Ronald Evans<\/a> y su becario postdoctoral Yong-Xu Wang, aparece en la edici\u00f3n de septiembre de la revista Public Library of Science Biology (PLoS Biology). Evans es tambi\u00e9n investigador del Howard Hughes Medical Institute.<\/p>\nEvans, Wang y su equipo descubrieron que la activaci\u00f3n del interruptor, un receptor llamado PPAR-delta, aumenta la tasa a la que el cuerpo quema grasa. Esto convierte al PPAR-delta en un objetivo potencial interesante para medicamentos que tratan la diabetes y los trastornos lip\u00eddicos.<\/p>\n
El equipo produjo un rat\u00f3n gen\u00e9ticamente modificado dotado de la forma activada de PPAR-delta en sus m\u00fasculos esquel\u00e9ticos. El resultado fue un aumento dr\u00e1stico en las c\u00e9lulas musculares \u201cque no se fatigan\u201d o \u201cde contracci\u00f3n lenta\u201d y un rat\u00f3n capaz de correr hasta el doble de la distancia de un compa\u00f1ero normal sin entrenamiento.<\/p>\n
Al expresar genes para una forma activada del receptor PPAR-delta, creamos un rat\u00f3n que, en comparaci\u00f3n con los ratones normales, pod\u00eda correr maratones, dijo Evans. La forma activada de PPAR-delta produjo fibras musculares que mejoraron el ejercicio de resistencia.\u201d<\/p>\n
Al activar elPPAR-delta, el equipo hab\u00eda producido fibras musculares de alta eficiencia que quemaban grasa m\u00e1s r\u00e1pidamente. Como resultado, los ratones eran casi incapaces de aumentar de peso incluso en ausencia de ejercicio. <\/p>\n
\u201cEstos m\u00fasculos tambi\u00e9n ofrecieron resistencia a la obesidad, a pesar del nivel de ejercicio\u201d, dijo Evans. \u201cManipulando este receptor, es posible dise\u00f1ar tratamientos que cambien nuestra composici\u00f3n muscular y ayuden a resistir la obesidad y los trastornos metab\u00f3licos asociados\".<\/p>\n
Para probar el concepto, Evans y su equipo trataron a ratones normales con un f\u00e1rmaco experimental llamado GW501516 que activa el PPAR-delta. Estos ratones tambi\u00e9n expresaron genes para m\u00fasculos de contracci\u00f3n lenta y ganaron menos peso cuando se les dio una dieta alta en grasas. Este f\u00e1rmaco se encuentra ahora en las etapas m\u00e1s tempranas de ser probado en humanos por sus efectos sobre la obesidad y otros trastornos del metabolismo de las grasas, como el colesterol alto en sangre.<\/p>\n
Este experimento subraya la importancia del metabolismo para combatir la obesidad y mejorar la condici\u00f3n f\u00edsica, dijo Evans. La activaci\u00f3n del interruptor PPAR puede prevenir la fatiga f\u00edsica y mejorar la calidad del ejercicio, lo que podr\u00eda conducir a una nueva clase de medicamentos para promover la p\u00e9rdida de peso y tratar enfermedades derivadas de una poblaci\u00f3n con sobrepeso.<\/p>\n
El Instituto Salk de Estudios Biol\u00f3gicos, ubicado en La Jolla, California, es una organizaci\u00f3n independiente sin fines de lucro dedicada a los descubrimientos fundamentales en las ciencias de la vida, la mejora de la salud y las condiciones de vida de las personas, y la formaci\u00f3n de las futuras generaciones de investigadores. El Dr. Jonas Salk fund\u00f3 el instituto en 1960 gracias a una donaci\u00f3n de terrenos por parte de la ciudad de San Diego y al apoyo financiero de la Fundaci\u00f3n March of Dimes para los Defectos Cong\u00e9nitos. <\/p>","protected":false},"featured_media":0,"template":"","faculty":[91],"disease-research":[],"class_list":["post-2254","disclosure","type-disclosure","status-publish","hentry","faculty-ronald-evans"],"acf":[],"yoast_head":"\n
Marathoning Mice Could Have Olympian Effects on Obesity - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/marathoning-mice-could-have-olympian-effects-on-obesity\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Marathoning Mice Could Have Olympian Effects on Obesity - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"La Jolla, CA \u2013 A molecular switch known to regulate fat metabolism appears to prevent obesity and turns laboratory mice into marathon runners, a Salk Institute study has found.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/marathoning-mice-could-have-olympian-effects-on-obesity\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/marathoning-mice-could-have-olympian-effects-on-obesity\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/marathoning-mice-could-have-olympian-effects-on-obesity\\\/\",\"name\":\"Marathoning Mice Could Have Olympian Effects on Obesity - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"datePublished\":\"2004-08-24T07:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/marathoning-mice-could-have-olympian-effects-on-obesity\\\/#breadcrumb\"},\"inLanguage\":\"es-MX\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/marathoning-mice-could-have-olympian-effects-on-obesity\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/marathoning-mice-could-have-olympian-effects-on-obesity\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Marathoning Mice Could Have Olympian Effects on Obesity\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es-MX\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Marathoning Mice Could Have Olympian Effects on Obesity - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/es\/news-release\/marathoning-mice-could-have-olympian-effects-on-obesity\/","og_locale":"es_MX","og_type":"article","og_title":"Marathoning Mice Could Have Olympian Effects on Obesity - Salk Institute for Biological Studies","og_description":"La Jolla, CA \u2013 A molecular switch known to regulate fat metabolism appears to prevent obesity and turns laboratory mice into marathon runners, a Salk Institute study has found.","og_url":"https:\/\/www.salk.edu\/es\/news-release\/marathoning-mice-could-have-olympian-effects-on-obesity\/","og_site_name":"Salk Institute for Biological Studies","og_image":[{"width":628,"height":329,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/marathoning-mice-could-have-olympian-effects-on-obesity\/","url":"https:\/\/www.salk.edu\/news-release\/marathoning-mice-could-have-olympian-effects-on-obesity\/","name":"Marathoning Mice Could Have Olympian Effects on Obesity - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"datePublished":"2004-08-24T07:00:00+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/marathoning-mice-could-have-olympian-effects-on-obesity\/#breadcrumb"},"inLanguage":"es-MX","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/marathoning-mice-could-have-olympian-effects-on-obesity\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/marathoning-mice-could-have-olympian-effects-on-obesity\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Marathoning Mice Could Have Olympian Effects on Obesity"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Instituto Salk de Estudios Biol\u00f3gicos","description":"El Poder de la Ciencia","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es-MX"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Instituto Salk de Estudios Biol\u00f3gicos","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"paper_url":"","journal_title":"","paper_author_list":"","paper_title":"","subhead":"","home_photo":"","listing_photo":"","line_2":"","line_1":"Marathoning Mice Could Have Olympian Effects on Obesity"},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/2254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":0,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/2254\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media?parent=2254"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/faculty?post=2254"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disease-research?post=2254"}],"curies":[{"name":"la hora de","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}