{"id":2062,"date":"2010-12-07T00:00:00","date_gmt":"2010-12-07T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/melanopsin-looks-on-the-bright-side-of-life\/"},"modified":"2010-12-07T00:00:00","modified_gmt":"2010-12-07T08:00:00","slug":"melanopsin-looks-on-the-bright-side-of-life","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/melanopsin-looks-on-the-bright-side-of-life\/","title":{"rendered":"Melanopsin looks on the bright side of life"},"content":{"rendered":"<p>LA JOLLA, CA\u2014Better known as the light sensor that sets the body&#8217;s biological clock, melanopsin also plays an important role in vision: Via its messengers-so-called melanopsin-expressing retinal ganglion cells, or mRGCs-it forwards information about the brightness of incoming light directly to conventional visual centers in the brain, reports an international collaboration of scientists in this week&#8217;s issue of <em>PLoS Biology<\/em>.\n<\/p>\n<p>\nThe findings reveal a new role for mRGCs during image-forming vision and suggest that these cells could make a significant contribution to assessing the intensity of light and supporting vision even in people with advanced retinal degeneration, the researchers say.\n<\/p>\n<div class=\"imageCaption\"><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/453_Melanopsin-Panda.jpg\" alt=\"Melanopsin\" \/><\/p>\n<p>Melanopsin, a light receptor that measures the intensity of incoming light is found in rare, specialized cells embedded in the retina. The different colors corresponds to different depths of the imaged tissue sample.<\/p>\n<p>\nImage: Courtesy of Dr. Satchin Panda, Salk Institute for Biological Studies and Dr. James Fitzpatrick, Waitt Advanced Biophotonics Center\n<\/p>\n<\/div>\n<p>\n&#8220;Millions of people worldwide suffer varying degrees of blindness because of rod and cone degeneration or dysfunction, but many of them can still perceive differences in brightness,&#8221; says senior author <a href=\"\/de\/faculty\/panda.html\/\">Satchidananda (Satchin) Panda<\/a>, Ph.D., an assistant professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies. &#8220;Melanopsin-expressing RGCs typically survive even complete rod and cone loss and could explain the light responses under these conditions,&#8221; he adds.\n<\/p>\n<p>\nFor the greater part of 100 years, it was thought that the ability to convert light into electrical signals in the mammalian retina was restricted to only two types of photoreceptors: rods and cones. This view changed dramatically when Panda discovered the existence of a third type of mammalian photoreceptor, which is only present in a few thousand cells embedded in the deeper layers of the retina.\n<\/p>\n<p>\nMelanopsin, a photopigment that measures the intensity of incoming light, is fundamentally different from the classical rod and cone opsins, which help us see. For one, it is much less sensitive to light and has far less spatial resolution-characteristics that fit perfectly with this light sensor&#8217;s primary function of signaling changes in ambient light levels to the brain throughout the day.\n<\/p>\n<div class=\"imageCaption\"><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/453_pandaimage2hr.jpg\" alt=\"Melanopsin\" \/><\/p>\n<p>Melanopsin-expressing retinal ganglion cells extend their axons-long, slender projections that connect with other neurons-all the way to the primary processing center for visual information received from the brain.<\/p>\n<p>\n Image: Courtesy of Dr. Satchin Panda, Salk Institute for Biological Studies and Dr. James Fitzpatrick, Waitt Advanced Biophotonics Center\n<\/p>\n<\/div>\n<p>\nIt sends its signals directly to the human circadian clock, which sits just above the point where the optic nerves cross. Although only half the size of a pencil eraser, it synchronizes the body&#8217;s daily rhythms with the rising and setting of the sun, telling the body when it is time to go to sleep, when to be hungry and when to wake up.  But it does more than that. Just like a meter in a camera that allows the aperture to be adjusted, mRGCs also control pupil size.\n<\/p>\n<p>\nUntil now, however, it was unknown whether mRGCs also contribute to conventional image-forming vision, especially the as-yet poorly understood mechanism of &#8220;brightness&#8221; and &#8220;lightness&#8221; perception.\n<\/p>\n<p>\nTo find out, Panda and his collaborators at the University of Manchester traced individual mRGCs&#8217; axons-long, slender projections that connect with other neurons-from the retina through the circadian clock and onward. They discovered that the axons reached all the way to the LGN, short for lateral geniculate nucleus, the primary processing center for visual information received from the retina.\n<\/p>\n<p>\n&#8220;We found widespread light responses in the LGN and visual cortex, even in mice lacking functional rods and cones, which are often used as a model of advanced retinal degeneration,&#8221; says Panda, who hopes that one day it might be possible to impart vision to blind individuals by gene therapy with a re-engineered melanopsin.\n<\/p>\n<p>\n&#8220;The density of mRGCs in the retina is too low for any meaningful resolution,&#8221; he says. &#8220;But if we could express melanopsin in a greater number of cells, we might be able to increase resolution to a point that allows blind people to safely navigate their environment.&#8221;\n<\/p>\n<p>\nResearchers who also contributed to the work include Timothy M. Brown, John Gigg and Robert J. Lucas at the University of Manchester, Manchester, United Kingdom; Carlos Gias, Ma&#8217;ayan Semo and Peter J. Coffey at University College London, London, United Kingdom; as well as Megumi Hatori, and Sheena Rachel Keding at the Salk Institute for Biological Studies in La Jolla.\n<\/p>\n<p>\nThe work was funded by grants from the Wellcome Trust, the National Institutes of Health, the Dana Foundation, a Pew Scholar award and the London Project to Cure Blindness.\n<\/p>\n<p>\n<strong>\u00dcber das Salk Institute for Biological Studies:<\/strong><br \/>\nDas Salk Institute for Biological Studies ist eine der weltweit f\u00fchrenden Institutionen f\u00fcr Grundlagenforschung, an der international renommierte Fakult\u00e4tsmitglieder grundlegende Fragen der Biowissenschaften in einem einzigartigen, kollaborativen und kreativen Umfeld untersuchen. Mit dem Fokus auf Entdeckungen und die Ausbildung zuk\u00fcnftiger Forschergenerationen leisten Salk-Wissenschaftler bahnbrechende Beitr\u00e4ge zu unserem Verst\u00e4ndnis von Krebs, Alterung, Alzheimer, Diabetes und Infektionskrankheiten durch die Untersuchung von Neurowissenschaften, Genetik, Zell- und Pflanzenbiologie sowie verwandten Disziplinen.\n<\/p>\n<p>\nDie Leistungen der Fakult\u00e4t wurden mit zahlreichen Auszeichnungen gew\u00fcrdigt, darunter Nobelpreise und Mitgliedschaften in der National Academy of Sciences. Das 1960 vom Polio-Impfstoff-Pionier Dr. Jonas Salk gegr\u00fcndete Institut ist eine unabh\u00e4ngige gemeinn\u00fctzige Organisation und ein architektonisches Wahrzeichen.\n<\/p>\n<p>\nThe Salk Institute proudly celebrates five decades of scientific excellence in basic research.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[105],"disease-research":[],"class_list":["post-2062","disclosure","type-disclosure","status-publish","hentry","faculty-satchidananda-panda"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Melanopsin looks on the bright side of life - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/melanopsin-looks-on-the-bright-side-of-life\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Melanopsin looks on the bright side of life - 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