{"id":23004,"date":"2019-06-06T00:00:05","date_gmt":"2019-06-06T07:00:05","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=23004"},"modified":"2024-01-30T14:55:33","modified_gmt":"2024-01-30T22:55:33","slug":"how-old-are-your-organs-to-scientists-surprise-organs-are-a-mix-of-young-and-old-cells","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/how-old-are-your-organs-to-scientists-surprise-organs-are-a-mix-of-young-and-old-cells\/","title":{"rendered":"\u00bfQu\u00e9 edad tienen tus \u00f3rganos? Para sorpresa de los cient\u00edficos, los \u00f3rganos son una mezcla de c\u00e9lulas j\u00f3venes y viejas"},"content":{"rendered":"<p>LA JOLLA: Los cient\u00edficos alguna vez pensaron que las neuronas, o posiblemente las c\u00e9lulas card\u00edacas, eran las c\u00e9lulas m\u00e1s antiguas del cuerpo. Ahora, investigadores del Instituto Salk han descubierto que el cerebro, el h\u00edgado y el p\u00e1ncreas de los ratones contienen poblaciones de c\u00e9lulas y prote\u00ednas con vidas extremadamente largas, algunas tan antiguas como las neuronas. Los hallazgos, que demuestran \u201cmosaicismo de edad\u201d, se publicaron en <a href=\"http:\/\/doi.org\/10.1016\/j.cmet.2019.05.010\" target=\"_blank\" rel=\"noopener\"><em>Metabolismo celular<\/em><\/a> el 6 de junio de 2019. Los m\u00e9todos del equipo podr\u00edan aplicarse a casi cualquier tejido del cuerpo para proporcionar informaci\u00f3n valiosa sobre la funci\u00f3n vitalicia de las c\u00e9lulas no divisoras y c\u00f3mo las c\u00e9lulas pierden el control sobre la calidad e integridad de las prote\u00ednas y las estructuras celulares importantes durante el envejecimiento.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-1dP5XB54YZ0\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/1dP5XB54YZ0?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>\u201cNos sorprendi\u00f3 bastante encontrar estructuras celulares que son esencialmente tan antiguas como el organismo en el que residen\u201d, afirma el Vicepresidente y Director Cient\u00edfico de Salk. <a href=\"https:\/\/www.salk.edu\/es\/scientist\/martin-hetzer\/\">Mart\u00edn Hetzer<\/a>, autor principal y profesor. \u201cEsto sugiere una complejidad celular a\u00fan mayor de lo que imagin\u00e1bamos y tiene implicaciones intrigantes sobre c\u00f3mo pensamos sobre el envejecimiento de \u00f3rganos, como el cerebro, el coraz\u00f3n y el p\u00e1ncreas\u201d.\u201d<\/p>\n<p>La mayor\u00eda de las neuronas en el cerebro no se dividen durante la adultez y, por lo tanto, experimentan una larga esperanza de vida y un declive relacionado con la edad. Sin embargo, en gran medida debido a limitaciones t\u00e9cnicas, ha sido dif\u00edcil determinar la esperanza de vida de las c\u00e9lulas fuera del cerebro.<\/p>\n<figure id=\"attachment_23019\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"370\" class=\"img-responsive wp-image-23019 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Hetzer-science-image-hr-458x370.jpg\" alt=\"Isotope imaging of different cells inside an islet of Langerhans within the pancreas. Older cells have a yellow-to-pink color scheme, while younger cells exhibit a blue-to-green color pattern.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Hetzer-science-image-hr-458x370.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Hetzer-science-image-hr-300x242.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Hetzer-science-image-hr-147x119.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Hetzer-science-image-hr-585x473.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Hetzer-science-image-hr-553x447.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Hetzer-science-image-hr-400x323.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Hetzer-science-image-hr.jpg 687w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><figcaption class=\"wp-caption-text\">Imagen isot\u00f3pica de diferentes c\u00e9lulas dentro de un islote de Langerhans en el p\u00e1ncreas. Las c\u00e9lulas m\u00e1s viejas tienen un esquema de color amarillo a rosa, mientras que las c\u00e9lulas m\u00e1s j\u00f3venes muestran un patr\u00f3n de color azul a verde.<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Hetzer-science-image-hr.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/p>\n<p>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>\u201cLos bi\u00f3logos se han preguntado: \u00bfqu\u00e9 edad tienen las c\u00e9lulas en un organismo? Existe esta idea general de que las neuronas son viejas, mientras que otras c\u00e9lulas en el cuerpo son relativamente j\u00f3venes y se regeneran a lo largo de la vida del organismo\u201d, dice Rafael Arrojo e Drigo, primer autor y cient\u00edfico del personal de Salk. \u201cNos propusimos ver si era posible que ciertos \u00f3rganos tambi\u00e9n tuvieran c\u00e9lulas que fueran tan longevas como las neuronas en el cerebro\u201d.