Fred H. Gage<\/a>, the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases, and his colleagues incubated mouse neural stem cells with human endothelial cells that form the lining of blood vessels. Within five days, six percent of the stem cells were showing the biochemical and structural characteristics of endothelial cells. The new cells had only one nucleus and contained only mouse chromosomes, indicating that they had, indeed, changed character and not simply fused with the surrounding endothelial cells.<\/p>\n“This indicates that neural stem cells have a broader developmental potential, or plasticity, than was previously believed,” said Gage.<\/p>\n
The Salk team confirmed their results in an experimental set-up closer to real life, by transplanting adult neural stem cells into the brains of embryonic mice. Within two days, approximately two percent of the stem cells had started converting to endothelial cells. <\/p>\n
The Salk findings also have dramatic implications for angiogenesis, the life-giving repair process by which endothelial cells migrate from the blood vessel wall to forge new networks of blood vessels into oxygen-deprived tissues. Although the prospect is far off, understanding how to harness angiogenesis could prove valuable for producing successful transplanted cells and possibly organs.<\/p>\n
“Our work raises the possibility that angiogenesis does not exclusively account for the formation of new endothelial cells in adults, but that stem cells in the brain function along with angiogenesis to create new endothelial cells,” said Andrew Wurmser, a research associate working with Gage. “Equally exciting is the prospect that this model for endothelial cell formation may ultimately be shown to be used by stem cells in other tissues.”<\/p>\n
El Instituto Salk de Estudios Biol\u00f3gicos, ubicado en La Jolla, California, es una organizaci\u00f3n independiente sin fines de lucro dedicada a los descubrimientos fundamentales en las ciencias de la vida, la mejora de la salud y las condiciones de vida de las personas, y la formaci\u00f3n de las futuras generaciones de investigadores. El Dr. Jonas Salk fund\u00f3 el instituto en 1960 gracias a una donaci\u00f3n de terrenos por parte de la ciudad de San Diego y al apoyo financiero de la Fundaci\u00f3n March of Dimes para los Defectos Cong\u00e9nitos. <\/p>","protected":false},"featured_media":0,"template":"","faculty":[76],"disease-research":[],"class_list":["post-2252","disclosure","type-disclosure","status-publish","hentry","faculty-rusty-gage"],"acf":[],"yoast_head":"\n
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