{"id":17373,"date":"2018-04-16T00:00:23","date_gmt":"2018-04-16T07:00:23","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=17373"},"modified":"2024-01-30T15:16:30","modified_gmt":"2024-01-30T23:16:30","slug":"grafted-brain-organoids-provide-insight-into-neurological-disorders","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/grafted-brain-organoids-provide-insight-into-neurological-disorders\/","title":{"rendered":"Grafted brain organoids provide insight into neurological disorders"},"content":{"rendered":"<p>LA JOLLA\u2014Many neurological disorders\u2014Alzheimer\u2019s, schizophrenia, autism, even depression\u2014have lagged behind in new therapies. Because the brain is so complex, it can be difficult to discover new drugs and even when a drug is promising in animal models, it often doesn\u2019t work for humans.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-GuhUb9-Syzo\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/GuhUb9-Syzo?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>Scientists are aiming to change that with stem cell technology by taking skin cells from a patient and turning those cells into neurons. Researchers can then test new drugs and study the development of disease in these lab-grown neurons, and even test the potential to use these \u201cpersonalized neurons\u201d for tissue replacement via transplantation to cure a damaged part of the brain. However, while biologists have already had success in growing tiny, stem-cell-based brain-like &#8220;organoids&#8221; in dishes or test tubes for diagnostic and therapeutic purposes, these model systems are still a long way from representing the complexity of the brain.<\/p>\n<p>Scientists from the Salk Institute report a new approach that can develop more sophisticated organoid models by ensuring they receive sufficient oxygen and other nutrients via transplantation into rodents. The work, published in <a href=\"https:\/\/www.nature.com\/articles\/nbt.4127\" target=\"_blank\" rel=\"noopener\"><em>Nature Biotechnology<\/em><\/a> on April 16, 2018, could yield insights into the development of cures for brain disorders; speed up the testing of drugs; and even pave the way for someday transplanting healthy populations of human cells into people&#8217;s brains to replace damaged or dysfunctional tissue.<\/p>\n<figure id=\"attachment_17376\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"298\" class=\"img-responsive wp-image-17376 size-full\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Human-organoid-tissue-green-grafted-into-mouse-tissue.-Neurons-are-labeled-with-red-dye..jpg\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Human-organoid-tissue-green-grafted-into-mouse-tissue.-Neurons-are-labeled-with-red-dye..jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Human-organoid-tissue-green-grafted-into-mouse-tissue.-Neurons-are-labeled-with-red-dye.-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Human-organoid-tissue-green-grafted-into-mouse-tissue.-Neurons-are-labeled-with-red-dye.-147x146.jpg 147w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-caption-text\">Human organoid tissue (green) grafted into mouse tissue. Neurons are labeled with red. <\/p>\n<p> <a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Human-organoid-tissue-green-grafted-into-mouse-tissue.-Neurons-are-labeled-with-red-dye..jpg\">Haga clic aqu\u00ed<\/a> for a high-resolution image <\/p>\n<p> Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>&#8220;Brain organoids are powerful tools for investigating human brain development and disorders,&#8221; says senior author <a href=\"https:\/\/www.salk.edu\/es\/scientist\/rusty-gage\/\">Rusty Gage<\/a>, professor of Salk\u2019s Laboratory of Genetics. &#8220;But currently they do not fully represent native physiological environments. This work brings us one step closer to a more faithful, functional representation of the human brain and could help us design better therapies for neurological and psychiatric diseases.&#8221;<\/p>\n<p>Brain organoids grown in culture dishes or test tubes are structurally and functionally limited because, without a system of blood vessels, nutrients cannot reach the interior of their 3D structure. This reduces organoids&#8217; survival time and complexity, as cells cannot undergo as many divisions to increase their number or to diversify cell type. Although some researchers have attempted to address these limitations by simultaneously grafting vascular tissue onto organoids, this approach still does not fully mimic the cellular microenvironment of an actual brain.<\/p>\n<p>The Gage lab sought to replicate a more supportive physiological environment by grafting human stem-cell-based organoids into a blood-vessel-rich area of the mouse brain. The grafted human organoids integrated into the host environment, formed both neurons and neuronal support cells called astrocytes, and were surveyed by immune cells. Significantly, the team saw not only native blood vessels, but vessels with blood flowing through them\u2014a first for organoids.