{"id":37390,"date":"2023-01-03T00:00:01","date_gmt":"2023-01-03T08:00:01","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=37390"},"modified":"2024-01-30T14:18:47","modified_gmt":"2024-01-30T22:18:47","slug":"microprotein-increases-appetite-in-mice","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/microprotein-increases-appetite-in-mice\/","title":{"rendered":"Mikroprotein steigert den Appetit bei M\u00e4usen"},"content":{"rendered":"

LA JOLLA \u2013 \u00dcbergewicht und Stoffwechselerkrankungen wie Diabetes sind in den Vereinigten Staaten extrem verbreitet. Winzige Proteine, sogenannte Mikroproteine, wurden in der Forschung lange Zeit \u00fcbersehen, aber neue Beweise zeigen, dass sie eine wichtige Rolle im Stoffwechsel spielen. Forscher des Salk Institute haben herausgefunden, dass sowohl braunes als auch wei\u00dfes Fett Tausende von bisher unbekannten Mikroproteinen enth\u00e4lt, und zeigen, dass eines dieser Mikroproteine namens Gm8773 den Appetit bei M\u00e4usen steigern kann.<\/p>\n

Diese Ergebnisse, ver\u00f6ffentlicht in Zellstoffwechsel<\/em><\/a> Am 3. Januar 2023 k\u00f6nnte dies zur Entwicklung einer Therapie f\u00fchren, die Menschen hilft, in bestimmten Krankheitszust\u00e4nden, beispielsweise w\u00e4hrend einer Chemotherapie gegen Krebs, an Gewicht zuzunehmen. Dar\u00fcber hinaus stellt das Team durch den Nachweis der Existenz dieser Mikropeptide der wissenschaftlichen Gemeinschaft eine wertvolle Ressource f\u00fcr die Erforschung von Mikropeptiden zur Verf\u00fcgung.<\/p>\n

\"From
Von links: Alan Saghatelian und Thomas Martinez
Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.
Quelle: Von links: Salk Institute und Steve Zylius von der UC Irvine<\/figcaption><\/figure>\n

\u201cUm verbesserte Therapien f\u00fcr die Zukunft bereitstellen zu k\u00f6nnen, ist es von entscheidender Bedeutung, die Prozesse, die die Fettleibigkeit und die Stoffwechselgesundheit regulieren, besser zu verstehen\u201d, sagt Salk-Professor\u00a0Alan Saghatelian<\/a>, Co-Korrespondenzautor der Studie und Inhaber des Dr. Frederik Paulsen Lehrstuhls. \u201cDiese Liste von Mikropeptiden wird dem Stoffwechselfeld dabei helfen, neue Akteure bei einer Vielzahl von Stoffwechselerkrankungen zu identifizieren. Und wir haben ein biologisch aktives Mikropeptid nachgewiesen, das das Fressverhalten f\u00f6rdert, sowie andere Mikropeptide, die am Fettstoffwechsel beteiligt sind.\u201d<\/p>\n

Fettgewebe sezerniert viele verschiedene Proteine, um die Nahrungsaufnahme, den Energiehaushalt und die W\u00e4rmeproduktion zu regulieren. Wei\u00dfes Fett, bekannt als \u201cschlechtes Fett\u201d, befindet sich oft direkt unter der Haut und im Bauchbereich. Diese Art von Fett dient als Energiespeicher und steht im Zusammenhang mit Fettleibigkeit und anderen Krankheiten, die durch \u00dcbergewicht verursacht werden. Im Gegensatz dazu befindet sich braunes Fett oder \u201cgutes Fett\u201d um die Schultern und entlang des R\u00fcckenmarks. Braunes Fett wird mit richtiger Ern\u00e4hrung, Bewegung und Gesundheit in Verbindung gebracht.<\/p>\n

In dieser Studie nutzten die Wissenschaftler innovative gentechnische Verfahren, um braunes, wei\u00dfes und beiges Fett (eine weitere Fettart mit Eigenschaften, die sowohl wei\u00dfem als auch braunem Fett \u00e4hneln) in Mausentierzellen zu untersuchen. Sie identifizierten 3.877 Gene, die in sowohl wei\u00dfem als auch braunem Fett Mikropeptide produzieren. Zus\u00e4tzlich untersuchten sie die Expression dieser Gene bei M\u00e4usen, die eine fettreiche westliche Di\u00e4t erhielten, und brachten Hunderte von Mikropeptiden mit Ver\u00e4nderungen im Fettstoffwechsel in Verbindung. Insgesamt hebt die Analyse erstmals viele wahrscheinlich Stoffwechsel-relevante Mikropeptide hervor.<\/p>\n

\u201cWir haben einen Fahrplan erstellt, wie unsere Daten am besten genutzt werden k\u00f6nnen, um die Rollen von Mikropoteinen in grundlegenden Stoffwechselwegen zu verkn\u00fcpfen und schlie\u00dflich zu charakterisieren\u201d, sagt Erstautor Thomas Martinez, ein ehemaliger Postdoktorand in Saghatelians Labor, der jetzt Assistenzprofessor an der UC Irvine ist.<\/p>\n

