{"id":1946,"date":"2008-11-10T00:00:00","date_gmt":"2008-11-10T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/"},"modified":"2008-11-10T00:00:00","modified_gmt":"2008-11-10T08:00:00","slug":"newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/","title":{"rendered":"Las neuronas reci\u00e9n nacidas en el cerebro adulto pueden asentarse en el barrio equivocado"},"content":{"rendered":"

La Jolla, CA \u2013 En un estudio que podr\u00eda tener consecuencias significativas para las estrategias de trasplante de tejido neural, investigadores del Salk Institute for Biological Studies informan que la inactivaci\u00f3n de un gen espec\u00edfico en c\u00e9lulas madre neurales adultas hace que las c\u00e9lulas nerviosas que emergen de esas c\u00e9lulas precursoras formen conexiones en la parte equivocada del cerebro adulto.<\/p>\n

En un art\u00edculo publicado en la edici\u00f3n del 11 de noviembre de PLoS Biolog\u00eda<\/em>, el equipo, liderado por Fred H. Gage<\/a>, Ph.D., profesor en el Laboratorio de Gen\u00e9tica, descubri\u00f3 que una prote\u00edna llamada cdk5 es necesaria tanto para la correcta elaboraci\u00f3n de antenas altamente ramificadas y complejas, conocidas como dendritas, que son extendidas por las neuronas, como para la migraci\u00f3n adecuada de las c\u00e9lulas que portan dichas antenas.\n<\/p>\n

\nLas funciones previamente descritas de cdk5 son m\u00faltiples, entre ellas la migraci\u00f3n neuronal y la orientaci\u00f3n de las dendritas de las neuronas nacidas durante el desarrollo embrionario. \u201cEl elemento sorprendente fue que las dendritas de las c\u00e9lulas granulares reci\u00e9n nacidas en el hipocampo adulto que carec\u00edan de cdk5 se estiraron en la direcci\u00f3n incorrecta y formaron sinapsis con las c\u00e9lulas equivocadas\u201d, explica Gage. Las sinapsis son los puntos de contacto especializados donde las dendritas reciben informaci\u00f3n de los largos procesos, o axones, de las neuronas vecinas.\n<\/p>\n

<\/p>\n

Las neuronas reci\u00e9n nacidas que carecen de cdk5 (verde) extienden dendritas aberrantes que, no obstante, se integran sin\u00e1pticamente en el circuito del giro dentado preexistente que contiene neuronas (rojo) y c\u00e9lulas gliales (azul). <\/p>\n

Imagen: Cortes\u00eda del Dr. Sebastian Jessberger, Instituto Federal de Tecnolog\u00eda, Z\u00farich, Suiza.<\/p>\n<\/div>\n

\nEstos hallazgos ofrecen informaci\u00f3n extremadamente valiosa, aunque imprevista, para los investigadores cuyo objetivo es desarrollar estrategias de trasplante para tratar lesiones cerebrales o neurodegeneraci\u00f3n.\n<\/p>\n

\n\u201cNuestros datos muestran que las c\u00e9lulas que no logran encontrar su \u2018lugar correcto\u2019 podr\u00edan integrarse en el cerebro e interferir con el procesamiento normal de la informaci\u00f3n\u201d, afirma el autor principal del estudio, Sebastian Jessberger, M. D., ex postdoctorado en el laboratorio de Gage y ahora profesor asistente en el Instituto Federal Suizo de Tecnolog\u00eda de Z\u00farich, Suiza.\n<\/p>\n

\nGage coincide en que esta es una posibilidad, se\u00f1alando que la focalizaci\u00f3n terap\u00e9utica de tejido nuevo \u2014que presumiblemente se derivar\u00eda de c\u00e9lulas madre\u2014 al cerebro o la m\u00e9dula espinal puede exigir una precisi\u00f3n extrema. \u201cNuestros hallazgos reflejan la necesidad de enfoques terap\u00e9uticos que aseguren que las c\u00e9lulas utilizadas en medicina regenerativa se coloquen estrat\u00e9gicamente para que establezcan conexiones apropiadas en lugar de promiscuas\u201d.\u201d\n<\/p>\n

