{"id":24666,"date":"2019-10-24T00:00:28","date_gmt":"2019-10-24T07:00:28","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=24666"},"modified":"2024-01-30T14:47:04","modified_gmt":"2024-01-30T22:47:04","slug":"mysterious-microproteins-have-major-implications-for-human-disease","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/","title":{"rendered":"Mysterious microproteins have major implications for human disease"},"content":{"rendered":"<p>LA JOLLA\u2014As the tools to study biology improve, researchers are beginning to uncover details into microproteins, small components that appear to be key to some cellular processes, including those involved with cancer. Proteins are made up of chains of linked amino acids and the average human protein contains around 300 amino acids. Meanwhile, microproteins have fewer than 100 amino acids.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-ZSKGY2FOrWI\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/ZSKGY2FOrWI?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>One such microprotein is the 54-amino acid microprotein called PIGBOS, which Salk scientists recently showed contributes to mitigating cell stress. The work, published on October 25, 2019, in the journal <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-12816-z\" target=\"_blank\" rel=\"noopener\"><em>Nature Communications<\/em><\/a>, indicates that PIGBOS could be a target for human disease.<\/p>\n<p>&#8220;This study is exciting because cell stress is important in a number of different diseases, including cancer and neurodegeneration,\u201d says Salk Professor <a href=\"https:\/\/www.salk.edu\/de\/scientist\/alan-saghatelian\/\">Alan Saghatelian<\/a>, co-corresponding author of the study. \u201cBy understanding the mechanisms behind these diseases, we think we\u2019ll have a better shot at treating them.\u201d<\/p>\n<figure id=\"attachment_24668\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"458\" class=\"img-responsive wp-image-24668 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-458x458.jpg\" alt=\"The microprotein PIGBOS (magenta) shown sitting on the outer membranes of mitochondria (green), where it is poised to make contact with other organelles in the cell.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-768x768.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-945x945.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-200x200.jpg 200w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image.jpg 1000w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><figcaption class=\"wp-caption-text\">The microprotein PIGBOS (magenta) shown sitting on the outer membranes of mitochondria (green), where it is poised to make contact with other organelles in the cell.<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image.jpg\">Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/p>\n<p>Credit: Salk Institute\/Waitt Advanced Biophotonics Core Facility<\/figcaption><\/figure>\n<p>The study began when Salk postdoctoral researcher and first author Qian Chu detected PIGBOS in mitochondria, small organelles that power important cell functions. Chu wondered what PIGBOS\u2019 role could be. He knew it wouldn\u2019t be easy to find the answer. Researchers had previously noted the gene that could code for PIGBOS, but no one knew where to find the protein or what it did in cells.<\/p>\n<p>That\u2019s when the team reached out to co-corresponding author <a href=\"https:\/\/www.salk.edu\/de\/scientist\/uri-manor\/\">Uri Manor<\/a>, director of the <a href=\"https:\/\/www.salk.edu\/de\/science\/core-facilities\/advanced-biophotonics\/\">Waitt Advanced Biophotonics Core Facility<\/a> at Salk. Manor\u2019s team uses tools like fluorescent protein tags to locate proteins and see what they are doing in cells.<\/p>\n<p>\u201cOnly now do we really have the sophisticated tools to probe interactions between proteins and see how they work and how they are regulated,\u201d says Manor.<\/p>\n<p>But Manor ran into a roadblock when he tried to attach a common tag, called green florescent protein (GFP), to PIGBOS. The microprotein was just too small relative to the size of GFP. Manor\u2019s team solved this problem by trying a less common approach called split GFP, where they fused just a small part of GFP, called a beta strand, to PIGBOS.<\/p>\n<p>At last, the researchers could see PIGBOS and study how it interacted with other proteins. As they mapped PIGBOS\u2019 location, they realized that it sits on the outer membrane of the mitochondria, poised to make contact with proteins on other organelles. They were surprised to see PIGBOS interacting with a protein called CLCC1, which is part of an organelle called the endoplasmic reticulum (ER).<\/p>\n<p>\u201cPIGBOS is like a connection to link mitochondria and ER together,\u201d says Chu. \u201cWe hadn\u2019t seen that before in microproteins\u2014and it\u2019s rare in just normal proteins.\u201d<\/p>\n<p>The researchers found that PIGBOS actually communicates with CLCC1 to regulate stress in the ER. Without PIGBOS, the ER is more likely to experience stress, which leads to a chain of events where the cell tries to clear out harmful misshapen proteins (called the unfolded protein response). If the cell fails to dispose of these proteins, it will initiate a self-destruct sequence and die.