{"id":20581,"date":"2018-10-22T12:41:26","date_gmt":"2018-10-22T19:41:26","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=20581"},"modified":"2024-01-30T15:05:20","modified_gmt":"2024-01-30T23:05:20","slug":"salk-scientists-advance-ultrasound-technology-for-neurological-therapy","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-advance-ultrasound-technology-for-neurological-therapy\/","title":{"rendered":"Cient\u00edficos de Salk avanzan en la tecnolog\u00eda de ultrasonido para terapia neurol\u00f3gica"},"content":{"rendered":"<p>LA JOLLA\u2014The emerging technology of <a href=\"https:\/\/sonogenetics.salk.edu\/\">sonogenetics<\/a>\u2014a technique where cells are controlled by sound\u2014offers the potential to one day replace pharmaceutical drugs or invasive surgical treatments for neurological conditions like epilepsy, Parkinson&#8217;s disease or posttraumatic stress disorder.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-_pxKj3f2G0Y\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/_pxKj3f2G0Y?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>The Salk Institute scientist who pioneered the idea of using ultrasonic waves to stimulate neurons and coined the term &#8220;sonogenetics&#8221; will participate in the Defense Advanced Research Projects Agency&#8217;s ElectRx program, aiming to take his lab&#8217;s work to the next level with $750,000 in new funding.<\/p>\n<p>&#8220;We initiated this project about six years ago, when we first brought ultrasound into the laboratory to study a biological system,&#8221; says Salk Associate Professor <a href=\"https:\/\/www.salk.edu\/es\/scientist\/sreekanth-chalasani\/\">Sreekanth Chalasani<\/a>, the principal investigator of the grant. &#8220;We wanted to know whether ultrasound could stimulate behavior in the nematode\u2014a simple organism whose basic neurological circuitry has similarities to our own\u2014and, strikingly, we found that it could.&#8221;<\/p>\n<figure id=\"attachment_20584\"  class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" class=\"img-responsive wp-image-20584 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/10\/Shrek767p-300x300.jpg\" alt=\"Sreekanth Chalasani\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/10\/Shrek767p-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/10\/Shrek767p-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/10\/Shrek767p-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/10\/Shrek767p-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/10\/Shrek767p-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/10\/Shrek767p-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/10\/Shrek767p-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/10\/Shrek767p.jpg 767w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-caption-text\">Sreekanth Chalasani<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/10\/Shrek767p.jpg\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<\/p>\n<p>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>In 2012, Chalasani received a Salk Innovation Grant to explore his idea of genetically engineering neurons in the worm to respond to sound waves. He <a href=\"https:\/\/www.salk.edu\/es\/news-release\/in-first-salk-scientists-use-sound-waves-to-control-brain-cells\/\">first demonstrated the technique on nematodes in 2015<\/a>, showing that low-intensity ultrasound waves propagating into the worms caused a chemically sensitive molecular channel called TRP-4 to open and activate brain cells. His team then used molecular biology techniques to add the TRP-4 channel to neurons that don&#8217;t usually react to ultrasound, successfully activating them and influencing the worms\u2019 behavior. The lab leveraged the early success of their approach into a <a href=\"https:\/\/www.salk.edu\/es\/news-release\/salk-neuroscientist-granted-1-million-harness-sound-control-brain-cells\/\">grant from the National Institutes of Health\u2019s (NIH) Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative<\/a> to explore additional molecular channels that could be targeted with ultrasound. The team also showed the technique works in a mouse model.<\/p>\n<p>Before the development of sonogenetics, scientists used a tool called optogenetics to stimulate neurons with light. While optogenetics continues to be a highly valuable tool for neuroscience research, the approach has some therapeutic limitations.<\/p>\n<p>&#8220;With optogenetics, you need to surgically implant some sort of probe or light-emitting device in or very near the tissue that you are targeting,&#8221; says Yusuf Tufail, a research scientist in the Chalasani lab. &#8220;But with sonogenetics, you don\u2019t need surgery, because the genetic components that make neurons sensitive to ultrasound can be delivered via therapeutic viruses, and then the ultrasound stimulation is applied from outside the body, just like a pregnancy ultrasound.&#8221;<\/p>\n<p>Now, the team aims to search for additional proteins that will respond to ultrasound\u2014but rather than activate neurons, these proteins would inhibit cells. Methods to both noninvasively inhibit as well as activate neurons have immense potential for therapies.<\/p>\n<p>&#8220;Sonogenetics is a very exciting way in which we could potentially treat different neurological conditions without having to invasively implant electrodes into patients,&#8221; says Corinne Lee-Kubli, a research associate in the Chalasani lab. &#8220;Parkinson&#8217;s disease, neuropathic pain, PTSD and movement disorders, such as paralysis, could theoretically all benefit from a sonogenetics approach.&#8221;<\/p>\n<p>With this new support, the team will build novel, custom-made instruments to develop and assess the technology.<\/p>\n<p>Adds Chalasani, &#8220;We are excited with the results that we have obtained. We&#8217;re excited with the prospects of this technology, which we think could revolutionize the fields of both neuroscience and medicine.&#8221;<\/p>","protected":false},"featured_media":20587,"template":"","faculty":[77],"disease-research":[124],"class_list":["post-20581","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-sreekanth-chalasani","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Salk scientists advance ultrasound technology for neurological therapy - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-advance-ultrasound-technology-for-neurological-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk scientists advance ultrasound technology for neurological therapy - 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