{"id":16834,"date":"2018-03-06T09:49:53","date_gmt":"2018-03-06T17:49:53","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=16834"},"modified":"2024-01-30T15:20:07","modified_gmt":"2024-01-30T23:20:07","slug":"salk-scientists-find-power-switch-muscles","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/de\/news-release\/salk-scientists-find-power-switch-muscles\/","title":{"rendered":"Salk-Wissenschaftler finden Schalter f\u00fcr Muskeln"},"content":{"rendered":"

LA JOLLA \u2013 Wenn Sie sich jemals gefragt haben, wie sich anstrengendes Training in bessere Ausdauer umwandelt, haben Forscher des Salk Institute vielleicht Ihre Antwort. In einer Studie, die in der Zeitschrift ver\u00f6ffentlicht wurde Cell Reports<\/em><\/a> am 6. M\u00e4rz 2018, Wissenschaftler in Ronald Evans\u2019<\/a> Labore haben gezeigt, dass das Protein ERR\u03b3 (ERR gamma) dabei hilft, viele der Vorteile zu liefern, die mit Ausdauertraining verbunden sind.<\/p>\n

\"Top
Oben links: Ein Mangel an PGC1 f\u00fchrt zu schweren Muskelsch\u00e4den, belegt durch zahlreiche zentralisierte Kerne (hervorgehoben mit Pfeilen), was wahrscheinlich auf eine beeintr\u00e4chtigte mitochondriale Energieverstoffwechselung zur\u00fcckzuf\u00fchren ist (unten links: blaue F\u00e4rbung zeigt beeintr\u00e4chtigte mitochondriale Aktivit\u00e4t). Solche Muskelsch\u00e4den und mitochondriale Beeintr\u00e4chtigung werden durch ERR\u03b3-\u00dcberexpression weitgehend behoben (oben und unten rechts). <\/p>\n

Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild. <\/p>\n

Kredit: Salk Institut<\/figcaption><\/figure>\n

\u201cERR\u03b3 macht Ausdauertraining m\u00f6glich\u201d, sagt Ronald Evans, Professor und Direktor des Gene Expression Laboratory sowie Co-Seniorautor der Arbeit. \u201cEs r\u00fcstet die energieerzeugenden Zellkraftwerke, bekannt als Mitochondrien, auf, schafft mehr Blutgef\u00e4\u00dfe, um Sauerstoff zuzuf\u00fchren, Giftstoffe abzuf\u00fchren und Sch\u00e4den im Zusammenhang mit der Muskelnutzung zu reparieren. Dies macht ERR\u03b3 zu einem wirklich interessanten potenziellen therapeutischen Ziel f\u00fcr Erkrankungen mit geschw\u00e4chten Muskeln.\u201d<\/p>\n

Die Geschichte beginnt mit den Proteinen PGC1\u03b1 und PGC1\u03b2, die 20 weitere Proteine stimulieren, die mit der Energieversorgung des Skelettmuskels und Ausdauer\u00fcbungen assoziiert sind, darunter ERR\u03b3 aus dem Evans-Labor. ERR\u03b3, ein Hormonrezeptor, schaltet wiederum Gene ein. Die Forscher des Evans-Labors wollten die Rolle von ERR\u03b3 bei der Energieproduktion des Skelettmuskels genau verstehen und wie sich dies auf die k\u00f6rperliche Ausdauer auswirkt.<\/p>\n

Um diese Beziehung zu entschl\u00fcsseln, untersuchte das Salk-Team M\u00e4use ohne PGC1\u03b1\/\u03b2. Bei einigen erh\u00f6hten sie ERR\u03b3 selektiv in Skelettmuskelzellen. Dieser Ansatz erm\u00f6glichte es ihnen, zu messen, wie ERR\u03b3 und PGC1 unabh\u00e4ngig voneinander wirken, sowie wie sie in Kombination funktionieren.<\/p>\n

Der Verlust von PGC1 hatte negative Auswirkungen auf die Muskelleistung und Ausdauer. Die Erh\u00f6hung von ERR\u03b3 stellte jedoch die Funktion wieder her. Das Team stellte fest, dass ERR\u03b3 f\u00fcr die Energieproduktion unerl\u00e4sslich ist, indem es Gene aktiviert, die mehr Mitochondrien bilden. Mit anderen Worten, sie fanden den Ein-Schalter f\u00fcr die Skelettmuskulatur.<\/p>\n

