{"id":2399,"date":"2012-10-26T00:00:00","date_gmt":"2012-10-26T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/salk-study-finds-diabetes-raises-levels-of-proteins-linked-to-alzheimers-features\/"},"modified":"2012-10-26T00:00:00","modified_gmt":"2012-10-26T07:00:00","slug":"salk-study-finds-diabetes-raises-levels-of-proteins-linked-to-alzheimers-features","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/salk-study-finds-diabetes-raises-levels-of-proteins-linked-to-alzheimers-features\/","title":{"rendered":"Estudio de Salk: la diabetes eleva los niveles de prote\u00ednas vinculadas a caracter\u00edsticas del Alzheimer"},"content":{"rendered":"

LA JOLLA, CA\u2014Growing evidence suggests that there may be a link between diabetes<\/a> y Enfermedad de Alzheimer<\/a>, but the physiological mechanisms by which diabetes impacts brain function and cognition are not fully understood. In a new study published in Aging Cell<\/em>, researchers at the Salk Institute for Biological Studies show, for the first time, that diabetes enhances the development of aging features that may underlie early pathological events in Alzheimer’s.\n<\/p>\n

\nSpecifically, the Salk team found increases in two hallmarks of Alzheimer’s-accumulations of amyloid beta (Abeta) and tau protein-in the brains of diabetic mice, especially in cells surrounding blood vessels. Abeta, the misfolded peptide that is thought in part to cause Alzheimer’s disease, aggregated inside astrocytes, star-shaped brain cells that, upon interaction with Abeta, release inflammatory molecules that can destroy neurons. Previously, this had not been shown in mouse models of type 1 diabetes (T1D).\n <\/p>\n

\"Research<\/p>\n

\nResearch associate Antonio Currais and Pamela Maher, senior staff scientist, Laboratory of Cellular Neurobiology.\n<\/p>\n

Imagen: Cortes\u00eda del Instituto Salk de Estudios Biol\u00f3gicos<\/p>\n<\/div>\n

\n“Our study supports and extends the links between diabetes, aging and Alzheimer’s,” says senior author Pamela Maher, a senior staff scientist in Salk’s Laboratory of Cellular Neurobiology<\/a>. “We show that type 1 diabetes increases vascular-associated amyloid beta buildup in the brain and causes accelerated brain aging.”\n <\/p>\n

\nThe findings suggest that the neurovascular system may be a good candidate for new therapeutic targets to treat Alzheimer’s in the early stages of the disease.\n <\/p>\n

\"immature<\/p>\n

\nThis microscope image shows blood vessels in the brain of mouse (green) surrounded by amyloid beta peptides (red), a component of the amyloid plaques found in the brains of Alzheimer’s patients. Salk researchers found that these peptides accumulate in the brains of diabetic and aged mice, a finding that may help explain the connection between diabetes and Alzheimer’s.\n<\/p>\n

Imagen: Cortes\u00eda del Instituto Salk de Estudios Biol\u00f3gicos\n<\/p>\n<\/div>\n

\nAlzheimer’s and diabetes are two diseases that are increasing at an alarming rate within the U.S. population. Alzheimer’s affects one in 10 Americans over 65 years of age and nearly 50 percent of those over 85. Similarly, more than 8 percent of Americans (approximately 26 million people) have diabetes, with the vast majority of those individuals being over 60.\n <\/p>\n

\nMaher says her team is uncertain of the precise mechanism behind the increase in Abeta and tau in the mouse brain, but their data suggest that changes in astrocytes, as well as other pro-inflammatory processes and the bonding of proteins with sugar molecules (called non-enzymatic glycation), may contribute.\n <\/p>\n

\n“Astrocytes play a key role in maintaining nerve cells in the brain,” says lead study author Antonio Currais, a postdoctoral researcher at Salk. “Both chronic peripheral inflammation and increased non-enzymatic glycation are associated with diabetes, and these changes may act on the brain to alter astrocyte function, which eventually leads to Alzheimer’s-like changes.”\n <\/p>\n

