{"id":56432,"date":"2026-04-07T09:00:14","date_gmt":"2026-04-07T16:00:14","guid":{"rendered":"https:\/\/www.salk.edu\/?post_type=disclosure&p=56432"},"modified":"2026-04-07T09:45:11","modified_gmt":"2026-04-07T16:45:11","slug":"salk-institute-to-lead-arpa-h-project-with-up-to-41-3m-to-advance-sonogenetics-as-a-noninvasive-therapeutic","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/salk-institute-to-lead-arpa-h-project-with-up-to-41-3m-to-advance-sonogenetics-as-a-noninvasive-therapeutic\/","title":{"rendered":"Salk Institute leitet ARPA-H-Projekt mit bis zu $41,3 Mio. zur F\u00f6rderung der Sonogenetik als nichtinvasive Therapie"},"content":{"rendered":"

LA JOLLA \u2013 Wissenschaftler des Salk Institute Sreekanth Chalasani, PhD<\/a>, eine Auszeichnung von bis zu $41,3 Millionen Dollar von der Advanced Research Projects Agency for Health (ARPA-H), einer Beh\u00f6rde im Rahmen des US-Gesundheitsministeriums, erhalten. Die Finanzierung wird es Chalasani und seinem Team erm\u00f6glichen, die Erkenntnisse seines Labors im Bereich der Sonogenetik \u2013 die Verwendung von Ultraschall zur pr\u00e4zisen Steuerung von S\u00e4ugetierzellen \u2013 in eine potenzielle neue Therapie f\u00fcr eine Reihe von menschlichen Erkrankungen, wie beispielsweise periphere Neuropathien, umzuwandeln.<\/p>\n

\"Sreekanth<\/a>
Sreekanth Chalasani, PhD
Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.
Kredit: Salk Institut<\/figcaption><\/figure>\n

Sonogenetik<\/a> ist ein aufkommender Ansatz, der durch die Ausstattung spezifischer Zelltypen mit Ultraschall-responsiven Proteinen f\u00fcr Ultraschall sensibilisiert, was eine pr\u00e4zise, nicht-invasive Steuerung erm\u00f6glicht. \u00dcber einen Zeitraum von bis zu 5,5 Jahren wird die ARPA-H-F\u00f6rderung eine Zusammenarbeit mehrerer Institutionen unterst\u00fctzen, die sich auf die Entwicklung von Kern-Biologietools, Ultraschall-Verabreichungssystemen der n\u00e4chsten Generation und die pr\u00e4klinischen Beweise konzentriert, die erforderlich sind, um die Sonogenetik in klinische Studien f\u00fcr Patienten zu \u00fcberf\u00fchren.<\/p>\n

\u201cDiese Auszeichnung ist ein wichtiger Schritt hin zu einem lang gehegten Ziel \u2013 einer medikamentenfreien Methode, um Therapien genau dort anzuwenden, wo sie ben\u00f6tigt werden, und nur dann, wenn sie ben\u00f6tigt werden\u201d, sagt Chalasani, Salk-Professor, Entwickler der Sonogenetik und leitender Hauptforscher f\u00fcr die ARPA-H-Auszeichnung. \u201cWir bauen eine Plattform, die gentechnisch ver\u00e4nderte Ultraschall-sensitive Proteine mit tragbarer Ultraschalltechnologie kombiniert, die uns im Gegensatz zu herk\u00f6mmlichen pharmazeutischen Behandlungen erm\u00f6glichen k\u00f6nnte, Erkrankungen mit zellul\u00e4rer und zeitlicher Steuerung zu behandeln.\u201c.<\/p>\n

Was ist Sonogenetik?<\/strong><\/h2>\n

Sonogenetik ist die Anwendung von niederfrequentem Ultraschall zur pr\u00e4zisen, nicht-invasiven Steuerung zellul\u00e4rer Aktivit\u00e4t. Chalasani leistete Pionierarbeit in diesem Konzept und pr\u00e4gte den Begriff \u201cSonogenetik\u201d. Im Jahr 2015 identifizierte seine Gruppe erstmals ein Protein im Rundwurm Caenorhabditis elegans<\/em> macht die Zellen empfindlich f\u00fcr niederfrequenten Ultraschall. Als die Forscher dieses Protein hinzuf\u00fcgten C. elegans<\/em> Neuronen, die dies normalerweise nicht hatten, konnten sie mit einem Ultraschallsto\u00df aktivieren \u2013 den gleichen Schallwellen, die bei medizinischen Sonogrammen verwendet werden. Das Team sowie mehrere andere weltweit hat seitdem auch die F\u00e4higkeit der Sonogenetik zur Manipulation von S\u00e4ugetierzellen gezeigt.<\/p>\n

Die ARPA-H-F\u00f6rderung wird es Chalasani und seinen Mitarbeitern erm\u00f6glichen, die Sonogenetik aus dem Labor in die Klinik zu bringen, indem der Ansatz als Therapie f\u00fcr medizinische Zust\u00e4nde wie periphere Neuropathie getestet wird.<\/p>\n

Was wird das von ARPA-H finanzierte Team f\u00fcr Sonja\u00adtik bauen? <\/strong><\/h2>\n

