Fred Gage<\/a>, PhD. <\/p>\nThe current study builds on research reported a year ago by The Salk Institute in which it was shown, for the first time, that young adult mice can receive a boost in brain cells when exposed to an enriched environment (April 3, 1997, Nature). <\/p>\n
“The results are even more pronounced in ‘senior citizen’ mice,” said Gerd Kempermann, MD, of The Salk Institute Laboratory of Genetics. <\/p>\n
In the current study, Kempermann and H. Georg Kuhn, PhD, separated 18-month-old “senior citizen” mice into two groups: one group housed in “standard” conditions (cage containing only food and water) and the other group placed in a large cage “enriched” with tunnels, toys and an exercise wheel. After sixty-eight days, the brains from both groups were compared for the number of new nerve cells. <\/p>\n
The mice living in enriched conditions were found to have generated three times as many new nerve cells in the hippocampus, a part of the brain important for learning and memory, when compared to the control group. The earlier experiments on younger animals from both enriched and standard groups displayed a difference of 60% between the groups. <\/p>\n
“The benefit of the enriched environment appears to be in fostering the survival of new brain cells,” said Kempermann. <\/p>\n
Scientists have known since the 1960s that laboratory animals raised in a complex environment out performed their litter mates on standard learning tests, such as navigating mazes. The biological mechanisms responsible for performance improvements were unknown but believed to lie in increased numbers of connections between existing cells. The 1997 study on young adult mice revealed that the number of new nerve cells in the brain actually increased. <\/p>\n
The research was supported by the National Institute of Neurological Disorders and Stroke, the National Institute on Aging, the American Paralysis Association and the International Spinal Research Trust. In addition, Kempermann is supported by the Deutsche Forschungsgemeinschaft and Kuhn receives funding from the Hereditary Disease Foundation.<\/p>\n
El Instituto Salk de Estudios Biol\u00f3gicos, ubicado en La Jolla, California, es una instituci\u00f3n independiente sin fines de lucro que realiza investigaci\u00f3n cient\u00edfica b\u00e1sica dedicada a la mejora de la salud humana y al aumento de la cantidad y calidad del suministro mundial de alimentos.<\/p>\n
Sus dos \u00e1reas principales de concentraci\u00f3n son neurociencia y biolog\u00eda molecular-celular y gen\u00e9tica; El Instituto Salk fue recientemente clasificado como la instituci\u00f3n de investigaci\u00f3n n\u00famero uno a nivel mundial en ambas \u00e1reas por el Instituto de Informaci\u00f3n Cient\u00edfica, con sede en Filadelfia.<\/p>\n
El Instituto Salk fue fundado en 1960 por Jonas Salk, MD, pionero de la vacuna contra la polio, con una donaci\u00f3n de terrenos por parte de la Ciudad de San Diego y el apoyo financiero de la March of Dimes Birth Defects Foundation. Thomas D. Pollard, MD, es el Presidente y Director Ejecutivo. <\/p>","protected":false},"featured_media":0,"template":"","faculty":[76],"disease-research":[],"class_list":["post-2214","disclosure","type-disclosure","status-publish","hentry","faculty-rusty-gage"],"acf":[],"yoast_head":"\n
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