{"id":2406,"date":"2013-01-23T00:00:00","date_gmt":"2013-01-23T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/salk-institute-awarded-historic-42-million-grant-from-the-helmsley-charitable-trust\/"},"modified":"2013-01-23T00:00:00","modified_gmt":"2013-01-23T08:00:00","slug":"salk-institute-awarded-historic-42-million-grant-from-the-helmsley-charitable-trust","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/salk-institute-awarded-historic-42-million-grant-from-the-helmsley-charitable-trust\/","title":{"rendered":"Salk Institute awarded historic $42 million grant from the Helmsley Charitable Trust"},"content":{"rendered":"

LA JOLLA, CA\u2014The Salk Institute for Biological Studies has received a $42 million gift-the largest in the Institute’s history-to establish the Helmsley Center for Genomic Medicine (HCGM), a research center dedicated to decoding the common genetic factors underlying many complex chronic human diseases.\n <\/p>\n

\nThe award, from the Die gemeinn\u00fctzige Stiftung von Leona M. und Harry B. Helmsley<\/a>, will support interdisciplinary research that paves the way to new therapies for chronic illnesses such as Krebs<\/a>, Diabetes<\/a> und Alzheimer’s disease<\/a>.\n <\/p>\n

\n“This remarkable gift reflects the strong partnership between Salk and the Helmsley Charitable Trust and their commitment that the Institute stay at the forefront of biomedical research,” said William R. Brody<\/a>, Salk president. “By working together, Salk and the Trust have successfully sculpted this unprecedented grant. It will provide vital funding to enable our scientists to pursue the kinds of transformative scientific discoveries and advancements that will have worldwide impact on people’s health for generations to come. With its scale and unique focus on supporting vitally important basic scientific research, the Helmsley Charitable Trust stands among philanthropy’s vanguard in promoting innovative cross-disciplinary initiatives such as this one.”\n <\/p>\n

\"The<\/p>\n

\n Left to right: Geoffrey Wahl, Marc Montminy, Jan Karlseder, Reuben Shaw, Fred Gage, William R. Brody, John Codey, Clodagh O’Shea, Inder Verma, Ronald Evans, Juan Carlos Izpisua Belmonte, Tony Hunter and Irwin Mark Jacobs.\n<\/p>\n

Bild: Mit freundlicher Genehmigung des Salk Institute for Biological Studies<\/p>\n<\/div>\n

\nJohn Codey, a trustee for the Helmsley Charitable Trust, said that the Trust decided to establish the center at Salk because of the Institute’s long track record of ground-breaking discoveries and the growing need to address chronic diseases.\n <\/p>\n

\n“Millions of people suffer from chronic illnesses, and these diseases are placing an unsustainable burden on our healthcare system,” Codey says. “The Helmsley Center for Genomic Medicine will help to address this by serving as an incubator for tomorrow’s clinical treatments and cures.”\n <\/p>\n

\nBroadly defined, genomic medicine is the science of using maps of human DNA-the genome-to understand how cells operate and generate new therapies for human disease. The Helmsley Center for Genomic Medicine (HCGM)will allow Salk researchers to use genomic data and powerful new technologies to decipher the molecular and genetic mechanisms that go awry in chronic disease.\n <\/p>\n

\nThe center will include scientists who are leaders in a range of biomedical research fields, including stem cell biology, endocrinology, cancer biology, metabolism,neurobiology, developmental biology, inflammation, and gene therapy. They will combine their efforts to understand how certain cellular pathways serve as lynchpins for chronic diseases, such as cancer,diabetes and neurodegenerative disorders. For instance, Salk researchers are finding that the cellular pathways involved in inflammation play a role in a range of diseases, including diabetes, heart disease and cancer. This suggests that developing therapies that address inflammation could help prevent and treat a broad range of disorders.\n <\/p>\n

\n The all-star team of Salk scientists includes Inder Verma<\/a>, Fred H. Gage<\/a>, Ronald Evans<\/a>, Juan Carlos Izpisua Belmonte<\/a>, Reuben Shaw<\/a> und Marc Montminy<\/a>.\n <\/p>\n

