{"id":28381,"date":"2020-10-21T00:00:29","date_gmt":"2020-10-21T07:00:29","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=28381"},"modified":"2020-11-09T08:04:20","modified_gmt":"2020-11-09T16:04:20","slug":"salk-assistant-professor-dannielle-engle-awarded-over-1-million-to-study-impact-of-tobacco-use-on-pancreatic-cancer","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/salk-assistant-professor-dannielle-engle-awarded-over-1-million-to-study-impact-of-tobacco-use-on-pancreatic-cancer\/","title":{"rendered":"Salk Assistant Professor Dannielle Engle awarded over $1 million to study impact of tobacco use on pancreatic cancer"},"content":{"rendered":"

LA JOLLA\u2014Salk Institute Assistant Professor Dannielle Engle<\/a> has been awarded a New Investigator Award from the Tobacco-Related Disease Research Program (TRDRP) to examine how tobacco use promotes cellular changes that lead to pancreatic cancer. The TRDRP funds research that \u201cenhances understanding of tobacco use, prevention and cessation, the social, economic and policy-related aspects of tobacco use, and tobacco-related diseases in California,\u201d according to their website. Engle will receive over $1 million over three years to develop new models for examining how tobacco carcinogens (cancer-causing substances) lead to tumor development and metastasis.<\/p>\n

\"Dannielle
Dannielle Engle<\/p>\n

Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/p>\n

Kredit: Salk Institut<\/figcaption><\/figure>\n

\u201cWe are excited that Dannie\u2019s work will be funded by the TRDRP, as her project has great potential to uncover the molecular drivers of pancreatic cancer that are amplified by exposure to tobacco,\u201d says Salk President\u00a0Rusty Gage<\/a>. \u201cPancreatic cancer remains one of the deadliest cancers in the United States, and the Engle lab\u2019s work is a critical part of the life-changing research being conducted here at Salk.\u201d<\/p>\n

The incidence of pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDA), is on the rise, and a significant risk factor for developing PDA is smoking. Investigation of the molecular connection between smoking and developing PDA may uncover ways to intercept transformation. Engle thinks that the carcinogens in tobacco likely increase inflammation and promote cellular stress leading to tumor development. To test this theory, Engle\u2019s team will use pancreatic organoids, three-dimensional cellular models of the pancreas, to examine the changes that occur during the development of tumors after exposure to tobacco. Her goals are to establish organoid models for studying the effect of tobacco on cells and evaluate how different levels of tobacco exposure impact the formation and spread of pancreatic tumors.<\/p>\n

\u201cI am incredibly thankful for the support of the TRDRP,\u201d says Engle, a member of Salk\u2019s National Cancer Institute (NCI)-designated Salk Cancer Center. \u201cThis funding will enable my lab to investigate the underlying reasons why carcinogens present in tobacco products increase the risk for developing pancreas cancer. Our cutting-edge pancreatic organoid models are uniquely suited to identifying the mechanisms by which carcinogen exposure potentiates transformation.\u201d<\/p>\n

Engle was previously awarded the NIH NCI Career Transition K99\/R00 award, the California Breast Cancer Research Program Fellowship and the UC San Diego Chancellor\u2019s Fellowship.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[345],"disease-research":[46,172],"class_list":["post-28381","disclosure","type-disclosure","status-publish","hentry","faculty-dannielle-engle","disease-research-cancer-biology","disease-research-pancreatic-cancer"],"acf":[],"yoast_head":"\nSalk Assistant Professor Dannielle Engle awarded over $1 million to study impact of tobacco use on pancreatic cancer - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/salk-assistant-professor-dannielle-engle-awarded-over-1-million-to-study-impact-of-tobacco-use-on-pancreatic-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk Assistant Professor Dannielle Engle awarded over $1 million to study impact of tobacco use on pancreatic cancer - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Salk Institute Assistant Professor Dannielle Engle has been awarded a New Investigator Award from the Tobacco-Related Disease Research Program (TRDRP) to examine how tobacco use promotes cellular changes that lead to pancreatic cancer. 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