{"id":2248,"date":"2004-06-07T00:00:00","date_gmt":"2004-06-07T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/a-new-view-of-hiv\/"},"modified":"2004-06-07T00:00:00","modified_gmt":"2004-06-07T07:00:00","slug":"a-new-view-of-hiv","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/a-new-view-of-hiv\/","title":{"rendered":"A New View of HIV"},"content":{"rendered":"<p>La Jolla, CA \u2013 Scientists will have a new view of how the AIDS virus (HIV) enters a target cell and begins its process of infection, thanks to a technique created by researchers at the Salk Institute.<\/p>\n<p>The technique allows scientists to observe for the first time the steps taken by viruses like HIV after they enter a cell. The study was done with a chicken virus that was modified to contain the genes of HIV. Both the chicken virus and HIV are retroviruses, which means their genomes are made from RNA rather than DNA. When the viruses enter a host cell, their RNA genomes are converted to DNA, which integrates into the DNA of the host cell. This step is essential for the formation of new virus particles.<\/p>\n<p><a href=\"\/es\/faculty\/young.html\/\">John Young<\/a>, a Salk professor of infectious disease, and colleague Shakti Narayan reported their findings in the May 18 edition of the Proceedings of the National Academy of Sciences.<\/p>\n<p>The research provides new insights into the chemical events that allow viruses like HIV to replicate within cells. Scientists have long known how HIV breaks into the host cell by merging with its surface layer. They&#8217;ve also known how the viral genome is copied and can hitch onto the cell&#8217;s genetic material and begin expressing proteins that aid infection. But they didn&#8217;t know the steps in between.<\/p>\n<p>&#8220;This technique shows us what happens after the virus first steps in the door, and removes its coating,&#8221; said Young. &#8220;We now know that molecules exist in cells that help the virus convert its RNA genome to DNA but we don&#8217;t yet know what those molecules are. Once we identify them, which this system allows, we may be able to manipulate them to halt viral DNA synthesis, and produce a new therapy for AIDS.&#8221; This new technique uses a test-tube system to study the chemical players in virus infectivity, thereby allowing scientists to analyze infectivity in a setting not complicated by other cellular structures.<\/p>\n<p>AIDS is a major epidemic in many developing countries in Africa and Asia, and has been responsible for more than 500,000 deaths in the United States. About 47 million people worldwide are afflicted with AIDS. <\/p>\n<p>AIDS is currently incurable. However, cocktails that contain chemical agents that block various steps of viral replication have allowed millions of people to survive with the disease.  &#8220;This work could provide us with another class of molecules to add to the cocktail,&#8221; said Young. &#8220;Once we identify cellular factors that regulate HIV replication, we may be able devise new treatments for other viral infections, as well.&#8221;<\/p>\n<p>El Instituto Salk de Estudios Biol\u00f3gicos, ubicado en La Jolla, California, es una organizaci\u00f3n independiente sin fines de lucro dedicada a los descubrimientos fundamentales en las ciencias de la vida, la mejora de la salud y las condiciones de vida de las personas, y la formaci\u00f3n de las futuras generaciones de investigadores. El Dr. Jonas Salk fund\u00f3 el instituto en 1960 gracias a una donaci\u00f3n de terrenos por parte de la ciudad de San Diego y al apoyo financiero de la Fundaci\u00f3n March of Dimes para los Defectos Cong\u00e9nitos.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[],"disease-research":[],"class_list":["post-2248","disclosure","type-disclosure","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A New View of HIV - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/a-new-view-of-hiv\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A New View of HIV - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"La Jolla, CA \u2013 Scientists will have a new view of how the AIDS virus (HIV) enters a target cell and begins its process of infection, thanks to a technique created by researchers at the Salk Institute.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/a-new-view-of-hiv\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/a-new-view-of-hiv\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/a-new-view-of-hiv\\\/\",\"name\":\"A New View of HIV - 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