En el estudio, los investigadores primero inyectaron retrovirus en una parte del cerebro de ratones adultos conocida como el hipocampo, que es necesaria para la formaci\u00f3n de la memoria, para etiquetar y eliminar la actividad de cdk5 en las neuronas de gr\u00e1nulos reci\u00e9n nacidas. Con el tiempo, observaron que las neuronas reci\u00e9n nacidas no solo no se movieron a su posici\u00f3n correcta en el cerebro, sino que tambi\u00e9n presentaron dendritas atrofiadas y mal dirigidas.\n<\/p>\n

\nJessberger explica que uno podr\u00eda haber predicho lo contrario: que si las neuronas inmaduras en el cerebro adulto orientaban accidentalmente sus antenas en la direcci\u00f3n equivocada, podr\u00edan no conectarse con las c\u00e9lulas de esa red, o incluso morir. Que formaran puntos de contacto sin\u00e1ptico fue muy inesperado. \u201cDescubrimos que las dendritas de las c\u00e9lulas que carec\u00edan de cdk5 parec\u00edan integrarse en el cerebro sin importar la direcci\u00f3n en que crecieran\u201d, dice.\n<\/p>\n

\nDe hecho, las conexiones sin\u00e1pticas inapropiadas establecidas por las c\u00e9lulas deficientes en cdk5 persistieron durante meses despu\u00e9s del tratamiento con retrovirus que antagonizan la cdk5. \u201cUno podr\u00eda haber predicho que las neuronas inmaduras aberrantes ser\u00edan expulsadas del circuito m\u00e1s adelante\u201d, informa Jessberger, quien sigui\u00f3 el comportamiento de las nuevas c\u00e9lulas granulares en ratones tratados mucho despu\u00e9s de que se eliminara la actividad de la cdk5. \u201cIncluso despu\u00e9s de un a\u00f1o, algunas de esas c\u00e9lulas permanecieron en la parte incorrecta del hipocampo\u201d.\u201d\n<\/p>\n

\nEl PLoS Biolog\u00eda<\/em> el art\u00edculo es parte de un extenso cuerpo de trabajo aportado por el laboratorio de Gage al campo de la neurog\u00e9nesis adulta. Hace una d\u00e9cada, Gage se convirti\u00f3 en uno de los primeros investigadores en el mundo en demostrar la aparici\u00f3n de nuevas neuronas en el cerebro de mam\u00edferos adultos, incluidos los humanos. El estudio actual extiende espec\u00edficamente una investigaci\u00f3n de 2005 PNAS<\/em> estudio en el que el laboratorio busc\u00f3 en todo el genoma puntos calientes cromos\u00f3micos asociados con la neurog\u00e9nesis adulta.\n<\/p>\n

\nEse estudio, que fue iniciado por el ex becario postdoctoral Gerd Kempermann, M.D., coautor en el PLoS Biolog\u00eda<\/em> papel y, actualmente profesor en el Centro de Terapias Regenerativas de Dresde (CRTD), hab\u00eda identificado una gran regi\u00f3n del cromosoma 5 de rat\u00f3n como un \u00e1rea de inter\u00e9s, y cdk5 era un gen incrustado dentro de ese locus.\n <\/p>\n

\n\u201cLa parte interesante de esta historia es que surgi\u00f3 de un enfoque de gen\u00e9tica de sistemas\u201d, dice Gage. \u201cContin\u00faa nuestro esfuerzo por aplicar el an\u00e1lisis gen\u00e9tico para encontrar regiones cromos\u00f3micas que albergan genes que pueden desempe\u00f1ar un papel cr\u00edtico en la neurog\u00e9nesis\u201d.\u201d\n<\/p>\n

\nTambi\u00e9n contribuyeron al estudio, del laboratorio Gage, Stefan Aigner, Ph.D., Gregory D. Clemenson, Jr., Nicolas Toni, Ph.D., y D. Chichung Lie, M.D. \u00d6zlem Karalay de ETH y Rupert Overall de CRTD tambi\u00e9n fueron autores del art\u00edculo.\n<\/p>\n

