{"id":49703,"date":"2024-06-05T09:18:18","date_gmt":"2024-06-05T16:18:18","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=49703"},"modified":"2024-06-05T10:14:47","modified_gmt":"2024-06-05T17:14:47","slug":"cooperative-proteins-help-the-immune-system-identify-and-attack-invaders","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/cooperative-proteins-help-the-immune-system-identify-and-attack-invaders\/","title":{"rendered":"Kooperative Proteine helfen dem Immunsystem, Eindringlinge zu erkennen und zu bek\u00e4mpfen"},"content":{"rendered":"

LA JOLLA\u2014Bacteria, parasites, viruses\u2014the immune system tackles them all. At the front line of the human immune response are cells called macrophages, which are responsible for correctly identifying intruders and then directing how the entire immune system responds. Researchers at the Salk Institute have now discovered a molecular mechanism that helps macrophages mount a coordinated response tailored to a specific immune challenge. \r\n<\/p>

\r\nActivating macrophages requires the work of three versions of a protein complex called SWI\/SNF: cBAF, ncBAF, and PBAF. Scientists already knew these variants had slightly different structures, but the new findings reveal that these differences have real functional consequences. Salk researchers discovered that each variant plays a distinct role in initiating macrophages\u2019 responses to intruders and, consequently, how the immune system regulates inflammation.\r\n<\/p>

\"From<\/a>
From left: Diana Hargreaves and Jingwen Liao.

Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.
Kredit: Salk Institut<\/figcaption><\/figure>

\r\nBy delineating these SWI\/SNF variants, the team has revealed new immune system mechanisms that could be targeted with therapeutics to regulate inflammation associated with conditions like sepsis, cytokine storm, COVID-19, and many more. \r\n<\/p>

\r\nThe findings were published in Immunity<\/a><\/em> on June 5, 2024.\r\n<\/p>

\r\n\u201cMacrophages are our first line of defense and the recruiters for adaptive immune cells, so understanding how they work is key to understanding our immune response,\u201d says Diana Hargreaves<\/a>, senior author and associate professor at Salk. \u201cIf we can figure out how macrophages tailor their responses to a given immune signal, we\u2019ll have a better idea of how we can therapeutically target them to create desirable immune system behaviors.\u201d\r\n<\/p>

\r\nMacrophages are the first to sense an intruder in the body, so it is their responsibility to accurately identify the intruder and instruct the rest of the immune system\u2019s response. To ensure that the correct response is mounted, macrophages require very specific internal signaling.\r\n<\/p>

\r\nEach macrophage contains a set of identity-forming instructions encoded in strands of DNA, which are wrapped around protein complexes called histones and then wound into a 3D structure called chromatin. Changes to histones and chromatin impact the identity of a cell, since their modifications can expose or conceal stretches of DNA responsible for the cell\u2019s behavior. \r\n<\/p>\r\n

\"Three<\/a>
Three SWI\/SNF protein complex variants, cBAF, ncBAF, and PBAF, gather around a campfire roasting marshmallows, with sashes symbolizing their different but cooperative identities. Together, they coordinate macrophage activity and control inflammation, represented by the fire.

Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.
Kredit: Salk Institut<\/figcaption><\/figure>

\r\nThe SWI\/SNF protein complex was already known to carry out such changes, but it was unclear whether each of the three variants did so in a unique way or led to distinct macrophage behavior. To learn more about the SWI\/SNF variants, the researchers observed how macrophages in mice responded to bacterial infection and paid close attention to differences among cBAF, ncBAF, and PBAF activity.\r\n<\/p>

\r\n\"We found the SWI\/SNF variants each serve a unique, important purpose in reorganizing chromatin across the genome and enabling macrophage inflammatory responses,\u201d says first author Jingwen Liao, a graduate student in Hargreaves\u2019 lab. \u201cThis is a major leap in our understanding of how immune systems respond with such a high level of specificity.\u201d\r\n<\/p>

\r\nWhen confronted with a bacterial threat, each of the three SWI\/SNF variants regulated distinct portions of the macrophages\u2019 DNA, producing distinct cellular responses. cBAF remodeled chromatin to promote inflammation, while ncBAF modified histones to stimulate an antiviral response. PBAF also modified histones, but the result of those modifications was less clear than cBAF or ncBAF.\r\n<\/p>

\r\nThe three acted distinctly and cooperatively to coordinate a complicated immune response that calls on the rest of the immune system to effectively and efficiently rid the body of threats.\r\n<\/p>

\r\n\u201cChronic inflammation is a major cause of mortality across many diseases,\u201d says Hargreaves. \u201cWhen patients succumb to COVID, for example, that\u2019s often a product of inflammation. This makes our findings really exciting, because we\u2019ve found a new way to potentially toggle the immune system\u2019s inflammatory pathways to improve outcomes in patients with chronic inflammation.\u201d\r\n<\/p>

\r\nThe team will continue to study the effects of histone modification by PBAF in follow-up research. Given that cBAF and ncBAF inhibitors are already in clinical trials for cancer treatment, Hargreaves is optimistic about translating their findings into future drugs for chronic inflammation.\r\n<\/p>

\r\nOther authors include Josephine Ho and Mannix Burns at Salk, as well as Emily Dykhuizen at Purdue University.\r\n<\/p>

\r\nThe work was supported by the National Institutes of Health (NCI CCSG: P30 014195, AI151123, GM128943, R21 MH128678-01), Pew-Stewart Scholars for Cancer Research, and the American Cancer Society.<\/p>","protected":false},"featured_media":49726,"template":"","faculty":[74],"disease-research":[122,456],"class_list":["post-49703","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-diana-hargreaves","disease-research-immune-system-biology","disease-research-inflammation"],"acf":[],"yoast_head":"\nCooperative proteins help the immune system identify and attack invaders - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/cooperative-proteins-help-the-immune-system-identify-and-attack-invaders\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cooperative proteins help the immune system identify and attack invaders - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Bacteria, parasites, viruses\u2014the immune system tackles them all. 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