Das Labor zeigte auch, dass eine erh\u00f6hte ERR\u03b3-Expression bei PGC1-defizienten M\u00e4usen ihre sportliche Leistung steigerte. Durch Messung des freiwilligen Laufrad-Laufs stellten sie fest, dass die Erh\u00f6hung der ERR\u03b3-Expression zu einer Verf\u00fcnffachung der Zeit f\u00fchrte, die mit Sport verbracht wurde, im Vergleich zu M\u00e4usen mit keinem PGC1 und normalen ERR\u03b3-Spiegeln.<\/p>\n

\"From
Von links (vordere Reihe): Ruth Yu, Ronald Evans, Wanda Waizenegger; (mittlere Reihe): Annette Atkins, Nanhai He, Weiwei Fan; (hintere Reihe): Michael Downes, Zong Wei. <\/p>\n

Klicken Sie hier<\/a> f\u00fcr ein hochaufl\u00f6sendes Bild. <\/p>\n

Kredit: Salk Institut<\/figcaption><\/figure>\n

\u201cJetzt, da wir dieses direkte Ziel (ERR\u03b3) f\u00fcr trainingsinduzierte Ver\u00e4nderungen identifiziert haben\u201d, sagt Weiwei Fan, wissenschaftlicher Mitarbeiter am Salk Institute und Erstautor der Arbeit, \u201ck\u00f6nnten wir m\u00f6glicherweise ERR\u03b3 aktivieren und die gleichen Ver\u00e4nderungen hervorrufen, die durch Training induziert werden.\u201d<\/p>\n

Zus\u00e4tzlich zur Erh\u00f6hung der Anzahl von Mitochondrien in Skelettmuskelzellen erh\u00f6hte ERR\u03b3 auch den muskul\u00e4ren Blutfluss.<\/p>\n

\u201cMan braucht eine bessere Blutzufuhr, um mehr Energie zu bekommen und toxische Metaboliten abzutransportieren\u201d, sagt Michael Downes, leitender Wissenschaftler am Salk Institute und Co-Seniorautor der Arbeit. \u201cERR\u03b3 f\u00f6rdert die Vaskularisation und die Mitochondrien.\u201d<\/p>\n

Aber vielleicht ist die wichtigste Erkenntnis, dass ERR\u03b3 ein bedeutendes therapeutisches Ziel sein k\u00f6nnte, um gesch\u00e4digte Muskeln zu reparieren.<\/p>\n

\u201cMitochondrien spielen eine zentrale Rolle in Zellen im ganzen K\u00f6rper, aber besonders in Muskelzellen, die tendenziell mehr Energie ben\u00f6tigen\u201d, sagt Evans. \u201cWir wissen jetzt, dass ERR\u03b3 durch Steigerung der mitochondrialen Energieproduktion tats\u00e4chlich gesch\u00e4digte Muskeln retten kann. Wenn wir kleine Molek\u00fcle identifizieren k\u00f6nnen, die gezielt auf ERR\u03b3 abzielen, hoffen wir Menschen mit Muskeldystrophie und anderen Skelettmuskelerkrankungen helfen zu k\u00f6nnen.\u201d<\/p>\n

Weitere Autoren waren Nanhai He, Chun Shi Lin, Zong Wei, Nasun Hah, Wanda Waizenegger, Ming-Xiao He, Ruth T. Yu und Annette R. Atkins am Salk und Christopher Liddle an der Sydney Medical School.<\/p>\n

