{"id":2340,"date":"2008-02-21T00:00:00","date_gmt":"2008-02-21T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/pnas-article-by-salk-scientists-wins-2007-cozzarelli-prize\/"},"modified":"2008-02-21T00:00:00","modified_gmt":"2008-02-21T08:00:00","slug":"pnas-article-by-salk-scientists-wins-2007-cozzarelli-prize","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/pnas-article-by-salk-scientists-wins-2007-cozzarelli-prize\/","title":{"rendered":"PNAS article by Salk scientists wins 2007 Cozzarelli Prize"},"content":{"rendered":"<p>La Jolla, CA \u2013 The editors of the <em>Actas de la Academia Nacional de Ciencias<\/em> (PNAS) selected the article &#8220;Targeted delivery of proteins across the blood-brain barrier&#8221; by Brian J. Spencer, Ph.D. and <a href=\"\/es\/faculty\/verma.html\/\">Inder M. Verma<\/a>, Ph.D., for the 2007 Cozzarelli Prize, which recognizes papers that reflect the highest standards of scientific excellence and originality.<\/p>\n<p>The award was established in 2005 as the PNAS Paper of the Year Prize and renamed the Cozzarelli Prize in 2007 to honor late PNAS Editor-in-Chief Nicholas R. Cozzarelli. The annual award acknowledges papers published in PNAS during the previous year that represent exceptional contributions to the scientific disciplines represented by the National Academy of Sciences. The 2007 awards will be presented at the PNAS Editorial Board Meeting on April 27, 2008, in Washington, DC.<\/p>\n<p>Just six papers were chosen from more than 3,600 research articles published by PNAS in 2007 representing the six broadly defined classes under which the National Academy of Sciences is organize (Physical and Mathematical Sciences, Biological Sciences, Engineering and Applied Sciences, Biomedical Sciences, Behavioral and Social Sciences, Applied Biological, Agricultural, and Environmental Sciences).<\/p>\n<p>In their outstanding study, which falls into the category Biomedical Sciences, the Salk team led by Verma, a professor in the Laboratory of Genetics, successfully delivered a protein across the blood-brain barrier by equipping a protein with a small homing device. Circumventing this barrier \u2013 specifically designed to keep substances out of the brain \u2013 is a crucial step for the delivery of drugs to the central nervous system (CNS).<\/p>\n<p>Unlike peripheral capillaries, which allow the relatively free exchange of substances with the surrounding tissue, the capillaries in the brain are tightly packed with endothelial cells. This physical barrier severely limits access to brain tissue, and only lets a select few chemicals slip in. The blood-brain barrier not only protects the brain from pathogens and potentially harmful substances, it also makes neural disorders such as Alzheimer&#8217;s and Gaucher&#8217;s disease extremely difficult to treat.<\/p>\n<p>&#8220;The failure rate to deliver drugs to CNS is unfortunately very high, so any new methods of drug, protein and gene delivery should be welcome,&#8221; says Verma.<\/p>\n<p>A press release describing the research in more detail is available at:<br \/>\n<a href=\"https:\/\/www.salk.edu\/es\/news\/news_press_details_20070515.php\/\">https:\/\/www.salk.edu\/news\/news_press_details_20070515.php<\/a><\/p>\n<h3>About the <em>Actas de la Academia Nacional de Ciencias<\/em><\/h3>\n<p>PNAS is one of the world&#8217;s most cited multidisciplinary scientific journals. PNAS broadly spans the biological, physical, and social sciences by publishing cutting-edge research reports, feature articles, commentaries, reviews, perspectives, colloquium papers, letters, and actions of the Academy. PNAS publishes weekly in print and daily online in PNAS Early Edition <a href=\"http:\/\/www.pnas.org\/papbyrecent.shtml\" target=\"_blank\">http:\/\/www.pnas.org\/papbyrecent.shtml<\/a>.<\/p>\n<p>For more information on PNAS or the National Academy of Sciences, visit<br \/> <a href=\"http:\/\/www.pnas.org\/\" target=\"_blank\">http:\/\/www.pnas.org\/<\/a> or <a href=\"http:\/\/www.nas.edu\/\" target=\"_blank\">http:\/\/www.nas.edu\/<\/a><br \/>\nClass IV (Biomedical Sciences) <\/p>\n<p>&#8220;Targeted Delivery of Proteins across the Blood-Brain Barrier&#8221;<br \/>\nby Brian J. Spencer and Inder M. Verma<br \/>\n<a href=\"http:\/\/www.pnas.org\/cgi\/doi\/10.1073\/pnas.0702170104\" target=\"_blank\">http:\/\/www.pnas.org\/cgi\/doi\/10.1073\/pnas.0702170104 <\/a><\/p>\n<p>A commentary accompanying this article is available:<br \/> <a href=\"http:\/\/www.pnas.org\/cgi\/content\/full\/104\/18\/7315\" target=\"_blank\">http:\/\/www.pnas.org\/cgi\/content\/full\/104\/18\/7315<\/a><\/p>\n<h3>About the Salk Institute:<\/h3>\n<p>El Instituto Salk de Estudios Biol\u00f3gicos en La Jolla, California, es una organizaci\u00f3n independiente sin fines de lucro dedicada a descubrimientos fundamentales en las ciencias de la vida, la mejora de la salud humana y la formaci\u00f3n de futuras generaciones de investigadores. Jonas Salk, M.D., cuya vacuna contra la polio pr\u00e1cticamente erradic\u00f3 la debilitante enfermedad de la poliomielitis en 1955, inaugur\u00f3 el Instituto en 1965 con un donativo de terrenos de la Ciudad de San Diego y el apoyo financiero de la March of Dimes.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[115],"disease-research":[],"class_list":["post-2340","disclosure","type-disclosure","status-publish","hentry","faculty-inder-verma"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PNAS article by Salk scientists wins 2007 Cozzarelli Prize - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/pnas-article-by-salk-scientists-wins-2007-cozzarelli-prize\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PNAS article by Salk scientists wins 2007 Cozzarelli Prize - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"La Jolla, CA \u2013 The editors of the Proceedings of the National Academy of Sciences (PNAS) selected the article &#8220;Targeted delivery of proteins across the blood-brain barrier&#8221; by Brian J. 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