\nEl estudio fue financiado por la Fundaci\u00f3n Nacional Suiza para la Ciencia y la Deutsche Forschungsgemeinschaft y subvenciones de los National Institutes of Health, el Lookout Fund, la Christopher and Dana Reeve Foundation, la Picower Foundation, la James S. McDonnell Foundation, y la Damon Runyon Cancer Research Foundation.\n<\/p>\n

\nEl Instituto Salk de Estudios Biol\u00f3gicos en La Jolla, California, es una organizaci\u00f3n independiente sin fines de lucro dedicada a descubrimientos fundamentales en las ciencias de la vida, la mejora de la salud humana y la formaci\u00f3n de futuras generaciones de investigadores. Jonas Salk, M.D., cuya vacuna contra la polio pr\u00e1cticamente erradic\u00f3 la paralizante poliomielitis en 1955, fund\u00f3 el Instituto en 1960 con un donativo de terrenos de la Ciudad de San Diego y el apoyo financiero de la March of Dimes.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[76],"disease-research":[],"class_list":["post-1946","disclosure","type-disclosure","status-publish","hentry","faculty-rusty-gage"],"acf":[],"yoast_head":"\nNewborn neurons in the adult brain can settle in the wrong neighborhood - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Newborn neurons in the adult brain can settle in the wrong neighborhood - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"La Jolla, CA\u2013In a study that could have significant consequences for neural tissue transplantation strategies, researchers at the Salk Institute for Biological Studies report that inactivating a specific gene in adult neural stem cells makes nerve cells emerging from those precursors form connections in the wrong part of the adult brain.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\\\/\",\"name\":\"Newborn neurons in the adult brain can settle in the wrong neighborhood - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/GAGEnov2008PRpage.jpg\",\"datePublished\":\"2008-11-10T08:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\\\/#breadcrumb\"},\"inLanguage\":\"es-MX\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/GAGEnov2008PRpage.jpg\",\"contentUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/GAGEnov2008PRpage.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Newborn neurons in the adult brain can settle in the wrong neighborhood\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es-MX\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Newborn neurons in the adult brain can settle in the wrong neighborhood - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/es\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/","og_locale":"es_MX","og_type":"article","og_title":"Newborn neurons in the adult brain can settle in the wrong neighborhood - Salk Institute for Biological Studies","og_description":"La Jolla, CA\u2013In a study that could have significant consequences for neural tissue transplantation strategies, researchers at the Salk Institute for Biological Studies report that inactivating a specific gene in adult neural stem cells makes nerve cells emerging from those precursors form connections in the wrong part of the adult brain.","og_url":"https:\/\/www.salk.edu\/es\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/","og_site_name":"Salk Institute for Biological Studies","og_image":[{"width":628,"height":329,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/","url":"https:\/\/www.salk.edu\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/","name":"Newborn neurons in the adult brain can settle in the wrong neighborhood - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/#primaryimage"},"thumbnailUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/GAGEnov2008PRpage.jpg","datePublished":"2008-11-10T08:00:00+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/#breadcrumb"},"inLanguage":"es-MX","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/"]}]},{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/#primaryimage","url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/GAGEnov2008PRpage.jpg","contentUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/GAGEnov2008PRpage.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/newborn-neurons-in-the-adult-brain-can-settle-in-the-wrong-neighborhood\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Newborn neurons in the adult brain can settle in the wrong neighborhood"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Instituto Salk de Estudios Biol\u00f3gicos","description":"El Poder de la Ciencia","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es-MX"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Instituto Salk de Estudios Biol\u00f3gicos","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"paper_url":"","journal_title":"","paper_author_list":"","paper_title":"","subhead":"","home_photo":"hp_gage_327.jpg","listing_photo":"","line_2":"","line_1":"Newborn neurons in the adult brain can settle in the wrong neighborhood"},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/1946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":0,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/1946\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media?parent=1946"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/faculty?post=1946"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disease-research?post=1946"}],"curies":[{"name":"la hora de","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}