{"id":2472,"date":"2014-04-11T00:00:00","date_gmt":"2014-04-11T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/salk-cancer-metabolism-expert-reuben-shaw-promoted-to-full-professor\/"},"modified":"2014-04-11T00:00:00","modified_gmt":"2014-04-11T07:00:00","slug":"salk-cancer-metabolism-expert-reuben-shaw-promoted-to-full-professor","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/salk-cancer-metabolism-expert-reuben-shaw-promoted-to-full-professor\/","title":{"rendered":"Salk cancer metabolism expert Reuben Shaw promoted to full professor"},"content":{"rendered":"

\nLA JOLLA\u2014Reuben Shaw<\/a>, a member of the Salk Institute’s Labor f\u00fcr Molekular- und Zellbiologie<\/a> and a Howard Hughes Medical Institute early career scientist, has been promoted from associate professor to full professor.
\nAfter a rigorous evaluation process by Salk senior faculty, nonresident fellows and scientific peers, the promotion was announced Friday.\n<\/p>\n

\n“We are pleased to recognize Professor Shaw’s original, innovative and notable contributions to biological research in pathways that underlie the development of cancer and metabolic disorders,” says Salk President William R. Brody<\/a>.\n<\/p>\n

While investigating one of the most commonly mutated genes in lung Krebs<\/a>, Shaw discovered an energy-sensing pathway that shuts down cell growth and reprograms metabolism when nutrients are scarce. His lab went on to molecularly decode a number of new components of this biochemical pathway, which connects nutrition and exercise to suppression in both cancer and Diabetes<\/a>.\n<\/p>\n

\"BRCA1\"<\/p>\n

\nReuben Shaw, Professor – Molecular and Cell Biology Laboratory\n <\/p>\n

\nBild: Mit freundlicher Genehmigung des Salk Institute for Biological Studies\n<\/p>\n<\/div>\n

\nThis biochemical circuit, the AMPK pathway, is activated by exercise and caloric restriction and serves to tell cells to lower their glucose, lipids and cell growth. This pathway halts the growth tumor cells, which have aberrant revved-up metabolism, but also acts to restore normal function to the liver and other tissues in diabetics. Shaw’s lab followed up on a prediction from its previous studies to recently test whether drugs widely used to treat type 2 diabetes could work as cancer treatments. The team found specific efficacy in some forms of lung cancer for which there are currently no good therapies.\n<\/p>\n

\nIn addition, researchers in Shaw’s lab use genetic mouse models to further examine the connections between cancer and metabolic diseases, and to tease out the precise role of each component of the signaling pathway. In the past five years at Salk, the lab’s studies have lead to the discovery of new therapies for both cancer and type 2 diabetes.\n<\/p>\n

\n\u00dcber das Salk Institute for Biological Studies:<\/strong>
\nDas Salk Institute for Biological Studies ist eine der weltweit f\u00fchrenden Institutionen f\u00fcr Grundlagenforschung, wo international anerkannte Fakult\u00e4tsmitglieder in einem einzigartigen, kooperativen und kreativen Umfeld grundlegende Fragen der Lebenswissenschaften erforschen. Mit Fokus auf sowohl Entdeckungen als auch die Ausbildung zuk\u00fcnftiger Forschergenerationen leisten Salk-Wissenschaftler bahnbrechende Beitr\u00e4ge zu unserem Verst\u00e4ndnis von Krebs, Altern, Alzheimer, Diabetes und Infektionskrankheiten durch die Erforschung von Neurowissenschaften, Genetik, Zell- und Pflanzenbiologie sowie verwandten Disziplinen.\n<\/p>\n

\nDie Leistungen der Fakult\u00e4t wurden mit zahlreichen Auszeichnungen gew\u00fcrdigt, darunter Nobelpreise und Mitgliedschaften in der National Academy of Sciences. Das 1960 vom Polio-Impfstoff-Pionier Dr. Jonas Salk gegr\u00fcndete Institut ist eine unabh\u00e4ngige gemeinn\u00fctzige Organisation und ein architektonisches Wahrzeichen.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[45],"disease-research":[46,165,164,123],"class_list":["post-2472","disclosure","type-disclosure","status-publish","hentry","faculty-reuben-shaw","disease-research-cancer-biology","disease-research-diabetes-type-2","disease-research-lung-cancer","disease-research-metabolism-and-diabetes"],"acf":[],"yoast_head":"\nSalk cancer metabolism expert Reuben Shaw promoted to full professor - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/salk-cancer-metabolism-expert-reuben-shaw-promoted-to-full-professor\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk cancer metabolism expert Reuben Shaw promoted to full professor - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Reuben Shaw, a member of the Salk Institute’s Molecular and Cell Biology Laboratory and a Howard Hughes Medical Institute early career scientist, has been promoted from associate professor to full professor. 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