\"Microproteins
Mikroproteine und kleine Proteine, sogenannte smORFs, sind potenziell eine reiche Quelle f\u00fcr uncharakterisierte Regulatoren des Stoffwechsels.
Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.
Quelle: Salk Institute und Zellstoffwechsel<\/em><\/figcaption><\/figure>\n

Das Team konzentrierte sich auch auf ein Mikoprotein namens Gm8773, das sich im Fresszentrum des Gehirns, dem Hypothalamus, befindet. Die Lokalisation des Mikoproteins im Gehirn deutete darauf hin, dass es eine Rolle beim Appetit spielen k\u00f6nnte. Tats\u00e4chlich fra\u00dfen \u00fcbergewichtige M\u00e4use mehr, als die Wissenschaftler ihnen Gm8773 verabreichten. Es gibt auch ein menschliches Gen, das Gm8773 \u00e4hnelt und FAM237B genannt wird, und dieses Gen k\u00f6nnte beim Menschen \u00e4hnlich wirken, um das Essverhalten zu f\u00f6rdern. Laut den Forschern k\u00f6nnte dieses Mikoprotein schlie\u00dflich zu einem Therapeutikum entwickelt werden, das die Gewichtszunahme bei Menschen mit extremem Gewichtsverlust f\u00f6rdert.<\/p>\n

\u201cDie neuen Mikroproteine, die in unserer Studie vorgestellt werden, sind aufregende Entdeckungen f\u00fcr das Stoffwechselgebiet und f\u00fcr die Untersuchung der Fettbiologie\u201d, sagt der Co-Korrespondenzautor Chris Barnes, fr\u00fcher vom Novo Nordisk Research Center Seattle, Inc., jetzt Leiter der Proteomik bei Velia Therapeutics. \u201cWir hoffen, dass diese Ressource zur Generierung zahlreicher neuer experimenteller Hypothesen f\u00fcr die wissenschaftliche Gemeinschaft genutzt wird, die in ihren eigenen Labors getestet werden k\u00f6nnen, und dass diese Arbeit zur Identifizierung neuartiger Mechanismen in der Biologie f\u00fchrt.\u201d<\/p>\n

In Zukunft planen Wissenschaftler, Werkzeuge zu entwickeln, um die Rollen von Gm8773 und FAM237B zu untersuchen, mit dem Ziel, schlie\u00dflich ein Therapeutikum zu entwickeln, das den Appetit beim Menschen steigern kann.<\/p>\n

Weitere Autoren sind Cynthia Donaldson, Joan M. Vaughan, Calvin Lau und Maxim N. Shokhirev vom Salk; Brian C. Searle von der Ohio State University; Lindsay K. Pino und Michael J. MacCoss von der University of Washington; Eduardo V. De Souza und Cristiano V. Bizarro von der Pontifcia Universidade Catolica do Rio Grande do Sul in Brasilien; und Sally Lyons-Abbott, Angie L. Bookout, Ariel Abramov, Arian F. Baquero, Karalee Baquero, Dave Friedrich, Justin Huard, Ray Davis, Bong Kim, Ty Koch, Aaron J. Mercer, Ayesha Misquith, Sara A. Murray, Sakara Perry, Christina Sanford, Alex Simon, Yu Zhang, Garrett Zipp und Andrew J. Whittle vom Novo Nordisk Research Center Seattle, Inc.<\/p>\n

Die Arbeit wurde finanziell unterst\u00fctzt durch die National Institutes of Health (R01 GM133981, P41 GM103533, R24GM141156, U19 AG065156, P30CA014195, R01GM102491, RC2DK129961 und K01CA249038), Frederick Paulsen und die Ferring Foundation, eine Forschungsvereinbarung mit Novo Nordisk Research Center Seattle, Inc., das National Institute of Science and Technology on Tuberculosis, Brasilien (421703-2017-2\/17-1265-8\/14.2.0914.1), den National Council for Scientific and Technological Development of Brazil (310344\/2016-6) und die Coordena\u00e7\u00e3o de Aperfeic\u0327oamento de Pessoal de N\u00edvel Superior\u2014Brasil.<\/p>","protected":false},"featured_media":37503,"template":"","faculty":[111],"disease-research":[449,173,165,166],"class_list":["post-37390","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-alan-saghatelian","disease-research-biochemistry-and-biophysics","disease-research-diabetes-type-1","disease-research-diabetes-type-2","disease-research-obesity"],"acf":[],"yoast_head":"\nMicroprotein increases appetite in mice - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/microprotein-increases-appetite-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Microprotein increases appetite in mice - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Obesity and metabolic diseases, such as diabetes, are extremely common in the United States. 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