{"id":21807,"date":"2019-02-19T00:00:43","date_gmt":"2019-02-19T08:00:43","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=21807"},"modified":"2019-07-22T13:47:30","modified_gmt":"2019-07-22T20:47:30","slug":"putting-the-brakes-on-aging","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/putting-the-brakes-on-aging\/","title":{"rendered":"Frenar el envejecimiento"},"content":{"rendered":"<p>LA JOLLA\u2014El envejecimiento es un factor de riesgo principal para una serie de afecciones debilitantes, como enfermedades card\u00edacas, c\u00e1ncer y enfermedad de Alzheimer, por nombrar algunas. Esto hace que la necesidad de terapias antienvejecimiento sea a\u00fan m\u00e1s urgente. Ahora, investigadores del Salk Institute han desarrollado una nueva terapia g\u00e9nica para ayudar a ralentizar el proceso de envejecimiento.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-12zTbeGddY4\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/12zTbeGddY4?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>Los hallazgos, publicados el 18 de febrero de 2019 en la revista <a href=\"https:\/\/doi.org\/10.1038\/s41591-019-0343-4\" target=\"_blank\" rel=\"noopener\"><em>Nature Medicine<\/em><\/a>, resaltar una novedosa terapia de edici\u00f3n gen\u00f3mica CRISPR\/Cas9 que puede suprimir el envejecimiento acelerado observado en ratones con el s\u00edndrome de progeria de Hutchinson-Gilford, un trastorno gen\u00e9tico raro que tambi\u00e9n afecta a los humanos. Este tratamiento proporciona informaci\u00f3n importante sobre las v\u00edas moleculares involucradas en el envejecimiento acelerado, as\u00ed como sobre c\u00f3mo reducir las prote\u00ednas t\u00f3xicas mediante terapia g\u00e9nica.<\/p>\n<p>\u201cEl envejecimiento es un proceso complejo en el que las c\u00e9lulas comienzan a perder su funcionalidad, por lo que es fundamental que encontremos formas efectivas de estudiar los motores moleculares del envejecimiento\u201d, dice <a href=\"https:\/\/www.salk.edu\/es\/scientist\/juan-carlos-izpisua-belmonte\/\">Juan Carlos Izpisua Belmonte<\/a>, profesor en el Laboratorio de Expresi\u00f3n G\u00e9nica de Salk y autor principal del art\u00edculo. \u201cLa progeria es un modelo ideal de envejecimiento porque nos permite idear una intervenci\u00f3n, refinarla y probarla de nuevo r\u00e1pidamente\u201d.\u201d<\/p>\n<figure id=\"attachment_21810\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"222\" class=\"img-responsive wp-image-21810 size-medium\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-progeria-mouse-300x222.png\" alt=\"This image shows two mice of the same age with progeria. The larger and healthier mouse on the left received the gene therapy, while the mouse on the right did not.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-progeria-mouse-300x222.png 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-progeria-mouse-147x109.png 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-progeria-mouse.png 394w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-caption-text\">Esta imagen muestra dos ratones de la misma edad con progeria. El rat\u00f3n m\u00e1s grande y sano de la izquierda recibi\u00f3 la terapia g\u00e9nica, mientras que el rat\u00f3n de la derecha no.<\/p>\n<p>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>Con una aparici\u00f3n temprana y r\u00e1pida progresi\u00f3n, la progeria es una de las formas m\u00e1s severas de un grupo de trastornos degenerativos causados por una mutaci\u00f3n en el gen LMNA. Tanto los ratones como los humanos con progeria muestran muchos signos de envejecimiento, incluido da\u00f1o en el ADN, disfunci\u00f3n card\u00edaca y una esperanza de vida dr\u00e1sticamente acortada. El gen LMNA normalmente produce dos prote\u00ednas similares dentro de una c\u00e9lula: lamin A y lamin C. La progeria cambia la producci\u00f3n de lamin A a progerina. La progerina es una forma acortada y t\u00f3xica de lamin A que se acumula con la edad y se agrava en quienes padecen progeria.<\/p>\n<p>\u201cNuestro objetivo era disminuir la toxicidad de la mutaci\u00f3n del gen LMNA que conduce a la acumulaci\u00f3n de progerina dentro de la c\u00e9lula\u201d, dice el coautor Hsin-Kai Liao, investigador adjunto en el laboratorio de Izpisua Belmonte. \u201cRazonamos que la progeria podr\u00eda tratarse mediante la interrupci\u00f3n dirigida con CRISPR\/Cas9 tanto de la lamin A como de la progerina\u201d.\u201d<\/p>\n<p>Los investigadores utilizaron el sistema CRISPR\/Cas9 para administrar la terapia g\u00e9nica en las c\u00e9lulas del modelo de rat\u00f3n con progeria que expresa Cas9. Se inyect\u00f3 un virus adenoasociado (AAV) que conten\u00eda dos ARN gu\u00eda sint\u00e9ticos y un gen reportero. El ARN gu\u00eda dirige la prote\u00edna Cas9 a una ubicaci\u00f3n espec\u00edfica en el ADN, donde puede realizar un corte para dejar la laminina A y la progerina no funcionales, sin alterar la laminina C. El reportero ayuda a los investigadores a rastrear los tejidos infectados con el AAV.