{"id":49140,"date":"2024-05-09T08:20:01","date_gmt":"2024-05-09T15:20:01","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=49140"},"modified":"2024-05-09T11:00:05","modified_gmt":"2024-05-09T18:00:05","slug":"salk-institute-receives-5-million-gift-from-paul-m-angell-foundation-to-develop-pancreatic-cancer-diagnostics-and-therapies","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/salk-institute-receives-5-million-gift-from-paul-m-angell-foundation-to-develop-pancreatic-cancer-diagnostics-and-therapies\/","title":{"rendered":"Salk Institute erh\u00e4lt $5-Millionen-Spende der Paul M. Angell Foundation zur Entwicklung von Diagnostika und Therapien f\u00fcr Bauchspeicheldr\u00fcsenkrebs"},"content":{"rendered":"

LA JOLLA\u2014The Salk Institute will receive a four-year, $5 million gift from the Paul M. Angell Family Foundation<\/a> to support pancreatic cancer research. The project\u2019s leaders, Salk Assistant Professor Dannielle Engle<\/a>, Professor Ronald Evans<\/a>, and Professor Reuben Shaw<\/a>, will establish a novel pipeline from patients to the laboratory and back to the clinic. The approach will provide a unique opportunity to uncover new diagnostics and therapies for pancreatic cancer. \r\n<\/p>

\r\nPancreatic cancer is one of the most devastating cancers, in part because it is so difficult to diagnose. The condition is generally asymptomatic until the later stages of the disease, and by then, for most patients, it is too late to intervene. Pancreatic cancer is also notoriously resistant to therapy, partly because the tumors grow encased in a thick layer of protective tissue.\r\n<\/p>

\r\nThe generous gift from the Paul M. Angell Family Foundation will enable Salk scientists to analyze patient tumor samples in the laboratory, construct corresponding pancreatic tumor organoids, and screen compounds\u2014potential drug precursors\u2014to find those that block tumor growth and progression. \r\n<\/p>

\r\nPancreatic organoids are patient-specific miniature pancreases that provide a realistic representation of functioning human pancreases. They allow scientists to analyze a patient\u2019s tumor as well as its microenvironment of cells and surrounding tissues. One example compound that will be tested on these organoids is an activator of the vitamin D receptor, which has been shown to prevent the formation of fibrotic tissue shells around pancreatic tumors. These findings will be shared back to the clinic, where the researchers aim to provide personalized medicine and targeted therapeutics.\r\n<\/p>

\r\n\u201cWe are honored by the tremendous support the Angell Foundation has shown Salk,\u201d says Salk President Gerald Joyce<\/a>. \u201cThis level of philanthropic investment will enable us to substantially accelerate this expert team\u2019s high-risk, high-reward approach, expand our role as a leader in this area, and most importantly, potentially improve outcomes for patients diagnosed with pancreatic cancer.\u201d \r\n<\/p>

\r\nAbout the researchers:<\/strong>\r\n<\/p>\r\n

\r\n
\r\n \"Dannielle\r\n \r\n
Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/figcaption>\r\n <\/figure>\r\n
\r\n

Dannielle Engle<\/strong> is an assistant professor in the Regulatory Biology Laboratory and the Helen McLoraine Developmental Chair. She discovered that the glycoprotein CA19-9 causes pancreatitis and accelerates pancreatic tumor progression in mouse models. Her laboratory uses pancreatic organoids to study both inflammation and cancer of the pancreas. Her team is now evaluating the therapeutic potential of CA19-9-targeted therapies for the treatment of pancreatitis and pancreatic cancer.<\/p>\r\n <\/div><\/div>\r\n\r\n

\r\n
\r\n \r\n \"Ronald\r\n \r\n
Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/figcaption> \r\n <\/figure>\r\n
\r\n

Ronald Evans<\/strong> is a professor, director of the Gene Expression Laboratory, and March of Dimes Chair in Molecular and Developmental Biology. He is a world-renowned expert on the role of nuclear hormone receptors in cell growth and metabolism. He identified novel pathways involved in cancer and metabolic diseases that are targetable by drugs that modulate these receptors. His laboratory showed that a modified form of vitamin D renders pancreatic tumors more vulnerable to chemotherapy. This compound is currently being evaluated in four clinical trials for pancreatic cancer.<\/p>\r\n <\/div><\/div>\r\n\r\n\r\n

\r\n \r\n
\r\n \"Reuben\r\n \r\n
Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/figcaption> \r\n <\/figure>\r\n
\r\n

Reuben Shaw<\/strong> is a professor in the Molecular and Cell Biology Laboratory, director of Salk\u2019s National Cancer Institute-designated Cancer Center, and the William R. Brody Chair. He discovered direct connections between cancer and metabolism. He continues to investigate how nutrient deprivation and cellular energy levels impact cancer, including pancreatic tumors.<\/p>\r\n <\/div><\/div>","protected":false},"featured_media":0,"template":"","faculty":[345,45,91],"disease-research":[172],"class_list":["post-49140","disclosure","type-disclosure","status-publish","hentry","faculty-dannielle-engle","faculty-reuben-shaw","faculty-ronald-evans","disease-research-pancreatic-cancer"],"acf":[],"yoast_head":"\nSalk Institute receives $5 million gift from Paul M. 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