{"id":26343,"date":"2020-04-28T09:21:11","date_gmt":"2020-04-28T16:21:11","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=26343"},"modified":"2020-08-04T05:08:25","modified_gmt":"2020-08-04T12:08:25","slug":"new-insights-into-how-genes-control-courtship-and-aggression","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/new-insights-into-how-genes-control-courtship-and-aggression\/","title":{"rendered":"New insights into how genes control courtship and aggression"},"content":{"rendered":"

LA JOLLA\u2014Fruit flies, like many animals, engage in a variety of courtship and fighting behaviors. Now, Salk scientists have uncovered the molecular mechanisms by which two sex-determining genes affect fruit fly behavior. The male flies\u2019 courtship and aggression behaviors, they showed, are mediated by two distinct genetic programs. The findings, both published in eLife <\/em>on April 21, 2020, demonstrate the complexity of the link between sex and behavior.<\/p>\n

\"Researchers
Researchers studied how sex-determining genes affect neurons known to control courtship (shown in orange on the left) and aggression (shown in blue on the right) in fly brains.<\/p>\n

Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/p>\n

Kredit: Salk Institut<\/figcaption><\/figure>\n

\u201cCourtship and aggression seem to be controlled somewhat separately by these two genes,\u201d says Kenta Asahina<\/a>, an assistant professor in Salk\u2019s Molecular Neurobiology Laboratory and senior author of the two papers. <\/em>\u201cHaving behaviors controlled by different genetic mechanisms can have some benefits in terms of evolution.\u201d In other words, he explains, a fly population that is under evolutionary pressure to compete more\u2014perhaps due to limited resources\u2014can evolve aggressive behaviors without affecting courtship.<\/p>\n

Male fruit flies\u2019 aggression is primarily toward other males, while their courtship behaviors\u2014which involve a series of movements and songs\u2014are toward female flies. Both behaviors are reinforced by evolution over time, because the ability of male flies to compete with other males and attract females directly affects their ability to mate and pass on their genes.<\/p>\n

Researchers already knew which neurons in the brain are important for controlling aggression and courtship. In general, studies had suggested that specialized brain cells called P1\/pC1 neurons, promote both courtship and aggression while Tk-GAL4FruM<\/sup> neurons promote aggression specifically. They also knew that the two sex-determining genes fruitless (fru) and doublesex (dsx) played key roles in this behavior. But the connection between the genes and the behaviors hadn\u2019t been clear.<\/p>\n

\"From
From left: Kenta Asahina, Margot Wohl and Kenichi Ishii.<\/p>\n

Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/p>\n

Kredit: Salk Institut<\/figcaption><\/figure>\n

In the new study, Asahina and his colleagues raised Drosophila <\/em>fruit flies that contained light-activatable versions of the courtship and aggression neurons. The team could turn the neurons on at any time by shining a light on the flies. The researchers next altered the fru or dsx genes in some of these male flies. <\/em>They then developed an automated system using machine-learning to analyze videos of the flies and count how often they carried out aggressive or courtship behaviors.<\/p>\n

\u201cWe made a computer system to capture aggressive behaviors and courtship behaviors to more quickly and accurately count actions,\u201d says Salk postdoctoral fellow Kenichi Ishii, co-first author of both of the new papers. \u201cGetting the program to work was actually difficult and time-consuming but in the end, it made it easier for us to get good data.\u201d<\/p>\n

The team found that dsx was required for the formation of courtship-inducing neurons: when the fruit flies had the female version of dsx, the courtship neurons were no longer present. On the other hand, fru played a different role\u2014without this gene, flies could still be coaxed to perform courtship behaviors by activating courtship neurons but the courtship was directed at both males and females, suggesting that fru was required for flies to differentiate between the sexes. For aggression, however, the findings were the opposite: fru but not dsx was required for the activation of aggression neurons to cause fighting in male flies<\/p>\n

\u201cThis is an important example of the neurobiological differences between sexes and what kind of approaches we can use to study sexually-linked behaviors,\u201d says Asahina,<\/u> who holds the Helen McLoraine Developmental Chair in Neurobiology.<\/p>\n

\u201cI think the interesting part of this is understanding that sex is really not a binary thing,\u201d says UC San Diego doctoral student Margot Wohl, co-first author of both of the new papers. \u201cA lot of factors come together to control behaviors that differ between the sexes.\u201d<\/p>\n

Since sex determination in flies is very different than in humans\u2014fruit flies don\u2019t have sex hormones, for instance\u2014the new findings don\u2019t carry over to how biological sex may impact behavior in people. But Asahina says his approach\u2014the combination of optogenetics and sex-linked gene manipulation\u2014may be useful in understanding behaviors that vary by sex in other animals.<\/p>\n

Andre DeSouza of Salk was also an author on one of the two papers.<\/p>\n

The work was supported by grants from the National Institute of General Medical Sciences (GM119844); the National Institute on Deafness and Other Communication Disorders (DC015577); the Naito Foundation; the Japan Society for the Promotion of Science; the Mary K. Chapman Foundation; and the Rose Hills Foundation.<\/p>\n

 <\/p>\n

Journal Information<\/strong><\/p>\n

 <\/p>\n

Journal: eLife<\/a><\/em>
\nTitle: Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons
\nAuthors: Kenichi Ishii, Margot Wohl, Andre DeSouza and Kenta Asahina
\nDOI: 10.7554\/eLife.52701<\/p>\n

 <\/p>\n

Journal: eLife<\/a><\/em>
\nTitle: Layered roles of fruitless isoforms in specification and function of male aggression-promoting neurons in Drosophilaneurons
\nAuthors: Margot Wohl, Kenichi Ishii and Kenta Asahina
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