<\/p>\n<p>Dos meses despu\u00e9s de la administraci\u00f3n de la terapia, los ratones estaban m\u00e1s fuertes y activos, con una salud cardiovascular mejorada. Mostraron una menor degeneraci\u00f3n de una importante arteria y un retraso en la aparici\u00f3n de bradicardia (una frecuencia card\u00edaca anormalmente lenta), dos problemas com\u00fanmente observados en la progeria y la vejez. En general, los ratones con progeria tratados tuvieron niveles de actividad similares a los de los ratones normales y su esperanza de vida aument\u00f3 aproximadamente un 25 por ciento.<\/p>\n<figure id=\"attachment_21809\"  class=\"wp-caption alignleft\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"305\" class=\"img-responsive wp-image-21809 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-458x305.jpg\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-458x305.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-300x200.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-768x512.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-1024x683.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-147x98.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-585x390.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-553x369.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-750x500.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-767x511.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-945x630.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-1250x833.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-400x267.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500.jpg 1500w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">De izquierda a derecha: (adelante) Reyna Hernandez-Benitez, Hsin-Kai Liao; (atr\u00e1s) Pradeep Reddy, Mako Yamamoto, Juan Carlos Izpisua Belmonte<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/p>\n<p>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>\u201cUna vez que mejoremos la eficiencia de nuestros virus para infectar un amplio rango de tejidos, confiamos en que podremos aumentar a\u00fan m\u00e1s la esperanza de vida\u201d, dice Pradeep Reddy, investigador postdoctoral en el laboratorio de Izpisua Belmonte y autor del art\u00edculo.<\/p>\n<p>En conjunto, los resultados sugieren que la focalizaci\u00f3n de la laminina A y la progerina utilizando un sistema CRISPR\/Cas9 puede mejorar dr\u00e1sticamente la salud fisiol\u00f3gica y la esperanza de vida de los ratones con progeria. Estos resultados brindan una nueva e importante comprensi\u00f3n de c\u00f3mo los cient\u00edficos eventualmente podr\u00e1n atacar los impulsores moleculares del envejecimiento en los humanos.<\/p>\n<p>Los esfuerzos futuros se centrar\u00e1n en hacer que la terapia sea m\u00e1s efectiva y en refinarla para su uso en humanos. Actualmente, no existe una cura para la progeria, por lo que los s\u00edntomas se manejan y las complicaciones se tratan a medida que surgen.<\/p>\n<p>\u201cEsta es la primera vez que se aplica una terapia de edici\u00f3n gen\u00e9tica para tratar el s\u00edndrome de progeria\u201d, afirma Izpisua Belmonte, titular de la C\u00e1tedra Roger Guillemin. \u201cNecesitar\u00e1 algunos refinamientos, pero tiene muchos menos efectos negativos en comparaci\u00f3n con otras opciones disponibles. Este es un avance emocionante para el tratamiento de la progeria\u201d.\u201d<\/p>\n<p>Otros autores incluyeron a Ergin Beyret, Mako Yamamoto, Reyna Hern\u00e1ndez-Ben\u00edtez, Yunpeng Fu y Galina Erikson de la <a href=\"https:\/\/www.salk.edu\/es\/\">Instituto Salk de Estudios Biol\u00f3gicos<\/a>.<\/p>\n<p>El trabajo fue financiado por la Fundaci\u00f3n Catharina, la Asociaci\u00f3n de Distrofia Muscular, el NIH-NCI CCSG: P30 014195, el Helmsley Trust, la Fundaci\u00f3n de Investigaci\u00f3n Progeria, la Universidad Cat\u00f3lica San Antonio de Murcia (UCAM), la Fundaci\u00f3n Dr. Pedro Guill\u00e9n, la Fundaci\u00f3n Caritativa G. Harold y Leila Y. Mathers, la Fundaci\u00f3n Glenn y la Fundaci\u00f3n Moxie.<\/p>","protected":false},"featured_media":21809,"template":"","faculty":[85],"disease-research":[146],"class_list":["post-21807","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-juan-carlos-izpisua-belmonte","disease-research-aging-and-regenerative-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Putting the brakes on aging - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/putting-the-brakes-on-aging\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Putting the brakes on aging - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer\u2019s disease, to name a few. 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