tecnol\u00f3gico de Israel (Technion); Yuqiang Wang, de la Universidad de Jinan en China y del Instituto de Investigaci\u00f3n Panorama en California; Loren H. Parsons, David G. Stouffer, Matthew W. Buczynski, Amanda Roberts, James P. Solomon, Evan T. Powers y Jeffery W. Kelly, del Instituto de Investigaci\u00f3n Scripps; Sarah Michael y Eliezer Masliah, de la Facultad de Medicina de la UCSD.<\/p>\n<p>\nEste trabajo fue financiado por la <a href=\"http:\/\/www.nih.gov\/\">Institutos Nacionales de Salud<\/a>, <a href=\"http:\/\/www.defense.gov\/\">Departamento de Defensa<\/a>, <a href=\"http:\/\/www.ninds.nih.gov\/\">Instituto Nacional de Trastornos Neurol\u00f3gicos y Accidentes Cerebrovasculares<\/a>, <a href=\"http:\/\/www.heart.org\/HEARTORG\/\">Asociaci\u00f3n Americana del Coraz\u00f3n<\/a> y el Ministerio de Educaci\u00f3n y Ciencia de Espa\u00f1a.<\/p>\n<p><strong><br \/>\nAcerca del Instituto Salk de Estudios Biol\u00f3gicos:<\/strong><\/p>\n<p>El Instituto Salk de Estudios Biol\u00f3gicos es una de las instituciones de investigaci\u00f3n b\u00e1sica m\u00e1s destacadas del mundo, donde un cuerpo docente de prestigio internacional investiga cuestiones fundamentales de las ciencias de la vida en un entorno \u00fanico, colaborativo y creativo. Centrados tanto en el descubrimiento como en la formaci\u00f3n de las futuras generaciones de investigadores, los cient\u00edficos del Salk realizan contribuciones revolucionarias a nuestra comprensi\u00f3n del c\u00e1ncer, el envejecimiento, el Alzheimer, la diabetes y las enfermedades infecciosas mediante el estudio de la neurociencia, la gen\u00e9tica, la biolog\u00eda celular y vegetal, y otras disciplinas relacionadas.\n<\/p>\n<p>\nLos logros del cuerpo docente han sido reconocidos con numerosos galardones, entre los que se incluyen premios Nobel y la pertenencia a la Academia Nacional de Ciencias. Fundado en 1960 por el Dr. Jonas Salk, pionero en la vacuna contra la poliomielitis, el Instituto es una organizaci\u00f3n independiente sin fines de lucro y un hito arquitect\u00f3nico.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[],"disease-research":[127,146,124],"class_list":["post-2449","disclosure","type-disclosure","status-publish","hentry","disease-research-alzheimers-disease","disease-research-aging-and-regenerative-medicine","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Salk scientists and colleagues discover important mechanism underlying Alzheimer&#039;s disease - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-and-colleagues-discover-important-mechanism-underlying-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk scientists and colleagues discover important mechanism underlying Alzheimer&#039;s disease - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA, CA\u2014Alzheimer&#8217;s disease affects more than 26 million people worldwide. 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