{"id":11516,"date":"2016-11-10T15:56:35","date_gmt":"2016-11-10T23:56:35","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=11516"},"modified":"2016-11-10T15:54:26","modified_gmt":"2016-11-10T23:54:26","slug":"new-technique-increase-success-infertility-treatment","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/new-technique-increase-success-infertility-treatment\/","title":{"rendered":"New technique could increase success of infertility treatment"},"content":{"rendered":"

PORTLAND, Ore, and LA JOLLA, Calif.\u2014Families struggling with infertility or a genetic predisposition for debilitating mitochondrial diseases may someday benefit from a new breakthrough led by scientists at OHSU and the Salk Institute for Biological Studies.<\/p>\n

In a study published today in the journal Cell Stem Cell<\/a><\/em>, researchers discovered it\u2019s possible to regenerate human eggs or oocytes\u2014the cellular beginning of an embryo\u2014by making use of genetic material that normally goes to waste. <\/p>\n

This DNA comes from small cells called polar bodies that form off of eggs and contain the same genetic material as in a woman\u2019s egg nucleus. Until now, polar bodies had never been shown to be potentially useful for generating functional human eggs for fertility treatments. In the study, scientists successfully transplanted a polar body from a woman\u2019s developing oocyte into the cytoplasm of a donor oocyte stripped of its nucleus.<\/p>\n

Though the technique could be years away from progressing to clinical trials, the advancement eventually could be significant for women of advanced maternal age. One recent survey showed that the average age of first-time mothers increased in the United States from 21.4 years in 1970 to 25.0 years in 2006.<\/p>\n

\u201cWe know that fertility declines as women get older,\u201d said Shoukhrat Mitalipov, PhD, co-senior author and director of the OHSU Center for Embryonic Cell and Gene Therapy. \u201cThis is potentially a way to double the number of eggs we\u2019re able to get from one session of in vitro fertilization.\u201d <\/p>\n

\u201cAlthough it was only possible to examine a limited number of lines, from the point of view of epigenomic profiles, the quality of polar body-derived embryonic cells looks quite promising,\u201d says co-senior author Joseph Ecker<\/a>, PhD, Salk professor and director of the Genomic Analysis Laboratory. <\/p>\n

By rescuing polar bodies that would otherwise simply bud off the developing oocyte, researchers were able to form additional oocytes genetically related to the mother through nuclear transfer. When fertilized with sperm, the new oocytes developed into viable embryos. None of the embryos were implanted to carry out an actual pregnancy.<\/p>\n

\u201cNormally, polar bodies disintegrate and disappear during egg development,\u201d said co-first author Hong Ma, MD, PhD, with OHSU\u2019s Center for Embryonic Cell and Gene Therapy. \u201cWe were able to recycle them. We hope that by doing this, we can double the number of patient eggs available for in vitro fertilization.\u201d<\/p>\n

\u201cThis is the first investigation into the surprising viability of human polar bodies and it reveals a new source of previously discarded genetic material to study,\u201d says Ryan O\u2019Neil, co-first author and Salk researcher.<\/p>\n

In addition to potentially benefitting women of advanced maternal age, the technique may present another opportunity to help women known to have mutations in their mitochondria, the tiny powerhouses inside nearly every cell of the body. Mutations in mitochondria can result in debilitating forms of disease in children. <\/p>\n

\u201cThis new technique maximizes the chances of families having a child through in vitro fertilization free of genetic mutations,\u201d Mitalipov said.<\/p>\n

Mitalipov previously developed a mitochondrial replacement therapy involving the implantation of patient\u2019s egg nucleus\u2014or spindle\u2014into a healthy donated egg stripped of its original nucleus. Mitalipov also has successfully demonstrated the spindle-transfer technique in the healthy offspring of rhesus macaque monkeys. <\/p>\n

In addition to Mitalipov, Ecker, Ma and O\u2019Neil, authors of the study include Ryan C. O\u2019Neil and Yupeng He, of the Genomic Analysis Laboratory at the Salk Institute and the Bioinformatics Program at the University of California and San Diego; Joseph R. Ecker, Ph.D., of the Salk Institute and Howard Hughes Medical Institute; Nuria Marti Gutierrez, Eunju Kang, Yeonmi Lee, Tomonari Hayama, M.D., Ph.D., Amy Koski, Rebecca Tippner-Hedges, Riffat Ahmed, Crystal Van Dyken, Ying Li, and Don P. Wolf, Ph.D., of the OHSU Center for Embryonic Cell and Gene Therapy; Manoj Hariharan, Ph.D., Zhuzhu Z. Zhang, Ph.D., Joseph Nery and Rosa Castanon, of the Salk Institute; Susan Olson, Ph.D., of the OHSU Department of Molecular and Medical Genetics; David Battaglia, Ph.D., H.C.L.D., David M. Lee, M.D., Diana H. Wu, M.D., and Paula Amato, M.D., of the OHSU Department of Obstetrics and Gynecology; and Cengiz Cinnioglu, Ph.D., and Refik Kayali, Ph.D., of IviGen Los Angeles.<\/p>\n

Content provided by OHSU [LINK]<\/a><\/p>\n

About OHSU<\/strong><\/p>\n

Oregon Health & Science University<\/a> is a nationally prominent research university and Oregon\u2019s only public academic health center. It serves patients throughout the region with a Level 1 trauma center and nationally recognized Doernbecher Children\u2019s Hospital. OHSU operates dental, medical, nursing and pharmacy schools that rank high both in research funding and in meeting the university\u2019s social mission. OHSU\u2019s Knight Cancer Institute helped pioneer personalized medicine through a discovery that identified how to shut down cells that enable cancer to grow without harming healthy ones. OHSU Brain Institute scientists are nationally recognized for discoveries that have led to a better understanding of Alzheimer\u2019s disease and new treatments for Parkinson\u2019s disease, multiple sclerosis and stroke. OHSU\u2019s Casey Eye Institute is a global leader in ophthalmic imaging, and in clinical trials related to eye disease.<\/p>\n

About the Salk Institute for Biological Studies<\/strong><\/p>\n

Every cure has a starting point. The Salk Institute embodies Jonas Salk\u2019s mission to dare to maek dreams into reality. Its internationally renowned and award-winning scientists explore the very foundations of life, seeking new understandings in neuroscience, genetics, immunology and more. The institute is an independent nonprofit organization and architectural landmark: small by choice, intimate by nature and fearless in the face of any challenge. Be it cancer or Alzheimer\u2019s, aging or diabetes, Salk is where cures begin. Learn more at: salk.edu.<\/p>\n","protected":false},"featured_media":0,"template":"","faculty":[42],"disease-research":[],"class_list":["post-11516","disclosure","type-disclosure","status-publish","hentry","faculty-joseph-ecker"],"acf":[],"yoast_head":"\nNew technique could increase success of infertility treatment - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/new-technique-increase-success-infertility-treatment\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New technique could increase success of infertility treatment - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"PORTLAND, Ore, and LA JOLLA, Calif.\u2014Families struggling with infertility or a genetic predisposition for debilitating mitochondrial diseases may someday benefit from a new breakthrough led by scientists at OHSU and the Salk Institute for Biological Studies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/new-technique-increase-success-infertility-treatment\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/new-technique-increase-success-infertility-treatment\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/new-technique-increase-success-infertility-treatment\\\/\",\"name\":\"New technique could increase success of infertility treatment - 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