{"id":2152,"date":"2012-02-03T00:00:00","date_gmt":"2012-02-03T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/discovery-of-extremely-long-lived-proteins-may-provide-insight-into-cell-aging-and-neurodegenerative-diseases\/"},"modified":"2016-01-23T11:32:51","modified_gmt":"2016-01-23T19:32:51","slug":"discovery-of-extremely-long-lived-proteins-may-provide-insight-into-cell-aging-and-neurodegenerative-diseases","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/discovery-of-extremely-long-lived-proteins-may-provide-insight-into-cell-aging-and-neurodegenerative-diseases\/","title":{"rendered":"El descubrimiento de prote\u00ednas de vida extremadamente larga podr\u00eda ofrecer informaci\u00f3n sobre el envejecimiento celular y las enfermedades neurodegenerativas."},"content":{"rendered":"<p>LA JOLLA, CA\u2014Uno de los grandes misterios de la biolog\u00eda es por qu\u00e9 las c\u00e9lulas envejecen. Ahora, cient\u00edficos del Instituto Salk de Estudios Biol\u00f3gicos informan que han descubierto una debilidad en un componente de las c\u00e9lulas cerebrales que podr\u00eda explicar c\u00f3mo ocurre el proceso de envejecimiento en el cerebro.\n<\/p>\n<p>\nLos cient\u00edficos descubrieron que ciertas prote\u00ednas, denominadas prote\u00ednas extremadamente longevas (ELLPs), que se encuentran en la superficie del n\u00facleo de las neuronas, tienen una vida \u00fatil notablemente larga.\n<\/p>\n<p>\nSi bien la vida \u00fatil de la mayor\u00eda de las prote\u00ednas no supera los dos d\u00edas, las del Salk<br \/>\nInvestigadores del instituto identificaron ELLPs en el cerebro de ratas que ten\u00edan la misma antig\u00fcedad<br \/>\ncomo el organismo, un hallazgo que informaron en <em>Ciencia<\/em>.\n<\/p>\n<p><iframe src=\"https:\/\/www.youtube.com\/embed\/MH80WhU3KTs?rel=0\" frameborder=\"0\" allowfullscreen><\/iframe><\/p>\n<p>\nLos cient\u00edficos de Salk son los primeros en descubrir una m\u00e1quina intracelular esencial cuyos componentes incluyen prote\u00ednas de esta edad. Sus resultados sugieren que las prote\u00ednas duran toda la vida, sin ser reemplazadas.\n<\/p>\n<p>\nLas ELLP conforman los canales de transporte en la superficie del n\u00facleo; compuertas que controlan qu\u00e9 materiales entran y salen. Su larga vida \u00fatil podr\u00eda ser una ventaja si no fuera por el desgaste que estas prote\u00ednas experimentan con el tiempo. A diferencia de otras prote\u00ednas en el cuerpo, las ELLP no se reemplazan cuando sufren modificaciones qu\u00edmicas an\u00f3malas y otros da\u00f1os.\n<\/p>\n<p>\nEl da\u00f1o a las ELLP debilita la capacidad de los canales de transporte tridimensionales que componen estas prote\u00ednas para proteger el n\u00facleo de la c\u00e9lula de toxinas, dice <a href=\"\/es\/faculty\/hetzer.html\/\">Mart\u00edn Hetzer<\/a>, profesor del Instituto Salk <a href=\"\/es\/faculty\/molecular_and_cell_biology_laboratory.html\/\">Laboratorio de Biolog\u00eda Molecular y Celular<\/a>, quien encabez\u00f3 la investigaci\u00f3n. Estas toxinas pueden alterar el ADN de la c\u00e9lula y, por ende, la actividad de los genes, lo que resulta en el envejecimiento celular.\n<\/p>\n<p>\nFinanciado por <a href=\"http:\/\/www.ellisonfoundation.org\/\">Fundaci\u00f3n M\u00e9dica Ellison<\/a> y el <a href=\"http:\/\/glennfoundation.org\/\">Fundaci\u00f3n Glenn para la Investigaci\u00f3n M\u00e9dica<\/a>, el grupo de investigaci\u00f3n de Hetzer es el \u00fanico laboratorio en el mundo que investiga el papel de estos canales de transporte, llamados complejo de poros nucleares (NPC), en el proceso de envejecimiento.