Naturaleza<\/em> que las c\u00e9lulas que componen un nicho especializado en los test\u00edculos de las moscas de la fruta en realidad emergen de c\u00e9lulas madre adultas, un hallazgo con implicaciones para la medicina regenerativa, la investigaci\u00f3n sobre el envejecimiento y las terapias contra el c\u00e1ncer.<\/p>\nAnteriormente, los investigadores pensaban que la asignaci\u00f3n de c\u00e9lulas de nicho testicular de una mosca de la fruta se entregaba al nacer y estaba destinada a durar toda la vida. \u201cLo que este art\u00edculo demuestra es que una vez que una mosca se convierte en adulta, algunas c\u00e9lulas madre que funcionan en la espermatog\u00e9nesis comienzan a fabricar las mismas c\u00e9lulas que las sustentan\u201d, dijo Jones. \u201cUna vez que una mosca se desarrolla hasta la adultez, algunas de estas c\u00e9lulas de nicho pueden ser reemplazadas\u201d.\u201d<\/p>\n
Utilizando microscop\u00eda y marcadores fluorescentes que les permitieron observar tipos de c\u00e9lulas espec\u00edficas a lo largo del tiempo, el grupo de Jones, dirigido por el primer autor Justin Voog, captur\u00f3 realmente a una poblaci\u00f3n de c\u00e9lulas madre testiculares en el proceso de convertirse en su propio nicho, conocido en el test\u00edculo de la mosca como el centro.<\/p>\n
\u201cUsamos una estrategia detallada de rastreo del linaje para diferenciar entre c\u00e9lulas madre som\u00e1ticas (SSC) individuales y c\u00e9lulas del n\u00facleo\u201d, dijo Voog, estudiante de M.D.\/Ph.D. en el laboratorio de Jones. El n\u00facleo contiene aproximadamente 10 c\u00e9lulas que secretan factores que promueven la autorrenovaci\u00f3n de dos poblaciones de c\u00e9lulas madre vecinas: las c\u00e9lulas madre de la l\u00ednea germinal, que se convierten en espermatozoides, y las SSC, que se desarrollan en una estructura que encapsula a los espermatozoides en maduraci\u00f3n. \u2019Rastreando las c\u00e9lulas durante varios d\u00edas, vimos que las SSC pueden generar no solo otras SSC inmaduras, sino tambi\u00e9n sus c\u00e9lulas de soporte de nicho\u201c, dijo Voog. Por el contrario, las c\u00e9lulas madre germinales parec\u00edan incapaces de generar c\u00e9lulas del n\u00facleo.<\/p>\n
Su estudio tambi\u00e9n explora la base molecular de las interacciones entre c\u00e9lulas madre y su nicho. \u201cLas SSC en el test\u00edculo se parecen a las c\u00e9lulas del centro\u201d, explic\u00f3 Jones. \u201cAmbos tipos de c\u00e9lulas expresan muchas de las mismas prote\u00ednas\u201d. El equipo disminuy\u00f3 experimentalmente los niveles de una de ellas, una prote\u00edna de superficie pegajosa llamada DE-cadherina que probablemente permite que las c\u00e9lulas madre se adhieran al centro de soporte, pero solo en las c\u00e9lulas madre som\u00e1ticas. Cuando lo hicieron, la expresi\u00f3n de DE-cadherina en las c\u00e9lulas del centro tambi\u00e9n disminuy\u00f3, lo que proporciona un apoyo circunstancial adicional a la idea de que las c\u00e9lulas del centro surgen de las SSC.<\/p>\n
\u201cLa biolog\u00eda de c\u00e9lulas madre es un campo que avanza r\u00e1pidamente y los conocimientos obtenidos de organismos modelo como Drosophila<\/em> \u201dbrinda una gran perspectiva sobre c\u00f3mo se regula el comportamiento de las c\u00e9lulas madre\u201c, dijo Voog. \u201dLa arquitectura del test\u00edculo de la mosca de la fruta lo convierte en un sistema ideal para abordar preguntas sobre qu\u00e9 regula las interacciones de las c\u00e9lulas madre dentro de su nicho\u201d.\u201d <\/p>\nJones concuerda y se\u00f1ala que la espermatog\u00e9nesis tambi\u00e9n es un gran sistema para manipular experimentalmente. \u201cLa espermatog\u00e9nesis es menos compleja que los sistemas de c\u00e9lulas madre que dan lugar a m\u00faltiples tipos celulares, como las c\u00e9lulas madre sangu\u00edneas\u201d, dijo. \u201cSolo emerge un tipo celular del proceso, el espermatozoide, por lo que si algo sale mal en el sistema, es inmediatamente aparente: no se formar\u00e1n espermatozoides\u201d.\u201d<\/p>\n
Seg\u00fan Jones, los nichos de c\u00e9lulas madre de mam\u00edferos no est\u00e1n tan bien caracterizados. Aunque se conoce su ubicaci\u00f3n en tejidos como el cerebro o la m\u00e9dula \u00f3sea, la forma en que los compartimentos del nicho se relacionan con sus respectivas cargas de c\u00e9lulas madre neurales o sangu\u00edneas es una pregunta abierta.<\/p>\n
Los problemas planteados por este estudio deber\u00e1n abordarse en humanos antes de que las c\u00e9lulas madre buenas sean explotadas o las malas sean erradicadas. \u00bfLas c\u00e9lulas madre trasplantadas en terapias de regeneraci\u00f3n propuestas establecer\u00e1n su propio equipo de soporte o se requerir\u00e1 un \u201ctrasplante de nicho\u201d para mantenerlas?<\/p>\n
\u00bfO, las llamadas c\u00e9lulas madre cancerosas, que se cree que forman la ra\u00edz de la mayor\u00eda de los tumores, crean una estructura an\u00e1loga al nicho, y si lo hacen, \u00bfpodr\u00eda ser un objetivo para la terapia contra el c\u00e1ncer? <\/p>\n
Jones dice que ahora recae en los bi\u00f3logos de c\u00e9lulas madre de mam\u00edferos responder a estas preguntas. \u201cEn los mam\u00edferos, el campo todav\u00eda est\u00e1 en la etapa de identificaci\u00f3n de una c\u00e9lula madre, lo que precede a la caracterizaci\u00f3n de las c\u00e9lulas que las sustentan\u201d, dijo Jones. \u201cEn nuestro sistema, podemos decir definitivamente que algunas c\u00e9lulas madre pueden crear un microambiente que les permite sobrevivir. Si tuviera que decir si ocurren procesos similares en c\u00e9lulas de mam\u00edferos, supongo que s\u00ed\u201d.\u201d<\/p>\n