Das Projekt wird mehrere technische Bereiche integrieren, um eine End-to-End-Therapiestrategie zu entwickeln: ein Toolkit aus Ultraschall-sensitiven Proteinen, ein nicht-invasives Ultraschallabgabesystem, das f\u00fcr den Langzeitgebrauch geeignet ist, und die translationalen Beweise, die zur Unterst\u00fctzung der regulatorischen Weiterentwicklung erforderlich sind.<\/p>\n

Zusammenarbeitende Teams, aufgef\u00fchrt in der Reihenfolge des Arbeitsablaufs vom Entdecken bis zur \u00dcbersetzung, umfassen:<\/p>\n

    \n
  • Scripps Research<\/strong>\u2014Ein Team unter der Leitung des Nobelpreistr\u00e4gers Ardem Patapoutian, PhD, wird die Entdeckung und das Engineering von Ultraschall-sensitiven Proteinen unterst\u00fctzen und dabei auf tiefgreifende Expertise in mechanosensitiven Kan\u00e4len zur\u00fcckgreifen.<\/li>\n
  • Boniface Hospital Forschung\/Universit\u00e4t Manitoba<\/strong>\u2014Ein Team unter der Leitung von Paul Fernyhough, PhD, wird dabei helfen zu definieren, wie Ultraschall-ausgel\u00f6ste Signale durch zellul\u00e4re Maschinen propagieren und Signalwege zur Nervenreparatur steuern.<\/li>\n
  • Duke University<\/strong>\u2014Ein Team unter der Leitung von Aravind Asokan, PhD, wird ultraschall-sensitive Proteine, die gezielt zu spezifischen Zelltypen im K\u00f6rper transportiert werden, entwickeln, um die Translation der fokussierten Ultraschall-Kontrollplattform zu erm\u00f6glichen.<\/li>\n<\/ul>\n
      \n
    • Massachusetts Institute of Technology Abteilung f\u00fcr Maschinenbau (MIT MechE)<\/strong>\u2014Ein von Xuanhe Zhao, PhD, geleitetes Team wird Ultraschall-Verabreichungssysteme f\u00fcr relevante Ziele bei Tieren und Menschen entwickeln.<\/li>\n<\/ul>\n
        \n
      • Universit\u00e4t von Kalifornien, San Diego<\/strong>\u2014Ein von Nigel Calcutt, PhD, geleitetes Team wird die Wirksamkeit des sonogenetischen Ansatzes anhand etablierter Paradigmen und klinisch relevanter funktioneller Messungen in S\u00e4ugetiersystemen validieren.<\/li>\n
      • California Medical Innovations Institute (Calmi2)<\/strong>Ein Team unter der Leitung von Ghassan Kassab, PhD, wird fortschrittliche translationale Validierung und klinisch relevante Bewertungen in pr\u00e4klinischen Systemen unterst\u00fctzen.<\/li>\n
      • Neu<\/strong>\u2014Ein strategisches Startup, mitbegr\u00fcndet von General Inception, wird die Forschungsaktivit\u00e4ten \u00fcber alle Standorte hinweg vereinen und das Programm auf einem klaren regulatorischen Weg in Richtung FDA-Bewertung und Kommerzialisierung vorantreiben.<\/li>\n<\/ul>\n

        Von der grundlegenden Entdeckung zu einem translationalen Programm<\/strong><\/h2>\n

        Chalasani's wegweisende Arbeit zur Sonogenetik begann mit Experimenten an W\u00fcrmern, unterst\u00fctzt durch Anschubfinanzierung im Jahr 2011 aus dem Salk Innovation and Collaboration Grants Program, erm\u00f6glicht durch die Philanthropen Joan und Irwin Jacobs, Mitbegr\u00fcnder von Qualcomm und ehemaliger Vorsitzender des Salk Board of Trustees. Diese Fr\u00fchphasenunterst\u00fctzung half, eine k\u00fchne, unerprobte und schwer zu finanzierende Idee durch traditionelle Mechanismen auf den Weg zu bringen \u2013 ein Ansatz, den Salk im Rahmen seines Engagements f\u00fcr Grundlagenforschung, die zuk\u00fcnftige Therapien und Innovationen erm\u00f6glicht, f\u00f6rdern will. Die neue Auszeichnung durch ARPA-H wird die Sonogenetik nun zu einem klinischen Nachweis der Machbarkeit in der Peripherie vorantreiben.<\/p>\n

        Danksagung der Finanzierung und Haftungsausschluss<\/strong><\/h2>\n

        Dieses Projekt wird von der Advanced Research Projects Agency for Health (ARPA-H) unter der F\u00f6rdernummer D26AC50003-00 finanziert. Der Inhalt liegt in der alleinigen Verantwortung der Autoren und spiegelt nicht notwendigerweise die offiziellen Ansichten der Advanced Research Projects Agency for Health wider.<\/p>","protected":false},"featured_media":56436,"template":"","faculty":[77],"disease-research":[124],"class_list":["post-56432","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-sreekanth-chalasani","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nSalk Institute to lead ARPA-H project with up to $41.3M to advance sonogenetics as a noninvasive therapeutic - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/salk-institute-to-lead-arpa-h-project-with-up-to-41-3m-to-advance-sonogenetics-as-a-noninvasive-therapeutic\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk Institute to lead ARPA-H project with up to $41.3M to advance sonogenetics as a noninvasive therapeutic - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Salk Institute scientist Sreekanth Chalasani, PhD, has received an award of up to $41.3 million from the Advanced Research Projects Agency for Health (ARPA-H), an agency within the United States Department of Health and Human Services. 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