{"id":2055,"date":"2010-11-03T00:00:00","date_gmt":"2010-11-03T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/helmsley-charitable-trust-awards-more-than-15-million-to-salk-institute-columbia-university-collaborative-stem-cell-research-effort\/"},"modified":"2010-11-03T00:00:00","modified_gmt":"2010-11-03T07:00:00","slug":"helmsley-charitable-trust-awards-more-than-15-million-to-salk-institute-columbia-university-collaborative-stem-cell-research-effort","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/helmsley-charitable-trust-awards-more-than-15-million-to-salk-institute-columbia-university-collaborative-stem-cell-research-effort\/","title":{"rendered":"Helmsley Charitable Trust awards more than $15 million to Salk Institute-Columbia University collaborative stem cell research effort"},"content":{"rendered":"

LA JOLLA, CA–The Salk Institute for Biological Studies and Columbia University Medical Center have been awarded a $15 million grant by The Leona M. and Harry B. Helmsley Charitable Trust, establishing a collaborative program to fast-track the use of induced pluripotent stem (iPS) cells to gain new insight into disease mechanisms and screen for novel therapeutic drugs.\n<\/p>\n

\n“Stem cell research is of immense importance to the future of biomedical research and will have a major impact in treating and preventing devastating diseases,” said Fred H. Gage, Ph.D., a professor in the Laboratory for Genetics at the Salk Institute and the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases.\n<\/p>\n

\n“The funding from The Helmsley Trust will accelerate and deepen our research efforts in stem cell biology, already an area of strength at the Salk Institute. In addition, this funding allows researchers at the Salk to join forces with outstanding researchers at Columbia University in a synergistic enterprise that will bring stem cell research closer to fulfilling its promise,” he said.\n<\/p>\n

\"nueral<\/p>\n

The image shows six-week-old neurons derived from induced pluripotent stem cells which were first generated from skin cells taken from an autistic patient. Neurons are shown in green, dendrites-the signal-receiving ends of neurons-in red and cell nuclei are stained blue.\n<\/p>\n

\nImage: Courtesy of Drs. Fred Gage and Kristen Brennand, Salk Institute for Biological Studies\n<\/p>\n<\/div>\n

\nThe ability to reprogram adult human cells into iPS cells, which by all appearances look and act like embryonic stem cells, creates a unique opportunity to study human disease in revolutionary ways. After taking a few skin cells from patients, researchers can generate iPS cells and differentiate them into the type of tissue where a disease is manifest.\n<\/p>\n

\nOver the course of the three-year grant, the Salk will develop a stem cell bank of well-characterized iPS cells derived from patients suffering from debilitating neurological, cardiac and hematological conditions. Both institutions will use these cell lines and other stem cell-based tools to generate the cell types (nerve cells, muscle, blood cells and other tissues) affected in a wide range of diseases, and to determine the molecular causes of disease phenotypes.\n<\/p>\n

\nThese cell-based models of disease will allow investigators from both institutions to screen at Columbia tens of thousands of chemical compounds to uncover novel drug therapies for hitherto untreatable diseases. The grant will therefore create a pipeline of new models and molecules that will start from individual patients and create new avenues back to the clinic.\n<\/p>\n

\nChristopher E. Henderson, Ph.D., Director of the Columbia Stem Cell Initiative, and Co-Director of the Columbia Motor Neuron Center, said, “Although much public interest has been focused on the use of stem cells for tissue replacement, we and our collaborators at the Salk believe that in many clinical areas their major benefit will be to allow us to model diseases in the culture dish. Such cell-based models can generate new knowledge about the disease process itself, while also opening the way to high-throughput screening for test drug candidates.”\n<\/p>\n

\nHenderson added, “The Helmsley Trust support at Columbia will be focused on freeing up two key bottlenecks in this process. It will fund new protocols to allow scientists to transform stem cells into specific classes of differentiated cells, and will help support a facility that will allow researchers with a disease model to perform drug screening on a scale inaccessible in their own laboratories.”\n<\/p>\n

\n“The Helmsley Trust is showing great vision by investing in two scientific groups operating at the leading edge of stem cell research,” said Salk Institute President William R. Brody. “We are deeply grateful to the trustees and look forward to a very fruitful collaboration with our Columbia University colleagues.”\n<\/p>\n

