{"id":1880,"date":"2006-08-31T00:00:00","date_gmt":"2006-08-31T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/in-a-technical-tour-de-force-salk-scientists-take-a-global-view-of-the-epigenome\/"},"modified":"2015-12-03T18:14:08","modified_gmt":"2015-12-04T02:14:08","slug":"in-a-technical-tour-de-force-salk-scientists-take-a-global-view-of-the-epigenome","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/in-a-technical-tour-de-force-salk-scientists-take-a-global-view-of-the-epigenome\/","title":{"rendered":"En una proeza t\u00e9cnica, los cient\u00edficos del Instituto Salk adoptan una visi\u00f3n global del epigenoma"},"content":{"rendered":"<p>La Jolla, California \u2013 Una colaboraci\u00f3n entre investigadores del Instituto Salk de Estudios Biol\u00f3gicos y la Universidad de California en Los \u00c1ngeles ha logrado determinar el patr\u00f3n de metilaci\u00f3n del ADN a nivel gen\u00f3mico de la planta <em>Arabidopsis thaliana<\/em>  \u2013 la \u201crata de laboratorio\u201d del mundo vegetal \u2013 de un solo golpe. <\/p>\n<p>\u201cEn un solo experimento hemos sintetizado los hallazgos anecd\u00f3ticos de los \u00faltimos 20 a\u00f1os y mucho m\u00e1s\u201d, afirma el autor principal <a href=\"\/es\/faculty\/ecker.html\/\">Joseph Ecker<\/a>, doctor en Filosof\u00eda y profesor del Laboratorio de Biolog\u00eda Vegetal del Instituto Salk. \u201cHasta ahora, solo se sab\u00eda que unos pocos genes vegetales estaban regulados por la metilaci\u00f3n. Adem\u00e1s de esos, hemos descubierto cientos m\u00e1s\u201d.\u201d<\/p>\n<div class=\"imageCaption\"><img decoding=\"async\" src=\"https:\/\/www.salk.eduhttps:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/caption_20060831.jpg\" alt=\"Arabidopsis rosette \" width=\"300\"> <\/p>\n<p>La roseta de Arabidopsis aparece en un mapa de transcritos que se expresan en diversos mutantes de Arabidopsis incapaces de modificar su ADN mediante un proceso denominado metilaci\u00f3n. Muchos cientos de esos transcritos eran hasta ahora desconocidos y se descubri\u00f3 que proceden de la regi\u00f3n interg\u00e9nica <em>materia oscura<\/em>.<\/p>\n<\/div>\n<p>Estas innovaciones tecnol\u00f3gicas, impulsadas por el equipo de Ecker y el del Dr. Steve Jacobsen, investigador del Instituto M\u00e9dico Howard Hughes en la UCLA, deber\u00edan tener un amplio impacto en el an\u00e1lisis del genoma humano, la biolog\u00eda de las c\u00e9lulas madre y la clonaci\u00f3n terap\u00e9utica. Sus hallazgos se publicar\u00e1n en un pr\u00f3ximo n\u00famero de <em>C\u00e9lula<\/em>.<\/p>\n<p>Nuestra visi\u00f3n de la herencia se ha expresado en gran medida en el lenguaje del ADN, pero los recientes descubrimientos en un campo conocido como epigen\u00e9tica \u2014el estudio de los cambios hereditarios en la funci\u00f3n de los genes que se producen sin alterar las letras del alfabeto del ADN\u2014 demuestran que <em>c\u00f3mo<\/em> Es fundamental que una c\u00e9lula \u201clea\u201d esas letras. <\/p>\n<p>La metilaci\u00f3n es una modificaci\u00f3n qu\u00edmica de una de las cuatro bases (A, G, C y T) que se repiten en nuestro ADN, concretamente de la citosina (C). La adici\u00f3n de un voluminoso grupo metilo a la C suele bloquear la interacci\u00f3n con las prote\u00ednas necesarias para activar la expresi\u00f3n g\u00e9nica, lo que silencia de manera efectiva el gen metilado. <\/p>\n<p>Ecker y Jacobsen recibieron financiaci\u00f3n del Instituto Nacional de Investigaci\u00f3n del Genoma Humano (NHGRI), que puso en marcha un consorcio p\u00fablico conocido como ENCODE, para el <u>Enc<\/u>enciclopedia <u>O<\/u>f <u>D<\/u>NA <u>E<\/u>elementos. Ahora que se ha secuenciado el genoma humano, ENCODE tiene como objetivo desarrollar tecnolog\u00eda para descifrar qu\u00e9 \u201csignifican\u201d esos 30 millones (1%) de letras, identificando no solo qu\u00e9 genes codifican, sino tambi\u00e9n c\u00f3mo las modificaciones epigen\u00e9ticas activan y desactivan los genes. Una vez logrado esto, el proyecto se ampliar\u00e1 para conocer mejor la din\u00e1mica de todo el genoma humano.<\/p>\n<p>El m\u00e9todo desarrollado por Ecker y sus colaboradores podr\u00eda permitir a los investigadores hacer precisamente eso. \u201cHemos logrado incluir todo el genoma de Arabidopsis \u2014unos 120 millones de bases\u2014 en un solo microarray de alta densidad\u201d, afirma Ecker. \u201cPara analizar todo el genoma humano, solo se necesitar\u00edan seis chips m\u00e1s\u201d.\u201d<\/p>\n<p>Cada microarray o chip de ADN contiene 6 millones de fragmentos cortos de ADN que abarcan el <em>Arabidopsis<\/em> el genoma como si fueran baldosas. Los investigadores aislaron primero todo el ADN metilado de las c\u00e9lulas vegetales y localizaron d\u00f3nde se situaban esos fragmentos en la matriz. A continuaci\u00f3n, determinaron qu\u00e9 genes estaban activos y cu\u00e1les no, con el fin de comparar la activaci\u00f3n g\u00e9nica con el patr\u00f3n de metilaci\u00f3n.