\n<\/p>\n<div class=\"imageCaption\"><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2012\/01\/540_hetzer.jpg\" alt=\"extremely long-lived proteins\" width=\"300\"><\/p>\n<p>Esta imagen microsc\u00f3pica muestra prote\u00ednas de vida extremadamente larga, o ELLP, brillando en verde en el exterior del n\u00facleo de una c\u00e9lula cerebral de rata. El ADN dentro del n\u00facleo se muestra en azul.\n<\/p>\n<p>\nLos cient\u00edficos de Salk descubrieron que las ELLPs, que forman canales a trav\u00e9s de la pared del n\u00facleo, duraron m\u00e1s de un a\u00f1o sin ser reemplazadas. El deterioro de estas prote\u00ednas puede permitir que las toxinas entren en el n\u00facleo, lo que resulta en el envejecimiento celular.\n<\/p>\n<p>Imagen: Cortes\u00eda de Brandon Toyama, Salk Institute for Biological Studies <\/p>\n<\/div>\n<p>\nEstudios previos han revelado que las alteraciones en la expresi\u00f3n g\u00e9nica subyacen al proceso de envejecimiento. Sin embargo, hasta el descubrimiento del laboratorio Hetzer de que las CPNs de los mam\u00edferos poseen un tal\u00f3n de Aquiles que permite la entrada de toxinas que da\u00f1an el ADN al n\u00facleo, la comunidad cient\u00edfica ha tenido pocas pistas s\u00f3lidas sobre c\u00f3mo ocurren estas alteraciones gen\u00e9ticas.\n<\/p>\n<p>\n\u201cLa caracter\u00edstica definitoria fundamental del envejecimiento es una disminuci\u00f3n general en la capacidad funcional de varios \u00f3rganos, como el coraz\u00f3n y el cerebro\u201d, dice Hetzer. \u201cEsta disminuci\u00f3n resulta del deterioro de la homeostasis, o estabilidad interna, dentro de las c\u00e9lulas que componen esos \u00f3rganos. Investigaciones recientes en varios laboratorios han relacionado la desintegraci\u00f3n de la homeostasis proteica con la disminuci\u00f3n de la funci\u00f3n celular\u201d.\u201d\n<\/p>\n<p>\nLos resultados que Hetzer y su equipo reportan hoy sugieren que la disminuci\u00f3n de la funci\u00f3n neuronal puede originarse en los ELLP que se deterioran como resultado de da\u00f1os a lo largo del tiempo.\n<\/p>\n<p>\n\u201cLa mayor\u00eda de las c\u00e9lulas, pero no las neuronas, combaten el deterioro funcional de sus componentes proteicos a trav\u00e9s del proceso de recambio de prote\u00ednas, en el cual las partes potencialmente afectadas de las prote\u00ednas se reemplazan con copias funcionales nuevas\u201d, afirma Hetzer.\n<\/p>\n<p>\n\u201cNuestros resultados tambi\u00e9n sugieren que el deterioro de los poros nucleares podr\u00eda ser un mecanismo general de envejecimiento que conduce a defectos relacionados con la edad en la funci\u00f3n nuclear, como la p\u00e9rdida de programas de expresi\u00f3n g\u00e9nica juveniles\u201d, agrega.\n<\/p>\n<p>\nLos hallazgos podr\u00edan resultar relevantes para comprender los or\u00edgenes moleculares del envejecimiento y trastornos neurodegenerativos como la enfermedad de Alzheimer y la enfermedad de Parkinson.\n<\/p>\n<p>\nEn estudios anteriores, Hetzer y su equipo descubrieron grandes filamentos en los n\u00facleos de las neuronas de ratones y ratas viejas, cuyos or\u00edgenes rastrearon hasta el citoplasma. Estos filamentos se han relacionado con varios trastornos neurol\u00f3gicos, incluida la enfermedad de Parkinson. A\u00fan no se ha determinado si las mol\u00e9culas mal ubicadas son una causa o una consecuencia de la enfermedad.\n<\/p>\n<p>\nAsimismo, en estudios anteriores, Hetzer y su equipo documentaron una disminuci\u00f3n, relacionada con la edad, en el funcionamiento de las NPC en las neuronas de ratas sanas de edad avanzada, que constituyen modelos de laboratorio de la biolog\u00eda humana.