El estudio fue financiado por la G. Harold and Leila Y. Mathers Charitable Foundation, la American Cancer Society, el California Institute for Regenerative Medicine y los NIH. <\/p>\n
Cecilia D\u2019Alterio tambi\u00e9n contribuy\u00f3 a este estudio del laboratorio Jones.<\/p>\n
El Instituto Salk de Estudios Biol\u00f3gicos en La Jolla, California, es una organizaci\u00f3n independiente sin fines de lucro dedicada a descubrimientos fundamentales en las ciencias de la vida, la mejora de la salud humana y la formaci\u00f3n de futuras generaciones de investigadores. Jonas Salk, M.D., cuya vacuna contra la polio pr\u00e1cticamente erradic\u00f3 la debilitante enfermedad de la poliomielitis en 1955, inaugur\u00f3 el Instituto en 1965 con un donativo de terrenos de la Ciudad de San Diego y el apoyo financiero de la March of Dimes.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[],"disease-research":[],"class_list":["post-2360","disclosure","type-disclosure","status-publish","hentry"],"acf":[],"yoast_head":"\n
Stem cell chicken and egg debate moves to unlikely arena: the testes - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stem cell chicken and egg debate moves to unlikely arena: the testes - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"La Jolla, CA \u2013 Logic says it has to be the niche. As air and water preceded life, so the niche, that hospitable environment that shelters adult stem cells in many tissues and provides factors necessary to keep them young and vital, must have emerged before its stem cell dependents.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\\\/\",\"name\":\"Stem cell chicken and egg debate moves to unlikely arena: the testes - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\\\/#primaryimage\"},\"thumbnailUrl\":\"..https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/caption_20080721.jpg\",\"datePublished\":\"2008-07-21T07:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\\\/#breadcrumb\"},\"inLanguage\":\"es-MX\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\\\/#primaryimage\",\"url\":\"..https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/caption_20080721.jpg\",\"contentUrl\":\"..https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/caption_20080721.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Stem cell chicken and egg debate moves to unlikely arena: the testes\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es-MX\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Stem cell chicken and egg debate moves to unlikely arena: the testes - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/es\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/","og_locale":"es_MX","og_type":"article","og_title":"Stem cell chicken and egg debate moves to unlikely arena: the testes - Salk Institute for Biological Studies","og_description":"La Jolla, CA \u2013 Logic says it has to be the niche. As air and water preceded life, so the niche, that hospitable environment that shelters adult stem cells in many tissues and provides factors necessary to keep them young and vital, must have emerged before its stem cell dependents.","og_url":"https:\/\/www.salk.edu\/es\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/","og_site_name":"Salk Institute for Biological Studies","og_image":[{"width":628,"height":329,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/","url":"https:\/\/www.salk.edu\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/","name":"Stem cell chicken and egg debate moves to unlikely arena: the testes - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/#primaryimage"},"thumbnailUrl":"..https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/caption_20080721.jpg","datePublished":"2008-07-21T07:00:00+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/#breadcrumb"},"inLanguage":"es-MX","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/"]}]},{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/#primaryimage","url":"..https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/caption_20080721.jpg","contentUrl":"..https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/caption_20080721.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/stem-cell-chicken-and-egg-debate-moves-to-unlikely-arena-the-testes\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Stem cell chicken and egg debate moves to unlikely arena: the testes"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Instituto Salk de Estudios Biol\u00f3gicos","description":"El Poder de la Ciencia","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es-MX"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Instituto Salk de Estudios Biol\u00f3gicos","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"paper_url":"","journal_title":"","paper_author_list":"","paper_title":"","subhead":"Which came first: the stem cell or the niche?","home_photo":"","listing_photo":"","line_2":"Which came first: the stem cell or the niche?","line_1":"Stem cell chicken and egg debate moves to unlikely arena: the testes"},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/2360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":0,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/2360\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media?parent=2360"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/faculty?post=2360"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disease-research?post=2360"}],"curies":[{"name":"la hora de","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
![](\"..https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/caption_20080721.jpg\")
<\/p>\n