{"id":21055,"date":"2018-12-04T17:59:51","date_gmt":"2018-12-05T01:59:51","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=21055"},"modified":"2018-12-20T22:45:04","modified_gmt":"2018-12-21T06:45:04","slug":"nicola-allen-receives-2-5-million-chan-zuckerberg-initiative-early-career-award","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/nicola-allen-receives-2-5-million-chan-zuckerberg-initiative-early-career-award\/","title":{"rendered":"Nicola Allen erh\u00e4lt Auszeichnung fr\u00fchkarriere der Chan Zuckerberg Initiative in H\u00f6he von $2,5 Millionen Euro"},"content":{"rendered":"

LA JOLLA\u2014Nicola Allen<\/a>, Als Assistenzprofessor im Labor f\u00fcr Molekulare Neurobiologie des Salk Institute hat er einen f\u00fcnfj\u00e4hrigen, $2,5 Millionen US-Dollar schweren Ben Barres Early Career Acceleration Award von der Chan Zuckerberg Initiative<\/a> (CZI), als Teil einer $51,95 Millionen Dollar teuren Initiative zur Gr\u00fcndung des CZI Neurodegeneration Challenge Network. Dieses neue Netzwerk bringt experimentelle Wissenschaftler aus verschiedenen Forschungsbereichen \u2013 Neurowissenschaften, Zellbiologie, Biochemie, Immunologie und Genomik \u2013 sowie computergest\u00fctzte Biologen und \u00c4rzte zusammen, um die zugrunde liegenden Ursachen von Krankheiten wie Alzheimer, Parkinson, Huntington und ALS zu verstehen.<\/p>\n

Im Rahmen der Bem\u00fchungen des Netzwerks, die grundlegende Biologie dessen zu verstehen, was diese Krankheiten verursacht und wie sie fortschreiten, wird Allen die Rolle von Gehirnzellen namens Astrozyten untersuchen. Diese sternf\u00f6rmigen Unterst\u00fctzungszellen wurden k\u00fcrzlich als entscheidend f\u00fcr die Gesundheit des Gehirns identifiziert, und weitere Einblicke in ihre Aktivit\u00e4ten k\u00f6nnten Details zu m\u00f6glichen Ursachen \u2013 und Behandlungen \u2013 f\u00fcr Demenz aufdecken.<\/p>\n

\"Nicola
Nicola Allen<\/p>\n

Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild.<\/p>\n

Kredit: Salk Institut<\/figcaption><\/figure>\n

\u201cNat\u00fcrlich ist Nikolas Fachwissen, das viel dringender ben\u00f6tigte Aufmerksamkeit auf Astrozyten als wichtige Akteure in der Gehirnentwicklung und -funktion lenkt\u201d, sagt der Salk-Pr\u00e4sident und Neurowissenschaftler Rusty Gage. \u201cDie Alzheimer-Krankheit und andere neurodegenerative Erkrankungen sind f\u00fcr die Gesellschaft verheerend. Mit Unterst\u00fctzung durch Initiativen wie die Chan Zuckerberg Initiative hoffen wir, dass wir endlich greifbare Fortschritte bei der Aufdeckung der Mechanismen dieser Krankheiten und potenzieller Angriffspunkte f\u00fcr Therapien erzielen k\u00f6nnen.\u201d<\/p>\n

Neurodegenerative Erkrankungen, darunter Alzheimer, Parkinson, Chorea Huntington und ALS, sind eine Klasse von Krankheiten, die Millionen von Menschen weltweit betreffen. Allein die Alzheimer-Krankheit ist die f\u00fcnftth\u00e4ufigste Todesursache f\u00fcr Amerikaner \u00fcber 65<\/a>, und die Zahl der Menschen mit Alzheimer und verwandten Demenzerkrankungen wird voraussichtlich bis 2060 von 5 Millionen auf 14 Millionen Menschen fast verdreifacht werden. In der Zwischenzeit sind die Ursachen der meisten neurodegenerativen Erkrankungen nur teilweise bekannt, und es gibt noch keine wirksamen Therapien, um die meisten dieser Erkrankungen zu heilen, zu verhindern oder auch nur zu behandeln.<\/p>\n

\u201cTrotz enormer Investitionen und Fortschritte im Verst\u00e4ndnis dieser Krankheiten gibt es \u00fcberraschend viele grundlegende Informationen \u00fcber ihre Biologie, die wir noch nicht kennen\u201d, sagt Katja Brose, CZI Science Program Officer. \u201cDurch die Unterst\u00fctzung dieser interdisziplin\u00e4ren Kooperationen und die Schaffung gemeinsamer Werkzeuge, Ressourcen und Plattformen hoffen wir, einen neuen Ansatz zur Bek\u00e4mpfung neurodegenerativer Erkrankungen zu inspirieren \u2013 einen, der die kombinierte Kraft von Grundlagenforschung und Technologie nutzt, um den Fortschritt in Richtung klinischer Ziele zu beschleunigen.\u201d<\/p>\n