\n<\/p>\n<p>\nEl equipo de Hetzer incluye a sus colegas del Instituto Salk, as\u00ed como a John Yates III, profesor en el Departamento de Fisiolog\u00eda Qu\u00edmica del Instituto de Investigaci\u00f3n Scripps. Los co-primeros autores del estudio fueron Brandon H. Toyama, investigador postdoctoral en el laboratorio de Hetzer, y Jeffrey N. Savas, investigador postdoctoral en el laboratorio de Yates.\n<\/p>\n<p>\nCuando Hetzer decidi\u00f3 hace tres a\u00f1os investigar si el NPC juega un papel en iniciar o contribuir al inicio del envejecimiento y ciertas enfermedades neurodegenerativas, algunos miembros de la comunidad cient\u00edfica le advirtieron que tal estudio era demasiado audaz y ser\u00eda dif\u00edcil y costoso de llevar a cabo. Pero Hetzer estaba decidido a pesar de las advertencias.\n<\/p>\n<p>\n\u00c9l a\u00f1ade que sin la financiaci\u00f3n de la fundaci\u00f3n, el estudio no habr\u00eda avanzado al punto de que sus hallazgos se publiquen en una revista l\u00edder.<\/p>\n<p>\n<strong><br \/>\nAcerca del Instituto Salk de Estudios Biol\u00f3gicos:<br \/><\/strong><br \/>\nEl Instituto Salk de Estudios Biol\u00f3gicos es una de las instituciones de investigaci\u00f3n b\u00e1sica m\u00e1s destacadas del mundo, donde un cuerpo docente de prestigio internacional investiga cuestiones fundamentales de las ciencias de la vida en un entorno \u00fanico, colaborativo y creativo. Centrados tanto en el descubrimiento como en la formaci\u00f3n de las futuras generaciones de investigadores, los cient\u00edficos del Salk realizan contribuciones revolucionarias a nuestra comprensi\u00f3n del c\u00e1ncer, el envejecimiento, el Alzheimer, la diabetes y las enfermedades infecciosas mediante el estudio de la neurociencia, la gen\u00e9tica, la biolog\u00eda celular y vegetal, y otras disciplinas relacionadas.\n<\/p>\n<p>\nLos logros del cuerpo docente han sido reconocidos con numerosos galardones, entre los que se incluyen premios Nobel y la pertenencia a la Academia Nacional de Ciencias. Fundado en 1960 por el Dr. Jonas Salk, pionero en la vacuna contra la poliomielitis, el Instituto es una organizaci\u00f3n independiente sin fines de lucro y un hito arquitect\u00f3nico.<\/p>\n<p><strong>Para m\u00e1s informaci\u00f3n:<\/strong><br \/>\n<em>Ciencia<\/em><br \/>\nAutores: Jeffrey N. Savas, Brandon H. Toyama, Tao Xu, John R. Yates y Martin W. Hetzer<br \/>\n<a href=\"http:\/\/www.sciencemag.org\/content\/early\/2012\/02\/01\/science.1217421.abstract?sid=6b60fd73-8b71-4ae0-90d5-a183a69d40d0\">Prote\u00ednas de los poros nucleares de vida extremadamente larga en el cerebro de la rata<\/a><\/p>","protected":false},"featured_media":0,"template":"","faculty":[86],"disease-research":[127,146,124,162],"class_list":["post-2152","disclosure","type-disclosure","status-publish","hentry","faculty-martin-hetzer","disease-research-alzheimers-disease","disease-research-aging-and-regenerative-medicine","disease-research-neuroscience-and-neurological-disorders","disease-research-parkinsons-disease"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Discovery of extremely long-lived proteins may provide insight into cell aging and neurodegenerative diseases - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/discovery-of-extremely-long-lived-proteins-may-provide-insight-into-cell-aging-and-neurodegenerative-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discovery of extremely long-lived proteins may provide insight into cell aging and neurodegenerative diseases - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA, CA\u2014One of the big mysteries in biology is why cells age. 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