{"id":5351,"date":"2015-10-25T13:09:54","date_gmt":"2015-10-25T20:09:54","guid":{"rendered":"https:\/\/vermont.salk.edu\/?page_id=5351"},"modified":"2024-08-31T14:40:14","modified_gmt":"2024-08-31T21:40:14","slug":"faq","status":"publish","type":"page","link":"https:\/\/www.salk.edu\/de\/science\/research-centers\/waitt-advanced-biophotonics-center\/faq\/","title":{"rendered":"FAQ"},"content":{"rendered":"<strong>What is biophotonics?<\/strong>\r\n<a class=\"btn -toggle -readmore\" href=\"#\" data-reveal=\"self\" data-toggle=\"Answer\u00bb, Close\">Answer\u00bb<\/a>\r\n<div class=\"entries\" style=\"display: none;\">\r\n<div class=\"entry\">\r\n\r\nIn the most general terms biophotonics is the convergence of photonics and the life sciences.\r\n\r\nPhotonics - the science and technology of generation, manipulation and detection of light - uses photons, quantum-like particles of light, instead of electrons to transmit, process, and store information. The invention of lasers, a concentrated source of monochromatic and highly directional light, revolutionized photonics in the 1960s and brought us technological advancements such as bar code scanners, CD players, and, with fluorescence microscopes, the first taste of the power of biophotonics.\r\n\r\nToday, biophotonics is widely regarded as a key science upon which the next generation of biomedical research instrumentation and clinical tools will be based. Although nature has used the principle of biophotonics for millennia (e.g., to harness light for photosynthesis and to create vision), it wasn\u2019t until the recent past that a substantial transfer of photonics technologies to biological applications began to transform medical and life sciences.\r\n\r\nThanks to brighter light-emitting dyes, faster and more sensitive detectors, automation technology and computing capacity that can handle storing vast amounts of image data, it is now possible for scientists to probe the cellular and molecular mechanisms of life at unprecedented resolutions. The convergence of technological advances puts the formerly unthinkable within the grasp of scientific inquiry, offering unparalleled opportunities to understand the physiology of human disease and to find new ways to treat it.\r\n\r\nThe ability to probe and image (see) tissues is also leading to a wide range of novel diagnostic methods and therapeutic applications. Examples include coherence optical tomography (OCT), which has revolutionized the field of ophthalmology by allowing the early diagnosis of macular degeneration (MD) in the retina, and photodynamic therapy (PDT) approaches for treatment of cancers by retarding the growth of new blood vessels and vasculature.\r\n\r\n<\/div>\r\n<\/div>\r\n\r\n<hr \/>\r\n\r\n<strong>What is the goal of the biophotonics center? <\/strong>\r\n<a class=\"btn -toggle -readmore\" href=\"#\" data-reveal=\"self\" data-toggle=\"Answer\u00bb, Close\">Answer\u00bb<\/a>\r\n<div class=\"entries\" style=\"display: none;\">\r\n<div class=\"entry\">\r\n\r\nThe goal of the center is to develop, test and disseminate new technologies that enable groundbreaking biological discoveries. Removing long-standing technical barriers in a field is a prerequisite for transforming the study of biological systems which ultimately helps prevent, detect, diagnose, or treat human disease and disability.\r\n\r\n<\/div>\r\n<\/div>\r\n\r\n<hr \/>\r\n\r\n<strong>What is the distinction between the biophotonics center and the core?<\/strong>\r\n<a class=\"btn -toggle -readmore\" href=\"#\" data-reveal=\"self\" data-toggle=\"Answer\u00bb, Close\">Answer\u00bb<\/a>\r\n<div class=\"entries\" style=\"display: none;\">\r\n<div class=\"entry\">\r\n\r\nThe overarching center is made up of a) faculty labs and b) the core.\r\n\r\nThe faculty labs are engaged in both development and application of new imaging technologies to find solutions to fundamental problems in life sciences.\r\n\r\nThe core makes commercial technology available to researchers at Salk, collaborators of Salk, and other institutions in the area.\r\n\r\n<\/div>\r\n<\/div>\r\n\r\n<hr \/>\r\n\r\n<strong>What technologies are available at Salk in the biophotonics core?<\/strong>\r\n<a class=\"btn -toggle -readmore\" href=\"#\" data-reveal=\"self\" data-toggle=\"Answer\u00bb, Close\">Answer\u00bb<\/a>\r\n<div class=\"entries\" style=\"display: none;\">\r\n<div class=\"entry\">\r\n\r\nThe core is equipped with some of the latest cutting-edge commercial imaging and data analysis technologies, enabling its users the integration of imaging tools into their biological research programs.