{"id":2068,"date":"2011-01-04T00:00:00","date_gmt":"2011-01-04T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/salk-institute-and-sanford-burnham-study-selected-most-cited-paper-in-molecular-biology-genetics\/"},"modified":"2011-01-04T00:00:00","modified_gmt":"2011-01-04T08:00:00","slug":"salk-institute-and-sanford-burnham-study-selected-most-cited-paper-in-molecular-biology-genetics","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/salk-institute-and-sanford-burnham-study-selected-most-cited-paper-in-molecular-biology-genetics\/","title":{"rendered":"Salk Institute and Sanford-Burnham study selected most-cited paper in Molecular Biology &#038; Genetics"},"content":{"rendered":"<p>LA JOLLA, CA\u2014A collaborative paper by <a href=\"\/de\/faculty\/young.html\/\">John A.T. Young<\/a>, Ph.D., Nomis Foundation professor at the Salk Institute for Biological Studies and Sumit Chanda, Ph.D., associate professor at Sanford-Burnham Institute, has been identified by <em>Science Watch\u00ae<\/em> as the most-cited paper in the category of Molecular Biology &#038; Genetics and is currently featured as a Fast-Moving Front paper on their website.\n<\/p>\n<p>\nThe paper titled <em>&#8220;Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication&#8221;<\/em> published in October 3, 2008 issue of <em>Zelle<\/em> provided new insight into how the human immunodeficiency virus (HIV) exploits cellular functions and becomes entrenched in infected cells.\n<\/p>\n<div class=\"imageCaption\"><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2011\/01\/CELLcover.jpg\" alt=\"Cell Cover\" width=\"300\"><\/p>\n<p>The human immunodeficiency virus (HIV) only brings along a minimalist&#8217;s survival gear \u2013 just nine genes, coding for 15 proteins \u2013 and relies on its host cell to provide what&#8217;s missing.\n<\/p>\n<p>\nImage courtesy of Dr. John Young, Salk Institute for Biological Studies\n<\/p>\n<\/div>\n<p>\nThe study combined several layers of genome-wide analysis and identified 295 host cell factors proteins that aid the virus in establishing an infection and, for the first time, provided a physical and genetic map of host-pathogen interactions that are required for a virus to replicate in a host cell. Their study could lead to the development of a new class of HIV therapeutics aimed at disrupting the human-HIV interactions that lead to viral infection.\n<\/p>\n<p>\n&#8220;This was one of the first studies to combine genome-wide RNAi screening and bioinformatics to identify the range of host cellular factors that help facilitate HIV replication in human cells,&#8221; said Young, who heads the Nomis Center for Immunobiology and Microbial Pathogenesis. &#8220;It represents a significant advance in our understanding of viral-host interactions by providing a blueprint of the machinery that is exploited by the virus. This information provides a clearer understanding of the many ways that our cells contribute to HIV replication and also suggests new approaches for developing antiviral treatments.&#8221;\n<\/p>\n<p>\nClick to read the <a href=\"http:\/\/sciencewatch.com\/dr\/fmf\/2011\/11janfmf\/11janfmfYounET\/\"><em>Science Watch\u00ae<\/em> interview with John A.T. Young and Sumit Chanda<\/a>.\n<\/p>\n<p><strong><br \/>\nFast moving research fronts:<\/strong>\n<\/p>\n<p>\n<em>Science Watch\u00ae<\/em>, produced by Thomson Reuters in Philadelphia, creates a picture of the state of a specific research area by looking at the papers that constitute its core of seminal work.? Research areas in science, particularly those at the cutting edge of their fields, are characterized by patterns of intense communication between scientists. This communication manifests itself in various ways, both formally and informally, but prominent among these are citations of one scientist&#8217;s work by another.\n<\/p>\n<p>\nBy identifying the most-cited papers within a discipline over a sliding six-year period, and then determining how often these papers have been jointly cited, a set of core papers emerges. Fast Moving Fronts are those having the largest percentage increase in number of core papers from one period to the next in their respective fields.\n<\/p>\n<p><strong><br \/>\n\u00dcber das Salk Institute for Biological Studies:<\/strong><br \/>\nDas Salk Institute for Biological Studies ist eine der weltweit f\u00fchrenden Institutionen f\u00fcr Grundlagenforschung, an der international renommierte Fakult\u00e4tsmitglieder grundlegende Fragen der Biowissenschaften in einem einzigartigen, kollaborativen und kreativen Umfeld untersuchen. Mit dem Fokus auf Entdeckungen und die Ausbildung zuk\u00fcnftiger Forschergenerationen leisten Salk-Wissenschaftler bahnbrechende Beitr\u00e4ge zu unserem Verst\u00e4ndnis von Krebs, Alterung, Alzheimer, Diabetes und Infektionskrankheiten durch die Untersuchung von Neurowissenschaften, Genetik, Zell- und Pflanzenbiologie sowie verwandten Disziplinen.\n<\/p>\n<p>\nDie Leistungen der Fakult\u00e4t wurden mit zahlreichen Auszeichnungen gew\u00fcrdigt, darunter Nobelpreise und Mitgliedschaften in der National Academy of Sciences. Das 1960 vom Polio-Impfstoff-Pionier Dr. Jonas Salk gegr\u00fcndete Institut ist eine unabh\u00e4ngige gemeinn\u00fctzige Organisation und ein architektonisches Wahrzeichen.\n<\/p>\n<p><strong><br \/>\nAbout Sanford-Burnham Medical Research Institute<\/strong><br \/>\nSanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. Sanford-Burnham, with operations in California and Florida, is one of the fastest-growing research institutes in the country. The Institute ranks among the top independent research institutions nationally for NIH grant funding and among the top organizations worldwide for its research impact. From 1999 \u2013 2009, Sanford-Burnham ranked #1 worldwide among all types of organizations in the fields of biology and biochemistry for the impact of its research publications, defined by citations per publication, according to the Institute for Scientific Information.  According to government statistics, Sanford-Burnham ranks #2 nationally among all organizations in capital efficiency of generating patents, defined by the number of patents issued per grant dollars awarded.\n<\/p>\n<p>\nSanford-Burnham utilizes a unique, collaborative approach to medical research and has established major research programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases.  The Institute is especially known for its world-class capabilities in stem cell research and drug discovery technologies. Sanford-Burnham is a nonprofit public benefit corporation. For more information, please visit www.sanfordburnham.org.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[],"disease-research":[],"class_list":["post-2068","disclosure","type-disclosure","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Salk Institute and Sanford-Burnham study selected most-cited paper in Molecular Biology &amp; Genetics - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/salk-institute-and-sanford-burnham-study-selected-most-cited-paper-in-molecular-biology-genetics\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk Institute and Sanford-Burnham study selected most-cited paper in Molecular Biology &amp; Genetics - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA, CA\u2014A collaborative paper by John A.T. 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