{"id":1863,"date":"2006-04-20T00:00:00","date_gmt":"2006-04-20T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\/"},"modified":"2006-04-20T00:00:00","modified_gmt":"2006-04-20T07:00:00","slug":"researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\/","title":{"rendered":"Investigadores resuelven el misterio de c\u00f3mo los poros nucleares se duplican antes de la divisi\u00f3n celular"},"content":{"rendered":"<p>La Jolla, CA \u2013 Los investigadores se han preguntado durante mucho tiempo c\u00f3mo los poros nucleares \u2013los canales important\u00edsimos que controlan el flujo de informaci\u00f3n dentro y fuera del n\u00facleo de una c\u00e9lula\u2013 se duplican para prepararse para la divisi\u00f3n que ocurrir\u00e1 cuando una c\u00e9lula se divida. Ahora, por primera vez, los cient\u00edficos del Instituto Salk de Estudios Biol\u00f3gicos observaron c\u00f3mo se formaron nuevas estructuras de poros en forma de embudo desde cero y se insertaron en la membrana nuclear. <\/p>\n<p>Este descubrimiento se suma a la imagen de c\u00f3mo una c\u00e9lula se divide de tal manera que el genoma (el plano gen\u00e9tico) encerrado dentro del n\u00facleo puede seguir comunic\u00e1ndose con el resto de la c\u00e9lula. \u201cEste asunto es tan importante para entender el ciclo celular como lo es la pregunta de c\u00f3mo se replica el ADN\u201d, dice <a href=\"\/es\/faculty\/hetzer.html\/\">Mart\u00edn Hetzer<\/a>, Ph.D., profesor asistente en el Laboratorio de Biolog\u00eda Molecular y Celular y autor principal del estudio publicado en la edici\u00f3n del 21 de abril de la revista <em>Ciencia<\/em>.<\/p>\n<p>Los poros nucleares son estructuras gigantescas que controlan el transporte de mol\u00e9culas como el ARN y las prote\u00ednas hacia y desde el santuario interior de una c\u00e9lula, el n\u00facleo, que protege el \u201ccerebro gen\u00f3mico\u201d de la c\u00e9lula. Todas las reacciones qu\u00edmicas que ocurren en una c\u00e9lula emanan de los genes dentro del n\u00facleo. \"Quiz\u00e1s no sea sorprendente que cualquier alteraci\u00f3n en el flujo de informaci\u00f3n a trav\u00e9s de la membrana nuclear pueda alterar el funcionamiento celular\", dice Hetzer.<\/p>\n<p>\u201cLos poros nucleares son realmente asombrosos\u201d, dice el investigador postdoctoral y coautor principal Maximiliano D\u2019Angelo, Ph.D. \u201cSon las estructuras de prote\u00ednas m\u00e1s grandes dentro de una c\u00e9lula y controlan todo el tr\u00e1fico de entrada y salida del n\u00facleo de la c\u00e9lula, desde mol\u00e9culas diminutas como las histonas, que se unen al ADN, hasta estructuras enormes como los ribosomas\u201d, explic\u00f3. <\/p>\n<p> Para formar los canales de transporte que abarcan la membrana nuclear, 30 prote\u00ednas diferentes, llamadas nucleoporinas, se unen de manera ordenada y se insertan en la envoltura nuclear, donde forman complejos de poro nuclear con simetr\u00eda octogonal. Cada prote\u00edna est\u00e1 presente en copias de ocho o m\u00faltiplos de ocho, formando una estructura que contiene varios cientos de prote\u00ednas y es 30 veces el tama\u00f1o de un ribosoma, la f\u00e1brica de prote\u00ednas celular. \u201cPero c\u00f3mo las nucleoporinas encuentran su camino hacia la membrana nuclear y si los poros existentes sirven como plantillas hab\u00eda sido desconocido\u201d, dice D'Angelo.<\/p>\n<p>Para estudiar este proceso, los investigadores de Salk crearon un sistema sin c\u00e9lulas basado en \u00f3vulos de rana (ovocitos) que fue capaz de recapitular la inserci\u00f3n del complejo del poro nuclear en la membrana nuclear. Utilizando herramientas avanzadas de imagen en tiempo real, los cient\u00edficos observaron c\u00f3mo se formaba una membrana nuclear, con poros y todo, en menos de una hora. <\/p>\n<p>\u201cPudimos visualizar complejos individuales del poro nuclear\u201d, dice el estudiante de posgrado y coautor principal Daniel Anderson. \u201cEsto nos permiti\u00f3 no solo observar c\u00f3mo se formaban los poros individuales, sino tambi\u00e9n demostrar que se formaban desde cero sin la ayuda de poros ya existentes\u201d.\u201d <\/p>\n<p>En otro experimento, el grupo utiliz\u00f3 microscop\u00eda confocal de cuatro dimensiones para seguir la formaci\u00f3n en c\u00e9lulas humanas cultivadas de un solo poro que hab\u00eda sido marcado con una etiqueta fluorescente. Si el poro nuclear se hubiera dividido para dar lugar a dos poros hijos, habr\u00edan surgido dos puntos brillantes de uno; sin embargo, los investigadores rastrearon el movimiento de un solo punto, confirmando su hallazgo anterior de que los poros se formaron desde cero.<\/p>\n<p>Investigaciones adicionales demostraron que los ensamblajes del poro nuclear se a\u00f1aden en un proceso coordinado y por etapas que requiere componentes en ambos lados de la membrana nuclear. \u201cEsto tiene importantes consecuencias para el pr\u00f3ximo gran tema: la cuesti\u00f3n de c\u00f3mo todas estas estructuras se fusionan\u201d, dice Hetzer.