\r\n\r\n<strong>Equipment and services available in the core:<\/strong>\r\n\r\n<strong>Super-Resolution Microscopy<\/strong>\r\nZeiss Elyra PS.1 Super-Resolution Microscope\r\nZeiss LSM 880 Rear Port Laser Scanning Confocal and Airyscan FAST Microscope\r\nOxford Nanoimaging 3D STORM and TIRF system\r\n<strong>Confocal Microscopy<\/strong>\r\nZeiss LSM 710 Laser Scanning Confocal Microscope\r\nZeiss CSU Spinning Disk Confocal Microscope\r\nYokogawa Cell Voyager 1000 Spinning Disk Confocal Microscope\r\n<strong>Lightsheet Microscopy<\/strong>\r\nZeiss Lightsheet Z.1 Dual Illumination Microscope\r\n<strong>Two-photon Microscopy<\/strong>\r\nOlympus FV1000MPE Two-photon \/ CARS Microscope\r\n<strong>TIRF Microscopy<\/strong>\r\nNikon Ti:E PFS TIRF Microscope\r\n<strong>Slide Scanning Microscopy<\/strong>\r\nOlympus VS-120 Virtual Slde Scanning Microscope\r\n<strong>Laser Capture Microdissection<\/strong>\r\nZeiss PALM Microbeam V4 Capture Microdissection System\r\n<strong>Basic Wide-field\/Epi-fluorescence Microscopy<\/strong>\r\nZeiss Vivatome Optical Sectioning System\r\nZeiss StereoLumar V12. Fluorescence Stereoscope\r\nIncucyte ZOOM\r\n<strong>Transmission Electron Microscope<\/strong>\r\nCarl Zeiss Libra 120kV PLUS Energy Filtered Transmission Electron Microscope (TEM)\r\n<strong>Scanning Electron Microscope<\/strong>\r\nCarl Zeiss SIGMA Variable Pressure Field Emission Gun Scanning Electron Microscope (SEM)\r\n<strong>Serial Block Face Scanning Electron Microscope System<\/strong>\r\nThe Gatan 3View Fully Automated Serial Block Face Scanning Electron Microscope (SBFSEM) system.\r\n<strong>Sample preparation instrumentation and services<\/strong>\r\nThe sample preparation instrumentation includes:\r\nPelco BioWave Pro Microwave\r\nLeica UC7\/FC7 ultramicrotome\r\nLeica EM PACT High-Pressure Freezer\r\nLeica AFS Automatic Freeze Substitution\r\nLeica EM GP Automatic Plunge Freezing\r\nLeica EM CPD300 Automated Critical Point Dryer\r\nLeica EM SCD500 Sputter Coater\/Evaporator\r\n\r\n<\/div>\r\n<\/div>\r\n\r\n<hr \/>\r\n\r\n<strong>How can a researcher gain access to this technology?<\/strong>\r\n<a class=\"btn -toggle -readmore\" href=\"#\" data-reveal=\"self\" data-toggle=\"Answer\u00bb, Close\">Answer\u00bb<\/a>\r\n<div class=\"entries\" style=\"display: none;\">\r\n<div class=\"entry\">\r\n\r\nPlease contact Faye <a href=\"mailto:fmcdonald@salk.edu\">fmcdonald@salk.edu<\/a> or Uri Manor <a href=\"mailto:umanor@salk.edu\">umanor@salk.edu<\/a>.\r\n\r\n<\/div>\r\n<\/div>\r\n\r\n<hr \/>\r\n\r\n<strong>How can I support the biophotonics center and its mission?<\/strong>\r\n<a class=\"btn -toggle -readmore\" href=\"#\" data-reveal=\"self\" data-toggle=\"Answer\u00bb, Close\">Answer\u00bb<\/a>\r\n<div class=\"entries\" style=\"display: none;\">\r\n<div class=\"entry\">\r\n\r\nIf you would like to make a tax-deductible donation to support training of the next generation of cross-disciplinary scientists, or the development of new imaging technologies to advance our understanding of biological processes in health and disease, including viral infection, aging, stroke and cancer, please click on the link below. Under the Donate Now tab in the Special Instructions field please indicate Salk Biophotonics Center and optionally Trainee Fellowships or Technology Innovation Funds.\r\n\r\n<a href=\"https:\/\/www.salk.edu\/de\/donate\/donation-options\/\">DONATE TO SALK BIOPHOTONICS CENTER<\/a>\r\n\r\n<\/div>\r\n<\/div>\r\n\r\n<hr \/>","protected":false},"excerpt":{"rendered":"<str","protected":false},"author":3,"featured_media":0,"parent":5348,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-sidebar-right.php","meta":{"_acf_changed":false,"footnotes":""},"folder":[526],"class_list":["post-5351","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>FAQ - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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href=\"https:\/\/www.salk.edu\/de\/science\/research-centers\/waitt-advanced-biophotonics-center\/\">Overview<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5355\"><a href=\"https:\/\/www.salk.edu\/de\/science\/research-centers\/waitt-advanced-biophotonics-center\/research\/\">Research<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-25897\"><a href=\"https:\/\/www.salk.edu\/de\/science\/research-centers\/waitt-advanced-biophotonics-center\/meet-the-scientists\/\">Meet the Scientists<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-54001\"><a href=\"https:\/\/www.salk.edu\/de\/science\/research-centers\/waitt-advanced-biophotonics-center\/fellows\/\">Fellows<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5353\"><a href=\"https:\/\/www.salk.edu\/de\/science\/research-centers\/waitt-advanced-biophotonics-center\/news-events\/\">News &#038; Events<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-25869\"><a target=\"_blank\" href=\"https:\/\/www.salk.edu\/science\/core-facilities\/advanced-biophotonics\/\">Shared Resources<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5354\"><a href=\"https:\/\/www.salk.edu\/de\/science\/research-centers\/waitt-advanced-biophotonics-center\/faq\/\">FAQ<\/a><\/li>\n<\/ul><\/div>","poster_quote":"","salk_custom_body_class":"","salk_sidebar":"<h5>Contact<\/h5>\n<p><strong>Salk Institute for Biological Studies\u2028<\/strong><br \/>\nWaitt Advanced Biophotonics Center<br \/>\n10010 N Torrey Pines Rd<br \/>\nLa Jolla, CA 92037<br \/>\nTelephone: (858) 453-4100 x1951<\/p>\n"},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/pages\/5351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/comments?post=5351"}],"version-history":[{"count":11,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/pages\/5351\/revisions"}],"predecessor-version":[{"id":50734,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/pages\/5351\/revisions\/50734"}],"up":[{"embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/pages\/5348"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/media?parent=5351"}],"wp:term":[{"taxonomy":"folder","embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/folder?post=5351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}