\u201d<\/p>\n<p>Dado que los investigadores sab\u00edan que la mayor\u00eda de las neuronas no se reemplazan durante la vida, las usaron como una \u201cl\u00ednea de base de edad\u201d para comparar otras c\u00e9lulas no divisibles. El equipo combin\u00f3 el marcado isot\u00f3pico de electrones con un m\u00e9todo de imagen h\u00edbrido (MIMS-EM) para visualizar y cuantificar la edad celular y proteica y la renovaci\u00f3n en el cerebro, p\u00e1ncreas e h\u00edgado de modelos de roedores j\u00f3venes y viejos.<\/p>\n<p>Para validar su m\u00e9todo, los cient\u00edficos primero determinaron la edad de las neuronas y descubrieron que \u2014como se sospechaba\u2014 eran tan viejas como el organismo. Sin embargo, sorprendentemente, las c\u00e9lulas que recubren los vasos sangu\u00edneos, llamadas c\u00e9lulas endoteliales, tambi\u00e9n eran tan viejas como las neuronas. Esto significa que algunas c\u00e9lulas no neuronales no se replican ni se reemplazan a s\u00ed mismas durante toda la vida.<\/p>\n<p>El p\u00e1ncreas, un \u00f3rgano responsable de mantener los niveles de az\u00facar en sangre y secretar enzimas digestivas, tambi\u00e9n mostr\u00f3 c\u00e9lulas de diferentes edades. Una peque\u00f1a porci\u00f3n del p\u00e1ncreas, conocida como los islotes de Langerhans, se present\u00f3 ante los investigadores como un rompecabezas de c\u00e9lulas j\u00f3venes y viejas interconectadas. Algunas c\u00e9lulas beta, que liberan insulina, se replicaron a lo largo de la vida y eran relativamente j\u00f3venes, mientras que otras no se dividieron y vivieron mucho tiempo, de forma similar a las neuronas. Otro tipo de c\u00e9lula, llamada c\u00e9lula delta, no se dividi\u00f3 en absoluto. El p\u00e1ncreas fue un claro ejemplo de mosaicismo de edad, es decir, una poblaci\u00f3n de c\u00e9lulas id\u00e9nticas que se distinguen por su esperanza de vida.<\/p>\n<p>Estudios previos han sugerido que el h\u00edgado tiene la capacidad de regenerarse durante la adultez, por lo que los investigadores seleccionaron este \u00f3rgano esperando observar c\u00e9lulas hep\u00e1ticas relativamente j\u00f3venes. Para su sorpresa, se descubri\u00f3 que la gran mayor\u00eda de las c\u00e9lulas hep\u00e1ticas en ratones adultos sanos ten\u00edan la misma edad que el animal, mientras que las c\u00e9lulas que recubren los vasos sangu\u00edneos y las c\u00e9lulas tipo estrellado, otro tipo de c\u00e9lula hep\u00e1tica, viv\u00edan mucho menos. As\u00ed, inesperadamente, el h\u00edgado tambi\u00e9n demostr\u00f3 mosaicismo de edad, lo que apunta a nuevas v\u00edas potenciales de investigaci\u00f3n regenerativa para este \u00f3rgano.<\/p>\n<figure id=\"attachment_23020\"  class=\"wp-caption alignleft\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"305\" class=\"img-responsive wp-image-23020 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-458x305.jpg\" alt=\"From left: Rafael Arrojo e Drigo and Martin W. Hetzer\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-458x305.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-300x200.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-768x512.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-1024x683.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-147x98.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-585x390.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-553x369.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-750x500.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-767x511.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-945x630.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-1250x833.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr-400x267.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr.jpg 1500w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">De izquierda a derecha: Rafael Arrojo e Drigo y Martin W. Hetzer<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/PR_Hetzer_CellMetab_hr.jpg\">Haga clic aqu\u00ed<\/a> para una imagen de alta resoluci\u00f3n<\/p>\n<p>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>A escala molecular, una selecci\u00f3n de las c\u00e9lulas longevas observadas conten\u00eda complejos proteicos que mostraban mosaicismo de envejecimiento. Por ejemplo, los cilios primarios (ap\u00e9ndices parecidos a pelos en el exterior de las c\u00e9lulas) de las c\u00e9lulas beta del p\u00e1ncreas y las neuronas conten\u00edan regiones proteicas de duraciones de vida muy diferentes. En marcado contraste, las c\u00e9lulas del h\u00edgado no conten\u00edan ninguna prote\u00edna longeva.<\/p>\n<p>\u201cGracias a las nuevas tecnolog\u00edas de visualizaci\u00f3n, podemos determinar la edad de las c\u00e9lulas y sus complejos supramoleculares con mayor precisi\u00f3n que nunca. Esto abre nuevas puertas para el estudio de todas las c\u00e9lulas, tejidos y \u00f3rganos en estados normales y de enfermedad \u2014dice Mark Ellisman, profesor distinguido de neurociencias en la Facultad de Medicina de UC San Diego y col\u00edder del estudio junto con Hetzer. Su laboratorio, el Centro Nacional de Investigaci\u00f3n de Microscop\u00eda e Im\u00e1genes, desarroll\u00f3 y proporcion\u00f3 los nuevos m\u00e9todos de imagen tisular para microscop\u00eda multiescala y multimodal correlacionada. Estos m\u00e9todos proporcionaron las nuevas tecnolog\u00edas habilitadoras que permitieron llevar a cabo este estudio.