{"id":2147,"date":"2012-01-06T00:00:00","date_gmt":"2012-01-06T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/wylie-vale-salk-scientist-pioneer-and-leader-dies-at-70\/"},"modified":"2012-01-06T00:00:00","modified_gmt":"2012-01-06T08:00:00","slug":"wylie-vale-salk-scientist-pioneer-and-leader-dies-at-70","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/wylie-vale-salk-scientist-pioneer-and-leader-dies-at-70\/","title":{"rendered":"Wylie Vale, Salk scientist, pioneer and leader, dies at 70"},"content":{"rendered":"<p>LA JOLLA, CA\u2014Dr. Wylie Vale, a Salk Institute professor and world-renowned expert on brain hormones, died January 3 while on vacation in Hana, Hawaii. He was 70 years old.\n<\/p>\n<p>\nVale was head of the Clayton Foundation Laboratories for Peptide Biology and the Helen McLoraine Chair in Molecular Neurobiology at the Salk.\n<\/p>\n<p>\nHe was highly regarded as the global authority on peptide hormones and growth factors that provide communication between the brain and endocrine system. Vale and his collaborators identified the central switchboard, a group of neuropeptides and their receptors that mediate the body&#8217;s responses to stress and stress-related disorders. Their research led to new methods for the diagnosis of pituitary disease and opened new possibilities for the development of drugs aimed at treating anxiety, depression, irritable bowel syndrome and even drug abuse.\n<\/p>\n<div class=\"imageCaption\"><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2012\/01\/ValeWylie_535.jpg\" alt=\"Wylie Vale\" width=\"300\"><\/p>\n<p>Wylie W. Vale<br \/>\n<br \/>\nProfesor y Jefe de Laboratorio<br \/>\n<br \/>\nC\u00e1tedra Helen McLoraine en Neurobiolog\u00eda Molecular<br \/>\n<br \/>\nLaboratorios de la Fundaci\u00f3n Clayton para la Biolog\u00eda de los P\u00e9ptidos<\/p>\n<p>Image: Courtesy of Salk Institute for Biological Studies\n<\/p>\n<\/div>\n<p>\nVale was born in Houston, Texas, on July 3, 1941. He earned his B.A. degree in biology from Rice University and his Ph.D. in physiology and biochemistry from Baylor College of Medicine. He would later work with Roger Guillemin, Nobel laureate and Salk scientist, before joining the Salk in 1970.\n<\/p>\n<p>\nVale received his distinguished appointment as professor at the institute in 1980. Since then, he discovered more than a dozen novel peptide hormones and receptors, co-authored more than 600 peer-reviewed papers and is among the most cited scientific authors of the past several decades. He was also an adjunct professor of medicine at the University of California, San Diego.\n<\/p>\n<p>\nIn 1981, Vale and his colleagues became the first to characterize the peptide known as corticotropin releasing factor (CRF). They demonstrated that the production of CRF by certain cells in the brain triggered many of the body&#8217;s hormonal, immune and behavioral responses to stressful situations. Vale&#8217;s work revealed that an unusual high production of CRF is associated with several disorders, including anxiety, drug abuse, depression and anorexia.\n<\/p>\n<p>\nIn 2004, Vale and his colleagues at the University of California, San Diego established the firmest link between a family of hormones that helps the body adapt to stress and possible new treatments for congestive heart failure. Vale discovered that the hormone urocortin-2 has a positive impact on heart function, and the hormone was shown to significantly enhance heart muscle contractions.\n<\/p>\n<p>\nAs a result of Vale&#8217;s research, he co-founded Neurocrine Biosciences, a public company based in part upon his identification and study of peptides and receptors. His discoveries also led to several other companies in the world to work on CRF blockers, leading to clinical trials for the treatment of anxiety and depression.\n<\/p>\n<p>\n&#8220;Wylie was a brilliant scientist, witty, always optimistic, full of life and one of the wisest faculty colleagues,&#8221; said Inder Verma, a professor in Salk&#8217;s Laboratory of Genetics. &#8220;I will miss his constant bantering and self-deprecating humor more than I can imagine.&#8221;<\/p>\n<p>\nIn recognition of his scientific achievements, Vale was elected as a member of the National Academy of Sciences, the Institute of Medicine and the American Academy of Arts and Sciences. He also served as the president of the American Endocrine Society and the International Society of Endocrinology.\n<\/p>\n<p>\nHe spent more than 40 years conducting groundbreaking research at the Salk Institute. Vale passed away in his sleep. He is survived by his wife Betty, their daughters, Elizabeth and Susannah, and his granddaughter Celeste. A private service is planned for the family.<\/p>\n<p><a href=\"http:\/\/tributes.com\/show\/Wylie-Walker-Vale-93057863\" target=\"_blank\">Click to view Wylie Vale&#8217;s tribute page and leave a memory>><\/a><\/p>\n<p><strong><br \/>\nAcerca del Instituto Salk de Estudios Biol\u00f3gicos:<\/strong><\/p>\n<p>El Instituto Salk de Estudios Biol\u00f3gicos es una de las instituciones de investigaci\u00f3n b\u00e1sica m\u00e1s destacadas del mundo, donde un cuerpo docente de prestigio internacional investiga cuestiones fundamentales de las ciencias de la vida en un entorno \u00fanico, colaborativo y creativo. Centrados tanto en el descubrimiento como en la formaci\u00f3n de las futuras generaciones de investigadores, los cient\u00edficos del Salk realizan contribuciones revolucionarias a nuestra comprensi\u00f3n del c\u00e1ncer, el envejecimiento, el Alzheimer, la diabetes y las enfermedades infecciosas mediante el estudio de la neurociencia, la gen\u00e9tica, la biolog\u00eda celular y vegetal, y otras disciplinas relacionadas.\n<\/p>\n<p>\nLos logros del cuerpo docente han sido reconocidos con numerosos galardones, entre los que se incluyen premios Nobel y la pertenencia a la Academia Nacional de Ciencias. Fundado en 1960 por el Dr. Jonas Salk, pionero en la vacuna contra la poliomielitis, el Instituto es una organizaci\u00f3n independiente sin fines de lucro y un hito arquitect\u00f3nico.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[],"disease-research":[161,124],"class_list":["post-2147","disclosure","type-disclosure","status-publish","hentry","disease-research-depression","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Wylie Vale, Salk scientist, pioneer and leader, dies at 70 - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/wylie-vale-salk-scientist-pioneer-and-leader-dies-at-70\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Wylie Vale, Salk scientist, pioneer and leader, dies at 70 - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA, CA\u2014Dr. Wylie Vale, a Salk Institute professor and world-renowned expert on brain hormones, died January 3 while on vacation in Hana, Hawaii. 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