{"id":2075,"date":"2011-02-03T00:00:00","date_gmt":"2011-02-03T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/stem-cell-leader-awarded-2-3-million-grant-for-parkinsons\/"},"modified":"2016-01-18T10:16:10","modified_gmt":"2016-01-18T18:16:10","slug":"stem-cell-leader-awarded-2-3-million-grant-for-parkinsons","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/stem-cell-leader-awarded-2-3-million-grant-for-parkinsons\/","title":{"rendered":"Stem cell leader awarded $2.3 million grant for Parkinson’s"},"content":{"rendered":"

LA JOLLA, CA\u2014The Salk Institute has been awarded a $2.3 million grant by the California Institute for Regenerative Medicine (CIRM) for translational research focusing on developing a novel stem cell based therapy for Parkinson’s disease.\n<\/p>\n

\nThe research will concentrate on studying human induced pluripotent stem (iPS) cells derived from patients suffering from Parkinson’s disease to replicate the disorder in the lab and investigate the role of inflammation in the cause and progression of the neurodegeneration typical of the disease.\n<\/p>\n

\nLed by <\/faculty\/gage.html\">Fred H. Gage<\/a>, Ph.D., a professor in the Salk’s Laboratory of Genetics and holder of the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases, the grant will fund a joint effort between Salk researchers, the team of Christopher Glass, Ph.D., a professor of Medicine and Cellular and Molecular Medicine at the University of California, San Diego, and international collaborators in Germany.\n<\/p>\n

\"dopaminergic<\/p>\n

These images show dopaminergic neurons, the cell type implicated in Parkinson’s Disease, differentiated from human pluripotent stem cells.\n<\/p>\n

\n Image: Courtesy of Leah Boyer, Salk Institute for Biological Studies\n<\/p>\n<\/div>\n

\nParkinson’s disease is a chronic, progressive neurological disease that usually occurs later in life and is linked to decreased dopamine production, the chemical messenger involved in communication between the brain and the muscles. The most common neurodegenerative movement disorder, Parkinson’s disease is characterized by motor impairment such as slowness of movements, shaking and gait disturbances.\n<\/p>\n

\n“Given that age is the most consistent risk factor for Parkinson’s, and we have an aging population, it is of utmost importance that we unravel the cellular, molecular, and genetic causes of the highly specific cell death characteristic of the disease and find new therapies to limit the social, economic and emotional impact,” said Gage.\n<\/p>\n

\nMost studies to find better drugs to treat Parkinson’s disease were done with mice and often failed when tested in patients. In the past, scientists had been limited to study the brains of people with Parkinson’s disease via imaging technologies or postmortem brain tissues. Now, the ability to obtain iPS cells from patients’ skin cells, which can be reprogrammed into neurons provides researchers with a model to study the pathological development of Parkinson’s in a human system.\n<\/p>\n

\nThe main goal of the collaborative effort is to identify key molecular events involved in the early stages of the disease, which can be exploited as potential points of therapeutic intervention.\n<\/p>\n

\n“This is an extremely exciting development – the ability to create stem cells from skin cells taken from patients with Parkinson’s disease, then use those stem cells to create networks of neurons which can then be studied to give clues about the abnormal function of nerve cells in this debilitating disease – that would never have been conceived, let alone come to fruition, without the significant investment in regenerative medicine by CIRM,” said Salk president William R. Brody, M.D., Ph.D.\n<\/p>\n


\n\u00dcber das Salk Institute for Biological Studies:<\/strong>
\nDas Salk Institute for Biological Studies ist eine der weltweit f\u00fchrenden Institutionen f\u00fcr Grundlagenforschung, an der international renommierte Fakult\u00e4tsmitglieder grundlegende Fragen der Biowissenschaften in einem einzigartigen, kollaborativen und kreativen Umfeld untersuchen. Mit dem Fokus auf Entdeckungen und die Ausbildung zuk\u00fcnftiger Forschergenerationen leisten Salk-Wissenschaftler bahnbrechende Beitr\u00e4ge zu unserem Verst\u00e4ndnis von Krebs, Alterung, Alzheimer, Diabetes und Infektionskrankheiten durch die Untersuchung von Neurowissenschaften, Genetik, Zell- und Pflanzenbiologie sowie verwandten Disziplinen.\n<\/p>\n

\nDie Leistungen der Fakult\u00e4t wurden mit zahlreichen Auszeichnungen gew\u00fcrdigt, darunter Nobelpreise und Mitgliedschaften in der National Academy of Sciences. Das 1960 vom Polio-Impfstoff-Pionier Dr. Jonas Salk gegr\u00fcndete Institut ist eine unabh\u00e4ngige gemeinn\u00fctzige Organisation und ein architektonisches Wahrzeichen.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[76],"disease-research":[],"class_list":["post-2075","disclosure","type-disclosure","status-publish","hentry","faculty-rusty-gage"],"acf":[],"yoast_head":"\nStem cell leader awarded $2.3 million grant for Parkinson's - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/stem-cell-leader-awarded-2-3-million-grant-for-parkinsons\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stem cell leader awarded $2.3 million grant for Parkinson's - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA, CA\u2014The Salk Institute has been awarded a $2.3 million grant by the California Institute for Regenerative Medicine (CIRM) for translational research focusing on developing a novel stem cell based therapy for Parkinson’s disease.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/de\/news-release\/stem-cell-leader-awarded-2-3-million-grant-for-parkinsons\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2016-01-18T18:16:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/stem-cell-leader-awarded-2-3-million-grant-for-parkinsons\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/stem-cell-leader-awarded-2-3-million-grant-for-parkinsons\\\/\",\"name\":\"Stem cell leader awarded $2.3 million grant for Parkinson's - 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