\n“The generosity of The Helmsley Trust enables research that ultimately may lead to prevention or treatment of diseases that currently have no cure,” said Lee Goldman, M.D., Dean of the Faculties of Health Sciences and Medicine and Executive Vice President for Health and Biomedical Sciences at Columbia University Medical Center. “We look forward to working with our collaborators at the Salk Institute and delivering on the promise of stem cell research.”\n<\/p>\n

\nJohn Codey, Trustee of The Helmsley Trust stated, “We are excited to bring together two world-class institutions to work collaboratively from the bench to the bedside in diseases including Alzheimer’s, ALS and Parkinson’s Disease. We hope this work will help advance this important work in these and other diseases.”\n<\/p>\n


\nAcerca del Instituto Salk de Estudios Biol\u00f3gicos<\/strong>
\nEl Instituto Salk de Estudios Biol\u00f3gicos es una de las instituciones de investigaci\u00f3n b\u00e1sica m\u00e1s destacadas del mundo, donde un cuerpo docente de prestigio internacional investiga cuestiones fundamentales de las ciencias de la vida en un entorno \u00fanico, colaborativo y creativo. Centrados tanto en el descubrimiento como en la formaci\u00f3n de las futuras generaciones de investigadores, los cient\u00edficos del Salk realizan contribuciones revolucionarias a nuestra comprensi\u00f3n del c\u00e1ncer, el envejecimiento, el Alzheimer, la diabetes y las enfermedades infecciosas mediante el estudio de la neurociencia, la gen\u00e9tica, la biolog\u00eda celular y vegetal, y otras disciplinas relacionadas.\n<\/p>\n

\nLos logros del cuerpo docente han sido reconocidos con numerosos galardones, entre los que se incluyen premios Nobel y la pertenencia a la Academia Nacional de Ciencias. Fundado en 1960 por el Dr. Jonas Salk, pionero en la vacuna contra la poliomielitis, el Instituto es una organizaci\u00f3n independiente sin fines de lucro y un hito arquitect\u00f3nico.\n<\/p>\n

\nEl Instituto Salk se enorgullece de celebrar cinco d\u00e9cadas de excelencia cient\u00edfica en la investigaci\u00f3n b\u00e1sica.\n<\/p>\n


\nAbout Columbia University Medical Center
\n<\/strong>
\nColumbia University Medical Center provides international leadership in basic, pre-clinical and clinical research, in medical and health sciences education, and in patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Established in 1767, Columbia’s College of Physicians and Surgeons was the first institution in the country to grant the M.D. degree and is now among the most selective medical schools in the country. Columbia University Medical Center is home to the most comprehensive medical research enterprise in New York City and State and one of the largest in the United States. Columbia University Medical Center is affiliated with NewYork-Presbyterian Hospital, the nation’s largest not-for-profit, non-sectarian hospital provider.\n<\/p>\n

\nFor more information, visit www.cumc.columbia.edu<\/a>.\n<\/p>\n

About The Leona M. and Harry B. Helmsley Charitable Trust<\/strong>
\nThe Leona M. and Harry B. Helmsley Charitable Trust, established in 1999, is administered by trustees selected by Leona Helmsley as a continuation of Mr. and Mrs. Helmsley’s generous giving through their lifetimes. The Trust aspires to improve lives by supporting effective nonprofits. The Trust supports a diverse range of organizations with a major focus on health and medical research, in addition to programs in human services, education and conservation. Since April of 2009, the Trust has made commitments of over $350 million in grants. For more information, please visit: www.helmsleytrust.org<\/a>.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[],"disease-research":[],"class_list":["post-2055","disclosure","type-disclosure","status-publish","hentry"],"acf":[],"yoast_head":"\nHelmsley Charitable Trust awards more than $15 million to Salk Institute-Columbia University collaborative stem cell research effort - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/helmsley-charitable-trust-awards-more-than-15-million-to-salk-institute-columbia-university-collaborative-stem-cell-research-effort\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Helmsley Charitable Trust awards more than $15 million to Salk Institute-Columbia University collaborative stem cell research effort - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA, CA–The Salk Institute for Biological Studies and Columbia University Medical Center have been awarded a $15 million grant by The Leona M. and Harry B. 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