\nAll nerve cells are closely connected to blood vessels, as they need nutrients\u2014especially glucose (sugar) and oxygen\u2014provided by the blood in order to function. Astrocytes facilitate the transfer of nutrients between blood vessels and cells. The buildup of Abeta at sites where astrocytes interact with blood vessels suggest that this could impair the transfer of nutrients. The type of Abeta localization seen in Maher’s mouse models is also found in human Alzheimer’s patients\n <\/p>\n

\nTo examine the contributions of diabetes to Alzheimer’s-related pathology in the aged brain, the Salk researchers induced T1D in two sets of mouse models. One set, known as SAMP8 mice, undergo accelerated aging and develop early deterioration in learning and memory, as well as a number of brain alterations similar to those found in Alzheimer’s. The other set, SAMR1 mice, which in this study came from the same gene pool as the SAMP8 mice, age normally.\n <\/p>\n

\nUsing these mice, Maher and her colleagues addressed how T1D interacts with age to contribute to Alzheimer’s-related pathology. They showed that T1D elicits a wide range of pathological changes in the brains of both strains of mice, which are exacerbated by premature aging.\n <\/p>\n

\nThe Salk study is the first to show that these modifications are similar to those seen in old nondiabetic SAMP8 mice and to identify unique pathological changes, such as increases in markers for inflammation, in aged, T1D SAMP8 mice.
\nUnlike most mouse studies of Alzheimer’s, Maher’s mice were not engineered to produce high levels of human Abeta or tau,so all of their observations came from naturally occurringAbeta and tau.\n <\/p>\n

\nOther researchers on the study were Marguerite Prior and Professor David Schubert, from Salk’s Laboratory for Cellular Neurobiology<\/a>; David Lo, from Salk’s Laboratory of Neuronal Structure and Function<\/a>; and Corinne Jolivalt of the Universidad de California, San Diego<\/a>.\n <\/p>\n

\nEl trabajo cont\u00f3 con el apoyo de la Institutos Nacionales de Salud<\/a>, the Fritz B. Burns Foundation, the Bundy Foundation, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia and the Alzheimer’s Association<\/a>.\n<\/p>\n


\nAcerca del Instituto Salk de Estudios Biol\u00f3gicos:<\/strong>
\nEl Instituto Salk de Estudios Biol\u00f3gicos es una de las instituciones de investigaci\u00f3n b\u00e1sica m\u00e1s destacadas del mundo, donde un cuerpo docente de prestigio internacional investiga cuestiones fundamentales de las ciencias de la vida en un entorno \u00fanico, colaborativo y creativo. Centrados tanto en el descubrimiento como en la formaci\u00f3n de las futuras generaciones de investigadores, los cient\u00edficos del Salk realizan contribuciones revolucionarias a nuestra comprensi\u00f3n del c\u00e1ncer, el envejecimiento, el Alzheimer, la diabetes y las enfermedades infecciosas mediante el estudio de la neurociencia, la gen\u00e9tica, la biolog\u00eda celular y vegetal, y otras disciplinas relacionadas.\n<\/p>\n

\nLos logros del cuerpo docente han sido reconocidos con numerosos galardones, entre los que se incluyen premios Nobel y la pertenencia a la Academia Nacional de Ciencias. Fundado en 1960 por el Dr. Jonas Salk, pionero en la vacuna contra la poliomielitis, el Instituto es una organizaci\u00f3n independiente sin fines de lucro y un hito arquitect\u00f3nico.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[],"disease-research":[127,146,123,124],"class_list":["post-2399","disclosure","type-disclosure","status-publish","hentry","disease-research-alzheimers-disease","disease-research-aging-and-regenerative-medicine","disease-research-metabolism-and-diabetes","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nSalk study finds diabetes raises levels of proteins linked to Alzheimer's features - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/salk-study-finds-diabetes-raises-levels-of-proteins-linked-to-alzheimers-features\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk study finds diabetes raises levels of proteins linked to Alzheimer's features - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA, CA\u2014Growing evidence suggests that there may be a link between diabetes and Alzheimer’s disease, but the physiological mechanisms by which diabetes impacts brain function and cognition are not fully understood. 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