\n“The scientific collaborations fostered by HCGM will far exceed
\n the efforts of any individual participating laboratory,” says Salk scientist Inder Verma, project leader of the new partnership between Salk and the Helmsley Charitable Trust. “The state-of-the-art core facilities made possible by this grant will offer access to technology and support that no researcher could get on their own.”\n <\/p>\n

\nIn addition to charting the common genomic basis for chronic conditions and uncovering new potential targets for therapies, the center’s researchers will explore how genomic networks control stem cell development. This will allow researchers to manipulate genes to make stem cells useful for studying disease and regenerative medicine. The center will also explore how disease alters the epigenome, chemical switches on the DNA molecule which influences genetic activity, which may explain why patients with similar genetic profiles respond differently to treatment.\n <\/p>\n

\n“Chronic illness leads to distinctive changes at the genetic level and this gives us a new way to approach diagnosis and treatment,” says Ronald M. Evans, professor in Salk’s Gene Expression Laboratory. “HCGM will allow experts in cellular genetics and genomics to team up and seek out common molecular signatures of disease. Chronic diseases are complex, and to understand them you need to blend science, medicine and new advances in drug discovery by approaching them from different angles.”\n <\/p>\n

\nThe Helmsley Charitable Trust’s important gift is one of several major contributions made to Salk by the Trust. In 2009, the Trust issued a $5.5 million grant to found the
\nSalk Center for Nutritional Genomics<\/a> to study nutrition at the molecular level and its impact on the role of metabolism in diabetes, obesity, cancer, exercise physiology and lifespan. The Trust awarded an additional $15 million in 2010 to create a collaborative stem cell project involving Salk and Columbia University to fast-track the use of induced pluripotent stem cells to gain new insight into disease mechanisms and screen for novel therapeutic drugs.\n<\/p>\n

\n“Our philanthropic investment in Salk has produced tangible and impactful results, upon which this latest grant will build significantly,” says Codey. “With the Helmsley Center for Genomic Medicine we are partnering with Salk to tackle some of the most devastating diseases facing humankind.”\n<\/p>\n


\n\u00dcber das Salk Institute for Biological Studies:<\/strong>
\nDas Salk Institute for Biological Studies ist eine der weltweit f\u00fchrenden Institutionen f\u00fcr Grundlagenforschung, an der international renommierte Fakult\u00e4tsmitglieder grundlegende Fragen der Biowissenschaften in einem einzigartigen, kollaborativen und kreativen Umfeld untersuchen. Mit dem Fokus auf Entdeckungen und die Ausbildung zuk\u00fcnftiger Forschergenerationen leisten Salk-Wissenschaftler bahnbrechende Beitr\u00e4ge zu unserem Verst\u00e4ndnis von Krebs, Alterung, Alzheimer, Diabetes und Infektionskrankheiten durch die Untersuchung von Neurowissenschaften, Genetik, Zell- und Pflanzenbiologie sowie verwandten Disziplinen.\n<\/p>\n

\nDie Leistungen der Fakult\u00e4t wurden mit zahlreichen Auszeichnungen gew\u00fcrdigt, darunter Nobelpreise und Mitgliedschaften in der National Academy of Sciences. Das 1960 vom Polio-Impfstoff-Pionier Dr. Jonas Salk gegr\u00fcndete Institut ist eine unabh\u00e4ngige gemeinn\u00fctzige Organisation und ein architektonisches Wahrzeichen.\n<\/p>\n


\nAbout The Leona M. and Harry B. Helmsley Charitable Trust:<\/strong>
\nThe Leona M. and Harry B. Helmsley Charitable Trust aspires to improve lives by supporting effective nonprofits in a variety of selected areas. Since 2009, when the Trust began its active grant-making, it has committed approximately $800 million to a wide range of charitable organizations. For more information on the Trust and its programs, please visit the website, www.helmsleytrust.org<\/a>.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[],"disease-research":[127,46,123,124],"class_list":["post-2406","disclosure","type-disclosure","status-publish","hentry","disease-research-alzheimers-disease","disease-research-cancer-biology","disease-research-metabolism-and-diabetes","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nSalk Institute awarded historic $42 million grant from the Helmsley Charitable Trust - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/salk-institute-awarded-historic-42-million-grant-from-the-helmsley-charitable-trust\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk Institute awarded historic $42 million grant from the Helmsley Charitable Trust - 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