<\/p>\n<p>El Instituto Salk de Estudios Biol\u00f3gicos en La Jolla, California, es una organizaci\u00f3n independiente sin fines de lucro dedicada a descubrimientos fundamentales en las ciencias de la vida, la mejora de la salud humana y la formaci\u00f3n de futuras generaciones de investigadores. Jonas Salk, M.D., cuya vacuna contra la polio pr\u00e1cticamente erradic\u00f3 la debilitante enfermedad de la poliomielitis en 1955, inaugur\u00f3 el Instituto en 1965 con un donativo de tierras de la Ciudad de San Diego y el apoyo financiero de la March of Dimes.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[86],"disease-research":[],"class_list":["post-1863","disclosure","type-disclosure","status-publish","hentry","faculty-martin-hetzer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Researchers solve mystery of how nuclear pores duplicate before cell division - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers solve mystery of how nuclear pores duplicate before cell division - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"La Jolla,  CA \u2013 Researchers have long wondered how nuclear pores  \u2013 the all-important channels that control the flow of information in and out of a cell&#8217;s nucleus \u2013 double in number to prepare for the split to come when a cell divides. Now, for the first time, scientists at the Salk Institute for Biological Studies watched as new funnel-like pore structures formed from scratch, and inserted themselves into the nuclear membrane.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\\\/\",\"name\":\"Researchers solve mystery of how nuclear pores duplicate before cell division - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"datePublished\":\"2006-04-20T07:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\\\/#breadcrumb\"},\"inLanguage\":\"es-MX\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Researchers solve mystery of how nuclear pores duplicate before cell division\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es-MX\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es-MX\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Researchers solve mystery of how nuclear pores duplicate before cell division - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/es\/news-release\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\/","og_locale":"es_MX","og_type":"article","og_title":"Researchers solve mystery of how nuclear pores duplicate before cell division - Salk Institute for Biological Studies","og_description":"La Jolla,  CA \u2013 Researchers have long wondered how nuclear pores  \u2013 the all-important channels that control the flow of information in and out of a cell&#8217;s nucleus \u2013 double in number to prepare for the split to come when a cell divides. Now, for the first time, scientists at the Salk Institute for Biological Studies watched as new funnel-like pore structures formed from scratch, and inserted themselves into the nuclear membrane.","og_url":"https:\/\/www.salk.edu\/es\/news-release\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\/","og_site_name":"Salk Institute for Biological Studies","og_image":[{"width":628,"height":329,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\/","url":"https:\/\/www.salk.edu\/news-release\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\/","name":"Researchers solve mystery of how nuclear pores duplicate before cell division - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"datePublished":"2006-04-20T07:00:00+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\/#breadcrumb"},"inLanguage":"es-MX","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/researchers-solve-mystery-of-how-nuclear-pores-duplicate-before-cell-division\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Researchers solve mystery of how nuclear pores duplicate before cell division"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Instituto Salk de Estudios Biol\u00f3gicos","description":"El Poder de la Ciencia","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es-MX"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Instituto Salk de Estudios Biol\u00f3gicos","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"es-MX","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"paper_url":"","journal_title":"","paper_author_list":"","paper_title":"","subhead":"","home_photo":"","listing_photo":"","line_2":"","line_1":"Researchers solve  mystery of how nuclear pores duplicate before cell division"},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/1863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":0,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/1863\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media?parent=1863"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/faculty?post=1863"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disease-research?post=1863"}],"curies":[{"name":"la hora de","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}