<\/p>\n<figure id=\"attachment_24669\"  class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"305\" class=\"img-responsive wp-image-24669 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-458x305.jpg\" alt=\"From left: Alan Saghatelian, Qian Chu and Uri Manor\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-458x305.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-300x200.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-768x512.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-1024x683.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-147x98.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-585x390.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-553x369.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-750x500.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-767x511.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-945x630.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-1250x833.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500-400x267.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500.jpg 1500w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><figcaption class=\"wp-caption-text\">From left: Alan Saghatelian, Qian Chu and Uri Manor<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Saghatelian_Manor-PR-1500.jpg\">Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/p>\n<p>Kredit: Salk Institut<\/figcaption><\/figure>\n<p>The scientists were not expecting to see a role for a mitochondrial protein in the unfolded protein response. This new understanding of PIGBOS opens the door to future therapies that can target cell stress.<\/p>\n<p>\u201cGoing forward, we might consider how PIGBOS is involved in disease like cancer,\u201d says Chu. \u201cIn cancer patients, the ER is more stressed than in a normal person, so ER stress regulation could be a good target.\u201d<\/p>\n<p>The researchers are interested in studying the roles of other mitochondrial proteins in ER stress, and in exploring how PIGBOS works in an animal model. The team is also forging ahead in characterizing the vast library of microproteins that may be crucial in cell biology.<\/p>\n<p>\u201cMicroproteins represent a fledgling field,\u201d says Saghatelian. \u201cBut I think this work has really impacted our understanding the impact that microproteins can have on biochemistry and cell biology.\u201d<\/p>\n<p>Manor adds, \u201cPIGBOS represents one of a limited set of microproteins that anyone has gone through the effort to characterize. And lo and behold it actually has a very important role.&#8221;<\/p>\n<p>Other authors of the study included Thomas F. Martinez, Sammy Weiser Novak, Cynthia J. Donaldson, Dan Tan, Joan M. Vaughan, Tina Chang, Jolene K. Diedrich, Leo Andrade, Andrew Kim and Tong Zhang of Salk.<\/p>\n<p>The research was supported by the National Institutes of Health (R01GM102491, P30 014195, NS072031, P30 CA014195), the Leona M. and Harry B. Helmsley Charitable Trust grant, Dr. Frederick Paulsen Chair\/Ferring Pharmaceuticals, the George E. Hewitt Foundation for Medical Research, the Anderson Foundation, the Waitt Foundation, and a National Institutes of Health F32 fellowship (GM123685) and Pioneer Fellowship.<\/p>","protected":false},"featured_media":24668,"template":"","faculty":[111,405],"disease-research":[46,331],"class_list":["post-24666","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-alan-saghatelian","faculty-uri-manor","disease-research-cancer-biology","disease-research-protein-interactions"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mysterious microproteins have major implications for human disease - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mysterious microproteins have major implications for human disease - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014As the tools to study biology improve, researchers are beginning to uncover details into microproteins, small components that appear to be key to some cellular processes, including those involved with cancer. Proteins are made up of chains of linked amino acids and the average human protein contains around 300 amino acids. Meanwhile, microproteins have fewer than 100 amino acids.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/de\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-30T22:47:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/mysterious-microproteins-have-major-implications-for-human-disease\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/mysterious-microproteins-have-major-implications-for-human-disease\\\/\",\"name\":\"Mysterious microproteins have major implications for human disease - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/mysterious-microproteins-have-major-implications-for-human-disease\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/mysterious-microproteins-have-major-implications-for-human-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2019\\\/10\\\/PIGBOS-image.jpg\",\"datePublished\":\"2019-10-24T07:00:28+00:00\",\"dateModified\":\"2024-01-30T22:47:04+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/mysterious-microproteins-have-major-implications-for-human-disease\\\/#breadcrumb\"},\"inLanguage\":\"de-DE\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/mysterious-microproteins-have-major-implications-for-human-disease\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de-DE\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/mysterious-microproteins-have-major-implications-for-human-disease\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2019\\\/10\\\/PIGBOS-image.jpg\",\"contentUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2019\\\/10\\\/PIGBOS-image.jpg\",\"width\":1000,\"height\":1000},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/mysterious-microproteins-have-major-implications-for-human-disease\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Mysterious microproteins have major implications for human disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de-DE\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de-DE\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Mysterious microproteins have major implications for human disease - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/de\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/","og_locale":"de_DE","og_type":"article","og_title":"Mysterious microproteins have major implications for human disease - Salk Institute for Biological Studies","og_description":"LA JOLLA\u2014As the tools to study biology improve, researchers are beginning to uncover details into microproteins, small components that appear to be key to some cellular processes, including those involved with cancer. Proteins are made up of chains of linked amino acids and the average human protein contains around 300 amino acids. Meanwhile, microproteins have fewer than 100 amino acids.","og_url":"https:\/\/www.salk.edu\/de\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/","og_site_name":"Salk Institute for Biological Studies","article_modified_time":"2024-01-30T22:47:04+00:00","og_image":[{"width":1000,"height":1000,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/","url":"https:\/\/www.salk.edu\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/","name":"Mysterious microproteins have major implications for human disease - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image.jpg","datePublished":"2019-10-24T07:00:28+00:00","dateModified":"2024-01-30T22:47:04+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/#breadcrumb"},"inLanguage":"de-DE","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/"]}]},{"@type":"ImageObject","inLanguage":"de-DE","@id":"https:\/\/www.salk.edu\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/#primaryimage","url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image.jpg","contentUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image.jpg","width":1000,"height":1000},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/mysterious-microproteins-have-major-implications-for-human-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Mysterious microproteins have major implications for human disease"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Salk-Institut f\u00fcr biologische Studien","description":"Die Macht der Wissenschaft","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"de-DE"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Salk-Institut f\u00fcr biologische Studien","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"de-DE","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"hero":"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/PIGBOS-image-header.jpg","line_1":"Mysterious microproteins have major implications for human disease","line_2":"Salk scientists discover how microprotein PIGBOS could be a target for cancer","poster_quote":"","paper_url":"https:\/\/www.nature.com\/articles\/s41467-019-12816-z","journal_title":"Nature Communications","paper_author_list":"Qian Chu, Thomas F. Martinez, Sammy Weiser Novak, Cynthia J. Donaldson, Dan Tan, Joan M. Vaughan, Tina Chang, Jolene K. Diedrich, Leo Andrade, Andrew Kim, Tong Zhang, Uri Manor, Alan Saghatelian","doi":"10.1038\/s41467-019-12816-z","paper_title":"Regulation of the ER stress response by a mitochondrial microprotein","subhead":"Salk scientists discover how microprotein PIGBOS could be a target for cancer","home_photo":"","listing_photo":"","legacy_boilerplate":[],"hide_boilerplate":[],"disable_date":false,"listing_excerpt":"","descriptive_blurb":"","has_journal_cover":false,"og_image_override":false,"gallery":false},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/24666","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":7,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/24666\/revisions"}],"predecessor-version":[{"id":24682,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/24666\/revisions\/24682"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/media\/24668"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/media?parent=24666"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/faculty?post=24666"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disease-research?post=24666"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}