Diese Studie wurde finanziert durch: das Office of Naval Research (ONR N00014-16-1-3159), die National Institutes of Health (DK057978, HL105278, HL088093, ES010337 und CA014195), das National Institute of Environmental Health Sciences (P42ES010337), das Department of the Navy, Office of Naval Research (N00014-16-1-3159), den National Health and Medical Research Council of Australia (512354 und 632886), den The Leona M. and Harry B. Helmsley Charitable Trust (#2017PG-MED001), die Samuel Waxman Cancer Research Foundation, Ipsen\/Biomeasure und die Glenn Foundation for Medical Research. Der Inhalt liegt allein in der Verantwortung der Autoren und spiegelt nicht notwendigerweise die offiziellen Ansichten der National Institutes of Health wider.<\/p>","protected":false},"featured_media":16836,"template":"","faculty":[91],"disease-research":[123],"class_list":["post-16834","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-ronald-evans","disease-research-metabolism-and-diabetes"],"acf":[],"yoast_head":"\nSalk scientists find power switch for muscles - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/de\/news-release\/salk-scientists-find-power-switch-muscles\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk scientists find power switch for muscles - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014If you\u2019ve ever wondered how strenuous exercise translates into better endurance, researchers at the Salk Institute may have your answer. In a study published in the journal Cell Reports on March 6, 2018, scientists in Ronald Evans\u2019 lab have shown that the protein ERR\u03b3 (ERR gamma) helps deliver many of the benefits associated with endurance exercise.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/de\/news-release\/salk-scientists-find-power-switch-muscles\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-30T23:20:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/03\/HEPKO-press3-1500.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"1500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-find-power-switch-muscles\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-find-power-switch-muscles\\\/\",\"name\":\"Salk scientists find power switch for muscles - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-find-power-switch-muscles\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-find-power-switch-muscles\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2018\\\/03\\\/HEPKO-press3-1500.jpg\",\"datePublished\":\"2018-03-06T17:49:53+00:00\",\"dateModified\":\"2024-01-30T23:20:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-find-power-switch-muscles\\\/#breadcrumb\"},\"inLanguage\":\"de-DE\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-find-power-switch-muscles\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de-DE\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-find-power-switch-muscles\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2018\\\/03\\\/HEPKO-press3-1500.jpg\",\"contentUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2018\\\/03\\\/HEPKO-press3-1500.jpg\",\"width\":1500,\"height\":1500},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-find-power-switch-muscles\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Salk scientists find power switch for muscles\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de-DE\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de-DE\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Salk scientists find power switch for muscles - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/de\/news-release\/salk-scientists-find-power-switch-muscles\/","og_locale":"de_DE","og_type":"article","og_title":"Salk scientists find power switch for muscles - Salk Institute for Biological Studies","og_description":"LA JOLLA\u2014If you\u2019ve ever wondered how strenuous exercise translates into better endurance, researchers at the Salk Institute may have your answer. In a study published in the journal Cell Reports on March 6, 2018, scientists in Ronald Evans\u2019 lab have shown that the protein ERR\u03b3 (ERR gamma) helps deliver many of the benefits associated with endurance exercise.","og_url":"https:\/\/www.salk.edu\/de\/news-release\/salk-scientists-find-power-switch-muscles\/","og_site_name":"Salk Institute for Biological Studies","article_modified_time":"2024-01-30T23:20:07+00:00","og_image":[{"width":1500,"height":1500,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/03\/HEPKO-press3-1500.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-find-power-switch-muscles\/","url":"https:\/\/www.salk.edu\/news-release\/salk-scientists-find-power-switch-muscles\/","name":"Salk scientists find power switch for muscles - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-find-power-switch-muscles\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-find-power-switch-muscles\/#primaryimage"},"thumbnailUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/03\/HEPKO-press3-1500.jpg","datePublished":"2018-03-06T17:49:53+00:00","dateModified":"2024-01-30T23:20:07+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-find-power-switch-muscles\/#breadcrumb"},"inLanguage":"de-DE","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/salk-scientists-find-power-switch-muscles\/"]}]},{"@type":"ImageObject","inLanguage":"de-DE","@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-find-power-switch-muscles\/#primaryimage","url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/03\/HEPKO-press3-1500.jpg","contentUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/03\/HEPKO-press3-1500.jpg","width":1500,"height":1500},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/salk-scientists-find-power-switch-muscles\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Salk scientists find power switch for muscles"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"Salk-Institut f\u00fcr biologische Studien","description":"Die Macht der Wissenschaft","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"de-DE"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"Salk-Institut f\u00fcr biologische Studien","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"de-DE","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"hero":"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/03\/HEPKO-press-header.jpg","line_1":"Salk scientists find power switch for muscles","line_2":"ERR\u03b3 gene enables endurance exercise and repairs type of damage seen in neuromuscular diseases","gallery":false,"paper_url":"http:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(18)30228-6","journal_title":"Cell Reports","paper_author_list":"Weiwei Fan, Nanhai He, Chun Shi Lin, Zong Wei, Nasun Hah, Wanda Waizenegger, Ming-Xiao He, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Michael Downes and Ronald M. Evans","paper_title":"ERR promotes angiogenesis, mitochondrial biogenesis and oxidative remodeling in PGC1\/-deficient muscle","subhead":"ERR\u03b3 gene enables endurance exercise and repairs type of damage seen in neuromuscular diseases","home_photo":"","listing_photo":"","legacy_boilerplate":[],"hide_boilerplate":[],"disable_date":false,"listing_excerpt":"","descriptive_blurb":"","has_journal_cover":false,"poster_quote":"","doi":"","og_image_override":false},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/16834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":11,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/16834\/revisions"}],"predecessor-version":[{"id":31290,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disclosure\/16834\/revisions\/31290"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/media\/16836"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/media?parent=16834"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/faculty?post=16834"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/de\/wp-json\/wp\/v2\/disease-research?post=16834"}],"curies":[{"name":"WP","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}