{"id":22074,"date":"2019-03-14T10:41:49","date_gmt":"2019-03-14T17:41:49","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=22074"},"modified":"2024-01-30T14:58:17","modified_gmt":"2024-01-30T22:58:17","slug":"guardians-of-the-synapse-scientists-identify-a-new-role-for-nerve-supporting-cells","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/guardians-of-the-synapse-scientists-identify-a-new-role-for-nerve-supporting-cells\/","title":{"rendered":"Guardians of the synapse: scientists identify a new role for nerve-supporting cells"},"content":{"rendered":"

LA JOLLA\u2014Salk researchers have found, for the first time, that a blood-clotting protein can, unexpectedly, degrade nerves\u2014and how nerve-supporting glial cells, including Schwann cells, provide protection. The findings, published March 14, 2019, in the journal PLOS Genetics<\/em><\/a>, show that Schwann cells protect nerves by blocking this blood-clotting protein as well as other potentially destructive enzymes released by muscle cells. The work could have implications for diseases as diverse as amyotrophic lateral sclerosis (ALS), multiple sclerosis, Alzheimer\u2019s disease or schizophrenia.<\/p>\n

\"Mouse
Left:<\/strong> Mouse nerves show tight bundling and orderly patterning facilitated by normal Schwann cells.\u00a0Middle:<\/strong> Nerves without Schwann cells but with acetylcholine experience degeneration from the blood-clotting protein thrombin.\u00a0Right:<\/strong> Nerves lacking both Schwann cells and acetylcholine are unable to individually bundle axons but do not undergo axon degeneration.<\/p>\n

Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/p>\n

Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n

\u201cThis is the first study to show that a molecule typically associated with blood clotting, thrombin, has a biological function outside of the liver system and plays an important role in nerve degeneration,\u201d says Salk Professor Kuo-Fen Lee<\/a>, senior author of the paper. \u201cWe further showed that Schwann cells can protect nerves against thrombin. The results were a complete surprise and raise intriguing questions about how synapses are formed and maintained in both health and disease.\u201d<\/p>\n

Schwann cells create a protective insulation around the threadlike projections of nerves called axons, and help form synapses, contacts where chemical signals are passed between cells. To better understand the role of Schwann cells in nerve health, the Salk team studied a specific synapse called a neuromuscular junction (NMJ), which interfaces between Schwann cells, nerves and muscles.<\/p>\n

In the absence of Schwann cells, the NMJ synapse in a mouse model degenerated after two days, confirming their role in synapse growth. The researchers found that without Schwann cells, acetylcholine\u2014the signaling molecule in the NMJ\u2014was a major culprit in why the nerves degraded. When the researchers did a deeper dive to find out why, they uncovered a previously unknown mechanism: left to its own devices, acetylcholine prompts muscle cells to release a blood-clotting protein called thrombin, among other enzymes, that degrade the nerve. In healthy nerves, Schwann cells release molecules that block thrombin to protect their synapses.<\/p>\n

\u201cWe were surprised that Schwann cells maintain developing neuromuscular synapses indirectly by inhibiting negative factors released from active muscle. One of these factors is thrombin, best known for its role in forming blood clots,\u201d says former Salk researcher Thomas Gould, first author of the paper and now an assistant professor at the University of Nevada Reno School of Medicine.<\/p>\n

To confirm the impact of thrombin on the NMJ, the researchers looked at a mouse model where thrombin was absent or nonfunctioning, and found that these mice experienced less nerve axon degeneration. These results affirm that thrombin plays a role in nerve axon degeneration.<\/p>\n

\u201cThis study provides an understanding of the genetic and molecular pathways that alter synapse development and maintenance,\u201d says Lee, holder of the Helen McLoraine Chair in Molecular Neurobiology. \u201cThe next step is to understand the mechanism of how thrombin and other enzymes destroy the synapse\u2014with the eventual goal of creating an intervention for diseases\u2014such as ALS, MS and Alzheimer\u2019s\u2014where thrombin accumulation or dysregulation has been implicated.\u201d<\/p>\n

Other authors included: Bertha Dominguez and Fred de Winter of Salk; Gene W. Yeo, Patrick Liu, Balaji Sundararaman, Thomas Stark and Anthony Vu of the University of California San Diego; Jay L. Degen of the Cincinnati Children\u2019s Hospital Research Foundation; and Weichun Lin of the University of Texas Southwestern Medical Center.<\/p>\n

The work was funded by grants from the National Institutes of Health (GM103554, NS107922, NS055028, NS075449, HG004659, HL096126, NS044420, NS060833, AG0476669, OD023076, MH114831, AG062232), The Clayton Foundation, the Schlink Foundation, the Gemcon Family Foundation, the Brown Foundation, and the Freeburg Foundation.<\/p>","protected":false},"featured_media":22077,"template":"","faculty":[95],"disease-research":[124],"class_list":["post-22074","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-kuo-fen-lee","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nGuardians of the synapse: scientists identify a new role for nerve-supporting cells - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/guardians-of-the-synapse-scientists-identify-a-new-role-for-nerve-supporting-cells\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Guardians of the synapse: scientists identify a new role for nerve-supporting cells - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Salk researchers have found, for the first time, that a blood-clotting protein can, unexpectedly, degrade nerves\u2014and how nerve-supporting glial cells, including Schwann cells, provide protection. 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