{"id":25522,"date":"2020-01-30T00:00:01","date_gmt":"2020-01-30T08:00:01","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=25522"},"modified":"2024-01-30T14:43:52","modified_gmt":"2024-01-30T22:43:52","slug":"the-first-roadmap-for-ovarian-aging","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/the-first-roadmap-for-ovarian-aging\/","title":{"rendered":"The first roadmap for ovarian aging"},"content":{"rendered":"

LA JOLLA\u2014Due to the modern tendency to postpone childbirth until later in life, a growing number of women are experiencing issues with infertility. Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear. Now, scientists from the U.S. and China have discovered, in unprecedented detail, how ovaries age in non-human primates. The findings, published in Zelle<\/em><\/a> on January 30, 2020, reveal several genes that could be used as biomarkers and point to therapeutic targets for diagnosing and treating female infertility and age-associated ovarian diseases, such as ovarian cancer, in humans.<\/p>\n

\"Immunofluorescence
Immunofluorescence analysis of classic markers for smooth muscle cells in the ovary, including muscle filaments (green), smooth muscle proteins (red) and nuclear DNA (blue).<\/p>\n

Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/p>\n

Credit: Guang-Hui Liu<\/figcaption><\/figure>\n

\u201cThis is the first in-depth analysis of ovarian aging at a single-cell resolution in a non-human primate model,\u201d says Juan Carlos Izpisua Belmonte<\/a>, one of the co-corresponding authors, professor in Salk\u2019s Gene Expression Laboratory and holder of the Roger Guillemin Chair. \u201cWe found that oxidative stress, the cellular stress that damages cells, is a key player in ovarian aging. This discovery provides valuable insight into the mechanisms by which ovaries age and eventually become infertile.\u201d<\/p>\n

The ovary is a complex reproductive organ in which an ovarian cell, called an oocyte, undergoes meiosis to become an egg. Current research suggests that women are born with a set number of oocytes that start to become less functional once women turn 35, leading to infertility. A better understanding of the ovarian environment as well as the mechanisms of healthy aging could inform new therapies for women with fertility issues.<\/p>\n

\u201cOur goal was to analyze each ovarian cell type along with patterns in gene expression in order to better understand exactly how ovaries age,\u201d says Jing Qu, co-corresponding author, professor at the Chinese Academy of Sciences and former Salk research associate. \u201cThis systematic approach provides a better understanding of the mechanisms of healthy ovarian aging.\u201d<\/p>\n

The scientists compared 2,601 ovarian cells from young and old non-human primates, and identified gene activity patterns for every type of primate ovarian cell including ooctyes and granulosa cells, which surround the oocytes as they develop. Similar to previous studies in rodents, the scientists observed changes in gene function related to cellular stress and cell division across the non-human primates. As the oocytes and granulosa cells aged, some of the genes that fight cellular stress became less active which led to damage and impairment in function.<\/p>\n

\"From<\/a>
From left: Concepcion Rodriguez Esteban and Juan Carlos Izpisua Belmonte.<\/p>\n

Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/p>\n

Kredit: Salk Institut<\/figcaption><\/figure>\n

The scientists then compared the primate data with granulosa cells from healthy women ranging in age from 21 to 46 years. They observed age-associated damage from cellular stress as well as cell death in the women\u2019s cells. Two key antioxidant genes (IDH1<\/em> und NDUFB10<\/em>) showed decreased function, as seen in the non-human primate cells. To better understand the connection between ovarian aging and the antioxidant genes, the scientists tested what happened to the human cells when the antioxidant genes were made non-functional. They found that without IDH1<\/em> oder NDUFB10<\/em>, the cells appeared old and similar to the old non-human primate cells.<\/p>\n

The results suggest that IDH1<\/em> und NDUFB10<\/em> play a critical role in protecting both human and non-human primate ovarian cells from cellular stress during aging. These genes represent promising biomarkers or therapeutic targets for the diagnosis and treatment of age-related decline of the ovaries.<\/p>\n

\u201cThis study provides a comprehensive understanding of the specific mechanisms of primate ovarian aging at single-cell resolution,\u201d says Guang-Hui Liu, co-corresponding author, professor at the Chinese Academy of Sciences and former Salk research associate. \u201cOur results will hopefully lead to the development of new tools to aid in the rejuvenation of aged ovarian cells.\u201d<\/p>\n