<\/p>\n<p>Los investigadores observaron cambios significativos al comparar la actividad g\u00e9nica de las plantas normales con la de mutantes vegetales incapaces de metilar el ADN. \u201cFue bastante impactante. Hay cientos de genes que nunca se ven expresados, salvo en los mutantes de metilaci\u00f3n\u201d, afirma Ecker. <\/p>\n<p>Casi un tercio de <em>Arabidopsis<\/em>\u2018~26 000 genes presentaban alg\u00fan tipo de metilaci\u00f3n, y el lugar donde se produc\u00eda esta metilaci\u00f3n determinaba el efecto. Al igual que en los mam\u00edferos, la metilaci\u00f3n en las regiones reguladoras situadas junto a los genes sol\u00eda silenciar estos. Sin embargo, la metilaci\u00f3n en el cuerpo del gen parec\u00eda correlacionarse con una mayor expresi\u00f3n\u00bb.<\/p>\n<p>Los distintos tipos de c\u00e9lulas presentan patrones de metilaci\u00f3n diferentes. La metilaci\u00f3n del ADN en las c\u00e9lulas madre difiere de la que se observa en una c\u00e9lula madura de la piel o del sistema nervioso. Es probable que parte de la transformaci\u00f3n a la que deben someterse las c\u00e9lulas maduras con fines de clonaci\u00f3n terap\u00e9utica implique la remodelaci\u00f3n de los patrones de metilaci\u00f3n para que se asemejen a los de las c\u00e9lulas madre. Adem\u00e1s, los estados patol\u00f3gicos, que van desde el retraso del desarrollo hasta el c\u00e1ncer, se caracterizan por una metilaci\u00f3n an\u00f3mala: algunos carcin\u00f3genos provocan c\u00e1ncer al metilar los genes \u201cequivocados\u201d, lo que da lugar a un crecimiento descontrolado. <\/p>\n<p>Una vez que se establece el patr\u00f3n de metilaci\u00f3n del ADN de una c\u00e9lula \u2014ya sea normal o patol\u00f3gico\u2014, los sitios metilados se transmiten fielmente a las c\u00e9lulas hijas. La capacidad de obtener una instant\u00e1nea de alta resoluci\u00f3n de qu\u00e9 genes est\u00e1n metilados y cu\u00e1les no durante diferentes etapas del desarrollo o estados patol\u00f3gicos podr\u00eda revelar c\u00f3mo se autorrenuevan las c\u00e9lulas o c\u00f3mo se desregulan los genes que controlan el crecimiento.<\/p>\n<p>Los investigadores tambi\u00e9n descubrieron que la metilaci\u00f3n silencia los transposones, los llamados \u201cgenes saltarines\u201d, que pueden causar estragos gen\u00f3micos al moverse por los cromosomas. En palabras de Ecker, los transposones submetilados \u201csimplemente se vuelven locos\u201d, lo que sugiere que la madre naturaleza mantiene a los transposones en un estado de \"tiempo fuera\" cubri\u00e9ndolos con grupos metilo.<\/p>\n<p>Adem\u00e1s de la financiaci\u00f3n del NHGRI, este trabajo tambi\u00e9n cont\u00f3 con el apoyo del Proyecto Arabidopsis 2010 de la Fundaci\u00f3n Nacional para la Ciencia, una iniciativa destinada a identificar las funciones de todos los genes de Arabidopsis.<\/p>\n<p>Entre los dem\u00e1s autores que han contribuido al estudio se encuentran los investigadores del Instituto Salk: el Dr. Junshi Yazaki, investigador posdoctoral; la estudiante de posgrado Ambika Sundaresan; y los investigadores asociados Paul Shinn y Huaming Chen. Otros colaboradores de la UCLA son el profesor adjunto Matteo Pellegrini, Ph.D., los investigadores posdoctorales Xiaoyu Zhang, Ph.D., Ian Henderson, Ph.D., y Simon Chan, Ph.D., y el asistente de investigaci\u00f3n Shawn Cokus.<\/p>\n<p>El Instituto Salk de Estudios Biol\u00f3gicos en La Jolla, California, es una organizaci\u00f3n independiente sin fines de lucro dedicada a descubrimientos fundamentales en las ciencias de la vida, la mejora de la salud humana y la formaci\u00f3n de futuras generaciones de investigadores. Jonas Salk, M.D., cuya vacuna contra la polio pr\u00e1cticamente erradic\u00f3 la paralizante enfermedad poliomielitis en 1955, inaugur\u00f3 el Instituto en 1965 con una donaci\u00f3n de terrenos de la Ciudad de San Diego y el apoyo financiero de la March of Dimes.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[42],"disease-research":[],"class_list":["post-1880","disclosure","type-disclosure","status-publish","hentry","faculty-joseph-ecker"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>In a technical tour de force, Salk scientists take a global view of the epigenome - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/in-a-technical-tour-de-force-salk-scientists-take-a-global-view-of-the-epigenome\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"In a technical tour de force, Salk scientists take a global view of the epigenome - 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