Als einen Ansatz zum Verst\u00e4ndnis von Neurodegeneration taucht Allen tief in die Frage ein, wie Astrozyten neuronale Verbindungen beeinflussen, mit dem Ziel, neue Wege zur Reparatur gesch\u00e4digter Verbindungen zu entwickeln, um kognitive Funktionen und Ged\u00e4chtnis zu verbessern. Sie entdeckte k\u00fcrzlich, dass Ein von Astrozyten produziertes Protein erm\u00f6glicht die Reifung des Gehirns und reguliert dessen Flexibilit\u00e4t<\/a> (Neuron<\/em>, Oktober 2018) sowie wie Gene, die zu Beginn der Gehirnentwicklung zur Beschneidung neuronaler Verbindungen eingeschaltet werden, bei alternden Astrozyten wieder aktiviert werden<\/a> (Cell Reports<\/em>, Januar 2018). Zuvor enth\u00fcllte sie in Neuron<\/em> Letztes Jahr Wie Astrozyten Neuronen helfen, erfolgreiche Verbindungen zu bilden<\/a>. Allen ist auch Teil eines neu gestarteten $19,2 Millionen Dollar umfassenden Projekts der American Heart Association-Allen Initiative, das 10 Labore des Salk Institute unterst\u00fctzt, um eine umfassende, multidisziplin\u00e4re Untersuchung der Mechanismen zu erm\u00f6glichen, die der Alzheimer-Krankheit und dem altersbedingten kognitiven Verfall zugrunde liegen.<\/p>\n

\u00dcber die Chan Zuckerberg Initiative: <\/strong>
\nDie Chan Zuckerberg Initiative wurde im Dezember 2015 von Mark Zuckerberg, Gr\u00fcnder und CEO von Facebook, und Priscilla Chan, Kinder\u00e4rztin sowie Gr\u00fcnderin und CEO von The Primary School in East Palo Alto, ins Leben gerufen. Die Chan Zuckerberg Initiative ist eine neue Art der Philanthropie, die darauf abzielt, Ver\u00e4nderungen im gro\u00dfen Ma\u00dfstab zu bewirken. Durch die Kombination von erstklassigem Engineering mit Zusch\u00fcssen, Impact Investing sowie Politik- und Lobbyarbeit hofft die CZI, eine Zukunft f\u00fcr alle zu gestalten. Zu den anf\u00e4nglichen Schwerpunkten geh\u00f6ren die Unterst\u00fctzung der Wissenschaft durch biomedizinische Grundlagenforschung und Bildung durch personalisiertes Lernen. Die CZI pr\u00fcft au\u00dferdem M\u00f6glichkeiten, Hindernisse f\u00fcr Gerechtigkeit und Chancen zu \u00fcberwinden \u2013 von der Strafrechtsreform \u00fcber den erweiterten Zugang bis hin zu wirtschaftlichen Chancen und bezahlbarem Wohnraum.<\/p>\n

\u00dcber die Ben Barres Early Career Acceleration Awards:<\/strong>
\nDie Ben Barres Early Career Acceleration Awards von CZI, benannt nach dem verstorbenen Ben Barres<\/a>, einer amerikanischen Neurobiologin und leidenschaftlichen F\u00fcrsprecherin f\u00fcr Nachwuchswissenschaftler, Frauen, Mentoring und Vielfalt in der Wissenschaft, wird Nachwuchswissenschaftler in ihrer fr\u00fchen Karriere unterst\u00fctzen \u2013 insbesondere diejenigen, die neu im Bereich der Neurodegeneration sind. CZI vergibt insgesamt $42,5 Millionen f\u00fcr diese Auszeichnungen. Jeder der 17 ausgew\u00e4hlten Wissenschaftler erh\u00e4lt $2,5 Millionen und profitiert zudem von der wissenschaftlichen und beruflichen Betreuung sowie der kollaborativen Unterst\u00fctzung des Challenge Network.<\/p>","protected":false},"featured_media":21062,"template":"","faculty":[81],"disease-research":[124],"class_list":["post-21055","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-nicola-allen","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nNicola Allen receives $2.5 million Chan Zuckerberg Initiative early career award - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/nicola-allen-receives-2-5-million-chan-zuckerberg-initiative-early-career-award\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nicola Allen receives $2.5 million Chan Zuckerberg Initiative early career award - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Nicola Allen, an assistant professor in Salk’s Molecular Neurobiology Laboratory, has received a five-year, $2.5 million Ben Barres Early Career Acceleration Award from the Chan Zuckerberg Initiative (CZI), as part of a $51.95 million effort launching the CZI Neurodegeneration Challenge Network. 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