{"id":1854,"date":"2008-03-24T00:00:00","date_gmt":"2008-03-24T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/salk-scientist-wins-2007-young-investigators-award-in-gene-therapy-for-cancer\/"},"modified":"2008-03-24T00:00:00","modified_gmt":"2008-03-24T07:00:00","slug":"salk-scientist-wins-2007-young-investigators-award-in-gene-therapy-for-cancer","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/salk-scientist-wins-2007-young-investigators-award-in-gene-therapy-for-cancer\/","title":{"rendered":"Salk-Wissenschaftler gewinnt 2007 den Young Investigator's Award f\u00fcr Gentherapie gegen Krebs"},"content":{"rendered":"

La Jolla, CA \u2013 Dr. Clodagh O\u2019Shea<\/a>, $, eine Assistenzprofessorin am Labor f\u00fcr Molekular- und Zellbiologie am Salk Institute for Biological Studies, wurde mit dem Young Investigator\u2019s Award in Gen-Therapie f\u00fcr Krebs 2007 ausgezeichnet. Sie erh\u00e4lt $ 500.000 \u00fcber einen Zeitraum von drei Jahren, um die \u201cOnkolytischen Adenoviren der n\u00e4chsten Generation f\u00fcr die p53-selektive Tumortherapie\u201d zu entwickeln.\u201d<\/p>\n

Established in 1986 by the Alliance for Cancer Gene Therapy, the Young Investigator’s Award in Gene Therapy for Cancer supports innovative efforts aimed at furthering the development of gene therapy approaches for the treatment of cancer.<\/p>\n

Most commonly used chemotherapies are little more than DNA poisons that slow down tumor growth but do not ultimately cure patients. Chemotherapy also has devastating side effects, which is especially tragic in children. There is a desperate need to identify new drugs and therapeutic modalities that conclusively ablate cancer cells but leave normal cells unharmed.<\/p>\n

The p53 tumor suppressor pathway is inactivated by mutations in almost every cancer and yet there are no drugs that specifically target p53 defective tumors. O’Shea is working on the development of viruses that act as p53 mutation-guided missiles, which unerringly home in on cancer cells throughout the body and implode them from the inside.<\/p>\n

Such oncolytic viruses offer a novel and potentially self-perpetuating cancer therapy: Each time a virus infects a cancer cell and successfully multiplies, the virus ultimately kills the cancer cell by bursting it open to release thousands of viral progenies, which are ready to seek out remaining tumor cells and distant micro-metastases.<\/p>\n

Probably no new therapy on the horizon holds more promise than ‘oncolytic viruses’, which have the potential to help save the lives of many cancer patients.<\/p>\n

About Clodagh O’Shea<\/h3>\n

Born and raised in Cork, Ireland, O’Shea earned her bachelor’s degree in Biochemistry and Microbiology from the University College Cork, Ireland and her doctorate in Immunology from the Imperial Cancer Research Fund (ICRF)\/Imperial College London, England. After completing a postdoctoral research fellowship at the University of California in San Francisco, she was recruited to the Salk Institute in La Jolla in 2007.<\/p>\n

About the Alliance for Cancer Gene Therapy<\/h3>\n

Founded in 2001, the Alliance for Cancer Gene Therapy is built on the premise that molecular medicine is the new paradigm to treat disease. Since its inception, the Alliance’s declared goal is to promote gene therapy to combat cancer. To this end, ACGT identifies, funds and monitors innovative research that meets a rigorous set of scientific standards and has the potential, in the foreseeable future, to treat cancers of all types.<\/p>\n

\u00dcber das Salk Institute<\/h3>\n

Das Salk Institute for Biological Studies in La Jolla, Kalifornien, ist eine unabh\u00e4ngige gemeinn\u00fctzige Organisation, die sich grundlegenden Entdeckungen in den Biowissenschaften, der Verbesserung der menschlichen Gesundheit und der Ausbildung zuk\u00fcnftiger Forschergenerationen widmet. Jonas Salk, M.D., dessen Polio-Impfstoff die l\u00e4hmende Kinderl\u00e4hmung im Jahr 1955 fast ausgerottet hat, er\u00f6ffnete das Institut 1965 mit einer Landschenkung der Stadt San Diego und der finanziellen Unterst\u00fctzung der March of Dimes.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[104],"disease-research":[],"class_list":["post-1854","disclosure","type-disclosure","status-publish","hentry","faculty-clodagh-oshea"],"acf":[],"yoast_head":"\nSalk scientist wins 2007 Young Investigator's Award in Gene Therapy for Cancer - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/salk-scientist-wins-2007-young-investigators-award-in-gene-therapy-for-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk scientist wins 2007 Young Investigator's Award in Gene Therapy for Cancer - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"La Jolla, CA \u2013 Dr. Clodagh O’Shea, an assistant professor in the Molecular and Cellular Biology Laboratory at the Salk Institute for Biological Studies, has been selected for the 2007 Young Investigator’s Award in Gene Therapy for Cancer. 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