\"Scientists
Scientists describe the first single-cell atlas of proteins from the ovaries of young and aged monkeys, to reveal new diagnostic biomarkers and potential therapeutic targets for human ovarian aging. This illustration for the work, selected for the cover of Zelle<\/em>, evokes the Chinese folktale, \u201cThe Monkeys Fish for the Moon,\u201d and symbolizes the hope for youth and rejuvenation.<\/p>\n

Credit: Credit: Guang-Hui Liu and Yizhu Wang<\/figcaption><\/figure>\n

“Our research is enabling the identification of new biomarkers for the diagnosis and treatment of female infertility as well as aging-associated human ovarian disorders,\u201d says Concepcion Rodriguez Esteban, an author on the paper and senior staff researcher in the Izpisua Belmonte lab. \u201cThese genes could possibly be targeted for the development of therapies to assist with fertility preservation.\u201d<\/p>\n

The study\u2019s first authors included Si Wang of the Chinese Academy of Sciences, Yuxuan Zheng of Peking University, Jingyi Li of the Chinese Academy of Sciences, Yang Yu of Peking University Third Hospital and Weiqi Zhang of the University of the Chinese Academy of Sciences. Other authors included Moshi Song, Zunpeng Liu, Huifang Hu, Ying Jing and Qi Zhou of the Chinese Academy of Sciences; Zheying Min, Lifang Ma and Jie Qiao of Peking University Third Hospital; Xiaojuan He and Piu Chan of the Xuanwu Hospital Capital Medical University; Liang Sun of the National Center of Gerontology; and Fuchou Tang of Peking University, who was also a corresponding author.<\/p>\n

This work was supported by the National Key Research and Development Program of China (2018YFC2000100), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16010100), the National Key Research and Development Program of China (2017YFA0102802, 2017YFA0103304, 2018YFC1003101, 2015CB964800, 2016YFC1000601, 2018YFA0107203, 2018YFC2000400), the National Natural Science Foundation of China (81921006, 81625009, 91749202, 91749123, 31671429, 81671377, 81771515, 31601158, 81701388, 81601233, 31601109, 81822018, 81870228, 81801399, 31801010, 81801370, 81861168034, 31900523, 81901432, 81901433, 31900524, 81922027, 81571400, 81771580, 81971381, 81730038, 81571385, 91849132), Beijing Natural Science Foundation (Z190019), Beijing Municipal Commission of Health and Family Planning (PXM2018_026283_000002), the Key Research Program of the Chinese Academy of Sciences (KFZD-SW-221), Advanced Innovation Center for Human Brain Protection (3500-1192012), Young Elite Scientists Sponsorship Program by CAST (2017QNRC001) and the State Key Laboratory of Membrane Biology, the Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine, Ferring Pharmaceuticals and Chinese Academy of Sciences (Grant No. FIRMC180305). J.C.I.B. was supported by the Moxie Foundation and the Glenn Foundation.<\/p>","protected":false},"featured_media":25525,"template":"","faculty":[85],"disease-research":[146],"class_list":["post-25522","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-juan-carlos-izpisua-belmonte","disease-research-aging-and-regenerative-medicine"],"acf":[],"yoast_head":"\nThe first roadmap for ovarian aging - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/the-first-roadmap-for-ovarian-aging\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The first roadmap for ovarian aging - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Due to the modern tendency to postpone childbirth until later in life, a growing number of women are experiencing issues with infertility. 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Molecular mechanisms of ovarian aging and female age-related fertility are topics of intense interest. In this issue, Wang et al. (585\u2013600) describe a single-cell transcriptomic atlas of ovaries from young and aged monkeys and reveal new diagnostic biomarkers and potential therapeutic targets for human ovarian aging. The cover, in the style of Chinese shadow puppetry, represents the Chinese folktale \u201cThe Monkeys Fish for the Moon,\u201d in which the monkeys aim to catch the moon's reflection in the water, signifying an ovary that has yet to undergo the damage associated with aging. Illustration credit: Yizhu Wang."},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/25522","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":13,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/25522\/revisions"}],"predecessor-version":[{"id":25646,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/25522\/revisions\/25646"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/media\/25525"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/media?parent=25522"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/faculty?post=25522"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disease-research?post=25522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}