<\/p>\n<p>&#8220;That was a big accomplishment,&#8221; says Abed AlFattah Mansour, a Salk research associate and the paper&#8217;s first author. &#8220;We saw infiltration of blood vessels into the organoid and supplying it with blood, which was exciting because it&#8217;s perhaps the ticket for organoids&#8217; long-term survival.&#8221;<\/p>\n<p>As part of the study, the Salk team divided each organoid in half before transplantation, and maintained one of the halves in culture so they could directly compare the benefit of both environments. They found that the cultured halves were filled with dying cells after a few months, while the age-matched organoids in the rodents were healthy.<\/p>\n<figure id=\"attachment_17375\"  class=\"wp-caption alignleft\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"305\" class=\"img-responsive wp-image-17375 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release-458x305.jpg\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release-458x305.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release-300x200.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release-768x512.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release-1024x683.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release-147x98.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release-585x390.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release-553x369.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release-750x500.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release-767x511.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release-945x630.jpg 945w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">From left: Sarah Fernandes, Daphne Quang, Stephen Johnston, Sarah Parylak, Rusty Gage, Abed AlFattah Mansour, Hao Li. <\/p>\n<p> <a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/04\/Gage-Natbiotech-press-release.jpg\">Haga clic aqu\u00ed<\/a> for a high-resolution image<\/p>\n<p> Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>To find out if the transplanted organoids were functional as well as healthy, the team conducted calcium imaging tests, in which neurons produce a dye when they fire. And, indeed, the neurons within the organoids were firing in a synchronized way. Additionally, the team used a technique called optogenetics (where cells are made responsive to light) to confirm that the grafted neurons were forming connections with each other and with the host organism, which is also a first.<\/p>\n<p>\u201cThis indicates that the increased blood supply not only helped the organoid to stay healthy longer, but also enabled it to achieve a level of neurological complexity that will help us better understand brain disease,\u201d says Mansour.<\/p>\n<p>Human transplantation in animals has been used for decades in brain and other tissues to enhance survival and test for mature function.<\/p>\n<p>&#8220;This work builds on a grafting technique I helped develop in 1984,&#8221; adds Gage, who holds the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases. &#8220;It is gratifying to see that it works so well with brain organoids, which have immense potential to elucidate brain function in neuropsychiatric disease.&#8221;<\/p>\n<p>Other authors included: J. Tiago Gon\u00e7alves, formerly of Salk and now at Albert Einstein College of Medicine; and Cooper W. Bloyd, Hao Li, Sarah Fernandes, Daphne Quang, Stephen Johnston, Sarah L. Parylak and Xin Jin of Salk.<\/p>\n<p>The work was funded by the National Institutes of Health (U19 MH106434, U01 MH106882), The Paul G. Allen Family Foundation, Bob and Mary Jane Engman, The Leona M. and Harry B. Helmsley Charitable Trust Grant (2012-PG-MED), Annette C. Merle-Smith, The G. Harold and Leila Y. Mathers Foundation, JPB Foundation, Dolby Family Ventures and NIH grants (R01NS083815, R01AG047669), the CIRM Bridges to Stem Cell Research Internship Program, an EMBO Postdoctoral Long-term Fellowship (ALTF 1214-2014\/European Commission FP7-Marie Curie Actions, LTFCOFUND2013 and GA-2013-609409) and the Human Frontiers Science Program (HFSP Long-Term Fellowship\u2014LT001074\/2015).<\/p>","protected":false},"featured_media":17380,"template":"","faculty":[76],"disease-research":[127,169,124,167],"class_list":["post-17373","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-rusty-gage","disease-research-alzheimers-disease","disease-research-autism","disease-research-neuroscience-and-neurological-disorders","disease-research-schizophrenia"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Grafted brain organoids provide insight into neurological disorders - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/grafted-brain-organoids-provide-insight-into-neurological-disorders\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Grafted brain organoids provide insight into neurological disorders - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Many neurological disorders\u2014Alzheimer\u2019s, schizophrenia, autism, even depression\u2014have lagged behind in new therapies. 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