<\/p>\n<p>\u201cDeterminar la edad de las c\u00e9lulas y las estructuras subcelulares en organismos adultos proporcionar\u00e1 nuevas perspectivas sobre los mecanismos de mantenimiento y reparaci\u00f3n celular y el impacto de los cambios acumulativos durante la edad adulta en la salud y el desarrollo de enfermedades\u201d, a\u00f1ade Hetzer. \u201cEl objetivo final es utilizar estos mecanismos para prevenir o retrasar el declive relacionado con la edad de los \u00f3rganos con renovaci\u00f3n celular limitada\u201d.\u201d<\/p>\n<p>A continuaci\u00f3n, los autores planean descifrar la diferencia en la longevidad de los \u00e1cidos nucleicos y los l\u00edpidos. Tambi\u00e9n quieren entender c\u00f3mo el mosaicismo de la edad se relaciona con la salud y enfermedades como la diabetes tipo 2.<\/p>\n<p>Otros autores incluyeron a Swati Tyagi de Salk; Varda Lev-ram, Ranjan Ramachandra, Thomas Deerinck, Eric Bushong y Sebastien Phan de UC San Diego; Victoria Orphan del Instituto de Tecnolog\u00eda de California; y Claude Lechene del Brigham and Women\u2019s Hospital.<\/p>\n<p>El trabajo fue financiado por los National Institutes of Health (R01 NS096786, NINDS NIH RO1 NS027177-30, NIGMS 5P41 GM103412-29), la Keck Foundation, la NOMIS Foundation, el Departamento de Energ\u00eda de EE. UU. (DE-SC0016469), NINDS Neuroscience Core (NS072031), la Waitt Foundation, la Chapman Foundation, el Helmsley Charitable Trust, una beca postdoctoral de la American Diabetes Association (#1-18-PMF-007) y el Cell and Tissue Imaging Facility del Institut Curie (PICT), miembro de la France BioImaging National Infrastructure (ANR-10-INBS-04).<\/p>","protected":false},"featured_media":23017,"template":"","faculty":[86],"disease-research":[146],"class_list":["post-23004","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-martin-hetzer","disease-research-aging-and-regenerative-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How old are your organs? To scientists\u2019 surprise, organs are a mix of young and old cells - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/how-old-are-your-organs-to-scientists-surprise-organs-are-a-mix-of-young-and-old-cells\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How old are your organs? To scientists\u2019 surprise, organs are a mix of young and old cells - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Scientists once thought that neurons, or possibly heart cells, were the oldest cells in the body. Now, Salk Institute researchers have discovered that the mouse brain, liver and pancreas contain populations of cells and proteins with extremely long lifespans\u2014some as old as neurons. The findings, demonstrating \u201cage mosaicism,\u201d were published in Cell Metabolism on June 6, 2019. The team&#8217;s methods could be applied to nearly any tissue in the body to provide valuable information about lifelong function of non-dividing cells and how cells lose control over the quality and integrity of proteins and important cell structures during aging.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/how-old-are-your-organs-to-scientists-surprise-organs-are-a-mix-of-young-and-old-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-30T22:55:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/05\/Hetzer-science-image-767.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"767\" \/>\n\t<meta property=\"og:image:height\" content=\"767\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/how-old-are-your-organs-to-scientists-surprise-organs-are-a-mix-of-young-and-old-cells\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/how-old-are-your-organs-to-scientists-surprise-organs-are-a-mix-of-young-and-old-cells\\\/\",\"name\":\"How old are your organs? 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To scientists\u2019 surprise, organs are a mix of young and old cells - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/es\/news-release\/how-old-are-your-organs-to-scientists-surprise-organs-are-a-mix-of-young-and-old-cells\/","og_locale":"es_MX","og_type":"article","og_title":"How old are your organs? To scientists\u2019 surprise, organs are a mix of young and old cells - Salk Institute for Biological Studies","og_description":"LA JOLLA\u2014Scientists once thought that neurons, or possibly heart cells, were the oldest cells in the body. Now, Salk Institute researchers have discovered that the mouse brain, liver and pancreas contain populations of cells and proteins with extremely long lifespans\u2014some as old as neurons. The findings, demonstrating \u201cage mosaicism,\u201d were published in Cell Metabolism on June 6, 2019. 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