{"id":2480,"date":"2014-05-01T00:00:00","date_gmt":"2014-05-01T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/salk-scientists-reveal-circuitry-of-fundamental-motor-circuit\/"},"modified":"2014-05-01T00:00:00","modified_gmt":"2014-05-01T07:00:00","slug":"salk-scientists-reveal-circuitry-of-fundamental-motor-circuit","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/salk-scientists-reveal-circuitry-of-fundamental-motor-circuit\/","title":{"rendered":"Salk scientists reveal circuitry of fundamental motor circuit"},"content":{"rendered":"

\nLA JOLLA\u2014Scientists at the Salk Institute have discovered the developmental source for a key type of neuron that allows animals to walk, a finding that could help pave the way for new therapies for spinal cord injuries or other motor impairments related to disease.\n<\/p>\n

\"Martyn<\/p>\n

\nMartyn Goulding, Professor – Molecular Neurobiology Laboratory, Frederick W. and Joanna J. Mitchell Chair\n <\/p>\n

\nBild: Mit freundlicher Genehmigung des Salk Institute for Biological Studies\n<\/p>\n<\/div>\n

\nThe spinal cord contains a network of neurons that are able to operate largely in an autonomous manner, thus allowing animals to carry out simple rhythmic walking movements with minimal attention\u2014giving us the ability, for example, to walk while talking on the phone. These circuits control properties such as stepping with each foot or pacing the tempo of walking or running.\n<\/p>\n

\nThe researchers, led by Salk professor Martyn Goulding<\/a>, identified for the first time which neurons in the spinal cord were responsible for controlling a key output of this locomotion circuit, namely the ability to synchronously activate and deactivate opposing muscles to create a smooth bending motion (dubbed flexor-extensor alternation). The findings were published April 2 in Neuron<\/a><\/em>.\n<\/p>\n

\nMotor circuits in the spinal cord are assembled from six major types of interneurons\u2014cells that interface between nerves descending from the brain and nerves that activate or inhibit muscles. Goulding and his team had previously implicated one class of interneuron, the V1 interneurons, as being a likely key component of the flexor-extensor circuitry. However when V1 interneurons were removed, the team saw that flexor-extensor activity was still intact, leading them to suspect another type of cell was also involved in coordinating this aspect of movement.\n<\/p>\n

\"V2b<\/p>\n

\nV2b interneurons, responsible for a key locomotion circuit, appear as green with yellow nuclei in a spinal cord while all other neurons are red.\n <\/p>\n

\nBild: Mit freundlicher Genehmigung des Salk Institute for Biological Studies\n<\/p>\n<\/div>\n

\nTo determine what other interneurons were at play in the flexor-extensor circuit, the team looked for other cells in the spinal cord with properties that were similar to those of the V1 neurons. In doing this they began to focus on another class of neuron, whose function was not known, V2b interneurons. Using a specialized experimental setup that allows one to monitor locomotion in the spinal cord itself, the team saw a synchronous pattern of flexor and extensor activity when V2b interneurons were inactivated along with the V1 interneurons.\n<\/p>\n

\nThe team also showed that this synchronicity led to newborn mice displaying a tetanus-like reaction when the two types of interneurons were inactivated: the limbs froze in one position because they no longer had the push-pull balance of excitation and inhibition that is needed to move.\n<\/p>\n

\nThese findings further confirm the hypothesis put forward over 120 years ago by the Nobel Prize-winning neuroscientist, Charles Sherrington, that flexor-extensor alternation is essential for locomotion in all animals that have limbs. He proposed that specialized cells in the spinal cord called switching cells performed this function. After 120 years, Goulding and researchers have now uncovered the identity of these switching cells.\n<\/p>\n

\"Ankle<\/p>\n

\nAnkle motor neurons (blue) show the inhibitory synaptic contacts (red) on their cell bodies, some of which are derived from V2b interneurons (yellow).\n <\/p>\n

\nBild: Mit freundlicher Genehmigung des Salk Institute for Biological Studies\n<\/p>\n<\/div>\n

\n“Our whole motor system is built around flexor-extension; this is the cornerstone component of movement,” says Goulding, holder of Salk’s Frederick W. and Joanna J. Mitchell Chair. “If you really want to understand how animals move you need to understand the contribution of these switching cells.”\n<\/p>\n

\nWith a more thorough understanding of the basic science around how this flexor-extensor circuit works, scientists will be in a better position to, for example, create a system that can reactivate the spinal cord or mimic signals sent from the brain to the spinal cord.\n<\/p>\n

\n\u00dcber das Salk Institute for Biological Studies:<\/strong><\/p>\n

Das Salk Institute for Biological Studies ist eine der weltweit f\u00fchrenden Institutionen f\u00fcr Grundlagenforschung, an der international renommierte Fakult\u00e4tsmitglieder grundlegende Fragen der Biowissenschaften in einem einzigartigen, kollaborativen und kreativen Umfeld untersuchen. Mit dem Fokus auf Entdeckungen und die Ausbildung zuk\u00fcnftiger Forschergenerationen leisten Salk-Wissenschaftler bahnbrechende Beitr\u00e4ge zu unserem Verst\u00e4ndnis von Krebs, Alterung, Alzheimer, Diabetes und Infektionskrankheiten durch die Untersuchung von Neurowissenschaften, Genetik, Zell- und Pflanzenbiologie sowie verwandten Disziplinen.\n<\/p>\n

\nDie Leistungen der Fakult\u00e4t wurden mit zahlreichen Auszeichnungen gew\u00fcrdigt, darunter Nobelpreise und Mitgliedschaften in der National Academy of Sciences. Das 1960 vom Polio-Impfstoff-Pionier Dr. Jonas Salk gegr\u00fcndete Institut ist eine unabh\u00e4ngige gemeinn\u00fctzige Organisation und ein architektonisches Wahrzeichen.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[75],"disease-research":[124,160],"class_list":["post-2480","disclosure","type-disclosure","status-publish","hentry","faculty-martyn-goulding","disease-research-neuroscience-and-neurological-disorders","disease-research-spinal-cord-injury"],"acf":[],"yoast_head":"\nSalk scientists reveal circuitry of fundamental motor circuit - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/salk-scientists-reveal-circuitry-of-fundamental-motor-circuit\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk scientists reveal circuitry of fundamental motor circuit - 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